Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(...Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(FASN).1,2 The bidirectional relationships of oncogenic signaling and de novo lipogenesis(DNL)suggest that FASN is a druggable target in many cancers.展开更多
Natural product biosynthesis is controlled at multiple levels.Characterization of naturally occurring promoters has facilitated the study of the synthetic biology of natural products.Herein,we report the discovery of ...Natural product biosynthesis is controlled at multiple levels.Characterization of naturally occurring promoters has facilitated the study of the synthetic biology of natural products.Herein,we report the discovery of two highyield actinomycin D(ActD)-producing streptomycetes and the identification of a strong bidirectional acmN2p promoter from the ActD gene clusters and its application in heterologous expression of three core genes involved in the bacterial alkaloid bohemamine biosynthesis,providing a good example for identification of new promoters for synthetic biological applications.展开更多
基金This work was supported in parts by the National Natural Science Foundation of China(82173688)the Chinese Ministry of Education 111 Project(BP0820034)+2 种基金The science and technology innovation Program of Hunan Province(2021 RC4067)Hunan Provincial Natural Science Foundation of China(2021J130791)the Hunan Provincial Innovation Foundation for Postgraduate(NO.2019zzts332).
文摘Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(FASN).1,2 The bidirectional relationships of oncogenic signaling and de novo lipogenesis(DNL)suggest that FASN is a druggable target in many cancers.
基金supported in parts by National Natural Science Foundation of China grants(82173688 and 82373772)The science and technology innovation Program of Hunan Province(2021RC4067)+2 种基金a research fund from Institute of Health and Medicine(IHM),Hefei Comprehensive National Science Center(to Y.H.)the Chinese Ministry of Education 111 Project(BP0820034)(to Y.D.)the Fundamental Research Funds for the Central Universities of Central South University 2020zzts247(to D.T.).
文摘Natural product biosynthesis is controlled at multiple levels.Characterization of naturally occurring promoters has facilitated the study of the synthetic biology of natural products.Herein,we report the discovery of two highyield actinomycin D(ActD)-producing streptomycetes and the identification of a strong bidirectional acmN2p promoter from the ActD gene clusters and its application in heterologous expression of three core genes involved in the bacterial alkaloid bohemamine biosynthesis,providing a good example for identification of new promoters for synthetic biological applications.
