Application effect of exercise rehabilitation therapy in elderly patients with chronic heart failure

Objective:To investigate the effects of rehabilitation exercise therapy on 6-minute walking distance (6 minute walk distance, 6MWD), brain natriuretic titanium (Brain natriuretic peptide, BNP) and (Minnesota heart failure quality of life scale, MLHFQ score in elderly patients with chronic heart failure (CHF).Methods: Choose xi'an medical college affiliated hospital heart treated with 96 cases of elderly patients with chronic heart failure (from January 2016 to January 2018), according to random number table method, divide the patients as control group and observation group 48 cases/group, control group to implement regular heart failure treatment, the observation group in the control group, the implementation of rehabilitation exercise therapy on the basis of comparing the clinical curative effect of two groups of indicators, heart colour to exceed, 6 MWDS, BNP levels, plate movement, MLHFQ score. Results: (1) compared with the control group, the total effective rate of the observation group was higher than that of the control group (P<0.05). (2). After treatment, the left ventricular end-diastolic diameter (Left ventricular end diastolic diameter, LVEDD) and the left ventricular end-systolic diameter (Left ventricular end systolic diameter, LVESD), BNP) in the observation group were higher than those in the control group. All the MLHFQ scores were lower than those in the control group (P<0.05). The left ventricular ejection fraction (Left ventricular ejection fraction, LVEF), stroke output (Stroke volume, SV) and treadmill metabolic equivalent (Metabolic equivalent, METs) were higher than those in the control group (P<0.05). The treadmill exercise time was longer than that in the control group (P<0.05), and its 6MWD was higher than that in the control group (P<0.05).Conclusion: Rehabilitation exercise therapy in elderly patients with chronic heart failure can effectively improve the cardiac function, enhance their exercise endurance and energy metabolism level, and improve the clinical efficacy and quality of life.

ART2 Networks Used for Paced ECG Analysis

The PQRST segment which include the major information in a heart beatis detected and used as the input pattern to cluster by ART2 model. The parametersof pacemaker which consist of pulse, QRS characteristics, clustering results andprogrammed parameters are combined in analyzing paced ECG (PECG) synthetically.

Construction of multiple concentration gradients for single-cell level drug screening

Isolation and manipulation of single cells play a crucial role in drug screening.However,previously reported single-cell drug screening lacked multiple-dose concentration gradient studies,which limits their ability to predict drug performance accurately.To solve this problem,we constructed a multiconcentration gradient generator in which a Tai Chi-spiral mixer can accelerate solution mixing in a short time and produce a linear concentration gradient.Later,a gradient generator combined with a single-cell capture array was adopted to investigate the effects of single or combined doses of 5-fluorouracil and cisplatin on human hepatoma cells and human breast carcinoma cells(at the single-cell level).The results showed that both drugs were effective in inhibiting the growth of cancer cells,and the combination was more effective for human hepatoma cells.In addition,the relationship between the biomechanical heterogeneity(e.g.,deformability and size)of tumor cells and potential drug resistance at the single-cellevel was investigated,indicating that small and/or deformable cells were more resistant than large and/or less deformable cells.The device provides a simple and reliable platform for studying the optimal dosage of different drug candidates at the single-cell level and effectively screening single-agent chemotherapy regimens and combination therapies.