In this study,the effects of intermetallic compounds(Mg_(17)Al_(12)and Al_(8)Mn_(5))on the Mg-Al layered double hydroxide(LDH)formation mechanism and corrosion behavior of an in-situ LDH/Mg(OH)_(2)steam coatings on AZ...In this study,the effects of intermetallic compounds(Mg_(17)Al_(12)and Al_(8)Mn_(5))on the Mg-Al layered double hydroxide(LDH)formation mechanism and corrosion behavior of an in-situ LDH/Mg(OH)_(2)steam coatings on AZ80 Mg alloy were investigated.Citric acid(CA)was used to activate the alloy surface during the pretreatment process.The alloy was first pretreated with CA and then subjected to a hydrothermal process using ultrapure water to produce Mg-Al-LDH/Mg(OH)_(2)steam coating.The effect of different time of acid pretreatment on the activation of the intermetallic compounds was investigated.The microstructure and elemental composition of the obtained coatings were analyzed using FE-SEM,EDS,XRD and FT-IR.The corrosion resistance of the coated samples was evaluated using different techniques,i.e.,potentiodynamic polarization(PDP),electrochemical impedance spectrum(EIS)and hydrogen evolution test.The results indicated that the CA pretreatment significantly influenced the activity of the alloy surface by exposing the intermetallic compounds.The surface area fraction of Mg_(17)Al_(12)and Al_(8)Mn_(5)phases on the surface of the alloy was significantly higher after the CA pretreatment,and thus promoted the growth of the subsequent Mg-Al-LDH coatings.The CA pretreatment for 30 s resulted in a denser and thicker LDH coating.Increase in the CA pretreatment time significantly led to the improvement in corrosion resistance of the coated AZ80 alloy.The corrosion current density of the coated alloy was lower by three orders of magnitude as compared to the uncoated alloy.展开更多
Background Boron(B)deficiency is an important factor for poor seed cotton yield and fiber quality.However,it is often missing in the plant nutrition program,particularly in developing countries.The current study inves...Background Boron(B)deficiency is an important factor for poor seed cotton yield and fiber quality.However,it is often missing in the plant nutrition program,particularly in developing countries.The current study investigated B’s effect on growth,yield,and fiber quality of Bt(CIM-663)and non-Bt(Cyto-124)cotton cultivars.The experimental plan consisted of twelve treatments:Control(CK);B at 1 mg·kg^(−1) soil application(SB1);2 mg·kg^(−1) B(SB2);3 mg·kg^(−1) B(SB3);0.2%B foliar spray(FB1);0.4%B foliar spray(FB2);1 mg·kg^(−1) B+0.2%B foliar spray(SB1+FB1);1 mg·kg^(−1) B+0.4%B foliar spray(SB1+FB2);2 mg·kg^(−1) B+0.2%B foliar spray(SB2+FB1);2 mg·kg^(−1) B+0.4%B foliar spray(SB2+FB2);3 mg·kg^(−1) B+0.2%B foliar spray(SB3+FB1);3 mg·kg^(−1) B+0.4%B foliar spray(SB3+FB2).Each treat-ment has three replications,one pot having two plants per replication.Results B nutrition at all levels and methods of application significantly(P≤0.05)affected the growth,physiological,yield,and fiber quality characteristics of both cotton cultivars.However,SB2 either alone or in combination with foliar spray showed superiority over others,particularly in the non-Bt cultivar which responded better to B nutrition.Maxi-mum improvement in monopodial branches(345%),sympodial branches(143%),chlorophyll-a(177%),chlorophyll-b(194%),photosynthesis(169%),and ginning out turn(579%)in the non-Bt cultivar was found with SB2 compared with CK.In Bt cultivar,although no consistent trend was found but integrated use of SB3 with foliar spray performed relatively better for improving cotton growth compared with other treatments.Fiber quality characteristics in both cultivars were improved markedly but variably with different B treatments.Conclusion B nutrition with SB2 either alone or in combination with foliar spray was found optimum for improving cotton’s growth and yield characteristics.展开更多
Objective:To determine the relationship between family functioning and depression in primary caregivers of stroke survivors in China.Design:Baseline cross-sectional data from an intervention study for stroke survivors...Objective:To determine the relationship between family functioning and depression in primary caregivers of stroke survivors in China.Design:Baseline cross-sectional data from an intervention study for stroke survivors and their families were used.Setting:Neurology inpatient service of a large urban hospital.Participants:Stroke survivors(n=180),each with a primary caregiver,were enrolled in this study.The mean age of stroke survivors was 65.60 years,and the mean age of primary caregivers was 57.60 years.Interventions:Not applicable.Methods:The Family Assessment Device(FAD)and Center for Epidemiologic Studies Depression Scale(CES-D),respectively,were used.Results:Following a stroke of a family member,71%of caregivers experienced depressive symptoms.Higher depression severity in caregivers was linked to caregiver education,stroke survivor ADLs,and family functioning.Conclusion:Assessment of family functioning may help determine which caregivers are most at risk for developing depressive syndrome.展开更多
In the field of information security,a gap exists in the study of coreference resolution of entities.A hybrid method is proposed to solve the problem of coreference resolution in information security.The work consists...In the field of information security,a gap exists in the study of coreference resolution of entities.A hybrid method is proposed to solve the problem of coreference resolution in information security.The work consists of two parts:the first extracts all candidates(including noun phrases,pronouns,entities,and nested phrases)from a given document and classifies them;the second is coreference resolution of the selected candidates.In the first part,a method combining rules with a deep learning model(Dictionary BiLSTM-Attention-CRF,or DBAC)is proposed to extract all candidates in the text and classify them.In the DBAC model,the domain dictionary matching mechanism is introduced,and new features of words and their contexts are obtained according to the domain dictionary.In this way,full use can be made of the entities and entity-type information contained in the domain dictionary,which can help solve the recognition problem of both rare and long entities.In the second part,candidates are divided into pronoun candidates and noun phrase candidates according to the part of speech,and the coreference resolution of pronoun candidates is solved by making rules and coreference resolution of noun phrase candidates by machine learning.Finally,a dataset is created with which to evaluate our methods using information security data.The experimental results show that the proposed model exhibits better performance than the other baseline models.展开更多
Using ab initio total energy calculations with the full-potential linearized augmented plane wave method, the possibilities of magnetism in one-dimensional In and Tl wires were explored and their properties as the fun...Using ab initio total energy calculations with the full-potential linearized augmented plane wave method, the possibilities of magnetism in one-dimensional In and Tl wires were explored and their properties as the function of geometric structures were studied. The results suggest that the linear In and Tl wires show magnetization at the equilibrium bond distance with magnetic moments of 0.71 and 0.67 μB/atom, respectively. Allowing ions to relax, the wires were deformed as zigzag structures, but no dimerization occurs. The zigzag wires also exhibit spontaneous magnetization, although the magnetic moments are lower than those of straight wires.展开更多
A novel side chain liquid crystalline polymer (SCLCP) combining the polysiloxane as main chain with azo-based mesogen moieties as side chain through a flexible spacer has been synthesized by the hydrosilylation reacti...A novel side chain liquid crystalline polymer (SCLCP) combining the polysiloxane as main chain with azo-based mesogen moieties as side chain through a flexible spacer has been synthesized by the hydrosilylation reaction using Cp_2PtCl_2 as catalyst. The phase transition behavior of both side chain monomer (AZO-C_6C_(11))and polymer (P-AZO-C_6C_(11))has been characterized via combination of hot-stage polarized microscope, DSC and X-ray diffraction methods (including temperature-variation and quenching techniques). As normal, the transition process included K→S→N→I. Some pretransition features have been observed.展开更多
Objective:To explore the best time for progesterone supplementation in AID ovulation induction cycles by Letrozole.Methods: The data analysed in this study were collected from 509 patients who were performed AID (Arti...Objective:To explore the best time for progesterone supplementation in AID ovulation induction cycles by Letrozole.Methods: The data analysed in this study were collected from 509 patients who were performed AID (Artificial Insemination by Donor) administrated letrozole (LE) between 2014.8-2015.7. All patients were randomly divided into 4 groups by the time of progesterone administrated, including experimental group and the control group. The experimental group was divided into group 1-72 h after ovulation, group 2-48 h after ovulation, group 3-24 h after ovulation and control group—without administrated LE. The gestation and live birth rate were evaluated by monitoring vaginal ultrasound and HCG blood value 14 d after AID.Results: The pregnancy rate with administrated progesterone added 72 h after ovulation was 31.9%, which was significantly higher than those of other groups, the same situation as groups added progesterone was significantly higher than the control group. However, there was no significant difference in the numbers of abortions among the four groups. The LBR of group 4 was significantly lower than that of group 1.Conclutions: Progesterone administrated 72 h after ovulation can promoted the gestation rate, but did not affect the rate of miscarrage .展开更多
The Wireless Local Area Network (WLAN) is a new and developing technology and the security problem is always important in all networks; therefore, the security problems will be discussed in this article. The article f...The Wireless Local Area Network (WLAN) is a new and developing technology and the security problem is always important in all networks; therefore, the security problems will be discussed in this article. The article firstly introduces the history of development of IEEE 802.11 and provides an overview of the Wireless LAN. The architecture of WLAN will be referred in next. Finally, the further of the wireless LAN will be prospected by this article.展开更多
Large deformability and high sensitivity is difficult to be realized simultaneously in flexible sensors.Herein,taking advantage of the high permittivity and highly active surfaces of the ultrasmall barium titanate nan...Large deformability and high sensitivity is difficult to be realized simultaneously in flexible sensors.Herein,taking advantage of the high permittivity and highly active surfaces of the ultrasmall barium titanate nanoparticles(BT NPs)and the high stretchability of the p(BA-GMA)elastomer matrix,we propose a high-performance soft stretchable sensor.The addition of the ultrasmall BT NPs can not only increase the permittivity and capacitance of polyacrylate-matrix composite dielectric material to obtain a high sensitivity,but also basically maintains the excellent mechanical properties of the polymer matrix.The dielectric constants of the composite films increase from 5.68 to 13.13 at 10 kHz with the increase of BT NPs content from 0 to 15 vol.%,which results in a high capacitance of 236.16 pF for 15 vol.%BT/p(BA-GMA)sensor.Combining the high permittivity and the large deformability(a maximal deformation of 87.2%),the 15 vol.%BT/p(BA-GMA)sensor has high sensitivity and shows high linearity and stable output even if under dynamic measurement.The dual-mode sensor that utilizes the orthogonality of capacitance-resistance is designed,which shows excellent performance in monitoring human body movements and noncontact measurement.The results present that the BT/p(BA-GMA)-based sensor has high stability and reliability not exceed 65C,which can meet the application requirements in dynamic monitoring.展开更多
Background:Endothelial dysfunction,the initial pathogenic factor in atherosclerosis,can be alleviated via transient limb ischemia.We observed the effects of regular transient limb ischemia (RTLI) on atherosclerosis in...Background:Endothelial dysfunction,the initial pathogenic factor in atherosclerosis,can be alleviated via transient limb ischemia.We observed the effects of regular transient limb ischemia (RTLI) on atherosclerosis in hypercholesterolemic rabbits.Methods:Twenty-eight rabbits were randomized to control,cholesterol,sham,ischemia groups (n=7 each) between October 2010 and March 2011.They were fed a normal diet in the control group and hypercholesterolemic diet in other groups for 12 weeks.Six cycles of RTLI were performed once per day on the ischemia group.Serum samples were prepared to measure the total cholesterol (TC),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C) before the experiment (W0),at the end of weeks 4,8,12 (W4,W8,W12).The whole aorta was harvested at W12 and stained using Sudan IV to identify the plaque.The plaque area was measured using Image J.Results were analyzed by analysis of variance or rank sum test.Results:Concentrations of TC in the cholesterol group were higher than those in the control group at W4 (29.60 [23.75,39.30] vs.1.00 [0.80,1.55],Z =–2.745,P = 0.006),W8 (41.78 [28.08,47.37] vs.0.35 [0.10,0.68],Z =–2.739,P = 0.006),W12 (48.32 [40.04,48.95] vs.0.61 [0.50,0.86],Z =–2.739,P = 0.006).Similar results were obtained for HDL-C and LDL-C.Serum concentrations of TC,HDL-C,and LDL-C in the hypercholesterolemic groups had no differences (all P > 0.05).The percentage of plaque area in the cholesterol group was higher than that in the control group (47.22 ± 23.89% vs.0,Z =–2.986,P = 0.003).Square root of the percentage of plaque area was smaller in the ischemia group than that in the cholesterol (0.44 ± 0.13 vs.0.67 ± 0.18,P = 0.014) or sham groups (0.44 ± 0.13 vs.0.61 ± 0.12,P = 0.049).Conclusion:In hypercholesterolemic rabbits,RTLI might prevent atherosclerosis progression by reducing the percentage of plaque area.展开更多
Colorectal cancer(CRC) is the second most common cause of cancer-related death in the world. The pro-viral integration site for Moloney murine leukemia virus 1(PIM1) is a proto-oncogene and belongs to the serine/threo...Colorectal cancer(CRC) is the second most common cause of cancer-related death in the world. The pro-viral integration site for Moloney murine leukemia virus 1(PIM1) is a proto-oncogene and belongs to the serine/threonine kinase family, which are involved in cell proliferation, migration,and apoptosis. Fibroblast growth factor receptor 1(FGFR1) is a tyrosine kinase that has been implicated in cell proliferation, differentiation and migration. Small molecule HCI-48 is a derivative of chalcone, a class of compounds known to possess anti-tumor, anti-inflammatory and antibacterial effects. However,the underlying mechanism of chalcones against colorectal cancer remains unclear. This study reports that HCI-48 mainly targets PIM1 and FGFR1 kinases, thereby eliciting antitumor effects on colorectal cancer growth in vitro and in vivo. HCI-48 inhibited the activity of both PIM1 and FGFR1 kinases in an ATPdependent manner, as revealed by computational docking models. Cell-based assays showed that HCI-48inhibited cell proliferation in CRC cells(HCT-15, DLD1, HCT-116 and SW620), and induced cell cycle arrest in the G2/M phase through modulation of cyclin A2. HCI-48 also induced cellular apoptosis, as evidenced by an increase in the expression of apoptosis biomarkers such as cleaved PARP, cleaved caspase 3 and cleaved caspase 7. Moreover, HCI-48 attenuated the activation of downstream components of the PIM1 and FGFR1 signaling pathways. Using patient-derived xenograft(PDX) murine tumor models,we found that treatment with HCI-48 diminished the PDX tumor growth of implanted CRC tissue expressing high protein levels of PIM1 and FGFR1. This study suggests that the inhibitory effect of HCI-48 on colorectal tumor growth is mainly mediated through the dual-targeting of PIM1 and FGFR1kinases. This work provides a theoretical basis for the future application of HCI-48 in the treatment of clinical CRC.展开更多
A systematic ab initio study on magnetism of the 3d transition metals(TM) from atom to monoatomic wire within density functional theory with generalized gradient approximation(GGA) was performed.The results show t...A systematic ab initio study on magnetism of the 3d transition metals(TM) from atom to monoatomic wire within density functional theory with generalized gradient approximation(GGA) was performed.The results show that the spin coupling has strong intraatomic exchange strengths about 1 eV for isolated 3d TM atoms.The magnetic moments are distinctly lower than those of free atoms for all dimers except Mn 2 .All the 3d TM elements exhibit magnetic ground states in the linear wire structure.展开更多
Objective:Liver cancer is one of the most common types of cancer.We aimed to use the cancer registration data in 2015 to estimate the incidence and mortality of liver cancer in Henan province.Methods:The data from 37 ...Objective:Liver cancer is one of the most common types of cancer.We aimed to use the cancer registration data in 2015 to estimate the incidence and mortality of liver cancer in Henan province.Methods:The data from 37 population-based cancer registries in Henan province were collected for this study.The pooled data were stratified by area,sex,and age group.New cases of liver cancer and deaths due to the disease were estimated using age-specific rates and provincial population in 2015.All incidence and death rates were age standardized to the 2000 Chinese standard population and Segi's population,which were expressed per 100,000 populations.Results:After clearance and assessment,data from 30 population-based cancer registries(5 in urban and 25 in rural areas)were included in the analysis.All 30 cancer registries encompassed a total population of 23,421,609(3,507,984 in urban and 19,913,625 in rural areas),accounting for 21.84% of the provincial population.The proportion of morphological verification(MV%),percentage of cancer cases identified with death certification only(DCO%),and mortality-to-incidence ratio(M/I)were 38.55%,2.34%,and 0.81,respectively.Approximately 31,639 new cases of liver cancer were diagnosed and 26,057 deaths from liver cancer occurred in Henan in 2015.The crude incidence rate of liver cancer was 27.05/100,000(36.24/100,000 in men and 17.35/100,000 in women).Age-standardized incidence rates by Chinese standard population and world standard population were 21.10/100,000 and 20.95/100,000,respectively.Liver cancer was more common in men than in women.The incidence rates in urban(26.31/100,000)and rural(27.18/100,000)areas were similar.The crude mortality rate of liver cancer was 21.98/100,000(29.33/100,000 in males and 14.22/100,000 in females).Age-standardized mortality rates by Chinese standard population and world standard population were 16.93/100,000 and 16.90/100,000,respectively.There was no distinct difference in mortality rates of liver cancer between urban(22.55/100,000)and rural(21.87/100,000)areas.Conclusions: Liver cancer has posed a heavy burden on people in Henan province. Comprehensive measures should be conductedto prevent the increase in the incidence of liver cancer.展开更多
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.51601108 and 52071191)the Natural Science Foundation of Shandong Province(ZR2020ME011).
文摘In this study,the effects of intermetallic compounds(Mg_(17)Al_(12)and Al_(8)Mn_(5))on the Mg-Al layered double hydroxide(LDH)formation mechanism and corrosion behavior of an in-situ LDH/Mg(OH)_(2)steam coatings on AZ80 Mg alloy were investigated.Citric acid(CA)was used to activate the alloy surface during the pretreatment process.The alloy was first pretreated with CA and then subjected to a hydrothermal process using ultrapure water to produce Mg-Al-LDH/Mg(OH)_(2)steam coating.The effect of different time of acid pretreatment on the activation of the intermetallic compounds was investigated.The microstructure and elemental composition of the obtained coatings were analyzed using FE-SEM,EDS,XRD and FT-IR.The corrosion resistance of the coated samples was evaluated using different techniques,i.e.,potentiodynamic polarization(PDP),electrochemical impedance spectrum(EIS)and hydrogen evolution test.The results indicated that the CA pretreatment significantly influenced the activity of the alloy surface by exposing the intermetallic compounds.The surface area fraction of Mg_(17)Al_(12)and Al_(8)Mn_(5)phases on the surface of the alloy was significantly higher after the CA pretreatment,and thus promoted the growth of the subsequent Mg-Al-LDH coatings.The CA pretreatment for 30 s resulted in a denser and thicker LDH coating.Increase in the CA pretreatment time significantly led to the improvement in corrosion resistance of the coated AZ80 alloy.The corrosion current density of the coated alloy was lower by three orders of magnitude as compared to the uncoated alloy.
文摘Background Boron(B)deficiency is an important factor for poor seed cotton yield and fiber quality.However,it is often missing in the plant nutrition program,particularly in developing countries.The current study investigated B’s effect on growth,yield,and fiber quality of Bt(CIM-663)and non-Bt(Cyto-124)cotton cultivars.The experimental plan consisted of twelve treatments:Control(CK);B at 1 mg·kg^(−1) soil application(SB1);2 mg·kg^(−1) B(SB2);3 mg·kg^(−1) B(SB3);0.2%B foliar spray(FB1);0.4%B foliar spray(FB2);1 mg·kg^(−1) B+0.2%B foliar spray(SB1+FB1);1 mg·kg^(−1) B+0.4%B foliar spray(SB1+FB2);2 mg·kg^(−1) B+0.2%B foliar spray(SB2+FB1);2 mg·kg^(−1) B+0.4%B foliar spray(SB2+FB2);3 mg·kg^(−1) B+0.2%B foliar spray(SB3+FB1);3 mg·kg^(−1) B+0.4%B foliar spray(SB3+FB2).Each treat-ment has three replications,one pot having two plants per replication.Results B nutrition at all levels and methods of application significantly(P≤0.05)affected the growth,physiological,yield,and fiber quality characteristics of both cotton cultivars.However,SB2 either alone or in combination with foliar spray showed superiority over others,particularly in the non-Bt cultivar which responded better to B nutrition.Maxi-mum improvement in monopodial branches(345%),sympodial branches(143%),chlorophyll-a(177%),chlorophyll-b(194%),photosynthesis(169%),and ginning out turn(579%)in the non-Bt cultivar was found with SB2 compared with CK.In Bt cultivar,although no consistent trend was found but integrated use of SB3 with foliar spray performed relatively better for improving cotton growth compared with other treatments.Fiber quality characteristics in both cultivars were improved markedly but variably with different B treatments.Conclusion B nutrition with SB2 either alone or in combination with foliar spray was found optimum for improving cotton’s growth and yield characteristics.
基金The research was funded by research grants from the Natural Science fund of He Nan Province,China.
文摘Objective:To determine the relationship between family functioning and depression in primary caregivers of stroke survivors in China.Design:Baseline cross-sectional data from an intervention study for stroke survivors and their families were used.Setting:Neurology inpatient service of a large urban hospital.Participants:Stroke survivors(n=180),each with a primary caregiver,were enrolled in this study.The mean age of stroke survivors was 65.60 years,and the mean age of primary caregivers was 57.60 years.Interventions:Not applicable.Methods:The Family Assessment Device(FAD)and Center for Epidemiologic Studies Depression Scale(CES-D),respectively,were used.Results:Following a stroke of a family member,71%of caregivers experienced depressive symptoms.Higher depression severity in caregivers was linked to caregiver education,stroke survivor ADLs,and family functioning.Conclusion:Assessment of family functioning may help determine which caregivers are most at risk for developing depressive syndrome.
基金This work was supported by the National Natural Science Foundation of China(grant no.61602515).
文摘In the field of information security,a gap exists in the study of coreference resolution of entities.A hybrid method is proposed to solve the problem of coreference resolution in information security.The work consists of two parts:the first extracts all candidates(including noun phrases,pronouns,entities,and nested phrases)from a given document and classifies them;the second is coreference resolution of the selected candidates.In the first part,a method combining rules with a deep learning model(Dictionary BiLSTM-Attention-CRF,or DBAC)is proposed to extract all candidates in the text and classify them.In the DBAC model,the domain dictionary matching mechanism is introduced,and new features of words and their contexts are obtained according to the domain dictionary.In this way,full use can be made of the entities and entity-type information contained in the domain dictionary,which can help solve the recognition problem of both rare and long entities.In the second part,candidates are divided into pronoun candidates and noun phrase candidates according to the part of speech,and the coreference resolution of pronoun candidates is solved by making rules and coreference resolution of noun phrase candidates by machine learning.Finally,a dataset is created with which to evaluate our methods using information security data.The experimental results show that the proposed model exhibits better performance than the other baseline models.
基金supported by the Natural Science Foundation of Henan Province(Grant No.82300443203)
文摘Using ab initio total energy calculations with the full-potential linearized augmented plane wave method, the possibilities of magnetism in one-dimensional In and Tl wires were explored and their properties as the function of geometric structures were studied. The results suggest that the linear In and Tl wires show magnetization at the equilibrium bond distance with magnetic moments of 0.71 and 0.67 μB/atom, respectively. Allowing ions to relax, the wires were deformed as zigzag structures, but no dimerization occurs. The zigzag wires also exhibit spontaneous magnetization, although the magnetic moments are lower than those of straight wires.
文摘A novel side chain liquid crystalline polymer (SCLCP) combining the polysiloxane as main chain with azo-based mesogen moieties as side chain through a flexible spacer has been synthesized by the hydrosilylation reaction using Cp_2PtCl_2 as catalyst. The phase transition behavior of both side chain monomer (AZO-C_6C_(11))and polymer (P-AZO-C_6C_(11))has been characterized via combination of hot-stage polarized microscope, DSC and X-ray diffraction methods (including temperature-variation and quenching techniques). As normal, the transition process included K→S→N→I. Some pretransition features have been observed.
基金National Natural Science Foundation project(81260124)Henan Province Department of Education Science and Technology Project(14B310019).
文摘Objective:To explore the best time for progesterone supplementation in AID ovulation induction cycles by Letrozole.Methods: The data analysed in this study were collected from 509 patients who were performed AID (Artificial Insemination by Donor) administrated letrozole (LE) between 2014.8-2015.7. All patients were randomly divided into 4 groups by the time of progesterone administrated, including experimental group and the control group. The experimental group was divided into group 1-72 h after ovulation, group 2-48 h after ovulation, group 3-24 h after ovulation and control group—without administrated LE. The gestation and live birth rate were evaluated by monitoring vaginal ultrasound and HCG blood value 14 d after AID.Results: The pregnancy rate with administrated progesterone added 72 h after ovulation was 31.9%, which was significantly higher than those of other groups, the same situation as groups added progesterone was significantly higher than the control group. However, there was no significant difference in the numbers of abortions among the four groups. The LBR of group 4 was significantly lower than that of group 1.Conclutions: Progesterone administrated 72 h after ovulation can promoted the gestation rate, but did not affect the rate of miscarrage .
文摘The Wireless Local Area Network (WLAN) is a new and developing technology and the security problem is always important in all networks; therefore, the security problems will be discussed in this article. The article firstly introduces the history of development of IEEE 802.11 and provides an overview of the Wireless LAN. The architecture of WLAN will be referred in next. Finally, the further of the wireless LAN will be prospected by this article.
基金supported by the National Natural Science Foundation of China(Grant Nos.51972032,51937007,and 51921005)Science and Technology Program of the State Grid Corporation of China(5500-201999527A-0-0-00)+1 种基金Science and Technology Program of Shenzhen Science and Technology Innovation Commission(Grant No.JCYJ20180306173235924)BUPT Excellent Ph.D.Students Foundation(CX2021128).
文摘Large deformability and high sensitivity is difficult to be realized simultaneously in flexible sensors.Herein,taking advantage of the high permittivity and highly active surfaces of the ultrasmall barium titanate nanoparticles(BT NPs)and the high stretchability of the p(BA-GMA)elastomer matrix,we propose a high-performance soft stretchable sensor.The addition of the ultrasmall BT NPs can not only increase the permittivity and capacitance of polyacrylate-matrix composite dielectric material to obtain a high sensitivity,but also basically maintains the excellent mechanical properties of the polymer matrix.The dielectric constants of the composite films increase from 5.68 to 13.13 at 10 kHz with the increase of BT NPs content from 0 to 15 vol.%,which results in a high capacitance of 236.16 pF for 15 vol.%BT/p(BA-GMA)sensor.Combining the high permittivity and the large deformability(a maximal deformation of 87.2%),the 15 vol.%BT/p(BA-GMA)sensor has high sensitivity and shows high linearity and stable output even if under dynamic measurement.The dual-mode sensor that utilizes the orthogonality of capacitance-resistance is designed,which shows excellent performance in monitoring human body movements and noncontact measurement.The results present that the BT/p(BA-GMA)-based sensor has high stability and reliability not exceed 65C,which can meet the application requirements in dynamic monitoring.
基金grants from the Science and Technology Project (No.2011B080701029)Natural Science Foundation (No.2016A030313303) from the Department of Science and Technology of Guangdong province.
文摘Background:Endothelial dysfunction,the initial pathogenic factor in atherosclerosis,can be alleviated via transient limb ischemia.We observed the effects of regular transient limb ischemia (RTLI) on atherosclerosis in hypercholesterolemic rabbits.Methods:Twenty-eight rabbits were randomized to control,cholesterol,sham,ischemia groups (n=7 each) between October 2010 and March 2011.They were fed a normal diet in the control group and hypercholesterolemic diet in other groups for 12 weeks.Six cycles of RTLI were performed once per day on the ischemia group.Serum samples were prepared to measure the total cholesterol (TC),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C) before the experiment (W0),at the end of weeks 4,8,12 (W4,W8,W12).The whole aorta was harvested at W12 and stained using Sudan IV to identify the plaque.The plaque area was measured using Image J.Results were analyzed by analysis of variance or rank sum test.Results:Concentrations of TC in the cholesterol group were higher than those in the control group at W4 (29.60 [23.75,39.30] vs.1.00 [0.80,1.55],Z =–2.745,P = 0.006),W8 (41.78 [28.08,47.37] vs.0.35 [0.10,0.68],Z =–2.739,P = 0.006),W12 (48.32 [40.04,48.95] vs.0.61 [0.50,0.86],Z =–2.739,P = 0.006).Similar results were obtained for HDL-C and LDL-C.Serum concentrations of TC,HDL-C,and LDL-C in the hypercholesterolemic groups had no differences (all P > 0.05).The percentage of plaque area in the cholesterol group was higher than that in the control group (47.22 ± 23.89% vs.0,Z =–2.986,P = 0.003).Square root of the percentage of plaque area was smaller in the ischemia group than that in the cholesterol (0.44 ± 0.13 vs.0.67 ± 0.18,P = 0.014) or sham groups (0.44 ± 0.13 vs.0.61 ± 0.12,P = 0.049).Conclusion:In hypercholesterolemic rabbits,RTLI might prevent atherosclerosis progression by reducing the percentage of plaque area.
基金supported by grant funding from the National Natural Science Foundation of China(81972839,82002620 and 82073075)the Scientific and Technological Project in Henan Province and Henan Provincial Government(Nos.212102310882,and 222102310104,China).
文摘Colorectal cancer(CRC) is the second most common cause of cancer-related death in the world. The pro-viral integration site for Moloney murine leukemia virus 1(PIM1) is a proto-oncogene and belongs to the serine/threonine kinase family, which are involved in cell proliferation, migration,and apoptosis. Fibroblast growth factor receptor 1(FGFR1) is a tyrosine kinase that has been implicated in cell proliferation, differentiation and migration. Small molecule HCI-48 is a derivative of chalcone, a class of compounds known to possess anti-tumor, anti-inflammatory and antibacterial effects. However,the underlying mechanism of chalcones against colorectal cancer remains unclear. This study reports that HCI-48 mainly targets PIM1 and FGFR1 kinases, thereby eliciting antitumor effects on colorectal cancer growth in vitro and in vivo. HCI-48 inhibited the activity of both PIM1 and FGFR1 kinases in an ATPdependent manner, as revealed by computational docking models. Cell-based assays showed that HCI-48inhibited cell proliferation in CRC cells(HCT-15, DLD1, HCT-116 and SW620), and induced cell cycle arrest in the G2/M phase through modulation of cyclin A2. HCI-48 also induced cellular apoptosis, as evidenced by an increase in the expression of apoptosis biomarkers such as cleaved PARP, cleaved caspase 3 and cleaved caspase 7. Moreover, HCI-48 attenuated the activation of downstream components of the PIM1 and FGFR1 signaling pathways. Using patient-derived xenograft(PDX) murine tumor models,we found that treatment with HCI-48 diminished the PDX tumor growth of implanted CRC tissue expressing high protein levels of PIM1 and FGFR1. This study suggests that the inhibitory effect of HCI-48 on colorectal tumor growth is mainly mediated through the dual-targeting of PIM1 and FGFR1kinases. This work provides a theoretical basis for the future application of HCI-48 in the treatment of clinical CRC.
基金supported by the National Natural Science Foundation of China (Grant No.10774132)
文摘A systematic ab initio study on magnetism of the 3d transition metals(TM) from atom to monoatomic wire within density functional theory with generalized gradient approximation(GGA) was performed.The results show that the spin coupling has strong intraatomic exchange strengths about 1 eV for isolated 3d TM atoms.The magnetic moments are distinctly lower than those of free atoms for all dimers except Mn 2 .All the 3d TM elements exhibit magnetic ground states in the linear wire structure.
文摘Objective:Liver cancer is one of the most common types of cancer.We aimed to use the cancer registration data in 2015 to estimate the incidence and mortality of liver cancer in Henan province.Methods:The data from 37 population-based cancer registries in Henan province were collected for this study.The pooled data were stratified by area,sex,and age group.New cases of liver cancer and deaths due to the disease were estimated using age-specific rates and provincial population in 2015.All incidence and death rates were age standardized to the 2000 Chinese standard population and Segi's population,which were expressed per 100,000 populations.Results:After clearance and assessment,data from 30 population-based cancer registries(5 in urban and 25 in rural areas)were included in the analysis.All 30 cancer registries encompassed a total population of 23,421,609(3,507,984 in urban and 19,913,625 in rural areas),accounting for 21.84% of the provincial population.The proportion of morphological verification(MV%),percentage of cancer cases identified with death certification only(DCO%),and mortality-to-incidence ratio(M/I)were 38.55%,2.34%,and 0.81,respectively.Approximately 31,639 new cases of liver cancer were diagnosed and 26,057 deaths from liver cancer occurred in Henan in 2015.The crude incidence rate of liver cancer was 27.05/100,000(36.24/100,000 in men and 17.35/100,000 in women).Age-standardized incidence rates by Chinese standard population and world standard population were 21.10/100,000 and 20.95/100,000,respectively.Liver cancer was more common in men than in women.The incidence rates in urban(26.31/100,000)and rural(27.18/100,000)areas were similar.The crude mortality rate of liver cancer was 21.98/100,000(29.33/100,000 in males and 14.22/100,000 in females).Age-standardized mortality rates by Chinese standard population and world standard population were 16.93/100,000 and 16.90/100,000,respectively.There was no distinct difference in mortality rates of liver cancer between urban(22.55/100,000)and rural(21.87/100,000)areas.Conclusions: Liver cancer has posed a heavy burden on people in Henan province. Comprehensive measures should be conductedto prevent the increase in the incidence of liver cancer.