用Setaram Multi HTC高灵敏热分析仪在准平衡和动态两种情况下对一组经过电解渗氢/均匀化退火处理的N18锆合金的相变进行了研究。结果表明,随着氢含量的增加,N18的α/β相转变温度逐渐降低,并且β相转变越多,氢含量的影响越小;用JMAK模...用Setaram Multi HTC高灵敏热分析仪在准平衡和动态两种情况下对一组经过电解渗氢/均匀化退火处理的N18锆合金的相变进行了研究。结果表明,随着氢含量的增加,N18的α/β相转变温度逐渐降低,并且β相转变越多,氢含量的影响越小;用JMAK模型可以很好地模拟氢对N18合金相演化过程的影响。展开更多
For the two-dimensional Navier-Stokes equations of isentropic magnetohydrodynamics (MHD) with γ-law gas equation of state, γ≥ 1, and infinite electrical resistivity, we carry out a global analysis categorizing al...For the two-dimensional Navier-Stokes equations of isentropic magnetohydrodynamics (MHD) with γ-law gas equation of state, γ≥ 1, and infinite electrical resistivity, we carry out a global analysis categorizing all possible viscous shock profiles. Precisely, we show that the phase portrait of the traveling-wave ODE generically consists of either two rest points connected by a viscous Lax profile, or else four rest points, two saddles and two nodes. In the latter configuration, which rest points are connected by profiles depends on the ratio of viscosities, and can involve Lax, overcompressive, or undercompressive shock profiles. Considered as three-dimensional solutions, undercompressive shocks axe Lax-type (Alfven) waves. For the monatomic and diatomic cases γ= 5/3 and γ=7/5, with standard viscosity ratio for a nonmagnetic gas, we find numerically that the the nodes are connected by a family of overcompressive profiles bounded by Lax profiles connecting saddles to nodes, with no undercompressive shocks occurring. We carry out a systematic numerical Evans function analysis indicating that all of these two-dimensional shock pro- files are linearly and nonlinearly stable, both with respect to two- and three-dimensional perturbations. For the same gas constants, but different viscosity ratios, we investigate also cases for which undercompressive shocks appear; these are seen numerically to be stable as well, both with respect to two-dimensional and (in the neutral sense of convergence to nearby Riemann solutions) three-dimensional perturbations.展开更多
The messenger RNA 3'-untranslated region(3'UTR)plays an important role in regulation of gene expres-sion on the posttranscriptional level. The 3'UTR con-trols gene expression via orchestrated interactionbe...The messenger RNA 3'-untranslated region(3'UTR)plays an important role in regulation of gene expres-sion on the posttranscriptional level. The 3'UTR con-trols gene expression via orchestrated interactionbetween the structural components of mRNAs(cis-ele-ment) and the specific trans-acting factors(RNA bind-ing proteins and non-coding RNAs). The crosstalk ofthese factors is based on the binding sequences and/or direct protein-protein interaction, or just functionalinteraction. Much new evidence that has accumulatedsupports the idea that several RNA binding factors canbind to common mRNA targets: to the non-overlappingbinding sites or to common sites in a competitive fash-ion. Various factors capable of binding to the sameRNA can cooperate or be antagonistic in their actions.The outcome of the collective function of all factorsbound to the same mRNA 3'UTR depends on manycircumstances, such as their expression levels, affinity to the binding sites, and localization in the cell, which can be controlled by various physiological conditions. Moreover, the functional and/or physical interactions of the factors binding to 3'UTR can change the character of their actions. These interactions vary during the cell cycle and in response to changing physiological condi-tions. Abnormal functioning of the factors can lead to disease. In this review we will discuss how alterations of these factors or their interaction can affect cancer development and promote or enhance the malignant phenotype of cancer cells. Understanding these altera-tions and their impact on 3'UTR-directed posttran-scriptional gene regulation will uncover promising new targets for therapeutic intervention and diagnostics. We will also discuss emerging new tools in cancer di-agnostics and therapy based on 3'UTR binding factors and approaches to improve them.展开更多
The Gamma-Ray Monitor (GRM) is a high energy detector onboard the future Chinese-French satellite named the Space-based multi-band astronomical Variable Object Monitor which is dedicated to studies of gamma-ray burs...The Gamma-Ray Monitor (GRM) is a high energy detector onboard the future Chinese-French satellite named the Space-based multi-band astronomical Variable Object Monitor which is dedicated to studies of gamma-ray bursts (GRBs). This paper presents an investigation of the algorithms that look for GRBs by searching for a significant increase in the photon count rate for the computer onboard GRM. The trigger threshold and trigger efficiency, which are based on a given sample of GRBs, are calculated with the algorithms. The trigger characteristics of onboard instruments GRM and ECLAIRs are also analyzed. In addition, the impact of solar flares on GRM is estimated, and a method to distinguish solar flares from GRBs is investigated.展开更多
The second(O2)observational campaign of gravitational waves(GWs)organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of GW signals from merger systems involving black holes...The second(O2)observational campaign of gravitational waves(GWs)organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of GW signals from merger systems involving black holes or neutrons stars.During O2,14 GW alerts were sent to the astronomical community with sky regions mostly covering over hundreds of square degrees.Among them,six were finally confirmed as real astrophysical events.Since 2013,a new set of ground-based robotic telescopes called Ground-based Wide Angle Camera system(GWAC)project and its pathfinder mini-GWAC has been developed to contribute to the various challenges of multi-messenger and time domain astronomy.The GWAC system is built up in the framework of the ground-segment system of the SVOM mission that will be devoted to the study of the multi-wavelength transient sky in the next decade.During O2,only the mini-GWAC telescope network was fully operational.Due to the wide field of view and fast automatic follow-up capabilities of the mini-GWAC telescopes,they were adept to efficiently cover the sky localization areas of GW event candidates.In this paper,we present the mini-GWAC pipeline we have set up to respond to GW alerts and we report our optical follow-up observations of eight GW alerts detected during the O2 run.Our observations provided the largest coverage of the GW localization areas with a short latency made by any optical facility.We found tens of optical transient candidates in our images,but none of those could be securely associated with any confirmed black hole-black hole merger event.Based on this first experience and the near future technical improvements of our network system,we will be more competitive in detecting the optical counterparts from some GW events that will be identified during the upcoming O3 run,especially those emerging from binary neutron star mergers.展开更多
The solid solutions of In^(3+) doped M-type strontium hexaferrites were produced using a conventional solid-state reaction method,and Rietveld analysis of the neutron diffraction patterns was conducted.In^(3+) cations...The solid solutions of In^(3+) doped M-type strontium hexaferrites were produced using a conventional solid-state reaction method,and Rietveld analysis of the neutron diffraction patterns was conducted.In^(3+) cations occupy octahedral (4f_(Ⅵ)and 12 k) and tetrahedral (4f_(Ⅳ)) positions (SG=P6_(3)/mmc(No.194)).The average particle size is 837–650 nm.Curie tempearature (T_(C)) of the compounds monotonically decreased down to~520 K with increasing x.A frustrated magnetic state was detected from ZFC and FC magnetizations.saturation magnetization (M_(s)) and effective magnetocrystalline anisotropy coefficient (k_(eff)) were determined using the law of approach to saturation.A real permittivity (ε″) maximum of~3.3 at~45.5 GHz and an imaginary permittivity (ε′) of~1.6 at~42.3 GHz were observed for x=0.1.A real permeability (μ′) maximum of~1.5 at~36.2 GHz was observed for x=0.Aμ″imaginary permeability maximum of~0.8 at~38.3 GHz was observed for x=0.1.The interpretation of the results is based on the type of dielectric polarization and the natural ferromagnetic resonance features.展开更多
Biopolymers extracted from renewable resources like chitosan and collagen exhibit interesting properties for the elaboration of materials designed for tissue engineering applications,among which are their hydrophilici...Biopolymers extracted from renewable resources like chitosan and collagen exhibit interesting properties for the elaboration of materials designed for tissue engineering applications,among which are their hydrophilicity,biocompatibility and biodegradability.In many cases,functional recovery of an injured tissue or organ requires oriented cell outgrowth,which is particularly critical for nerve regeneration.Therefore,there is a growing interest for the elaboration of materials exhibiting functionalization gradients able to guide cells.Here,we explore an original way of elaborating such gradients by assembling particles from a library of functionalized microspheres.We propose a simple process to prepare chitosan-collagen hybrid microspheres by micro-and milli-fluidics,with adaptable dimensions and narrow size distributions.The adhesion and survival rate of PC12 cells on hybrid microspheres were compared to those on pure chitosan ones.Finally,functionalized microspheres were assembled into membranes exhibiting a functionalization gradient.展开更多
We analyze the statistical properties of the photons emitted at the junction of a scanning tunneling microscope at the solid/liquid interface by time-autocorrelated two-photon counting measurements, with time resoluti...We analyze the statistical properties of the photons emitted at the junction of a scanning tunneling microscope at the solid/liquid interface by time-autocorrelated two-photon counting measurements, with time resolutions down to the nanosecond scale. In the case of a gold-gold junction immersed in an inhomogeneous liquid, we show that the tip-induced luminescence exhibits a clear bunching phenomenon depending on the tip-sample distance.展开更多
The first SEASTAR (Shell Evolution and Search for Two-plus energies At RIBF) campaign was carried out inMay 2014. We are analyzing the data for 58??63V and 63??66Mn.The experiment was performed at the Radioactive Isot...The first SEASTAR (Shell Evolution and Search for Two-plus energies At RIBF) campaign was carried out inMay 2014. We are analyzing the data for 58??63V and 63??66Mn.The experiment was performed at the Radioactive Isotope Beam Factory in RIKEN. A high-intensity 238U beamwas accelerated to bombard beryllium target to produce secondary beams. The B??ΔE??B method was applied toselect and purify secondary beams. An ionization chamber located at the focal point F7 (F11) measured the energyloss ΔE, yielding the fragments' element number Z in BigRIPS (ZDS)[1].展开更多
The ANTARES collaboration is building a deep underwater neutrino telescope to be immersed in the Mediterranean Sea 40km off the French coast.This detector will be able to detect the Cherenkov light emitted by muons pr...The ANTARES collaboration is building a deep underwater neutrino telescope to be immersed in the Mediterranean Sea 40km off the French coast.This detector will be able to detect the Cherenkov light emitted by muons produced in neutrino interactions using a three-dimensional matrix of optical sensors,The telescope will be made of nearly 1000 of these elementary units distributed over a wide area of about 0.1 km2 at an average depth of 2400m In order to reach a sub-nanosecond resolution on ligh pulse detection ,signals from all OMs are analyzed and digitized locally before being sent to shore through a 50km electro-optical cable,Front-end electronics,time alignment (clock distribution),Triggering and data acquistition for such a large and remote detector represent a real hallenge and required considerable R&D studies,The technical solutions adopted by the collaboration will be described and their performances discussed.展开更多
Efficient and durable electrocatalysts are instrumental in enabling next-generation fuel cell technologies.At present,expensive precious metals are used as state-of-the-art catalysts.In this report,cost-effective nano...Efficient and durable electrocatalysts are instrumental in enabling next-generation fuel cell technologies.At present,expensive precious metals are used as state-of-the-art catalysts.In this report,cost-effective nanosized tantalum-based alternatives are synthesized for the first time via a green and scalable laser pyrolysis method as bifunctional catalysts for direct peroxide–peroxide fuel cells.This rapid laser pyrolysis strategy allows for the production of nanoparticles at a laboratory scale of grams per hour,compatible with a detailed exploration of the functional properties of as-synthesized nanoparticles.By varying the precursor ratio between ammonia and tantalum ethanolate,five tantalum-based nanomaterials(TaNOC)are prepared with crystalline phases of Ta_(2)O_(5),Ta_(4)N_(5),Ta_(3)N_(5),and TaN in tunable ratios.Electrochemical studies in neutral and alkaline conditions demonstrate that Ta_(4)N_(5) is the active component for both H_(2)O_(2) oxidation and reduction.Kinetic isotope effect studies show that protons are involved at or before the rate-determining step.Long-term stability studies indicate that Ta_(3)N_(5) grants surfactant-free TaNOC-enhanced longevity during electrocatalytic operations.Taken together,bifunctional TaNOC can act as active and robust electrocatalysts for H_(2)O_(2) reduction and oxidation.Laser pyrolysis is envisioned to produce refractory metal nanomaterials with boosted corrosion resistance for energy catalysis.展开更多
基金Commissaire Energie de Atomique de Francethe 9th Five-Year Major Program of the National Natural Science Foundation of China(39890390)+1 种基金the State Key Basic Research Development Plan of China(973)(G1998010100)Innovation of Laboratory of Photosynthests Basic Research,Institute of Botany,The Chinese Acadeny of Sciences
文摘用Setaram Multi HTC高灵敏热分析仪在准平衡和动态两种情况下对一组经过电解渗氢/均匀化退火处理的N18锆合金的相变进行了研究。结果表明,随着氢含量的增加,N18的α/β相转变温度逐渐降低,并且β相转变越多,氢含量的影响越小;用JMAK模型可以很好地模拟氢对N18合金相演化过程的影响。
基金supported in part by the National Science Foundation award numbers DMS-0607721the National Science Foundation award numbers DMS-0300487
文摘For the two-dimensional Navier-Stokes equations of isentropic magnetohydrodynamics (MHD) with γ-law gas equation of state, γ≥ 1, and infinite electrical resistivity, we carry out a global analysis categorizing all possible viscous shock profiles. Precisely, we show that the phase portrait of the traveling-wave ODE generically consists of either two rest points connected by a viscous Lax profile, or else four rest points, two saddles and two nodes. In the latter configuration, which rest points are connected by profiles depends on the ratio of viscosities, and can involve Lax, overcompressive, or undercompressive shock profiles. Considered as three-dimensional solutions, undercompressive shocks axe Lax-type (Alfven) waves. For the monatomic and diatomic cases γ= 5/3 and γ=7/5, with standard viscosity ratio for a nonmagnetic gas, we find numerically that the the nodes are connected by a family of overcompressive profiles bounded by Lax profiles connecting saddles to nodes, with no undercompressive shocks occurring. We carry out a systematic numerical Evans function analysis indicating that all of these two-dimensional shock pro- files are linearly and nonlinearly stable, both with respect to two- and three-dimensional perturbations. For the same gas constants, but different viscosity ratios, we investigate also cases for which undercompressive shocks appear; these are seen numerically to be stable as well, both with respect to two-dimensional and (in the neutral sense of convergence to nearby Riemann solutions) three-dimensional perturbations.
文摘The messenger RNA 3'-untranslated region(3'UTR)plays an important role in regulation of gene expres-sion on the posttranscriptional level. The 3'UTR con-trols gene expression via orchestrated interactionbetween the structural components of mRNAs(cis-ele-ment) and the specific trans-acting factors(RNA bind-ing proteins and non-coding RNAs). The crosstalk ofthese factors is based on the binding sequences and/or direct protein-protein interaction, or just functionalinteraction. Much new evidence that has accumulatedsupports the idea that several RNA binding factors canbind to common mRNA targets: to the non-overlappingbinding sites or to common sites in a competitive fash-ion. Various factors capable of binding to the sameRNA can cooperate or be antagonistic in their actions.The outcome of the collective function of all factorsbound to the same mRNA 3'UTR depends on manycircumstances, such as their expression levels, affinity to the binding sites, and localization in the cell, which can be controlled by various physiological conditions. Moreover, the functional and/or physical interactions of the factors binding to 3'UTR can change the character of their actions. These interactions vary during the cell cycle and in response to changing physiological condi-tions. Abnormal functioning of the factors can lead to disease. In this review we will discuss how alterations of these factors or their interaction can affect cancer development and promote or enhance the malignant phenotype of cancer cells. Understanding these altera-tions and their impact on 3'UTR-directed posttran-scriptional gene regulation will uncover promising new targets for therapeutic intervention and diagnostics. We will also discuss emerging new tools in cancer di-agnostics and therapy based on 3'UTR binding factors and approaches to improve them.
基金Supported by the National Natural Science Foundation of China
文摘The Gamma-Ray Monitor (GRM) is a high energy detector onboard the future Chinese-French satellite named the Space-based multi-band astronomical Variable Object Monitor which is dedicated to studies of gamma-ray bursts (GRBs). This paper presents an investigation of the algorithms that look for GRBs by searching for a significant increase in the photon count rate for the computer onboard GRM. The trigger threshold and trigger efficiency, which are based on a given sample of GRBs, are calculated with the algorithms. The trigger characteristics of onboard instruments GRM and ECLAIRs are also analyzed. In addition, the impact of solar flares on GRM is estimated, and a method to distinguish solar flares from GRBs is investigated.
基金supported by the National Natural Science Foundation of China(Grant Nos.11533003,11673006,U1331202,U1931133 and U1938201)the Guangxi Science Foundation(2016GXNSFFA380006,AD17129006and 2018GXNSFGA281007)+3 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB23040000)the Strategic Pioneer Program on Space Science,Chinese Academy of Sciences(XDA15052600)financial support from the Chinese Academy of Sciences PIFI post-doctoral fellowship program(program C)financial support of the Univ Earth S Labex program at Sorbonne Paris Cité(ANR-10-LABX-0023 and ANR-11-IDEX-0005-02)
文摘The second(O2)observational campaign of gravitational waves(GWs)organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of GW signals from merger systems involving black holes or neutrons stars.During O2,14 GW alerts were sent to the astronomical community with sky regions mostly covering over hundreds of square degrees.Among them,six were finally confirmed as real astrophysical events.Since 2013,a new set of ground-based robotic telescopes called Ground-based Wide Angle Camera system(GWAC)project and its pathfinder mini-GWAC has been developed to contribute to the various challenges of multi-messenger and time domain astronomy.The GWAC system is built up in the framework of the ground-segment system of the SVOM mission that will be devoted to the study of the multi-wavelength transient sky in the next decade.During O2,only the mini-GWAC telescope network was fully operational.Due to the wide field of view and fast automatic follow-up capabilities of the mini-GWAC telescopes,they were adept to efficiently cover the sky localization areas of GW event candidates.In this paper,we present the mini-GWAC pipeline we have set up to respond to GW alerts and we report our optical follow-up observations of eight GW alerts detected during the O2 run.Our observations provided the largest coverage of the GW localization areas with a short latency made by any optical facility.We found tens of optical transient candidates in our images,but none of those could be securely associated with any confirmed black hole-black hole merger event.Based on this first experience and the near future technical improvements of our network system,we will be more competitive in detecting the optical counterparts from some GW events that will be identified during the upcoming O3 run,especially those emerging from binary neutron star mergers.
基金conducted with financial support from the Russian Science Foundation (Agreement No. 19-19-00694 of 06 May 2019)。
文摘The solid solutions of In^(3+) doped M-type strontium hexaferrites were produced using a conventional solid-state reaction method,and Rietveld analysis of the neutron diffraction patterns was conducted.In^(3+) cations occupy octahedral (4f_(Ⅵ)and 12 k) and tetrahedral (4f_(Ⅳ)) positions (SG=P6_(3)/mmc(No.194)).The average particle size is 837–650 nm.Curie tempearature (T_(C)) of the compounds monotonically decreased down to~520 K with increasing x.A frustrated magnetic state was detected from ZFC and FC magnetizations.saturation magnetization (M_(s)) and effective magnetocrystalline anisotropy coefficient (k_(eff)) were determined using the law of approach to saturation.A real permittivity (ε″) maximum of~3.3 at~45.5 GHz and an imaginary permittivity (ε′) of~1.6 at~42.3 GHz were observed for x=0.1.A real permeability (μ′) maximum of~1.5 at~36.2 GHz was observed for x=0.Aμ″imaginary permeability maximum of~0.8 at~38.3 GHz was observed for x=0.1.The interpretation of the results is based on the type of dielectric polarization and the natural ferromagnetic resonance features.
文摘Biopolymers extracted from renewable resources like chitosan and collagen exhibit interesting properties for the elaboration of materials designed for tissue engineering applications,among which are their hydrophilicity,biocompatibility and biodegradability.In many cases,functional recovery of an injured tissue or organ requires oriented cell outgrowth,which is particularly critical for nerve regeneration.Therefore,there is a growing interest for the elaboration of materials exhibiting functionalization gradients able to guide cells.Here,we explore an original way of elaborating such gradients by assembling particles from a library of functionalized microspheres.We propose a simple process to prepare chitosan-collagen hybrid microspheres by micro-and milli-fluidics,with adaptable dimensions and narrow size distributions.The adhesion and survival rate of PC12 cells on hybrid microspheres were compared to those on pure chitosan ones.Finally,functionalized microspheres were assembled into membranes exhibiting a functionalization gradient.
文摘We analyze the statistical properties of the photons emitted at the junction of a scanning tunneling microscope at the solid/liquid interface by time-autocorrelated two-photon counting measurements, with time resolutions down to the nanosecond scale. In the case of a gold-gold junction immersed in an inhomogeneous liquid, we show that the tip-induced luminescence exhibits a clear bunching phenomenon depending on the tip-sample distance.
文摘The first SEASTAR (Shell Evolution and Search for Two-plus energies At RIBF) campaign was carried out inMay 2014. We are analyzing the data for 58??63V and 63??66Mn.The experiment was performed at the Radioactive Isotope Beam Factory in RIKEN. A high-intensity 238U beamwas accelerated to bombard beryllium target to produce secondary beams. The B??ΔE??B method was applied toselect and purify secondary beams. An ionization chamber located at the focal point F7 (F11) measured the energyloss ΔE, yielding the fragments' element number Z in BigRIPS (ZDS)[1].
文摘The ANTARES collaboration is building a deep underwater neutrino telescope to be immersed in the Mediterranean Sea 40km off the French coast.This detector will be able to detect the Cherenkov light emitted by muons produced in neutrino interactions using a three-dimensional matrix of optical sensors,The telescope will be made of nearly 1000 of these elementary units distributed over a wide area of about 0.1 km2 at an average depth of 2400m In order to reach a sub-nanosecond resolution on ligh pulse detection ,signals from all OMs are analyzed and digitized locally before being sent to shore through a 50km electro-optical cable,Front-end electronics,time alignment (clock distribution),Triggering and data acquistition for such a large and remote detector represent a real hallenge and required considerable R&D studies,The technical solutions adopted by the collaboration will be described and their performances discussed.
基金Edmund C.M.Tse would like to express gratitude to the National Natural Science Foundation of China(NSFC)for providing a Young Scientists Fund(No.22002132)the European Union(EU)for sponsoring the SABYDOMA project via the Horizon 2020 program(H2020:862296)+5 种基金on energy catalysis and sustainable nanomaterials.Xiaoyong Mo thanks Frankie Y.F.Chan at the Electron Microscope Unit(EMU)at the University of Hong Kong(HKU)for his help with the characterization of nanomaterials.Xiaoyong Mo was supported by an Algaia-HKU Chemistry RPg Award and an SZSTI Basic Science General Program(No.JCYJ20210324122011031)The authors thank the Research Grants Council(RGC)in Hong Kong(China)for an EU-HK Research and Innovation Cooperation Co-funding Mechanism(RGC:E-HKU704/19)a CAS-RGC Joint Laboratory Funding Scheme(RGC:JLFS/P-704/18)an Early Career Scheme(RGC:27301120)for expanding the electrochemical investigation capability as well as upgrading the nanomaterials characterization instruments at the HKU-CAS Joint Laboratory on New MaterialsThe authors also thank the support provided by the National Research Agency(ANR)through the SNON(Sun light oxi-nitrides for energetic applications project)project reference ANR-13-IS09-0003The help of two Master students,Laura Line Risal and Shunxing Deng,is gratefully acknowledged.The authors are also grateful to Jocelyne Leroy and Eddy Foy for performing XPS and XRD analyses.
文摘Efficient and durable electrocatalysts are instrumental in enabling next-generation fuel cell technologies.At present,expensive precious metals are used as state-of-the-art catalysts.In this report,cost-effective nanosized tantalum-based alternatives are synthesized for the first time via a green and scalable laser pyrolysis method as bifunctional catalysts for direct peroxide–peroxide fuel cells.This rapid laser pyrolysis strategy allows for the production of nanoparticles at a laboratory scale of grams per hour,compatible with a detailed exploration of the functional properties of as-synthesized nanoparticles.By varying the precursor ratio between ammonia and tantalum ethanolate,five tantalum-based nanomaterials(TaNOC)are prepared with crystalline phases of Ta_(2)O_(5),Ta_(4)N_(5),Ta_(3)N_(5),and TaN in tunable ratios.Electrochemical studies in neutral and alkaline conditions demonstrate that Ta_(4)N_(5) is the active component for both H_(2)O_(2) oxidation and reduction.Kinetic isotope effect studies show that protons are involved at or before the rate-determining step.Long-term stability studies indicate that Ta_(3)N_(5) grants surfactant-free TaNOC-enhanced longevity during electrocatalytic operations.Taken together,bifunctional TaNOC can act as active and robust electrocatalysts for H_(2)O_(2) reduction and oxidation.Laser pyrolysis is envisioned to produce refractory metal nanomaterials with boosted corrosion resistance for energy catalysis.