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Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes:A Randomized,Placebo-controlled,Calcium Supplementation Trial 被引量:6
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作者 YU Bo WU HongYing +5 位作者 LI Fang GONG Jie ZHOU DunJin ZHANG ZhiFeng YANG XiaoGuang HUANG ZhenWu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2011年第3期243-248,共6页
Objective To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different Fokl vitamin D receptor (VDR) genotypes (FF, Ff, and ff) after weaning or resumption o... Objective To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different Fokl vitamin D receptor (VDR) genotypes (FF, Ff, and ff) after weaning or resumption of menstruation during lactation. Methods A total of 40 subjects with the same Fokl VDR genotype were randomly divided into two groups: one received calcium tablet (600 mg once daily as CaCO3) and the other placebo tablet once daily for 1 year. At baseline, BMD was measured by dual-energy X-ray absorptiometry at lumbar spine (L2-L4) and at left hip whereas serum PICP, serum OC, and urinary CTX, serum 25(OH)VitD3, and serum estradiol were measured at weaning and I year thereafter. Results After the intervention, BMD at lumbar spine and at left hip increased significantly in all these women with a trend among different Fokl VDR genotypes such as FF 〉 Ff 〉 ff (P〈O.05, 〈0.01, and 〈0.001, respectively). BMD at lumbar spine in women with FF VDR genotype increased much more rapidly than in those with ff VDR genotype (P〈0.05). Compared with the control group women with the FF genotype regained more BMD after calcium supplementation (P〈0.05). Conclusion Daily calcium 600 mg supplementation has beneficial effect on the bone health of women with FF VDR genotype. 展开更多
关键词 Fokl VDR genotype Calcium supplementation Bone mineral accretion after weaning Chinese women Low dietary calcium intake.
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Disinfection and Protective Measures for Makeshift Hospitals 被引量:2
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作者 WANG Jia Qi LIU Xiao Li +6 位作者 DUAN Hong Yang CHEN Xiao Min QIAN Le LYU Xi Fang CHENG Yi Bin LIANG Jian Sheng YAO Xiao Yuan 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2020年第12期940-942,共3页
During the COVID-19 epidemic,Wuhan city had the hardest hit in China.The treatment capacity of the local medical system exceeded due to the rapid growth of COVID-19 cases.As a result,a considerable part of diagnosed p... During the COVID-19 epidemic,Wuhan city had the hardest hit in China.The treatment capacity of the local medical system exceeded due to the rapid growth of COVID-19 cases.As a result,a considerable part of diagnosed patients could not be admitted to hospitals for isolation and treatment in time,causing the risk of spreading in the community.To effectively achieve the goals of controlling the source of infection by cutting off the transmission route,increasing the cure rate and reducing the mortality rate,Wuhan has reconstructed several makeshift hospitals based on large public places. 展开更多
关键词 China. admitted WUHAN
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Molecular Epidemiology and Sequencing of the G-L Intergenic Region of Rabies Viruses Isolated in China 被引量:8
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作者 Sheng-Li MENG Ge-Lin XU +8 位作者 Jia-Xin YAN Ping-Gang MING Jie WU Xiao-MingYANG He-Tian MING Feng-Cai ZHU Dun-Jin ZHOU QI-You XIAO Guan-Mu DONG 《中国病毒学》 CSCD 2007年第1期26-33,共8页
一组 25 个狂犬病病毒(RABV ) ,从 24 条狗和一个人的盒子恢复了,在在 2004 和 2006 之间的中国从各种各样的区域被收集。G-L intergenic 区域的基因、种系发生的分析在 25 街 RABV 被执行孤立, CTN 疫苗 7 拉紧代。学习基于 519 bp... 一组 25 个狂犬病病毒(RABV ) ,从 24 条狗和一个人的盒子恢复了,在在 2004 和 2006 之间的中国从各种各样的区域被收集。G-L intergenic 区域的基因、种系发生的分析在 25 街 RABV 被执行孤立, CTN 疫苗 7 拉紧代。学习基于 519 bp 核苷酸顺序的比较,包含 G-L intergenic 区域。中国街紧张的核苷酸顺序相同从 95.5% ~ 100% 。种系发生的分析证明中国的所有孤立清楚地在 Lyssavirus 遗传型 1 支持了所有中国病毒的放置,他们根据他们的地理起源是分布式的。所有仔细中国紧张被联系,但是他们能仍然被划分成二个组:一些街紧张和一些 CTN 紧张。这研究基于 G-L Intergenic 区域的序列关于狂犬病病毒的分子的传染病学介绍细节。关键词狂犬病病毒 - 分子的传染病学 - G-L intergenic 区域 - 中国 CLC 数字 R373.33 基础条款:第 10 国家 five-year-plan (2004BA718 b03 ) 的关键技术 R&D 展开更多
关键词 Rabies virus Molecular Epidemiology G-L intergenic region China
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Combination Use of PFGE and Drug-resistant Analysis in the Epidemiological Investigation of Listeria Monocytogenes 被引量:2
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作者 LV Jun ZHENG Xiang Mei +2 位作者 CHENG Shi Xiu ZHENG Hua Ying ZENG Ying Chun 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第4期314-318,共5页
Listeria monocytogenes is the pathogen of listeriosis and it causes severe infections like septicemia, encephalitis, and meningitis, especially in immunocompromised individuals, newborns, and pregnant women. Its wide ... Listeria monocytogenes is the pathogen of listeriosis and it causes severe infections like septicemia, encephalitis, and meningitis, especially in immunocompromised individuals, newborns, and pregnant women. Its wide distribution in the environment and ability to survive or even grow under adverse conditions has made L. monocytogenes an important public health concern and in food industry. 展开更多
关键词 PFGE Combination Use of PFGE and Drug-resistant Analysis in the Epidemiological Investigation of Listeria Monocytogenes
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Seasonal variations of tris (2-chloroethyl) phosphate and cytotoxicity of organic extracts in water samples from Wuhan, China 被引量:1
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作者 Youjian Zhang Wenjuan Zhang +6 位作者 Jian Hou Xian Wang Wenhong Lu Hongyan Zheng Wei Xiong Junling Liu Jing Yuan 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2019年第2期299-309,共11页
Tris(2-chloroethyl) phosphate(TCEP) is a typical phosphate flame retardant. Its potential adverse health effects have recently aroused concern. We investigated the seasonal variations of TCEP concentrations in the raw... Tris(2-chloroethyl) phosphate(TCEP) is a typical phosphate flame retardant. Its potential adverse health effects have recently aroused concern. We investigated the seasonal variations of TCEP concentrations in the raw, finished and tap water samples from two drinking water treatment plants(DWTPs) in China, and evaluated the cytotoxicity and apoptosis/necrosis of organic extracts(OEs) in water samples. We enriched TCEP and OEs in water samples by solid-phase extraction method. The TCEP concentrations in water samples were determined by gas chromatography–mass spectrometry. Normal human liver cell line L02 was treated with OEs in the water samples, and then the cytotoxicity and apoptosis/necrosis were measured by 3-(4, 5-dimethyithiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay and flow cytometry, respectively. The results showed that cytotoxicities of OEs in raw water samples from both DWTPs in summer and winter were stronger than those in spring and autumn, cytotoxicity of OEs in finished and tap water samples from both DWTPs in summer and autumn were stronger than those in spring and winter. In all seasons, the maximal concentrations(100 mL water/mL cell culture) of OEs in the raw water samples from both DWTPs induced late apoptosis/necrosis. The reasons for seasonal variations of TCEP in water samples and potential toxic effects of other pollutants in the water samples need to be further investigated. 展开更多
关键词 TRIS (2-chloroethyl) PHOSPHATE CYTOTOXICITY Organic extract Apoptosis NECROSIS
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Implication of Reported Viral Hepatitis Incidence Rate Change in Hubei Province, China, between 2004-2010
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作者 胡樱 宇传华 +1 位作者 陈邦华 王雷 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2012年第3期428-433,共6页
This study examined the change of reported incidence rate for viral hepatitis in Hubei province, China, between 2004 to 2010 to provide scientific evidence for viral hepatitis control. Reported viral hepatitis infecti... This study examined the change of reported incidence rate for viral hepatitis in Hubei province, China, between 2004 to 2010 to provide scientific evidence for viral hepatitis control. Reported viral hepatitis infection cases were queried from Centre for Disease Control of Hubei Province, China. The incidence of viral hepatitis A decreased steadily across the study period. Viral hepatitis B composed 85% of the viral hepatitis cases. When reported incidence rates for chronic hepatitis B increased, the rates of acute and unclassified cases dropped from 2005 to 2010. The reported viral hepatitis B incidence rate for males was around 1.5-2 times higher than for females. The average annual percentage change of reported viral hepatitis B incidence rates was 4%. The same index for viral hepatitis C was 28%. The reported viral hepatitis B incidence rate of people under 20 years old declined over the period. This decrease was mainly attributed to the recent implementation of vaccination plan. Reported incidence rate of viral hepatitis E also rose in those years. Having a better understanding on reported incidence rates of the present surveillance system is important for developing strategies for further prevention of viral hepatitis. In addition, the data showed that a surveillance system that differentiates new and former infected cases will be more effective in providing evidence for disease control. 展开更多
关键词 viral hepatitis reported incidence rate VACCINATION PREVENTION
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An Outbreak of NCIP (2019-nCoV) Infection in China --Wuhan, Hubei Province, 2019−2020 被引量:31
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作者 The 2019-nCoV Outbreak Joint Field Epidemiology Investigation Team Qun Li 《China CDC weekly》 2020年第5期79-80,共2页
Emerging and re-emerging pathogens are great challenges to the public health(1).A cluster of cases of viral pneumonia of unknown etiology(VPUE),now known as novel coronavirus-infected pneumonia(NCIP),occurred in Wuhan... Emerging and re-emerging pathogens are great challenges to the public health(1).A cluster of cases of viral pneumonia of unknown etiology(VPUE),now known as novel coronavirus-infected pneumonia(NCIP),occurred in Wuhan,Hubei Province and was reported to health authorities on December 29,2019(2).A national,provincial,and municipal joint investigation team has been assembled to conduct field investigations and implement disease control and prevention measures.This report shows interim results of the investigation and makes recommendations for response measures. 展开更多
关键词 PREVENTION WUHAN HUBEI
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An investigation of changes in water quality throughout the drinking water production/distribution chain using toxicological and fluorescence analyses
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作者 Xue Han Xin Ji +5 位作者 Xuan Ma Jun-Ling Liu Zhen-Yu He Wei Chang Fei Tang Ai-Lin Liu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2020年第1期310-318,共9页
Changes in water quality from source water to finished water and tap water at two conventional drinking water treatment plants(DWTPs)were monitored.Beside the routine water quality testing,Caenorhabditis elegans-based... Changes in water quality from source water to finished water and tap water at two conventional drinking water treatment plants(DWTPs)were monitored.Beside the routine water quality testing,Caenorhabditis elegans-based toxicity assays and the fluorescence excitation–emission matrices technique were also applied.Both DWTPs supplied drinking water that met government standards.Under current test conditions,both the investigated finished water and tap water samples exhibited stronger lethal,genotoxic and reprotoxic potential than the relative source water sample,and the tap water sample was more lethal but tended to be less genotoxic than the corresponding finished water sample.Meanwhile,the nearly complete removal of tryptophan-like substances and newly generated tyrosine-like substances were observed after the treatment of drinking water,and humic-like substances were identified in the tap water.Based on these findings,toxic pollutants,including genotoxic/reproductive toxicants,are produced in the drinking water treatment and/or distribution processes.Moreover,further studies are needed to clarify the potentially important roles of tyrosine-like and humic-like substances in mediating drinking water toxicity and to identify the potential sources of these contaminants.Additionally,tryptophan-like fluorescence may be adopted as a useful parameter to monitor the treatment performance of DWTPs.Our observations provided insights into the importance of utilizing biotoxicity assays and fluorescence spectroscopy as tools to complement the routine evaluation of drinking water. 展开更多
关键词 BIOASSAY C.elegans EEM Water treatment Distribution system
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Detection of SARS-CoV-2 RNA in Medical Wastewater in Wuhan During the COVID-19 Outbreak
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作者 Jun-Bo Zhou Wen-Hua Kong +4 位作者 Sheng Wang Yi-Bing Long Lian-Hua Dong Zhen-Yu He Man-Qing Liu 《Virologica Sinica》 SCIE CAS CSCD 2021年第5期1077-1079,共3页
Dear Editor,The outbreak of 2019 novel coronavirus disease(COVID-19),caused by the infection of SARS-Co V-2,was first reported in Wuhan,China(Kong et al.2020a,2020b)and has become the most serious public health emerge... Dear Editor,The outbreak of 2019 novel coronavirus disease(COVID-19),caused by the infection of SARS-Co V-2,was first reported in Wuhan,China(Kong et al.2020a,2020b)and has become the most serious public health emergency in the century(Matsuzaki et al.2010;World Health Organization 2020).The fecal shedding of SARS-Co V-2 has been proven by the viral strains isolated from COVID-19 patient’s stool specimens(Wang et al.2020).It proposed the possibility that contaminated waste water and fomites might be involved in disease transmission(Tang et al.2020),especially at the healthcare facilities with large number of patients. 展开更多
关键词 WASTEWATER COV WUHAN
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Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study 被引量:111
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作者 Li-Li Ren Ye-Ming Wang +33 位作者 Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2020年第9期1015-1024,共10页
Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,... Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. 展开更多
关键词 Bat-origin CORONAVIRUS Zoonotic transmission PNEUMONIA ETIOLOGY Next-generation sequencing
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Serologic Response to SARS-CoV-2 in COVID-19 Patients with Different Severity 被引量:5
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作者 Wen-Hua Kong Rong Zhao +5 位作者 Jun-Bo Zhou Fang Wang De-Guang Kong Jian-Bin Sun Qiong-Fang Ruan Man-Qing Liu 《Virologica Sinica》 SCIE CAS CSCD 2020年第6期752-757,共6页
The immense patient number caused by coronavirus disease 2019(COVID-19)global pandemic brings the urge for more knowledge about its immunological features,including the profile of basic immune parameters.In this study... The immense patient number caused by coronavirus disease 2019(COVID-19)global pandemic brings the urge for more knowledge about its immunological features,including the profile of basic immune parameters.In this study,eighty-eight reported COVID-19 patients in Wuhan were recruited from January to February,2020,including 32 severe/critical cases and56 mild/moderate cases.Their mean age was 56.43 years(range 17–83)and gender ratio(male/female)was 43:45.We tested SARS-CoV-2 RNA with commercial kits,investigated the level of serologic IgM and IgG antibodies against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)using magnetic particle chemiluminescence immunoassays,and compared the results of serologic tests and nucleic acid test(NAT).Among 88 patients,95.45%were confirmed as positive by the combination of NAT and antibody test,which was significantly higher(P<0.001)than by single nucleic acid test(73.86%)or serologic test(65.91%).Then the correlation between temporal profile and the level of antibody response was analyzed.It showed that seroconversion started on day 5 after disease onset and IgG level was rose earlier than IgM.Comparison between patients with different disease severity suggested early seroconversion and high antibody titer were linked with less severe clinical symptoms.These results supported the combination of serologic testing and NAT in routine COVID-19 diagnosis and provided evidence on the temporal profile of antibody response in patients with different disease severity. 展开更多
关键词 COVID-19 Nucleic acid test(NAT) Serologic test Real-time polymerase chain reaction(RT-PCT) Chemiluminescence immunoassay(CLIA)
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