Radiation-induced heart disease(RIHD),characterized by severe oxidative stress and immune dysregulation,is a serious condition affecting cancer patients undergoing thoracic radiation.Unfortunately,clinical interventio...Radiation-induced heart disease(RIHD),characterized by severe oxidative stress and immune dysregulation,is a serious condition affecting cancer patients undergoing thoracic radiation.Unfortunately,clinical interventions for RIHD are lacking.Selenium(Se)is a trace element with excellent antioxidant and immune-modulatory properties.However,its application in heart radioprotection remains challenging.Herein,we developed a novel bioactive Cordyceps militaris-based Se oral delivery system(Se@CM),which demonstrated superior radioprotection effects in vitro against X-ray-induced damage in H9C2 cells through suppressing excessive ROS generation,compared to the radioprotectant Amifostine.Moreover,Se@CM exhibited exceptional cardioprotective effects in vivo against X-ray irradiation,reducing cardiac dysfunction and myocardial fibrosis by balancing the redox equilibrium and modulating the expression of Mn-SOD and MDA.Additionally,Se@CM maintained immuno-homeostasis,as evidenced by the upregulated population of T cells and M2 macrophages through modulation of selenoprotein expression after irradiation.Together,these results highlight the remarkable antioxidant and immunity modulation properties of Se@CM and shed light on its promising application for cardiac protection against IR-induced disease.This research provides valuable insights into developing effective strategies for preventing and managing RIHD.展开更多
基金supported by the National Science Fund for Distinguished Young Scholars (82225025)National Natural Science Foundation of China (21877049,32171296,32101044)+1 种基金Guangdong Natural Science Foundation (2020B1515120043)K.C.Wong Education Foundation and China Postdoctoral Science Foundation (2022M711341).
文摘Radiation-induced heart disease(RIHD),characterized by severe oxidative stress and immune dysregulation,is a serious condition affecting cancer patients undergoing thoracic radiation.Unfortunately,clinical interventions for RIHD are lacking.Selenium(Se)is a trace element with excellent antioxidant and immune-modulatory properties.However,its application in heart radioprotection remains challenging.Herein,we developed a novel bioactive Cordyceps militaris-based Se oral delivery system(Se@CM),which demonstrated superior radioprotection effects in vitro against X-ray-induced damage in H9C2 cells through suppressing excessive ROS generation,compared to the radioprotectant Amifostine.Moreover,Se@CM exhibited exceptional cardioprotective effects in vivo against X-ray irradiation,reducing cardiac dysfunction and myocardial fibrosis by balancing the redox equilibrium and modulating the expression of Mn-SOD and MDA.Additionally,Se@CM maintained immuno-homeostasis,as evidenced by the upregulated population of T cells and M2 macrophages through modulation of selenoprotein expression after irradiation.Together,these results highlight the remarkable antioxidant and immunity modulation properties of Se@CM and shed light on its promising application for cardiac protection against IR-induced disease.This research provides valuable insights into developing effective strategies for preventing and managing RIHD.
