Electroactive anticorrosion coatings are specialized surface treatments that prevent or minimize corrosion. Thestudy employs strategic thermodynamic equilibriumcalculations to pioneer a novel factor in corrosion prote...Electroactive anticorrosion coatings are specialized surface treatments that prevent or minimize corrosion. Thestudy employs strategic thermodynamic equilibriumcalculations to pioneer a novel factor in corrosion protection.A first-time proposal, the total acidity (TA) potential of the hydrogen (pH) concept significantly shapes medicalmagnesium alloys. These coatings are meticulously designed for robust corrosion resistance, blending theoreticalinsights and practical applications to enhance our grasp of corrosion prevention mechanisms and establisha systematic approach to coating design. The groundbreaking significance of this study lies in its innovativeintegration of the TA/pH concept,which encompasses the TA/pH ratio of the chemical environment. This approachsurpasses convention by acknowledging the intricate interplay between the acidity and pH levels within thecoating formulation, thereby optimizing metal-phosphate-based conversion coatings and transforming corrosionmitigation strategies. To authenticate the TA/pH concept, the study comprehensively compares its findings withexisting research, rigorously validating the theoretical framework and reinforcing the correlates among TA/pHvalues and observed corrosion resistance in the coatings. The influence of mutations that occur naturally inthe detergent solution on persistent phosphorus changes is shown by empirical confirmation, which improvescorrosion resistance. This realization advances the field ofmaterials and the field’s knowledge of coated generation,particularly anticorrosion converter layers.展开更多
[ Objective] To study the growth-development of Boer goats from embryo transplant. [ Method] With Boer goats from embryo transplant as the tested animals and natural breeding Boer goats born in the same period as CK, ...[ Objective] To study the growth-development of Boer goats from embryo transplant. [ Method] With Boer goats from embryo transplant as the tested animals and natural breeding Boer goats born in the same period as CK, the weight of Boer goats at birth and at the age of 1,3 and 6 months as well as the body size at the age of 3 and 6 months were investigated in this study, while their health conditions were also observed and recorded. [ Result] Under the normal feeding conditions, Boer goats from embryo transplant developed well at early stage, and their meat-using body type were also obvious. The average birth weight of bucks was (4.25±0.95) kg, and that of does was (3.74±0.10) kg. The average weight of bucks at the age of 6 months was (31.90 ±0.74) kg and that of was (25.90 ±0.67) kg. The daily gains of bucks and ewes from birth to 6 months of age were 153.64 and 123.11 g respectively, while their body length, body height and chest circumference increased obviously, and there was no significant difference in body weight or body size between them and natural breeding goats. [ Condusioa] The study lays a foundation for further studies on the breedinq and utilization of Boer noats from embryo transplant at early staae.展开更多
This paper presented a novel millimeterwave channel measurement platform for the 6G intelligent railway.This platform used phased array antenna with 64 elements and can support instant bandwidth up to 1 GHz.Combined w...This paper presented a novel millimeterwave channel measurement platform for the 6G intelligent railway.This platform used phased array antenna with 64 elements and can support instant bandwidth up to 1 GHz.Combined with improved multi-tone sounding signals,the platform can enhance dynamic measurement capability in high-speed railway scenarios.We performed calibration works about frequency flatness,frequency offset and proved platform reliability with channel emulator based closed-loop verification.We also carried out field trials in high-speed railway carriage scenarios.Based on measurement results,we extracted channel characteristic parameters of path loss,power delay profile and delay spread to further verify the field measurement performance of the platform.展开更多
Sepsis has been redefined as a disorder of host response to infection, systemic circulation and cell/metabolic abnormalities. Exosomes are small (30 - 150 nm) vesicles produced by all cells under physiological and pat...Sepsis has been redefined as a disorder of host response to infection, systemic circulation and cell/metabolic abnormalities. Exosomes are small (30 - 150 nm) vesicles produced by all cells under physiological and pathological conditions, with the potential to transfer proteins, lipids, small RNAs, messenger RNAs, or DNA between cells. Exosomes are natural cargoes for proteins, carbohydrates, nucleic acids and lipids. Exosomes play a central role in cellular communication and contribute to many pathophysiological processes, including immune responses and tumor progression. Exosomes have made great progress in many subject areas, and their potential role in sepsis is now being explored. In this review, several topics are mentioned. Firstly, we discuss the biological characteristics and functions of exosomes. Next, we focus on the diagnostic and therapeutic potential of exosomes in sepsis. Finally, we discuss some of the problems encountered by the current exosomes research institute. Therefore, the exosomes with combined diagnostic and therapeutic functions play a huge clinical application for the future research in sepsis.展开更多
X65, X70, and X80 belong to high grade pipeline steels. Toughness is one of the most important properties of pipeline steels when the pipeline transports the gas or oil, and the means to control toughness is very impo...X65, X70, and X80 belong to high grade pipeline steels. Toughness is one of the most important properties of pipeline steels when the pipeline transports the gas or oil, and the means to control toughness is very important for exploring even higher grade pipeline steels. We established the relationship between toughness and crystallographic parameters of high grade pipeline steels by studying the crystallographic parameters of X65, X70, and X80 using EBSD and analyzing Charpy CVN of X65, X70 and X80. The results show that the effective grain size, the frequency distribution of grain boundary misorientation and the ratio of high angle grain boundary to small angle grain boundary are important parameters. The finer the effective grain size, and the higher the frequency distribution of grain boundaries (〉 50~), the more excellent toughness of high grade pipeline steels will be.展开更多
This paper deals with the meta-mafic volcanic rocks of the Gongyiming iron deposit at Baotou, Inner Mongolia. The major and trace elements and REE data indicate that the meta-mafic volcanic rocks occurred in the envir...This paper deals with the meta-mafic volcanic rocks of the Gongyiming iron deposit at Baotou, Inner Mongolia. The major and trace elements and REE data indicate that the meta-mafic volcanic rocks occurred in the environment similar to a modern continental rift. Sm-Nd and Rb-Sr isotopic studies indicated that the meta-basic rocks were formed during the Early Neoarchean from 2800 Ma to 2900 Ma and reworked during the Late Neoarchean (2500 Ma) by metamorphism. Because of the separation of the North China Craton from the Siberia Craton during the Middle Proterozoic (1600 Ma), the Rb-Sr systematics of the rocks has been changed. The Se’ertengshan greenstone seems to occur during the Middle Archean. A stable continental crust may have existed during the Paleoarchean.展开更多
The numerical simulation program of PFC2D(Particle Flow Code in 2 Dimension)particle flow based on the flow-solid coupling principle and,on its built-in FISHTANK function library and FISH language,defines the flow equ...The numerical simulation program of PFC2D(Particle Flow Code in 2 Dimension)particle flow based on the flow-solid coupling principle and,on its built-in FISHTANK function library and FISH language,defines the flow equation and pressure equation of fluid domain respectively,and carries out numerical simulation calculations on the diffusion process and,on the morphology and particle displacement of slurry during the slurry injection process.By adjusting the parameters of hist,n_bond,s_bond and measure in the PFC command flow,the tracking of granular body displacement changes is achieved,and the mesoscopic mechanism such as the diffusion law of soil slurry at different depths and the change of formation porosity is revealed.The numerical calculations show that:the grouting pressure has a significant effect on the alteration and destruction of the formation structure,and the fracturing effect becomes gradually worse with increasing adhesive strength,while the porosity increases significantly with increasing grouting pressure.Based on the elastic-plastic theory of the Mohr-Colomb criterion to theoretically derive the stress field of the soil around the borehole,it is pointed out that the mechanical mechanism of annular tension and radial compression is the fundamental reason for the appearance of fracturing grouting action mode.The increase of slurry viscosity is beneficial to improve the grouting effect of fracturing-compacting grouting,while the increase of friction coefficient has little effect on the grouting effect.The comparative analysis of the laboratory tests shows that the PFC2D simulation of the grouting process is feasible.展开更多
Larger-sized primary carbides lead to stress concentration during the application of H13 hot-work die steel,resulting in microcracks and fatigue failure.Rare earth was usually added to modify the carbides and inclusio...Larger-sized primary carbides lead to stress concentration during the application of H13 hot-work die steel,resulting in microcracks and fatigue failure.Rare earth was usually added to modify the carbides and inclusions.The existing literature is reviewed on the effect of rare earth on primary carbides in H13 steel.A comprehensive review on the effect of rare earth on the characteristics of primary carbides,i.e.,number,size,morphology,and thermal stability in H13 steel,was done.The precipitation mechanism and nucleation of primary carbides with rare earth were summarized.The position and form of rare earth in steel and their effects on alloying elements segregation were reviewed.The addition techniques of rare earth in H13 steel were compared,and the prospects for other uncommon rare earth and emerging technology were present.Based on the current references,it can be known that adding rare earth facilitated refined and dispersed primary carbides.The size of primary carbides would be reduced,and their morphology would be improved because the rare earth inclusions formed in H13 steel can act as nucleation cores forγ-Fe orδ-Fe,refining the dendritic structure.Besides,the number of primary carbides at grain boundaries would be significantly reduced.However,rare earth had little impact on thermal stability.The nucleation of primary carbides tended to be inhibited due to the modification of inclusions by rare earth which were likely to be nucleation cores for primary carbides.Rare earth had been reported to affect the mechanism and process of primary carbide precipitation.Additionally,the addition of rare earth can inhibit the segregation of alloying elements and carbon diffusion by calculation.Thus,laboratory experiments and theoretical calcu-lations need to be conducted to study the states and evolution of rare earth steels.展开更多
In this paper we consider a property of claw-free graphs.We show that if d(u)+ d(v)≥ν(G)+2k+3,for every two nonadjacent vertices u and v,then G is 2k-vertex-deletable IM-extendable,whereν(G)=|V(G)|.And the bound is...In this paper we consider a property of claw-free graphs.We show that if d(u)+ d(v)≥ν(G)+2k+3,for every two nonadjacent vertices u and v,then G is 2k-vertex-deletable IM-extendable,whereν(G)=|V(G)|.And the bound is tight.展开更多
Augmented Reality is a technique that allows users to overlap digital information with their physical world.The Augmented Reality(AR)displays have an exceptional characteristic from the Human–Computer Interaction(HCI...Augmented Reality is a technique that allows users to overlap digital information with their physical world.The Augmented Reality(AR)displays have an exceptional characteristic from the Human–Computer Interaction(HCI)perspective.Due to its increasing popularity and application in diverse domains,increasing user-friendliness and AR usage are critical.Context-aware is one approach since an AR application can adapt to the user,environment,needs and enhance ergonomic principles and functionality.This paper proposes the Intelligent Contextaware Augmented Reality Model(ICAARM)for Human–Computer Interaction systems.This study explores and reduces interaction uncertainty by semantically modeling user-specific interaction with context,allowing personalised interaction.Sensory information is captured from an AR device to understand user interactions and context.These depictions carry semantics to Augmented Reality applications about the user’s intention to interact with a specific device affordance.Thus,this study describes personalised gesture interaction in VR/AR applications for immersive/intelligent environments.展开更多
Chinese medicine (CM) has been used in the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) for 30 years and the demonstrated therapeutic effects of CM, suc...Chinese medicine (CM) has been used in the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) for 30 years and the demonstrated therapeutic effects of CM, such as reducing plasma HIV viral load, increasing CD4*T cell counts, promoting immunity reconstitution, ameliorating symptoms and signs, improving the health related quality of life (HRQOL) and counteracting against the effects of anti-retroviral drugs, were summarized and reviewed in this article. The authors point out that it had been a good opportunity to use CM for the treatment of HIV infection and AIDS in the past and also there are huge challenges ahead for CM research and clinicians to discover more effective CM and its underlying mechanisms for treatment of AIDS.展开更多
Salvia miltiorrhiza is one of the 40 most commonly used traditional Chinese medicinal materials in clinics.It is effective in activating blood circulation,removing blood stasis,relieving pain through the meridian,clea...Salvia miltiorrhiza is one of the 40 most commonly used traditional Chinese medicinal materials in clinics.It is effective in activating blood circulation,removing blood stasis,relieving pain through the meridian,clearing the heart and removing irritations,and cooling blood and eliminating blemishes.Each main production area has developed a unique production method and processing technology,in accordance with local conditions.The processed products included in Chinese Pharmacopoeia are purified and wine-fried S.miltiorrhiza.In addition,the Chinese province’s standards include the vinegar-fried and wine-fried types.S.miltiorrhiza is produced in more areas and is more extensively processed,with large variations in specifications.The challenge in establishing a uniform quality standard affects the clinical application of decoction pieces.This review has explored the books of the past dynasties,summarized the relevant literature published in the past three decades,discussed the processing methods of S.miltiorrhiza,and provided a basis for further research on the processing method of the original sample.In particular,we integrate fresh cut processing as the starting point for in-depth research,discuss the processing technology specifications,and formulate quality product standards.展开更多
OBJECTIVE: To provide survival estimates of people living with human immunodeficiency virus(PLHIV) after treatment with Traditional Chinese Medicine(TCM) in rural China, to identify the prognostic factors at enrollmen...OBJECTIVE: To provide survival estimates of people living with human immunodeficiency virus(PLHIV) after treatment with Traditional Chinese Medicine(TCM) in rural China, to identify the prognostic factors at enrollment, and to explore the effectiveness of TCM intreating PLHIV.METHODS: PLHIV who enrolled in national TCM HIV treatment trial program in October 2004 were analyzed in this study and followed up to October 2010. Survival time was estimated by the Kaplan-Meier curve and hazard ratios, and identifying prognostic factors were computed through Cox proportional hazard models.RESULTS:A total of 1666 PLHIV were included with 102 591 person-months of follow-up. Overall, 312(18.7%) patients died. The total mortality rate over the study period was 3.6 per 100 person-years,which was lower than the worldwide rate. The cumulative survival rate was 95.9% at 1 year[95% confidence interval(CI)(94.8-96.8)] and 80.4% at 6years [95% CI(78.4-82.3)]. Elevated death risks emerged among males, older individuals, and thosewithlowerCD4+T-cellcounts.CONCLUSION: TCM could increase survival and lengthen the life span of PLHIV in Henan province of China, as shown by our retrospective cohort study. Factors such as sex, age, education, and CD4+ T-cell counts correlated to survival. However,retrospective cohorts bias the data, so more prospective studies should be performed to confirm our primary results.展开更多
基金the below mentioned organisation:Key Research and Development Special Project of Henan Provincial Science and Technology(222102230025)Key Research and Development Special Project of Henan Provincial Science and Technology(232102231015)+2 种基金Key Research and Development Special Project of Henan Provincial Science and Technology(232102231011)Natural Science Foundation of Henan Province(No.004053100)Major Science Research Project of High Education of Henan Province(No.23B430016).
文摘Electroactive anticorrosion coatings are specialized surface treatments that prevent or minimize corrosion. Thestudy employs strategic thermodynamic equilibriumcalculations to pioneer a novel factor in corrosion protection.A first-time proposal, the total acidity (TA) potential of the hydrogen (pH) concept significantly shapes medicalmagnesium alloys. These coatings are meticulously designed for robust corrosion resistance, blending theoreticalinsights and practical applications to enhance our grasp of corrosion prevention mechanisms and establisha systematic approach to coating design. The groundbreaking significance of this study lies in its innovativeintegration of the TA/pH concept,which encompasses the TA/pH ratio of the chemical environment. This approachsurpasses convention by acknowledging the intricate interplay between the acidity and pH levels within thecoating formulation, thereby optimizing metal-phosphate-based conversion coatings and transforming corrosionmitigation strategies. To authenticate the TA/pH concept, the study comprehensively compares its findings withexisting research, rigorously validating the theoretical framework and reinforcing the correlates among TA/pHvalues and observed corrosion resistance in the coatings. The influence of mutations that occur naturally inthe detergent solution on persistent phosphorus changes is shown by empirical confirmation, which improvescorrosion resistance. This realization advances the field ofmaterials and the field’s knowledge of coated generation,particularly anticorrosion converter layers.
基金supported by Talent Research Foundation of Henan University of Technology (09001095)Scientific and Technological Project of Henan Province " Research and Demonstration of Supporting Production Technology Systemfor High-quality Funiu White Goats" (072102130004)
文摘[ Objective] To study the growth-development of Boer goats from embryo transplant. [ Method] With Boer goats from embryo transplant as the tested animals and natural breeding Boer goats born in the same period as CK, the weight of Boer goats at birth and at the age of 1,3 and 6 months as well as the body size at the age of 3 and 6 months were investigated in this study, while their health conditions were also observed and recorded. [ Result] Under the normal feeding conditions, Boer goats from embryo transplant developed well at early stage, and their meat-using body type were also obvious. The average birth weight of bucks was (4.25±0.95) kg, and that of does was (3.74±0.10) kg. The average weight of bucks at the age of 6 months was (31.90 ±0.74) kg and that of was (25.90 ±0.67) kg. The daily gains of bucks and ewes from birth to 6 months of age were 153.64 and 123.11 g respectively, while their body length, body height and chest circumference increased obviously, and there was no significant difference in body weight or body size between them and natural breeding goats. [ Condusioa] The study lays a foundation for further studies on the breedinq and utilization of Boer noats from embryo transplant at early staae.
基金supported in part by the Fundamental Research Funds for the Central Universities under Grant 2022JBQY004,2022JBZY018 and 2022JBXT001in part by the Basic Research Project of Jiangsu Province Frontier Leading Technology under Grant BK20212002.
文摘This paper presented a novel millimeterwave channel measurement platform for the 6G intelligent railway.This platform used phased array antenna with 64 elements and can support instant bandwidth up to 1 GHz.Combined with improved multi-tone sounding signals,the platform can enhance dynamic measurement capability in high-speed railway scenarios.We performed calibration works about frequency flatness,frequency offset and proved platform reliability with channel emulator based closed-loop verification.We also carried out field trials in high-speed railway carriage scenarios.Based on measurement results,we extracted channel characteristic parameters of path loss,power delay profile and delay spread to further verify the field measurement performance of the platform.
文摘Sepsis has been redefined as a disorder of host response to infection, systemic circulation and cell/metabolic abnormalities. Exosomes are small (30 - 150 nm) vesicles produced by all cells under physiological and pathological conditions, with the potential to transfer proteins, lipids, small RNAs, messenger RNAs, or DNA between cells. Exosomes are natural cargoes for proteins, carbohydrates, nucleic acids and lipids. Exosomes play a central role in cellular communication and contribute to many pathophysiological processes, including immune responses and tumor progression. Exosomes have made great progress in many subject areas, and their potential role in sepsis is now being explored. In this review, several topics are mentioned. Firstly, we discuss the biological characteristics and functions of exosomes. Next, we focus on the diagnostic and therapeutic potential of exosomes in sepsis. Finally, we discuss some of the problems encountered by the current exosomes research institute. Therefore, the exosomes with combined diagnostic and therapeutic functions play a huge clinical application for the future research in sepsis.
基金Funded by China Postdoctoral Science Foundation(No.20060390319)
文摘X65, X70, and X80 belong to high grade pipeline steels. Toughness is one of the most important properties of pipeline steels when the pipeline transports the gas or oil, and the means to control toughness is very important for exploring even higher grade pipeline steels. We established the relationship between toughness and crystallographic parameters of high grade pipeline steels by studying the crystallographic parameters of X65, X70, and X80 using EBSD and analyzing Charpy CVN of X65, X70 and X80. The results show that the effective grain size, the frequency distribution of grain boundary misorientation and the ratio of high angle grain boundary to small angle grain boundary are important parameters. The finer the effective grain size, and the higher the frequency distribution of grain boundaries (〉 50~), the more excellent toughness of high grade pipeline steels will be.
文摘This paper deals with the meta-mafic volcanic rocks of the Gongyiming iron deposit at Baotou, Inner Mongolia. The major and trace elements and REE data indicate that the meta-mafic volcanic rocks occurred in the environment similar to a modern continental rift. Sm-Nd and Rb-Sr isotopic studies indicated that the meta-basic rocks were formed during the Early Neoarchean from 2800 Ma to 2900 Ma and reworked during the Late Neoarchean (2500 Ma) by metamorphism. Because of the separation of the North China Craton from the Siberia Craton during the Middle Proterozoic (1600 Ma), the Rb-Sr systematics of the rocks has been changed. The Se’ertengshan greenstone seems to occur during the Middle Archean. A stable continental crust may have existed during the Paleoarchean.
文摘The numerical simulation program of PFC2D(Particle Flow Code in 2 Dimension)particle flow based on the flow-solid coupling principle and,on its built-in FISHTANK function library and FISH language,defines the flow equation and pressure equation of fluid domain respectively,and carries out numerical simulation calculations on the diffusion process and,on the morphology and particle displacement of slurry during the slurry injection process.By adjusting the parameters of hist,n_bond,s_bond and measure in the PFC command flow,the tracking of granular body displacement changes is achieved,and the mesoscopic mechanism such as the diffusion law of soil slurry at different depths and the change of formation porosity is revealed.The numerical calculations show that:the grouting pressure has a significant effect on the alteration and destruction of the formation structure,and the fracturing effect becomes gradually worse with increasing adhesive strength,while the porosity increases significantly with increasing grouting pressure.Based on the elastic-plastic theory of the Mohr-Colomb criterion to theoretically derive the stress field of the soil around the borehole,it is pointed out that the mechanical mechanism of annular tension and radial compression is the fundamental reason for the appearance of fracturing grouting action mode.The increase of slurry viscosity is beneficial to improve the grouting effect of fracturing-compacting grouting,while the increase of friction coefficient has little effect on the grouting effect.The comparative analysis of the laboratory tests shows that the PFC2D simulation of the grouting process is feasible.
基金supported by the National Natural Science Foundation of China(Grant Nos.52064011 and 52274331)Guizhou Provincial Basic Research Program(Natural Science)(Nos.ZK[2021]258 and ZK[2022]Zhongdian 023)+1 种基金Guizhou Provincial Program on Commercialization of Scientific and Technological Achievements(No.[2022]089)Natural Science Research Project of Guizhou Provincial Department of Education(No.[2022]041).
文摘Larger-sized primary carbides lead to stress concentration during the application of H13 hot-work die steel,resulting in microcracks and fatigue failure.Rare earth was usually added to modify the carbides and inclusions.The existing literature is reviewed on the effect of rare earth on primary carbides in H13 steel.A comprehensive review on the effect of rare earth on the characteristics of primary carbides,i.e.,number,size,morphology,and thermal stability in H13 steel,was done.The precipitation mechanism and nucleation of primary carbides with rare earth were summarized.The position and form of rare earth in steel and their effects on alloying elements segregation were reviewed.The addition techniques of rare earth in H13 steel were compared,and the prospects for other uncommon rare earth and emerging technology were present.Based on the current references,it can be known that adding rare earth facilitated refined and dispersed primary carbides.The size of primary carbides would be reduced,and their morphology would be improved because the rare earth inclusions formed in H13 steel can act as nucleation cores forγ-Fe orδ-Fe,refining the dendritic structure.Besides,the number of primary carbides at grain boundaries would be significantly reduced.However,rare earth had little impact on thermal stability.The nucleation of primary carbides tended to be inhibited due to the modification of inclusions by rare earth which were likely to be nucleation cores for primary carbides.Rare earth had been reported to affect the mechanism and process of primary carbide precipitation.Additionally,the addition of rare earth can inhibit the segregation of alloying elements and carbon diffusion by calculation.Thus,laboratory experiments and theoretical calcu-lations need to be conducted to study the states and evolution of rare earth steels.
基金Supported by the National Natural Sciences Youth Foundation(10901144)
文摘In this paper we consider a property of claw-free graphs.We show that if d(u)+ d(v)≥ν(G)+2k+3,for every two nonadjacent vertices u and v,then G is 2k-vertex-deletable IM-extendable,whereν(G)=|V(G)|.And the bound is tight.
文摘Augmented Reality is a technique that allows users to overlap digital information with their physical world.The Augmented Reality(AR)displays have an exceptional characteristic from the Human–Computer Interaction(HCI)perspective.Due to its increasing popularity and application in diverse domains,increasing user-friendliness and AR usage are critical.Context-aware is one approach since an AR application can adapt to the user,environment,needs and enhance ergonomic principles and functionality.This paper proposes the Intelligent Contextaware Augmented Reality Model(ICAARM)for Human–Computer Interaction systems.This study explores and reduces interaction uncertainty by semantically modeling user-specific interaction with context,allowing personalised interaction.Sensory information is captured from an AR device to understand user interactions and context.These depictions carry semantics to Augmented Reality applications about the user’s intention to interact with a specific device affordance.Thus,this study describes personalised gesture interaction in VR/AR applications for immersive/intelligent environments.
基金The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg 2013 ~Supported by the National Special S&T Program on Major Infectious Diseases (No. 2013ZX10005001-001 and No. 2012ZX10005010-001-002), the Research Project for Practice Development of National Traditional Chinese Medicine Clinical Research Bases (No. JDZX2012023), and the Innovation Scientists and Technicians Troop Construction Projects of Zhengzhou City (No.10CXTD140)
文摘Chinese medicine (CM) has been used in the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) for 30 years and the demonstrated therapeutic effects of CM, such as reducing plasma HIV viral load, increasing CD4*T cell counts, promoting immunity reconstitution, ameliorating symptoms and signs, improving the health related quality of life (HRQOL) and counteracting against the effects of anti-retroviral drugs, were summarized and reviewed in this article. The authors point out that it had been a good opportunity to use CM for the treatment of HIV infection and AIDS in the past and also there are huge challenges ahead for CM research and clinicians to discover more effective CM and its underlying mechanisms for treatment of AIDS.
基金financially supported by the China Administration of TCM(00104296)Henan Science and Technology Innovation Outstanding Youth Project(184100510017)Henan Science and Technology Research Project(192102310443)
文摘Salvia miltiorrhiza is one of the 40 most commonly used traditional Chinese medicinal materials in clinics.It is effective in activating blood circulation,removing blood stasis,relieving pain through the meridian,clearing the heart and removing irritations,and cooling blood and eliminating blemishes.Each main production area has developed a unique production method and processing technology,in accordance with local conditions.The processed products included in Chinese Pharmacopoeia are purified and wine-fried S.miltiorrhiza.In addition,the Chinese province’s standards include the vinegar-fried and wine-fried types.S.miltiorrhiza is produced in more areas and is more extensively processed,with large variations in specifications.The challenge in establishing a uniform quality standard affects the clinical application of decoction pieces.This review has explored the books of the past dynasties,summarized the relevant literature published in the past three decades,discussed the processing methods of S.miltiorrhiza,and provided a basis for further research on the processing method of the original sample.In particular,we integrate fresh cut processing as the starting point for in-depth research,discuss the processing technology specifications,and formulate quality product standards.
基金Supported by Research Project for Practice Development of National Traditional Chinese Medicine Clinical Research Bases(No.JDZX2012023)Henan province colleges and universities key youth teachers scheme(No.2013GGJS-095)+1 种基金National Special Science and Technology Program on Major Infectious Diseases(No.2012ZX10005010-001)China Academy of Traditional Chinese Medicine Item(No.ZZ060813)
文摘OBJECTIVE: To provide survival estimates of people living with human immunodeficiency virus(PLHIV) after treatment with Traditional Chinese Medicine(TCM) in rural China, to identify the prognostic factors at enrollment, and to explore the effectiveness of TCM intreating PLHIV.METHODS: PLHIV who enrolled in national TCM HIV treatment trial program in October 2004 were analyzed in this study and followed up to October 2010. Survival time was estimated by the Kaplan-Meier curve and hazard ratios, and identifying prognostic factors were computed through Cox proportional hazard models.RESULTS:A total of 1666 PLHIV were included with 102 591 person-months of follow-up. Overall, 312(18.7%) patients died. The total mortality rate over the study period was 3.6 per 100 person-years,which was lower than the worldwide rate. The cumulative survival rate was 95.9% at 1 year[95% confidence interval(CI)(94.8-96.8)] and 80.4% at 6years [95% CI(78.4-82.3)]. Elevated death risks emerged among males, older individuals, and thosewithlowerCD4+T-cellcounts.CONCLUSION: TCM could increase survival and lengthen the life span of PLHIV in Henan province of China, as shown by our retrospective cohort study. Factors such as sex, age, education, and CD4+ T-cell counts correlated to survival. However,retrospective cohorts bias the data, so more prospective studies should be performed to confirm our primary results.