Accurate prediction of myopic progression and high myopia by machine learning

Background Myopia is a leading cause of visual impairment in Asia and worldwide.However,accurately predicting the progression of myopia and the high risk of myopia remains a challenge.This study aims to develop a predictive model for the development of myopia.Methods We first retrospectively gathered 612530 medical records from five independent cohorts,encompassing 227543 patients ranging from infants to young adults.Subsequently,we developed a multivariate linear regression algorithm model to predict the progression of myopia and the risk of high myopia.Result The model to predict the progression of myopia achieved an R^(2) value of 0.964 vs a mean absolute error(MAE)of 0.119D[95%confidence interval(CI):0.119,1.146]in the internal validation set.It demonstrated strong generalizability,maintaining consistent performance across external validation sets:R^(2)=0.950 vs MAE=0.119D(95%CI:0.119,1.136)in validation study 1,R^(2)=0.950 vs MAE=0.121D(95%CI:0.121,1.144)in validation study 2,and R^(2)=0.806 vs MAE=−0.066D(95%CI:−0.066,0.569)in the Shanghai Children Myopia Study.In the Beijing Children Eye Study,the model achieved an R^(2) of 0.749 vs a MAE of 0.178D(95%CI:0.178,1.557).The model to predict the risk of high myopia achieved an area under the curve(AUC)of 0.99 in the internal validation set and consistently high area under the curve values of 0.99,0.99,0.96 and 0.99 in the respective external validation sets.Conclusion Our study demonstrates accurate prediction of myopia progression and risk of high myopia providing valuable insights for tailoring strategies to personalize and optimize the clinical management of myopia in children.

A new insight for stem cell therapy:apoptotic stem cells as a key player

Recently,two studies on therapeutic effects of stem cell therapy were published in Signal Transduction and Target Therapy1 and Nature Communications.2These studies have shed the light on a unique aspect of stem cell therapy which involves a previously unrecognized key player,namely apoptotic cells.These two publications have elucidated how the apoptotic cells exert immunomodulatory effects in stem cell therapy in several animal models.