For the article entitled"Efficacy of a combination of dutasteride,tadalafil,and solifenacin in the treatment of previously unsuccessful patients"[Asian J Urol 9(2022)42-50,D0l:https://doi.org/10.1016/j.ajur....For the article entitled"Efficacy of a combination of dutasteride,tadalafil,and solifenacin in the treatment of previously unsuccessful patients"[Asian J Urol 9(2022)42-50,D0l:https://doi.org/10.1016/j.ajur.2021.04.002],the authors would like to correct some imprecise descriptions.The authors would like to sincerely apologize for these mistakes.展开更多
Objective To evaluate the efficacy and safety of simultaneous administration of dutasteride,tadalafil and solifenacin in the treatment of benign prostatic hyperplasia(BPH)with overactive bladder symptoms and lower uri...Objective To evaluate the efficacy and safety of simultaneous administration of dutasteride,tadalafil and solifenacin in the treatment of benign prostatic hyperplasia(BPH)with overactive bladder symptoms and lower urinary tract obstruction in previously unsuccessfully treated men.Methods Patients in Group A(n=97)received dutasteride 0.5 mg/day,tadalafil 2.5 mg/day,and solifenacin 2.5 mg/day;Group B(n=95)received dutasteride 0.5 mg/day,tadalafil 5 mg/day,and solifenacin 5 mg/day;Group C(n=103)received dutasteride 0.5 mg/day,tadalafil 20 mg/day,and solifenacin 10 mg/day.The functional status of the lower urinary tract was assessed using the International Prostate Symptom Score(I-PSS),Overactive Bladder Questionnaire(OABq),International Index of Erectile Function(IIEF),and Male Sexual Health Questionnaire Ejaculatory Dysfunction(MSHQ-EjD)as well as uroflowmetry.Results The total score of the sexual function remained unchanged in Group B of patients 81.3 points vs.80.2 points(p>0.05)according to MSHQ-EjD,61.4 points vs.51.2 points(p>0.05)according to IIEF data.The total assessment of symptoms of hyperactivity significantly decreased in Group C according to OABq data after the 4th week of the study(17.5 points vs.26.1 points,p<0.05)and remained below the baseline until the end of the study(15.2 points).Conclusions The simultaneous administration of standard doses of dutasteride,solifenacin,and tadalafil for 3 months is safe,effective,and can be recommended for patients with BPH to reduce symptoms of obstruction and hyperactivity of the bladder and maintain sexual function.展开更多
What is a lie? Why do people tell lies? What compels them to make false utterances? How do people treat lie, deception or fudge? Is the attitude to them the same in different cultures? If not, what differences ar...What is a lie? Why do people tell lies? What compels them to make false utterances? How do people treat lie, deception or fudge? Is the attitude to them the same in different cultures? If not, what differences are there? An answer to these and some other questions is being sought in the paper. Producing a false utterance, the sender deprives the communication partner of the right to receive full information. The article presents views of Russians and representatives of Anglo-American culture on telling lies drawing the readers' attention to very serious situations, such as family conflicts between spouses, aggravated with lies. The material for analysis is taken from the texts by Russian playwright Anton Chekhov and the American novel writer Irwin Shaw. The analysis is based on the study of verbal and non-verbal markers of false utterances generated by quarreling spouses. A complex method of researching the literary material combining linguistic, extra-linguistic, and paralinguistic analysis of conflict speech acts with false utterances of different kinds is applied.展开更多
文摘For the article entitled"Efficacy of a combination of dutasteride,tadalafil,and solifenacin in the treatment of previously unsuccessful patients"[Asian J Urol 9(2022)42-50,D0l:https://doi.org/10.1016/j.ajur.2021.04.002],the authors would like to correct some imprecise descriptions.The authors would like to sincerely apologize for these mistakes.
文摘Objective To evaluate the efficacy and safety of simultaneous administration of dutasteride,tadalafil and solifenacin in the treatment of benign prostatic hyperplasia(BPH)with overactive bladder symptoms and lower urinary tract obstruction in previously unsuccessfully treated men.Methods Patients in Group A(n=97)received dutasteride 0.5 mg/day,tadalafil 2.5 mg/day,and solifenacin 2.5 mg/day;Group B(n=95)received dutasteride 0.5 mg/day,tadalafil 5 mg/day,and solifenacin 5 mg/day;Group C(n=103)received dutasteride 0.5 mg/day,tadalafil 20 mg/day,and solifenacin 10 mg/day.The functional status of the lower urinary tract was assessed using the International Prostate Symptom Score(I-PSS),Overactive Bladder Questionnaire(OABq),International Index of Erectile Function(IIEF),and Male Sexual Health Questionnaire Ejaculatory Dysfunction(MSHQ-EjD)as well as uroflowmetry.Results The total score of the sexual function remained unchanged in Group B of patients 81.3 points vs.80.2 points(p>0.05)according to MSHQ-EjD,61.4 points vs.51.2 points(p>0.05)according to IIEF data.The total assessment of symptoms of hyperactivity significantly decreased in Group C according to OABq data after the 4th week of the study(17.5 points vs.26.1 points,p<0.05)and remained below the baseline until the end of the study(15.2 points).Conclusions The simultaneous administration of standard doses of dutasteride,solifenacin,and tadalafil for 3 months is safe,effective,and can be recommended for patients with BPH to reduce symptoms of obstruction and hyperactivity of the bladder and maintain sexual function.
文摘What is a lie? Why do people tell lies? What compels them to make false utterances? How do people treat lie, deception or fudge? Is the attitude to them the same in different cultures? If not, what differences are there? An answer to these and some other questions is being sought in the paper. Producing a false utterance, the sender deprives the communication partner of the right to receive full information. The article presents views of Russians and representatives of Anglo-American culture on telling lies drawing the readers' attention to very serious situations, such as family conflicts between spouses, aggravated with lies. The material for analysis is taken from the texts by Russian playwright Anton Chekhov and the American novel writer Irwin Shaw. The analysis is based on the study of verbal and non-verbal markers of false utterances generated by quarreling spouses. A complex method of researching the literary material combining linguistic, extra-linguistic, and paralinguistic analysis of conflict speech acts with false utterances of different kinds is applied.