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Objective To report the experience of treatment of childhood phimosis with topical steroid. Methods October 2001 to April 2003,40 boys with a mean 8.7 years diagnosed with phimosis were treated From age of with a topical steroid. The patients were prescribed with a lmonth course of 0.05 % betamethasone cream by applying twice per day.

Improvement of neurological function in rats with spinal cord injury after the transplantation of neural stem cells directly differentiated from bone marrow mesenchymal stem cells

Objective To study the effect and mechanism of neurological function recovery in rats with spinal cord injury ( SCI) rats after transplantation of neural stem cells which are directly differentiated from bone marrow mesenchymal stem cells ( BMSC ) ,and to investigate the suitable engraftment time. Methods BMSC at 3rd passage were differentiated into neural stem cells ( NSC) , and immunofluorescence staining was used to

Association between sleep quality/physical activity and metabolic syndrome in urban population of Xinjiang

Objective To explore the relationship between sleep/physical activity and metabolic syndrome(MS)in urban population of Xinjiang.Methods This is a prospective,cross-sectional study.From July 2019 to September 2021,a two-stage random sampling method was used to randomly select residents aged 30-74 years from two communities in Urumqi of northern Xinjiang and Korla of southern Xinjiang.General situation questionnaire。

Analysis of non-alcoholic fatty liver disease differences from metabolic dysfunction-associated fatty liver disease based on clinical features

Objective To explore the clinical features of fatty liver disease (FLD) from non-alcoholic fatty liver disease(NAFLD) to metabolic dysfunction-associated fatty liver disease (MASLD),so as to elucidate its clinical application value under three renames.

Analysis of clinical characteristics and risk factors for nosocomial mortality in patients with liver cirrhosis combined with atrial arrhythmia

Objective To analyze and explore the clinical characteristics and risk factors related to nosocomial mortality in patients with liver cirrhosis combined with atrial arrhythmia.Methods 252 hospitalized patients with liver cirrhosis combined with atrial arrhythmia from January 2014 to December 2021 were enrolled,and their clinical characteristics were analyzed.

Short-term efficacy and safety of cardiac contractility modulation in patients with heart failure

Objective To investigate the short-term efficacy and safety of cardiac contractility modulation (CCM) in patients with heart failure.Methods This was a cross-sectional study of patients with heart failure who underwent CCM placement at the First Affiliated Hospital of Xinjiang Medical University from February to June 2022.

The correlation between human leukocyte antigen-DRBl alleles and anti-neutrophil cytoplasmatic antibodies in Han and Uygur ulcerative colitis patients in Xinjiang region

Objective To study the correlation between human leukocyte antigen(HLA)-DRBl alleles and anti-neutrophil cytoplasmatic antibodies(ANCA) in Han and Uygur ulcerative colitis(UC) patients in Xinjiang region. Methods The serum ANCA was determined by indirect immunofluorescence assay in 62 Uygur UC patients,58

Association between LMNA mutation and familial and idiopathic dilated cardiomyopathy patients in Xinjiang

Objective To explore the association between LMNA gene mutation and familiar dilated cardiomyopathy(DCM)(FDCM)and idiopathic DCM(IDCM)in Uygurs and Han people in Xinjiang area.Methods Peripheral blood samples were collected from 28 family member with FDCM and 123 sporadic patients with IDCM(56 Uygur patients and 67 Han patients),80

Pulse pressure level and its related factors in patients with impaired fasting glucose in Xinjiang Uygur,Kazak and Han nationality

Objective To analyze pulse pressure(PP)level and its related factors in patients with impaired fasting glucose in Xinjiang Uygur,Kazak and Han nationality.Methods A cross-sectional survey was conducted in 6928subjects in Uygur,Kazak and Han residents aged 30 to80 years old in Xinjiang province.Pulse pressure level and its related factors in patients with impaired

Association of GCKR gene rs780094 polymorphism with hyperuricemia in Uygur in Xinjiang

Objective To investigate the relationship between glucokinase regulator protein(GCKR)gene polymorphism rs780094 and hyperuricemia in Uygur in Xinjiang.Methods A case-control study including 1 026 patients with hyperuricemia and 1 030 normal subjects was conducted.All the subjects were genotyped for GCKR

Impact of interaction between NLRP3,TLR4 gene polymorphisms and triglyceride-glucose index on gout

Objective To explore the effect of triglyceride glucose(TyG)index,single nucleotide polymorphism of Toll-like receptor 4(TLR4)and NOD-like receptor thermal protein domain associated protein 3(NLRP3)genes,and its interaction on the risk of gout.Methods A total of 315 male patients with gout and 499 men for health checkup at the same period were selected.General data were collected through questionnaires,and peripheral venous blood was collected for biochemical test.

Construction and validation of a Nomogram-based prediction model for the risk of gout in men

Objective To investigate the risk factors of gout and establish a columnar graph model to predict the risk of gout development.Methods A total of 1032 Han Chinese men attending the Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University,People’s Hospital of Xinjiang Uygur Autonomous Region,and the First Affiliated Hospital of Xinjiang Medical University from 2018 to 2020 were selected as study subjects and divided into training set(722 cases)and validation set(310 cases)by simple random sampling method in the ratio of 7:3.

Qihong capsule for chronic heart failure patients with Qi deficiency and blood stasis syndrome:a randomized controlled trial

Objective To observe the clinical efficacy of Qihong Capsule in the treatment of chronic heart failure(CHF).Methods By the method of random parallel controlled drugs,patients were randomly divided into trial group(39 cases)and control group(39 cases).Trial group was treated with the Western medicine to chronic heart failure(CHF)and Qihong Capsule foundation treatment。

Study on the correlation between dietary inflammatory index and reflux esophagitis

Objective To evaluate the correlation between inflammatory diet and reflux esophagitis(RE)with the dietary inflammatory index(DⅡ),and to provide scientific evidence for the prevention and treatment of RE at the level of dietary guidance.Methods From December 2021 to September 2022,145 RE patients(RE group)who visited the First Affiliated Hospital of Xinjiang Medical University were recruited.

基于缺口分析对新疆综合医院《医学科研诚信和相关行为规范》执行效果的实证研究

目的探讨新疆某综合医院《医学科研诚信和相关行为规范》执行效果,为医学科研诚信建设提供理论依据。方法根据缺口分析理论设计医院《医学科研诚信和相关行为规范》执行效果满意度调査问卷,对调査医院101名科研人员进行调查,了解其对医院科研诚信建设各方面政策的评价及应重点改进的方面。结果缺口分析结果显示医院在“科研诚信管理机构建设”和“学术不端行为处理办法及规定”建设方面缺口值较大,是目前科研诚信建设急需改进的方面。结论医院要进一步完善科研诚信建设制度,结合医学发展特点及国家相应政策发展,加强科研管理工作创新,为科研活动创造健康积极的环境,促进科研诚信建全面建设和长久发展。

Association of interleukin-6 and C-reactive protein genetic polymorphisms levels with venous thromboembolism

Background Increased levels of interleukin-6 （IL-6） and C-reactive protein （CRP） have been reported in patients with venous thromboembolisms （VTE）. However, prospective studies did not confirm an association between IL-6, CRP and their polymorphism with the risk of VTE. Methods One hundred and forty patients （including 66 males and 74 females, mean age （55.55±17.11） years） and one hundred and sixty controls （including 74 males and 86 females, mean age （56.58±12.24） years） were involved. An enzyme linked immunosorbent assay （ELISA） method was used for detecting the serum levels of inflammatory factors IL-6 and CRP in both groups. Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was used for analyzing the distribution of polymorphisms at the -572C/G and -597G/A sites of the promoter of the IL-6 gene and at 1059G/C of the CRP gene. Results Serum levels of IL-6 and CRP were significantly higher in the VTE group than in the control group （P 〈0.05）. The frequencies of-572C/G promoter polymorphisms CC, CG, and GG in the IL-6 gene were found to be 34%, 48%, and 18%, respectively, and the derived allele frequencies for the C and G alleles were 58% and 42%. There was a significant difference in the -572C/G promoter polymorphisms between the VTE group and control group （P 〈0.05）. For the -597G/A polymorphism, individuals all carried the GG and GA type; AA genotypes were not detected. The frequency of the GG, GC, and CC genotypes at the CRP1059G/C promoter was 87.57%, 7.86% and 3.57% in V-rE group, while 86.25%, 10%, and 3.75% in control group, respectively. The frequency of G and C alleles at CRP 1059G/C was 91.43% and 8.57% in VTE group and 91.56% and 8.44% in the control group. The results showed that there was no statistically significant difference of 1059G/C genotype and mutation frequency of the allele between the VTE group and control group （P 〉0.05）. Multiple Logistic regression analysis showed CC homozygotes of the IL-6 -572G/C, body mass index （BMI）, and CRP, IL-6, and high-density lipoprotein cholesterol （HDL-C） were independent risk factors for VTE （P 〈0.05）. Conclusions We found that V-rE was associated with IL-6 and CRP levels, and there was an association of IL-6 and its promoter polymorphism at -572G/C with the risk of VTE. Thus far, a causal relationship between inflammation and VTE remains to be clarified and more prospective data are required.

The association of serum uric acid level with prevalence of non-alcoholic fatty liver in Uyghur and Han ethnicities

Objective To explore the association of serum uric acid level with non-alcoholic fatty liver disease(NAFLD) in Han and Uyghur ethnic groups. Methods A cross-sectional study was performed in the population in 2011 in the First Affiliated Hospital of Xinjiang Medical University.

Effect of modified Zhisou powder on the lung function of chronic obstructive pulmonary disease model rats of northwest China cold dryness syndrome

Objective To observe Modified Zhisou Powder(MZP)on the lung function of chronic obstructive pulmonary disease(COPD)model rats of northwest China cold dryness syndrome(NCCDS).Methods Totally 90male Wistar rats were randomly divided into three groups,i.e.,the normal control group(n=20),the COPD model group(n=35),and the COPD of

The clinical analysis of atrial fibrillation of 1310 in patients in Urumqi of China

Objective To investigate the clinical features and current therapy of atrial fibrillation(AF)of inpatients in Urumqi,China.Methods The clinical data of inpatients diagnosed with AF from January 2008 to December,2012,in 12 hospitals in Urumqi were retrospectively analyzed.Results Totally 1 310 AF inpatients were enrolled in this study with the age of(64.8±3.3)years old and a men to women ratio of 1.39.Most

Transplantation of adipose-derived stem cells with fibrin glue for treatment of acute myocardial infarction in rat

Objective To investigate the cell survival of the combination of fibrin glue and adiposederived stem cells(ADSCs) in rats when implanted into ischemic myocardium and the improvement of heart function. Methods The rat ADSCs were isolated from the subcutaneous