A combinatorial strategy based on nucleic acid assembly and electrostatic complexation is developed for efficient small interfering ribonucleic acid(siRNA)delivery.In this approach,siRNAs are first loaded into a well-...A combinatorial strategy based on nucleic acid assembly and electrostatic complexation is developed for efficient small interfering ribonucleic acid(siRNA)delivery.In this approach,siRNAs are first loaded into a well-defined nanotube through programmable nucleic acid self-assembly.Compared to small rigid siRNA duplex,the obtained siRNA-bearing nanotube with large architecture is more readily to complex with cationic and ionizable poly(β-amino ester),resulting in the formation of a novel platform for efficient siRNA delivery.展开更多
基金This work was supported by the National Key Research and Development Program of China(Nos.2018YFC1106102,2018YFA0902600)the National Natural Science Foundation of China(Nos.51973112,51690151,81871329)+1 种基金the Science Foundation of the Shanghai Municipal Science and Technology Commission,China(Nos.18JC1410800,19JC1410300)the Project of the Shanghai Outstanding Technology Leader,China(No.19XD1431900).
文摘A combinatorial strategy based on nucleic acid assembly and electrostatic complexation is developed for efficient small interfering ribonucleic acid(siRNA)delivery.In this approach,siRNAs are first loaded into a well-defined nanotube through programmable nucleic acid self-assembly.Compared to small rigid siRNA duplex,the obtained siRNA-bearing nanotube with large architecture is more readily to complex with cationic and ionizable poly(β-amino ester),resulting in the formation of a novel platform for efficient siRNA delivery.
