Dermatomyositis (DM) is an inflammatory myopathy of skeletal muscle with characteristic cutaneous findings.It is a rare disorder with a bimodal age distribution that affects almost twice as many women as men.One categ...Dermatomyositis (DM) is an inflammatory myopathy of skeletal muscle with characteristic cutaneous findings.It is a rare disorder with a bimodal age distribution that affects almost twice as many women as men.One category of DM, normal-enzyme DM, is characterized by cutaneous changes only at baseline, normal serum muscle enzyme levels and myositis demonstrated by electromyography (EMG) and/or muscle biopsy specimens.Typically, patients with normal-enzyme DM progress to severe muscle involvement and require systemic corticosteroid therapy.The patient we report has normal-enzyme DM confirmed by serial serum enzymes, EMG, and skin and muscle biopsies but is unique in that she never experienced progression of muscle weakness although muscle involvement was documented histologically and by EMG.Follow-up examination after 1 year revealed near-complete resolution of cutaneous involvement after topical therapy and no evidence of muscle weakness.展开更多
Objective This article was to review the current status of adult mesenchymal stem cells transplantation for muscle regeneration in urinary tract and propose the future prospect in this field. Data sources The data use...Objective This article was to review the current status of adult mesenchymal stem cells transplantation for muscle regeneration in urinary tract and propose the future prospect in this field. Data sources The data used in this review were mainly obtained from articles listed in Medline and PubMed （2000- 2013）. The search terms were ＂mesenchymal stem cells＂, ＂bladder＂, ＂stress urinary incontinence＂ and ＂tissue engineering＂. Study selection Articles regarding the adult mesenchymal stem cells for tissue engineering of bladder and stress urinary incontinence were selected and reviewed. Results Adult mesenchymal stem cells had been identified and well characterized in human bone marrow, adipose tissue, skeletal muscle and urine, and demonstrated the capability of differentiating into smooth muscle cells and skeletal muscle ceils under myogenic differentiation conditions in vitro. Multiple preclinicat and clinical studies indicated that adult mesenchymal stem cells could restore and maintain the structure and function of urinary muscle tissues after transplanted, and potentially improve the quality of life in patients. Conclusions Smooth or skeletal myogenic differentiation of mesenchymal stem cells with regenerative medicine technology may provide a novel approach for muscle regeneration and tissue repair in urinary tract. The long-term effect and safety of mesenchymal stem cell transplantation should be further evaluated before this approach becomes widely used in patients.展开更多
文摘Dermatomyositis (DM) is an inflammatory myopathy of skeletal muscle with characteristic cutaneous findings.It is a rare disorder with a bimodal age distribution that affects almost twice as many women as men.One category of DM, normal-enzyme DM, is characterized by cutaneous changes only at baseline, normal serum muscle enzyme levels and myositis demonstrated by electromyography (EMG) and/or muscle biopsy specimens.Typically, patients with normal-enzyme DM progress to severe muscle involvement and require systemic corticosteroid therapy.The patient we report has normal-enzyme DM confirmed by serial serum enzymes, EMG, and skin and muscle biopsies but is unique in that she never experienced progression of muscle weakness although muscle involvement was documented histologically and by EMG.Follow-up examination after 1 year revealed near-complete resolution of cutaneous involvement after topical therapy and no evidence of muscle weakness.
基金grants from the National Natural Science Foundation of China，Specialized Research Fund for the Doctoral Program of Higher Education in China
文摘Objective This article was to review the current status of adult mesenchymal stem cells transplantation for muscle regeneration in urinary tract and propose the future prospect in this field. Data sources The data used in this review were mainly obtained from articles listed in Medline and PubMed （2000- 2013）. The search terms were ＂mesenchymal stem cells＂, ＂bladder＂, ＂stress urinary incontinence＂ and ＂tissue engineering＂. Study selection Articles regarding the adult mesenchymal stem cells for tissue engineering of bladder and stress urinary incontinence were selected and reviewed. Results Adult mesenchymal stem cells had been identified and well characterized in human bone marrow, adipose tissue, skeletal muscle and urine, and demonstrated the capability of differentiating into smooth muscle cells and skeletal muscle ceils under myogenic differentiation conditions in vitro. Multiple preclinicat and clinical studies indicated that adult mesenchymal stem cells could restore and maintain the structure and function of urinary muscle tissues after transplanted, and potentially improve the quality of life in patients. Conclusions Smooth or skeletal myogenic differentiation of mesenchymal stem cells with regenerative medicine technology may provide a novel approach for muscle regeneration and tissue repair in urinary tract. The long-term effect and safety of mesenchymal stem cell transplantation should be further evaluated before this approach becomes widely used in patients.
