In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip.The diffraction gratings used in spectral-domain optical coherence tomogr...In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip.The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating.Two arrayed waveguide grating designs with 256 channels were tested,which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements.Design 1 supports a bandwidth of 22nm,with which a sensitivity of up to 91 dB(830μW) and an axial resolution of 10.7 pm was measured.Design 2 supports a bandwidth of 48 nm,with which a sensitivity of 90 dB(480μW) and an axial resolution of 6.5μm was measured.The silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process,which allows their monolithic co-integration on top of an optoelectronic silicon chip.As a benchmark for chip-based optical coherence tomography,tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip gratings.The similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.展开更多
基金The authors thank Rene Werkmeister for data acquisition and permission to use the data from the commercial benchmark system and EXALOS AG for the booster amplifier.E.A.R.greatly acknowledges fruitful discussions with Fabian Placzek.This work was carried out in the framework of project COHESION,No.848588,funded by the Austrian Research Promotion Agency(FFG).This research has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No.688173(OCTCHIP).DJ.H.gratefully acknowledges financial support from the European Research Council(ERC)(No.640396 OPTIMALZ).
文摘In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip.The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating.Two arrayed waveguide grating designs with 256 channels were tested,which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements.Design 1 supports a bandwidth of 22nm,with which a sensitivity of up to 91 dB(830μW) and an axial resolution of 10.7 pm was measured.Design 2 supports a bandwidth of 48 nm,with which a sensitivity of 90 dB(480μW) and an axial resolution of 6.5μm was measured.The silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process,which allows their monolithic co-integration on top of an optoelectronic silicon chip.As a benchmark for chip-based optical coherence tomography,tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip gratings.The similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.
