信息化取得实效的关键是什么?

信息化建设,能力不等于应用,应用不等于实效。我们经常说,信息化要注重实效。如何把这一要求,从一般号召,变为扎实的行动,不光要有意愿,而且要有路数。

信息化企业的核心与要素

企业信息化不等于信息化企业。信息化企业是信息化融入企业本质,既具有先进发展方式,又具有基业长青能力的企业。信息化企业是适合21世纪经济环境的企业模式,代表了社会经济主体和企业发展的下一代方向。树立信息化企业理念,具有重要现实意义。

从企业信息化到信息化企业

信息化企业的核心词是企业．而不是信息化。 信息化企业是信息化融入企业本质．既具有先进发展方式，又具有基业长青能力的企业。信息化企业是适合21世纪经济环境的企业模式．代表了社会经济主体和企业发展的下一代方向。

2008年度中国企业信息化 500强调查报告

当前，在各国大型企业普遍受到国际金融危机冲击的情况下，中国大企业脱颖而出，为中国保持GDP增长8％的目标提供了坚强保障。中国大型企业中最优秀的代表，信息化水平已经达到或接近世界先进水平。信息化在推动中国企业迈向世界一流企业进程中，发挥了重要作用。推进信息化与工业化融合，从企业信息化走向信息化企业，成为提高我国企业国际竞争力、实现可持续发展的战略性选择。

2007年中国企业信息化500强调查报告

提高自主创新能力,大力推进信息化与工业化融合,是中国企业信息化科学发展的必由之路。

从企业信息化到信息化企业

在一次对国资监管信息化专家咨询组专家胡建生的专访中，他说：“中国向信息化要核心价值的时代已经到来。国家电网公司刘振亚总经理曾经提出‘信息化企业’的理念．作为一个全新的理念．‘信息化企业’在国际上并没有完整的理论．这让我悟出信息化思维或理论新的高度．像国家电网公司这样的企业都应该摆脱企业信息化过程中受具体应用的束缚。

信息化推动企业自主创新

CECA国家信息化测评中心日前的研究显示，信息化成为推动企业自主创新的强大动力。

共享节能环保新机遇开创绿色发展新未来2018中国节能与低碳发展论坛在京召开

2018年12月20日,由中国节能协会主办的“2018中国节能与低碳发展论坛”在北京召开。第十届全国人大常委会副委员长顾秀莲,第十届全国人大财经委主任委员、原铁道部部长、工程院院士傅志寰,国务院参事室原副主任蒋明麟,国家大气污染防治攻关联合中心副主任柴发合,中国节能协会理事长、工程院院士江亿,以及国家发展改革委、工信部、生态环境部、国家市场监管总局、国管局、行业协会等相关领导出席会议并发言。大会由中国节能协会副理事长房庆主持。

2007年中国企业信息化500强调查报告

信息化500强2007年销售收入近10万亿，覆盖了国民经济的骨干成分。500强的企业的销售规模和行业分布如图，其中百亿以上的企业占500强总数的33％。

信息化的新榜单——2006年度中国企业信息化500强发展报告

中国企业信息化500强，是信息化建设取得显著成效，具有良好的自主创新能力和品牌的并具有一定规模的优秀企业代表；“中国企业信息化500强”调查活动是中国企业信息化建设先进经验的总结，能有力地推动企业信息化的健康发展，并为政府制定相关决策提供支持依据。

Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells

AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the "minimal Feret's diameter" respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction.

Single Layer Centrifugation with Androcoll-E^(TM) improved progressive motility and percentage of live spermatozoa with intact acrosome of chilled stallion semen but did not have an effect on DNA integrity

A significant number of stallions produce low quality ejaculates with high sensibility to chilling. Single Layer Centrifugation (SLC) with Andro-coll-ETM has been presented as an efficient method of selecting good quality spermatozoa. In the current study, changes in sperm quality (motility, viability, acrosome integrity and DNA damage) occurring during storage at 5?C for a maximum of 72 h, were investigated. For that, one ejaculate from 12 stallions was split in two aliquots: control and SLC-selected. Both aliquots were chilled and stored at 5?C and spermatozoa were evaluated for motility, viability and acrosome integrity at 24, 48 and 72 h post collection. DNA damage was evaluated at 48 h post collection using the comet assay. In the SLC-selected aliquots, there was a significant improvement in terms of progressive motility (0 h: P = 0.005;24 h: P 0.05). SLC with Androcoll-ETM improved semen quality prolonging sperm longevity of chilled semen (P = 0.012). This positive effect was more evident in ejaculates most sensitive to chilling that had a sharp decrease in motility in the first 24 h of refrigeration and for all ejaculates at 72 h post-chilling. Therefore, this method reveals to be a useful technique for selecting spermatozoa and maintain sperm quality during storage.

Structure inversion asymmetry enhanced electronic structure and electrical transport in 2D A3SnO(A=Ca,Sr,and Ba)antiperovskite monolayers

Anti-perovskites A3SnO(A=Ca,Sr,and Ba)are an important class of materials due to the emergence of Dirac cones and tiny mass gaps in their band structures originating from an intricate interplay of crystal symmetry,spin–orbit coupling,and band overlap.This provides an exciting playground for modulating their electronic properties in the two-dimensional(2D)limit.Herein,we employ first-principles density functional theory(DFT)calculations by combining dispersion-corrected SCAN+rVV10 and mBJ functionals for a comprehensive side-by-side comparison of the structural,thermodynamic,dynamical,mechanical,electronic,and thermoelectric properties of bulk and monolayer(one unit cell thick)A3SnO anti-perovskites.Our results show that 2D monolayers derived from bulk A3SnO anti-perovskites are structurally and energetically stable.Moreover,Rashba-type splitting in the electronic structure of Ca3SnO and Sr3SnO monolayers is observed owing to strong spin–orbit coupling and inversion asymmetry.On the other hand,monolayer Ba3SnO exhibits Dirac cone at the high-symmetryΓpoint due to the domination of band overlap.Based on the predicted electronic transport properties,it is shown that inversion asymmetry plays an essential character such that the monolayers Ca3SnO and Sr3SnO outperform thermoelectric performance of their bulk counterparts.

营造良好的企业生态系统

一个社会的最高理想,是为大众谋幸福。一个公司的理想,为什么就不能为员工谋幸福呢？

Performance-Centric Optimization for Racetrack Memory Based Register File on GPUs

The key to high performance for GPU architecture lies in its massive threading capability to drive a large number of cores and enable execution overlapping among threads. However, in reality, the number of threads that can simultaneously execute is often limited by the size of the register file on GPUs. The traditional SRAM-based register file takes up so large amount of chip area that it cannot scale to meet the increasing demand of GPU applications. Racetrack memory （RM） is a promising technology for designing large capacity register file on GPUs due to its high data storage density. However, without careful deployment of RM-based register file, the lengthy shift operations of RM may hurt the performance. In this paper, we explore RM for designing high-performance register file for GPU architecture. High storage density RM helps to improve the thread level parallelism （TLP）, but if the bits of the registers are not aligned to the ports, shift operations are required to move the bits to the access ports before they are accessed, and thus the read/write operations are delayed. We develop an optimization framework for RM-based register file on GPUs, which employs three different optimization techniques at the application, compilation, and architecture level, respectively. More clearly, we optimize the TLP at the application level, design a register mapping algorithm at the compilation level, and design a preshifting mechanism at the architecture level. Collectively, these optimizations help to determine the TLP without causing cache and register file resource contention and reduce the shift operation overhead. Experimental results using a variety of representative workloads demonstrate that our optimization framework achieves up to 29% （21% on average） performance improvement.

Synthesizing molecularly imprinted polymer beads for the purification of vitamin E

Molecularly imprinted polymer(MIP)beads imprinted with vitamin E(V_(E))were synthesized via a two-step swelling polymerization method,using methacrylic acid(MAA)and other functional monomers together with polystyrene(PS)microspheres as the substrate.In initial trials,different functional monomers were assessed,along with a variety of solvents and imprinting ratios.The MIP_(MAA) sample exhibited the highest performance and was characterized and also assessed with regard to V_(E) adsorption under various experimental conditions.This material exhibited reasonably good sphericity,porosity and stability,along with an excellent adsorption capacity of 46 mg/g.This was much higher than the value for the corresponding non-imprinted polymer made with the same monomer,and 20%higher than that for an acrylamide-based MIP synthesized using a precipitation polymerization method.The core-shell structured MIP_(MAA) also demonstrated fast adsorption kinetics,a low pressure drop and good reusability in fixed bed experiments.The V_(E) adsorption equilibrium,selectivity,kinetics,thermodynamics and regeneration capacity of this material were also examined and are reported herein.

Dental pulp stem cells and BonelikeVR for bone regeneration in ovine model

Development of synthetic bone substitutes has arisen as a major research interest in the need to find an alternative to autologous bone grafts.Using an ovine model,the present pre-clinical study presents a synthetic bone graft(BonelikeVR)in combination with a cellular system as an alternative for the regeneration of non-critical defects.The association of biomaterials and cell-based therapies is a promising strategy for bone tissue engineering.Mesenchymal stem cells(MSCs)from human dental pulp have demonstrated both in vitro and in vivo to interact with diverse biomaterial systems and promote mineral deposition,aiming at the reconstruction of osseous defects.Moreover,these cells can be found and isolated from many species.Non-critical bone defects were treated with BonelikeVR with or without MSCs obtained from the human dental pulp.Results showed that BonelikeVR and MSCs treated defects showed improved bone regeneration compared with the defects treated with BonelikeVR alone.Also,it was observed that the biomaterial matrix was reabsorbed and gradually replaced by new bone during the healing process.We therefore propose this combination as an efficient binomial strategy that promotes bone growth and vascularization in non-critical bone defects.

Natural products,PGC-1α,and Duchenne muscular dystrophy

Peroxisome proliferator-activated receptorγ(PPARγ)is a transcriptional coactivator that binds to a diverse range of transcription factors.PPARγcoactivator 1(PGC-1)coactivators possess an extensive range of biological effects in different tissues,and play a key part in the regulation of the oxidative metabolism,consequently modulating the production of reactive oxygen species,autophagy,and mitochondrial biogenesis.Owing to these findings,a large body of studies,aiming to establish the role of PGC-1 in the neuromuscular system,has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases.Among these,some evidence has shown that various signaling pathways linked to PGC-1αare deregulated in muscular dystrophy,leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species(ROS)production.In the light of these results,any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies.PGC-1αis influenced by different patho-physiological/pharmacological stimuli.Natural products have been reported to display modulatory effects on PPARγactivation with fewer side effects in comparison to synthetic drugs.Taken together,this review summarizes the current knowledge on Duchenne muscular dystrophy,focusing on the potential effects of natural compounds,acting as regulators of PGC-1α.

Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute

The development of injectable bone substitutes(IBS)have obtained great importance in the bone re-generation field,as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies.In this scenario,the association of injectable hydrogels and bone graft granules is emerging as a well-established trend.Particularly,in situ forming hydrogels have arisen as a new IBS generation.An in situ forming and injectable dextrin-based hydrogel(HG)was developed,aiming to act as a carrier of granular bone substitutes and bioactive agents.In this work,the HG was associated to a granular bone substitute(Bonelike)and implanted in goat critical-sized calvarial defects(14mm)for 3,6 and 12weeks.The results showed that HG improved the han-dling properties of the Bonelike granules and did not affect its osteoconductive features,neither impairing the bone regener ation process.Human multipotent mesenchymal stromal cells from the umbilical cord,extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the IBS.These bioactive agents did not enhance the new bone formation significantly under the conditions tested,according to micro-computed tomography and histological analysis.