A scheme is proposed where two superconducting qubits driven by a classical field interacting separately with two distant LC circuits connected by another LC circuit through mutual inductance,are used for implementing...A scheme is proposed where two superconducting qubits driven by a classical field interacting separately with two distant LC circuits connected by another LC circuit through mutual inductance,are used for implementing quantum gates.By using dressed states,quantum state transfer and quantum entangling gate can be implemented.With the help of the time-dependent electromagnetic field,any two dressed qubits can be selectively coupled to the data bus (the last LC circuit),then quantum state can be transferred from one dressed qubit to another and multi-mode entangled state can also be formed.As a result,the promising perspectives for quantum information processing of mesoscopic superconducting qubits are obtained and the distributed and scalable quantum computation can be implemented in this scheme.展开更多
Mouse embryonic stem cells(mESCs)cycle in and out of a transient 2-cell(2C)-like totipotent state,driven by a com-plex genetic circuit involves both the coding and repetitive sections of the genome.While a vast array ...Mouse embryonic stem cells(mESCs)cycle in and out of a transient 2-cell(2C)-like totipotent state,driven by a com-plex genetic circuit involves both the coding and repetitive sections of the genome.While a vast array of regulators,including the multi-functional protein Rif1,has been reported to influence the switch of fate potential,how they act in concert to achieve this cellular plasticity remains elusive.Here,by modularizing the known totipotency regulatory factors,we identify an unprecedented functional connection between Rif1 and the non-canonical polycomb repres-sive complex PRC1.6.Downregulation of the expression of either Rif1 or PRC1.6 subunits imposes similar impacts on the transcriptome of mESCs.The LacO-LacI induced ectopic colocalization assay detects a specific interaction between Rif1 and Pcgf6,bolstering the intactness of the PRC1.6 complex.Chromatin immunoprecipitation followed by sequencing(ChIP-seq)analysis further reveals that Rif1 is required for the accurate targeting of Pcgf6 to a group of genomic loci encompassing many genes involved in the regulation of the 2C-like state.Depletion of Rif1 or Pcgf6 not only activates 2C genes such as Zscan4 and Zfp352,but also derepresses a group of the endogenous retroviral element MERVL,a key marker for totipotency.Collectively,our findings discover that Rif1 can serve as a novel auxiliary component in the PRC1.6 complex to restrain the genetic circuit underlying totipotent fate potential,shedding new mechanistic insights into its function in regulating the cellular plasticity of embryonic stem cells.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 11074072)the Natural Science Foundation of Hunan Province of China (Grant Nos. 07JJ3013 and 07JJ5003)the Science Foundation of the Education Bureau of Hunan Province of China (Grant No. 06A038)
文摘A scheme is proposed where two superconducting qubits driven by a classical field interacting separately with two distant LC circuits connected by another LC circuit through mutual inductance,are used for implementing quantum gates.By using dressed states,quantum state transfer and quantum entangling gate can be implemented.With the help of the time-dependent electromagnetic field,any two dressed qubits can be selectively coupled to the data bus (the last LC circuit),then quantum state can be transferred from one dressed qubit to another and multi-mode entangled state can also be formed.As a result,the promising perspectives for quantum information processing of mesoscopic superconducting qubits are obtained and the distributed and scalable quantum computation can be implemented in this scheme.
基金This project has been supported by the National Natural Science Foundation of China(32170821,31771589 to K.Y)Ministry of Science and Technology of the People’s Republic of China(2021YFC2701202)+1 种基金Department of Science&Technology of Hunan Province(2021JJ10054,2019SK1012,2018DK2015,2017RS3013,2017XK2011 to K.Y,2019JJ40478 to P.L,and the innovative team program 2019RS1010)Central South University(2018CX032 to K.Y,and the innovation-driven team project 2020CX016)。
文摘Mouse embryonic stem cells(mESCs)cycle in and out of a transient 2-cell(2C)-like totipotent state,driven by a com-plex genetic circuit involves both the coding and repetitive sections of the genome.While a vast array of regulators,including the multi-functional protein Rif1,has been reported to influence the switch of fate potential,how they act in concert to achieve this cellular plasticity remains elusive.Here,by modularizing the known totipotency regulatory factors,we identify an unprecedented functional connection between Rif1 and the non-canonical polycomb repres-sive complex PRC1.6.Downregulation of the expression of either Rif1 or PRC1.6 subunits imposes similar impacts on the transcriptome of mESCs.The LacO-LacI induced ectopic colocalization assay detects a specific interaction between Rif1 and Pcgf6,bolstering the intactness of the PRC1.6 complex.Chromatin immunoprecipitation followed by sequencing(ChIP-seq)analysis further reveals that Rif1 is required for the accurate targeting of Pcgf6 to a group of genomic loci encompassing many genes involved in the regulation of the 2C-like state.Depletion of Rif1 or Pcgf6 not only activates 2C genes such as Zscan4 and Zfp352,but also derepresses a group of the endogenous retroviral element MERVL,a key marker for totipotency.Collectively,our findings discover that Rif1 can serve as a novel auxiliary component in the PRC1.6 complex to restrain the genetic circuit underlying totipotent fate potential,shedding new mechanistic insights into its function in regulating the cellular plasticity of embryonic stem cells.
