Objective： To investigate the effect of pricking blood therapy on behavior and brainstem c-los and c-jun gene expression in migraine rats. Methods： A rat model of migraine was made with nitroglycerol. The rats were ...Objective： To investigate the effect of pricking blood therapy on behavior and brainstem c-los and c-jun gene expression in migraine rats. Methods： A rat model of migraine was made with nitroglycerol. The rats were treated by pricking blood. Rat behavior was observed. Brainstem c-fos and c-jun gene expression was examined by immunohistochemistry. Results： Ear redness improved significantly, the number of head scratchings decreased obviously （P〈0.05） and c-fos and c-jun expression was reduced markedly （P〈0.01） in the treatment group after pricking blood compared with the model group and the blank group. Conclusion： Pricking blood treatment can improve behavior indices and reduce c-fos and c-jun positive expression in migraine rats.展开更多
基金Administration of Traditional Chinese Medicine of Guangdong Province (2040049)
文摘Objective： To investigate the effect of pricking blood therapy on behavior and brainstem c-los and c-jun gene expression in migraine rats. Methods： A rat model of migraine was made with nitroglycerol. The rats were treated by pricking blood. Rat behavior was observed. Brainstem c-fos and c-jun gene expression was examined by immunohistochemistry. Results： Ear redness improved significantly, the number of head scratchings decreased obviously （P〈0.05） and c-fos and c-jun expression was reduced markedly （P〈0.01） in the treatment group after pricking blood compared with the model group and the blank group. Conclusion： Pricking blood treatment can improve behavior indices and reduce c-fos and c-jun positive expression in migraine rats.
