Purpose:To investigate the fundus and fluorescein angiographic features in the patients with radiation retinopathy.Clinical Materials:Color fundus photography and/or fluorescein angiography from 13 patients with nasop...Purpose:To investigate the fundus and fluorescein angiographic features in the patients with radiation retinopathy.Clinical Materials:Color fundus photography and/or fluorescein angiography from 13 patients with nasopharyngeal carcinomas received external beam radiation were retrospectively analyzed.Reslts:In this study,26 damaged eyes of 13 patients eveloped some degree of radiation retinopathy.The earliest and most common finding was macular microvascular changes (microaneurysms and/or telangiectasia),which was observed in 100%(26/26)of the eyes.Intraretinal hemorrhages,macular capillary nonperfusion,and macular edema were noted in 84%,50%,and 42% of the eyes,respectively.Conclusions:Radiation retinopathy is common after external beam radiation of nasopharyngeal carcinomas.The prominent changes include maular microvascular changes,intraretinal hemorrhages and macular capillary nonperfusion.展开更多
Objective:To observe the clinical efficacy of mind-refreshing and balance-restoring needling method combined with Frenkel exercises in treating ataxia after cerebral stroke.Methods:The recruited 120 patients were rand...Objective:To observe the clinical efficacy of mind-refreshing and balance-restoring needling method combined with Frenkel exercises in treating ataxia after cerebral stroke.Methods:The recruited 120 patients were randomized into an observation group and a control group,with 60 cases in each group.The control group was intervened by mind-refreshing and balance-restoring needling method,while the observation group was given additional lower-limb Frenkel exercises.Before and after treatment and at the follow-up,the ataxic lower-limb function was scored using Berg balance scale(BBS)and international cooperative ataxia rating scale(ICARS),and Barthel index(BI)was adopted to score the activities of daily living(ADL).Results:After treatment,the markedly effective rate was 70.2%and the total effective rate was 96.5%in the observation group,versus 39.7%and 87.9%in the control group,and the differences in the markedly effective rate and the total effective rate were statistically significant(P<0.01,P<0.05).The intra-group comparisons showed that the BBS,ICARS and BI scores after treatment and at the follow-up were significantly different from those before treatment in both groups(all P<0.01).There were significant differences in the BBS score between the two groups after treatment and at the follow-up(P<0.05,P<0.01);the between-group differences in the ICARS and BI scores were statistically insignificant after treatment(both P>0.05),while the between-group differences in the ICARS and BI scores were statistically significant at the follow-up(both P<0.05).The interaction effects between the scoring time of BBS and BI and the group factor were statistically significant(P<0.01,P<0.05).Conclusion:Mind-refreshing and balance-restoring needling can effectively improve the lower-limb ataxic symptoms and ADL after stroke;when combined with Fenkel exercises,this needling method can produce more significant efficacy.展开更多
Hydroxycarboxylic acid receptor 2(HCAR2),a member of Class A G-protein-coupled receptor(GPCR)family,plays a pivotal role in anti-lipolytic and anti-inflammatory effects,establishing it as a significant therapeutic tar...Hydroxycarboxylic acid receptor 2(HCAR2),a member of Class A G-protein-coupled receptor(GPCR)family,plays a pivotal role in anti-lipolytic and anti-inflammatory effects,establishing it as a significant therapeutic target for treating dyslipidemia and inflammatory diseases.展开更多
To improve the light environment and welfare of the turtle cultured indoors,the effects of lighting mode on growth performance,cortisol level,and oxidative stress of juvenile Chinese three-keeled pond turtle,Chinemys ...To improve the light environment and welfare of the turtle cultured indoors,the effects of lighting mode on growth performance,cortisol level,and oxidative stress of juvenile Chinese three-keeled pond turtle,Chinemys reevesii,were investigated in this study.The experimental turtles with an initial weight of 5.61±0.09 g were reared in tanks under four different lighting modes:three groups with light(lighting the basking area and water area,LBW;lighting the water area only,LW;lighting the basking area only,LB)and control group(no light,NL).The experiment was conducted for more than six months,with each group having three replicates.After 203 d of the experiment,the turtle in the LW group exhibited higher weight gain rate(WGR)and a specific growth rate(SGR,%/d)compared to other treatments.Also,results showed that the final body weight of the turtle exposed to LW was higher than that exposed to other treatments.On the physiological level,serum cortisol level in turtles exposed to LW was significantly lower than that in other treatments.Regarding oxidative stress,the level of catalase(CAT)in turtles exposed to LW and LB was significantly lower than that exposed to LBW and NL.The malonaldehyde(MDA)activity in turtles exposed to LW was significantly lower than other treatments.Based on the growth performance and health status,it is suggested that lighting the water area only is the optimal lighting mode for the juvenile threekeeled pond turtle cultured indoors.展开更多
Chiglitazar(Carfloglitazar)is a novel peroxisome proliferator-activated receptor(PPAR)pan-agonist that has shown promising effects on glycemic control and lipid regulation in patients with type 2 diabetes.In this rand...Chiglitazar(Carfloglitazar)is a novel peroxisome proliferator-activated receptor(PPAR)pan-agonist that has shown promising effects on glycemic control and lipid regulation in patients with type 2 diabetes.In this randomized phase 3 trial,we compared the efficacy and safety of chiglitazar with sitagliptin in patients with type 2 diabetes who had insufficient glycemic control despite a strict diet and exercise regimen.Eligible patients were randomized(1:1:1)to receive chiglitazar 32 mg(n=245),chiglitazar 48 mg(n=246),or sitagliptin 100 mg(n=248)once daily for 24 weeks.The primary endpoint was the change in glycosylated hemoglobin A_(1C)(HbA_(1c))from baseline at week 24 with the non-inferiority of chiglitazar over sitagliptin.Both chiglitazar and sitagliptin significantly reduced HbA1c at week 24 with values of-1.40%,-1.47%,and-1.39%for chiglitazar 32 mg,chiglitazar 48 mg,and sitagliptin 100 mg,respectively.Chiglitazar 32 and 48 mg were both non-inferior to sitagliptin 100 mg,with mean differences of-0.04%(95%confidential interval(Cl)-0.22 to 0.15)and-0.08%(95%Cl-0.27 to 0.10),respectively.Compared with sitagliptin,greater reduction in fasting and 2-h postprandial plasma glucose and fasting insulin was observed with chiglitazar.Overall adverse event rates were similar between the groups.A small increase in mild edema in the chiglitazar 48 mg group and slight weight gain in both chiglitazar groups were reported.The overall results demonstrated that chiglitazar possesses good efficacy and safety profile in patients with type 2 diabetes inadequately controlled with lifestyle interventions,thereby providing adequate supporting evidence for using this PPAR pan-agonist as a treatment option for type 2 diabetes.展开更多
文摘Purpose:To investigate the fundus and fluorescein angiographic features in the patients with radiation retinopathy.Clinical Materials:Color fundus photography and/or fluorescein angiography from 13 patients with nasopharyngeal carcinomas received external beam radiation were retrospectively analyzed.Reslts:In this study,26 damaged eyes of 13 patients eveloped some degree of radiation retinopathy.The earliest and most common finding was macular microvascular changes (microaneurysms and/or telangiectasia),which was observed in 100%(26/26)of the eyes.Intraretinal hemorrhages,macular capillary nonperfusion,and macular edema were noted in 84%,50%,and 42% of the eyes,respectively.Conclusions:Radiation retinopathy is common after external beam radiation of nasopharyngeal carcinomas.The prominent changes include maular microvascular changes,intraretinal hemorrhages and macular capillary nonperfusion.
文摘Objective:To observe the clinical efficacy of mind-refreshing and balance-restoring needling method combined with Frenkel exercises in treating ataxia after cerebral stroke.Methods:The recruited 120 patients were randomized into an observation group and a control group,with 60 cases in each group.The control group was intervened by mind-refreshing and balance-restoring needling method,while the observation group was given additional lower-limb Frenkel exercises.Before and after treatment and at the follow-up,the ataxic lower-limb function was scored using Berg balance scale(BBS)and international cooperative ataxia rating scale(ICARS),and Barthel index(BI)was adopted to score the activities of daily living(ADL).Results:After treatment,the markedly effective rate was 70.2%and the total effective rate was 96.5%in the observation group,versus 39.7%and 87.9%in the control group,and the differences in the markedly effective rate and the total effective rate were statistically significant(P<0.01,P<0.05).The intra-group comparisons showed that the BBS,ICARS and BI scores after treatment and at the follow-up were significantly different from those before treatment in both groups(all P<0.01).There were significant differences in the BBS score between the two groups after treatment and at the follow-up(P<0.05,P<0.01);the between-group differences in the ICARS and BI scores were statistically insignificant after treatment(both P>0.05),while the between-group differences in the ICARS and BI scores were statistically significant at the follow-up(both P<0.05).The interaction effects between the scoring time of BBS and BI and the group factor were statistically significant(P<0.01,P<0.05).Conclusion:Mind-refreshing and balance-restoring needling can effectively improve the lower-limb ataxic symptoms and ADL after stroke;when combined with Fenkel exercises,this needling method can produce more significant efficacy.
基金This work was supported by the National Natural Science Foundation of China(32100988 to W.Y.,31972916 to Z.S,82271190 and 32100965 to L.C.)Science and Technology Department of Sichuan Province(2020YFQ0055 to P.F.and 2022ZYD0085 to Z.S.)+1 种基金Ministry of Technology Department of China grant(2019YFA0508800 to Z.S)1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(ZYGD18027 to P.F,ZYYC20023 to Z.S).
文摘Hydroxycarboxylic acid receptor 2(HCAR2),a member of Class A G-protein-coupled receptor(GPCR)family,plays a pivotal role in anti-lipolytic and anti-inflammatory effects,establishing it as a significant therapeutic target for treating dyslipidemia and inflammatory diseases.
基金supported by the Key Program of Science and Technology of Zhejiang Province(Grant No.2023 C02050)the Open Fund of Zhejiang Institute of Freshwater Fisheries(Grant No.ZJK201905)+2 种基金the Technology Program of Department of Agriculture and Rural of Zhejiang Province,China(Grant No.2020XTTGSC01)the Rural Revitalization Project of Huzhou(No.2021ZD2039)the Fundamental Research Funds for the Central Universities(Grant No.2019QNA6005).
文摘To improve the light environment and welfare of the turtle cultured indoors,the effects of lighting mode on growth performance,cortisol level,and oxidative stress of juvenile Chinese three-keeled pond turtle,Chinemys reevesii,were investigated in this study.The experimental turtles with an initial weight of 5.61±0.09 g were reared in tanks under four different lighting modes:three groups with light(lighting the basking area and water area,LBW;lighting the water area only,LW;lighting the basking area only,LB)and control group(no light,NL).The experiment was conducted for more than six months,with each group having three replicates.After 203 d of the experiment,the turtle in the LW group exhibited higher weight gain rate(WGR)and a specific growth rate(SGR,%/d)compared to other treatments.Also,results showed that the final body weight of the turtle exposed to LW was higher than that exposed to other treatments.On the physiological level,serum cortisol level in turtles exposed to LW was significantly lower than that in other treatments.Regarding oxidative stress,the level of catalase(CAT)in turtles exposed to LW and LB was significantly lower than that exposed to LBW and NL.The malonaldehyde(MDA)activity in turtles exposed to LW was significantly lower than other treatments.Based on the growth performance and health status,it is suggested that lighting the water area only is the optimal lighting mode for the juvenile threekeeled pond turtle cultured indoors.
基金the Chinese National and Provincial Major Project for New Drug Innovation(National:2008ZX09101-002,2013ZX09401301Provincial:2011A080501010)Shenzhen Municipal Major Project(2010-1746)。
文摘Chiglitazar(Carfloglitazar)is a novel peroxisome proliferator-activated receptor(PPAR)pan-agonist that has shown promising effects on glycemic control and lipid regulation in patients with type 2 diabetes.In this randomized phase 3 trial,we compared the efficacy and safety of chiglitazar with sitagliptin in patients with type 2 diabetes who had insufficient glycemic control despite a strict diet and exercise regimen.Eligible patients were randomized(1:1:1)to receive chiglitazar 32 mg(n=245),chiglitazar 48 mg(n=246),or sitagliptin 100 mg(n=248)once daily for 24 weeks.The primary endpoint was the change in glycosylated hemoglobin A_(1C)(HbA_(1c))from baseline at week 24 with the non-inferiority of chiglitazar over sitagliptin.Both chiglitazar and sitagliptin significantly reduced HbA1c at week 24 with values of-1.40%,-1.47%,and-1.39%for chiglitazar 32 mg,chiglitazar 48 mg,and sitagliptin 100 mg,respectively.Chiglitazar 32 and 48 mg were both non-inferior to sitagliptin 100 mg,with mean differences of-0.04%(95%confidential interval(Cl)-0.22 to 0.15)and-0.08%(95%Cl-0.27 to 0.10),respectively.Compared with sitagliptin,greater reduction in fasting and 2-h postprandial plasma glucose and fasting insulin was observed with chiglitazar.Overall adverse event rates were similar between the groups.A small increase in mild edema in the chiglitazar 48 mg group and slight weight gain in both chiglitazar groups were reported.The overall results demonstrated that chiglitazar possesses good efficacy and safety profile in patients with type 2 diabetes inadequately controlled with lifestyle interventions,thereby providing adequate supporting evidence for using this PPAR pan-agonist as a treatment option for type 2 diabetes.
