A study of precancerous gastric lesion was conducted in a randomly selected high risk population in Linqu, Shandong Province of China. 849 subjects aged from 30-64 were examined bioptically. There were 8 cases of gast...A study of precancerous gastric lesion was conducted in a randomly selected high risk population in Linqu, Shandong Province of China. 849 subjects aged from 30-64 were examined bioptically. There were 8 cases of gastric cancer, the prevalence rate was 0.9%. 169 subjects were diagnosed to be dysplasia, the prevalence rate of dysplasia was increased significantly with age. The regression equation was Y=0.47X-0.25. The prevalence of CAG was found in 36 per cent of the studied subjects and both dysplasia and CAG were more serious in the antrum than the. fundus. The results showed a natural history of precancerous gastric lesions in a high risk population in a high risk area.展开更多
The relationships between serum pepsinogen (PG) levels and age, sex, ABO blood type, cigarette smoking and diet were studied among over 3, 000 residents selected at random in an area with high risk of stomach cancer i...The relationships between serum pepsinogen (PG) levels and age, sex, ABO blood type, cigarette smoking and diet were studied among over 3, 000 residents selected at random in an area with high risk of stomach cancer in Shandong Province, China. Males had significantly higher median PG Ⅰ and Ⅱ levels than feamles. PG Ⅰ tended to decrease and PG Ⅱ to rise with age. Subjects with blood type A had a higher PG Ⅱ level than subjects with other blood types. Both PG Ⅰ and Ⅱ levels rose with dally consumption of cigarettes. Alcohol consumption was not related to PG levels. The PG Ⅰ/Ⅱ ratio declined with increasing consumption of sour pancakes, a fermented staple food found to contain N-nitroso compounds and to be a risk factor for stomach cancer in this population.展开更多
A population-based screening for stomach cancer (SC) and its precancerous lesions was conducted in Linqu County, Shandong, China, one of the highest SC rates found in China and the world. An analysis of precancerous s...A population-based screening for stomach cancer (SC) and its precancerous lesions was conducted in Linqu County, Shandong, China, one of the highest SC rates found in China and the world. An analysis of precancerous stomach lesions revealed that chronic atrophic gastritis (CAG) was a universal common among people aged 35-64 (96-98%). For 52% and 20% of the residents in this age group had Intestinal metaplasia (IM) or dysplssia (DYS). These more advanced lesions were more pronounced in the antrum for both males and females. Age-specific prevalence rates in different anatomic locations sshowed that CAG, developed in the antrum, particularly along the lesser curvature earter than other sites and spread to fundus. IM and DYS accrued under the background of CAG with a leading time in the antrum than the other part of the stomach. Although CAG, IM and DYS prevalence rates were higher in the antrum than In the fundus, the prevalence rates showed a similar smoothly slope, a result of accumulated somatic geneticdamage, suggesting a similar biological response to the stimulation of initiator of carcinogenesis, promoter leading to progression to SC.展开更多
Objective To study the activity of Puerarin (Pue) in scavenging oxygen free radical (OFR) and its inhibitory effect on the oxidative modification of low density lipoprotein (LDL). Methods Riboflavin-light system was...Objective To study the activity of Puerarin (Pue) in scavenging oxygen free radical (OFR) and its inhibitory effect on the oxidative modification of low density lipoprotein (LDL). Methods Riboflavin-light system was used to generate superoxide anion, and Fenton reaction to generate hydroxyl free radical to study the activity of Pue in scavenging OFR. Hydrogen peroxide-induced hemolysis was used to study the effect of Pue on erythrocyte hemolysis and malondialdehyde (MDA) production. And ultraviolet ray and cupric sulfate were used to cause the oxidative modification of LDL for studying the inhibitory effect of Pue on LDL oxidative modification. Results (1) Pue could, at concentration of 0. 01 – 1.0 mmol/L, scavenge superoxide anion radical and at concentration of 7.5–75μmol/L scavenge hydroxyl radical in a concentration dependent manner. (2) Pue could, at concentration of 0.1–10 mmol/L, inhibit significantly oxidative hemolysis and MDA production of erythrocyte induced by hydrogen peroxide. (3) Pue of 0.01–1.0 mmol/L could inhibit the oxidative modification of LDL in a concentration dependent manner. Conclusion Pue has an anti-peroxidation effect and shows a potential effect in preventing atherosclerosis.展开更多
文摘A study of precancerous gastric lesion was conducted in a randomly selected high risk population in Linqu, Shandong Province of China. 849 subjects aged from 30-64 were examined bioptically. There were 8 cases of gastric cancer, the prevalence rate was 0.9%. 169 subjects were diagnosed to be dysplasia, the prevalence rate of dysplasia was increased significantly with age. The regression equation was Y=0.47X-0.25. The prevalence of CAG was found in 36 per cent of the studied subjects and both dysplasia and CAG were more serious in the antrum than the. fundus. The results showed a natural history of precancerous gastric lesions in a high risk population in a high risk area.
文摘The relationships between serum pepsinogen (PG) levels and age, sex, ABO blood type, cigarette smoking and diet were studied among over 3, 000 residents selected at random in an area with high risk of stomach cancer in Shandong Province, China. Males had significantly higher median PG Ⅰ and Ⅱ levels than feamles. PG Ⅰ tended to decrease and PG Ⅱ to rise with age. Subjects with blood type A had a higher PG Ⅱ level than subjects with other blood types. Both PG Ⅰ and Ⅱ levels rose with dally consumption of cigarettes. Alcohol consumption was not related to PG levels. The PG Ⅰ/Ⅱ ratio declined with increasing consumption of sour pancakes, a fermented staple food found to contain N-nitroso compounds and to be a risk factor for stomach cancer in this population.
文摘A population-based screening for stomach cancer (SC) and its precancerous lesions was conducted in Linqu County, Shandong, China, one of the highest SC rates found in China and the world. An analysis of precancerous stomach lesions revealed that chronic atrophic gastritis (CAG) was a universal common among people aged 35-64 (96-98%). For 52% and 20% of the residents in this age group had Intestinal metaplasia (IM) or dysplssia (DYS). These more advanced lesions were more pronounced in the antrum for both males and females. Age-specific prevalence rates in different anatomic locations sshowed that CAG, developed in the antrum, particularly along the lesser curvature earter than other sites and spread to fundus. IM and DYS accrued under the background of CAG with a leading time in the antrum than the other part of the stomach. Although CAG, IM and DYS prevalence rates were higher in the antrum than In the fundus, the prevalence rates showed a similar smoothly slope, a result of accumulated somatic geneticdamage, suggesting a similar biological response to the stimulation of initiator of carcinogenesis, promoter leading to progression to SC.
文摘Objective To study the activity of Puerarin (Pue) in scavenging oxygen free radical (OFR) and its inhibitory effect on the oxidative modification of low density lipoprotein (LDL). Methods Riboflavin-light system was used to generate superoxide anion, and Fenton reaction to generate hydroxyl free radical to study the activity of Pue in scavenging OFR. Hydrogen peroxide-induced hemolysis was used to study the effect of Pue on erythrocyte hemolysis and malondialdehyde (MDA) production. And ultraviolet ray and cupric sulfate were used to cause the oxidative modification of LDL for studying the inhibitory effect of Pue on LDL oxidative modification. Results (1) Pue could, at concentration of 0. 01 – 1.0 mmol/L, scavenge superoxide anion radical and at concentration of 7.5–75μmol/L scavenge hydroxyl radical in a concentration dependent manner. (2) Pue could, at concentration of 0.1–10 mmol/L, inhibit significantly oxidative hemolysis and MDA production of erythrocyte induced by hydrogen peroxide. (3) Pue of 0.01–1.0 mmol/L could inhibit the oxidative modification of LDL in a concentration dependent manner. Conclusion Pue has an anti-peroxidation effect and shows a potential effect in preventing atherosclerosis.
