Correlation Analysis of Personality Characteristics of Children with TIC Disorder with Family Factors

Objective To explore the personality characteristics of children with tic disorders and their relationship with family factors. Methods Sixty cases of children with tic disorders diagnosed in our hospital were selected as the case group and 65 cases of normal children were selected as the control group. The children of two groups were assessed using Eysenck Personality Questionnaire(EPQ), Family Environment Scale(FES-CV) and general situation questionnaire of family(GSQ), respectively. The scores of EPQ personality characteristics, FES-CV and GSQ scores were compared for the children in the two groups. The Person correlation analysis method was used to analyze the correlation between personality scores of children in case group and family environment factors. Results The general situation questionnaire results showed that there was significant statistically difference in parenting style, parental education level and family types of the children between case group and control group(P<0.05); EPQ results showed that the neuroticism and psychoticism scores of children in the case group were significantly higher than those in the control group(P<0.05) and the lying degree scores in the control group were significantly higher than those in the case group(P<0.05); FES-CV results showed that the family cohesion scores of the case group were significantly lower than those of the control group(P<0.05), and the family conflict scores in the case group were significantly higher than those in the control group(P<0.05). The Person correlation analysis results indicated that the psychoticism score was negatively correlated with the score of family cohesion(P<0.05), and positively correlated with family conflict(P<0.05), while the neuroticism score was positively correlated with family conflict score(P<0.05). Conclusion The children with tic disorders have significant personality deviation compared to the normal children, and the personality deviation degree is correlated to family contradiction, and family cohesion.

Clinical and genetic analysis of Dent disease with nephrotic range albuminuria in Shaanxi, China

Dear Editor,Dent disease is a rare X-linked recessive disease that was first reported by Charles Enrique Dent and M.Friedman in 1964(Dent and Friedman,1964).Dent disease is caused by mutations in the CLCN5(Dent disease 1)or OCRL1(Dent disease 2).The condition is characterized by proximal renal tubular dysfunction that manifests as low molecular weight proteinuria(LMWP),hypercalciuria,nephrocalcinosis or nephrolithiasis,and progressive renal failure.Typically,the total protein excretion in tubular proteinuria is lower than that in glomerular diseases;therefore,nephrotic range proteinuria(NP)is not prevalent in patients with documented CLCN5 or OCRL1 mutations.Here,we report the cases of six Chinese children with Dent disease who manifested NP and were finally diagnosed using genetic analysis.Our aim was to elucidate the characteristics of Dent disease in Shaanxi area to facilitate possible improvements in its detection and treatment.