Research on the Relationship Between Reading Anxiety and Reading Strategy in English Reading:A Quantitative Study in Chengdu University

According to a large number of studies since the 1970s,learners’emotional state is one of the important factors affecting learning effect of foreign language learning.In addition,reading is an important input and practice method in English learning,especially when it comes to language learning.102 students majoring in English at the Faculty of Foreign Languages of Chengdu University were investigated by using two scales,FLRAS and ERSS,based on the Individual Learner Differences and Affective filter hypothesis.This study uses the social science statistical tool SPSSPRO to process and analyze all the data,aiming to explore the degree of English reading anxiety and the relationship between reading anxiety and reading strategies in English reading.

Between the City and Images:An Analysis of Mainstream Media’s Paths of Constructing the Cultural Memory of a City:Taking Chengdu Radio and Television’s“Hi Chengdu”as an Example

Mainstream media play a crucial role in constructing the cultural memory of a city.This study used 319 short videos released by“Hi Chengdu,”a new media product of Chengdu Radio and Television,as samples.Based on the grounded theory,a research framework encompassing“content,technology,and discourse”was established to explore the paths through which mainstream media construct the cultural memory.Regarding content,this paper emphasized temporal and spatial contexts and urban spaces,delving deep into the themes of the cultural memory and vehicles for it.In terms of technology,this paper discussed the practice of leveraging audio/visual-mode discourse to stitch together the impressions of a city and evoke emotional resonance to create a“flow”of memory.As for discourse,this paper looked at the performance of a communication ritual to frame concepts and shape urban identity.It is essential to break free from conventional thinking and leverage local culture as the primary driving force to further boost a city’s productivity,in order to excel in cultural communication.

Joint Effects of Multipollutant Mixtures on Mortality in Chengdu,China

Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutants(e.g.,fine particulate matter:PM_(2.5);nitrogen dioxide:NO_(2);carbon monoxide,CO;or ozone:O_(3))have been widely explored^([4]).However,humans are constantly exposed to multipollutant mixtures in real life,and biological responses to inhaled pollutants are likely to depend on the interplay of pollutant mixtures.Therefore,it is critical and imperative to explore the joint effects of multipollutant mixtures on human beings.

Impact of the Urban Heat Island Effect on Ozone Pollution in Chengdu City,China

With the advancement of urbanization,the urban heat island effect and ozone pollution have become hot issues in urban research.The urban heat island effect can impact ozone conversion,but its mechanism of action is unclear.In this study,the effects of the urban heat island effect on ozone concentration in Chengdu City,China,were investigated by comparing the ozone concentration under different heat island levels with ozone data from March 2020 to February 2021 and the temperature and wind field data of ERA5-Land during the same period.The results showed that:1)regarding the distribution characteristics,the ozone concentration in Chengdu presented a‘high in summer and low in winter’distribution.The ozone concentration in summer(189.54µg/m^(3))was nearly twice that in winter(91.99µg/m^(3)),and the ozone diurnal variation presented a‘single peak and single valley’distribution,with a peak at 16:00.2)For the characteristics of the heat island effect,the heat island intensity in Chengdu was obviously higher in spring than in other seasons,and the diurnal variation showed a‘single peak and single valley’distribution,with the peak and trough values appearing at 9:00 and 17:00,respectively.Spatially,the eastern part of Chengdu was a heat island,while the western and northwestern parts were mostly cold island.3)The correlation analysis between heat island intensity and ozone concentration showed a significant positive correlation but with a 7–8 h time lag.Ambient air temperature was not the main factor affecting ozone concentration.The heat island effect impacts the ozone concentration in two ways:changing the local heat budget to promote ozone generation and forming local urban wind,which promotes ozone diffusion or accumulation and forms different areas of low and high ozone values.

The comparison and discussion of the teaching philosophy and curriculum setting in Edinburgh College of Art,Sichuan Fine Arts Institute and Chengdu University

I will discuss some similarities and differences between the Edinburgh College of Art,Sichuan Fine Arts Institute and Chengdu University in this paper,to find a brand new way for the teaching philosophy and curriculum setting.

Evaluation of Pre-Harvest Sprouting(PHS)Resistance and Screening of High-Quality Varieties from Thirty-Seven Quinoa(Chenopodium quinoa Willd.)Resources in Chengdu Plain

Pre-harvest sprouting(PHS)will have a serious effect both on the yield and quality of quinoa(Chenopodium quinoaWilld.).It is crucial to select and breed quinoa varieties with PHS resistance and excellent agronomic traits for guidance production and utilization of quinoa.A comprehensive evaluation of the PHS resistance and agronomic traits of 37 species of quinoa resources was conducted in Chengdu Plain.The evaluation used various methods,including grain germination rate(GR),grain germination index(GI),total spike germination rate(SR),total grain germination index(SI),grey correlation analysis(GCA),cluster analysis and correlation analysis.Results showed significant differences in PHS resistance and agronomic traits amongst the 37 quinoa resources.CDU-23 was most resistant to PHS within 24 h,with a germination rate of 2.67%and 0%according to the GR and SR results,respectively.However,in the same time,CDU-31 showed the maximum susceptibility to PHS based on the SR of 31.07%,while CDU-34 was the most sensitive to PHS according to the GR of 100%.The comprehensive evaluation identified one and nine kinds of high resistance species for grain and whole spike germination,respectively.In both cases,the coefficients of variation(CV)for these parameters were 34.78%and 82.13%,respectively.GCA results showed that the magnitude of the association between each trait and yield in the thirty-seven quinoa resources was in the following order:thousand grain weight>seed length>seed area>seed width.Although the seed weight of CDU-18 reached 3.7010 g,the seed weight of CDU-5 was only 1.6030 g.However,the size of the seeds,their width and area did not correlate with their 1000-grain weight.There was a complex correlation between PHS resistance index and agronomic traits.Based on clustering analysis,thirty-seven quinoa resources were classified into three taxa.It was found that various taxa differed in PHS resistance and agronomic traits.Several comparisons of the aggregated data led to the selection of five varieties of quinoa,of which CDU-2 presented excellent agronomic qualities and strong PHS resistance.This study has provided a reference for breeding excellent quinoa varieties with PHS resistance.

Thinking about Value Realization of Ecological Products under the Background of Urban-rural Integration in Chengdu“Western Control”Area

Chengdu's development strategy of“western control”has laid a solid ecological background for 8 western districts,cities and counties and cultivated good ecological resources.The integrated urban-rural development in the new era will realize the balanced development of urban and rural areas and give full play to the value of rural ecological resources through the“powerful combination”of urban and rural areas.To realize the urban-rural integration and high-quality rural development in Chengdu“western control”area,it is necessary to enhance the awareness of ecological resources and ecological products,and carry out unified planning of ecological infrastructure,ecological material products and ecological service products in the whole“western control”area.Meantime,ecological restoration must be carried out scientifically,and scene design for value transformation of ecological products should be implemented innovatively.

基于“培土生金”与肠道微生态探讨慢性阻塞性肺疾病的针灸治疗思路

肠道微生态在机体防御感染,调节免疫和代谢等方面具有重要作用,与慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Diseases,COPD)有密切关系。针灸在调节肠道菌群和防治COPD中均有较好的疗效,该文从针灸改善肠道菌群与防治COPD的古籍文献论述与现代研究文献入手,总结临床针灸治疗该病取穴规律,进一步探讨培土生金理论指导下的针灸取穴思路,临证选取手太阴、足太阴、足阳明经穴,以调理脾胃功能为主,辅以补肺,肺、脾、胃俞调理肺脾,定喘、膻中、中脘纳气平喘,根据五行相生理论选取太渊、太白穴,并结合全身兼证,随证(症)配穴。

Pathophysiological changes of muscle after ischemic stroke:a secondary consequence of stroke injury

Sufficient clinical evidence suggests that the damage caused by ischemic stroke to the body occurs not only in the acute phase but also during the recovery period,and that the latter has a greater impact on the long-term prognosis of the patient.However,current stroke studies have typically focused only on lesions in the central nervous system,ignoring secondary damage caused by this disease.Such a phenomenon arises from the slow progress of pathophysiological studies examining the central nervous system.Further,the appropriate therapeutic time window and benefits of thrombolytic therapy are still controversial,leading scholars to explore more pragmatic intervention strategies.As treatment measures targeting limb symptoms can greatly improve a patient’s quality of life,they have become a critical intervention strategy.As the most vital component of the limbs,skeletal muscles have become potential points of concern.Despite this,to the best of our knowledge,there are no comprehensive reviews of pathophysiological changes and potential treatments for post-stroke skeletal muscle.The current review seeks to fill a gap in the current understanding of the pathological processes and mechanisms of muscle wasting atrophy,inflammation,neuroregeneration,mitochondrial changes,and nutritional dysregulation in stroke survivors.In addition,the challenges,as well as the optional solutions for individualized rehabilitation programs for stroke patients based on motor function are discussed.

人工智能加速GPCR配体的发现

G protein-coupled receptors(GPCRs)are crucial players in various physiological processes,making them attractive candidates for drug discovery.However,traditional approaches to GPCR ligand discovery are time-consuming and resource-intensive.The emergence of artificial intelligence(AI)methods has revolutionized the field of GPCR ligand discovery and has provided valuable tools for accelerating the identification and optimization of GPCR ligands.In this study,we provide guidelines for effectively utilizing AI methods for GPCR ligand discovery,including data collation and representation,model selection,and specific applications.First,the online resources that are instrumental in GPCR ligand discovery were summarized,including databases and repositories that contain valuable GPCR-related information and ligand data.Next,GPCR and ligand representation schemes that can convert data into computer-readable formats were introduced.Subsequently,the key applications of AI methods in the different stages of GPCR drug discovery were discussed,ranging from GPCR function prediction to ligand design and agonist identification.Furthermore,an AI-driven multi-omics integration strategy for GPCR ligand discovery that combines information from various omics disciplines was proposed.Finally,the challenges and future directions of the application of AI in GPCR research were deliberated.In conclusion,continued advancements in AI techniques coupled with interdisciplina ry collaborations will offer great potential for improving the efficiency of GPCR ligand discovery.

Circulating proteomic biomarkers for diagnosing sporadic amyotrophic lateral sclerosis:a cross-sectional study

Biomarke rs are required for the early detection,prognosis prediction,and monitoring of amyotrophic lateral sclerosis,a progressive disease.Proteomics is an unbiased and quantitative method that can be used to detect neurochemical signatures to aid in the identification of candidate biomarke rs.In this study,we used a label-free quantitative proteomics approach to screen for substantially differentially regulated proteins in ten patients with sporadic amyotrophic lateral scle rosis compared with five healthy controls.Su bstantial upregulation of serum proteins related to multiple functional clusters was observed in patients with spo radic amyotrophic lateral sclerosis.Potential biomarke rs were selected based on functionality and expression specificity.To validate the proteomics profiles,blood samples from an additional cohort comprising 100 patients with sporadic amyotrophic lateral sclerosis and 100 healthy controls were subjected to enzyme-linked immunosorbent assay.Eight substantially upregulated serum proteins in patients with spora dic amyotrophic lateral sclerosis were selected,of which the cathelicidin-related antimicrobial peptide demonstrated the best discriminative ability between patients with sporadic amyotrophic lateral sclerosis and healthy controls(area under the curve[AUC]=0.713,P<0.0001).To further enhance diagnostic accuracy,a multi-protein combined discriminant algorithm was developed incorporating five proteins(hemoglobin beta,cathelicidin-related antimicrobial peptide,talin-1,zyxin,and translationally-controlled tumor protein).The algo rithm achieved an AUC of 0.811 and a P-value of<0.0001,resulting in 79%sensitivity and 71%specificity for the diagnosis of sporadic amyotrophic lateral scle rosis.Subsequently,the ability of candidate biomarkers to discriminate between early-stage amyotrophic lateral sclerosis patients and controls,as well as patients with different disease severities,was examined.A two-protein panel comprising talin-1 and translationally-controlled tumor protein effectively distinguished early-stage amyotrophic lateral sclerosis patients from controls(AUC=0.766,P<0.0001).Moreove r,the expression of three proteins(FK506 binding protein 1A,cathelicidin-related antimicrobial peptide,and hemoglobin beta-1)was found to increase with disease progression.The proteomic signatures developed in this study may help facilitate early diagnosis and monitor the progression of sporadic amyotrophic lateral sclerosis when used in co mbination with curre nt clinical-based parameters.

Investigation of the block toppling evolution of a layered model slope by centrifuge test and discrete element modeling

Primary toppling usually occurs in layered rock slopes with large anti-dip angles.In this paper,the block toppling evolution was explored using a large-scale centrifuge system.Each block column in the layered model slope was made of cement mortar.Some artificial cracks perpendicular to the block column were prefabricated.Strain gages,displacement gages,and high-speed camera measurements were employed to monitor the deformation and failure processes of the model slope.The centrifuge test results show that the block toppling evolution can be divided into seven stages,i.e.layer compression,formation of major tensile crack,reverse bending of the block column,closure of major tensile crack,strong bending of the block column,formation of failure zone,and complete failure.Block toppling is characterized by sudden large deformation and occurs in stages.The wedge-shaped cracks in the model incline towards the slope.Experimental observations show that block toppling is mainly caused by bending failure rather than by shear failure.The tensile strength also plays a key factor in the evolution of block toppling.The simulation results from discrete element method(DEM)is in line with the testing results.Tensile stress exists at the backside of rock column during toppling deformation.Stress concentration results in the fragmented rock column and its degree is the most significant at the slope toe.

Multiple enrichment mechanisms of organic matter in the Fengcheng Formation of Mahu Sag,Junggar Basin,NW China

Based on core and thin section data,the source rock samples from the Fengcheng Formation in the Mahu Sag of the Junggar Basin were analyzed in terms of zircon SIMS U-Pb geochronology,organic carbon isotopic composition,major and trace element contents,as well as petrology.Two zircon U-Pb ages of(306.0±5.2)Ma and(303.5±3.7)Ma were obtained from the first member of the Fengcheng Formation.Combined with carbon isotopic stratigraphy,it is inferred that the depositional age of the Fengcheng Formation is about 297-306 Ma,spanning the Carboniferous-Permian boundary and corresponding to the interglacial period between C4 and P1 glacial events.Multiple increases in Hg/TOC ratios and altered volcanic ash were found in the shale rocks of the Fengcheng Formation,indicating that multiple phases of volcanic activity occurred during its deposition.An interval with a high B/Ga ratio was found in the middle of the second member of the Fengcheng Formation,associated with the occurrence of evaporite minerals and reedmergnerite,indicating that the high salinity of the water mass was related to hydrothermal activity.Comprehensive analysis suggests that the warm and humid climate during the deposition of Fengcheng Formation is conducive to the growth of organic matter such as algae and bacteria in the lake,and accelerates the continental weathering,driving the input of nutrients.Volcanic activities supply a large amount of nutrients and stimulate primary productivity.The warm climate and high salinity are conducive to water stratification,leading to water anoxia that benefits organic matter preservation.The above factors interact and jointly control the enrichment of organic matter in the Fengcheng Formation of Mahu Sag.

A defective iron-based perovskite cathode for high-performance IT-SOFCs:Tailoring the oxygen vacancies using Nb/Ta co-doping

The sluggish kinetics of the electrochemical oxygen reduction reaction(ORR)in intermediatetemperature solid oxide fuel cells(IT-SOFCs)greatly limits the overall cell performance.In this study,an efficient and durable cathode material for IT-SOFCs is designed based on density functional theory(DFT)calculations by co-doping with Nb and Ta the B-site of the SrFeO_(3-δ)perovskite oxide.The DFT calculations suggest that Nb/Ta co-doping can regulate the energy band of the parent SrFeO_(3-δ)and help electron transfer.In symmetrical cells,such cathode with a SrFe_(0.8)Nb_(0.1)Ta_(0.1)O_(3-δ)(SFNT)detailed formula achieves a low cathode polarization resistance of 0.147Ωcm^(2) at 650℃.Electron spin resonance(ESR)and X-ray photoelectron spectroscopy(XPS)analysis confirm that the co-doping of Nb/Ta in SrFeO_(3-δ)B-site increases the balanced concentration of oxygen vacancies,enhancing the electrochemical performance when compared to 20 mol%Nb single-doped perovskite oxide.The cathode button cell with NiSDC|SDC|SFNT configuration achieves an outstanding peak power density of 1.3 W cm^(-2)at 650℃.Moreover,the button cell shows durability for 110 h under 0.65 V at 600℃ using wet H_(2) as fuel.

Absorption properties and mechanism of lightweight and broadband electromagnetic wave-absorbing porous carbon by the swelling treatment

Bioderived carbon materials have garnered considerable interest in the fields of microwave absorption and shielding due to their reproducibility and environmental friendliness.In this study,KOH was evenly distributed on biomass Tremella using the swelling induction method,leading to the preparation of a three-dimensional network-structured hierarchical porous carbon(HPC)through carbonization.The achieved microwave absorption intensity is robust at-47.34 dB with a thin thickness of 2.1 mm.Notably,the widest effective absorption bandwidth,reaching 7.0 GHz(11–18 GHz),is attained at a matching thickness of 2.2 mm.The exceptional broadband and reflection loss performance are attributed to the 3D porous networks,interface effects,carbon network defects,and dipole relaxation.HPC has outstanding absorption characteristics due to its excellent impedance matching and high attenuation constant.The uniform pore structures considerably optimize the impedance-matching performance of the material,while the abundance of interfaces and defects enhances the dielectric loss,thereby improving the attenuation constant.Furthermore,the impact of carbonization temperature and swelling rate on microwave absorption performance was systematically investigated.This research presents a strategy for preparing absorbing materials using biomass-derived HPC,showcasing considerable potential in the field of electromagnetic wave absorption.

Improving creep strength of the fine-grained heat-affected zone of novel 9Cr martensitic heat-resistant steel via modified thermo-mechanical treatment

The infamous type Ⅳ failure within the fine-grained heat-affected zone (FGHAZ) in G115 steel weldments seriously threatens the safe operation of ultra-supercritical (USC) power plants.In this work,the traditional thermo-mechanical treatment was modified via the replacement of hot-rolling with cold rolling,i.e.,normalizing,cold rolling,and tempering (NCT),which was developed to improve the creep strength of the FGHAZ in G115 steel weldments.The NCT treatment effectively promoted the dissolution of preformed M_(23)C_(6)particles and relieved the boundary segregation of C and Cr during welding thermal cycling,which accelerated the dispersed reprecipitation of M_(23)C_(6) particles within the fresh reaustenitized grains during post-weld heat treatment.In addition,the precipitation of Cu-rich phases and MX particles was promoted evidently due to the deformation-induced dislocations.As a result,the interacting actions between precipitates,dislocations,and boundaries during creep were reinforced considerably.Following this strategy,the creep rupture life of the FGHAZ in G115 steel weldments can be prolonged by 18.6%,which can further push the application of G115 steel in USC power plants.

Comparison between ozonesonde measurements and satellite retrievals over Beijing,China

从2013年开始,作者团队使用自主研发电化学原理臭氧探空仪在华北平原北京地区进行每周一次观测.本研究首次使用2013-2019年期间北京地区臭氧探空数据评估Aqua卫星搭载大气红外探测仪(AIRS)和Aura卫星搭载微波临边探测器(MLS)反演垂直臭氧廓线,并对比臭氧探空,AIRS和Aura卫星搭载臭氧监测仪(OMI)臭氧柱总量结果.尽管臭氧探空与卫星反演垂直臭氧廓线在局部高度处差异较大,但整体来说两者较为接近(相对偏差大多<10%).臭氧探空,AIRS和OMI三种仪器测量臭氧柱总量的年变化特征较为一致,其年均臭氧柱总量分别为351.8±18.4 DU,348.8±19.5 DU和336.9±14.2 DU.后续对国内多站点观测数据分析将有助于进一步理解臭氧探空与卫星反演臭氧资料在不同区域的一致性.

Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue.Its high recurrence rate and impaired restoration of bone deficiencies are major challenges in treatment.Microbes have evolved numerous mechanisms to effectively evade host intrinsic and adaptive immune attacks to persistently localize in the host,such as drug-resistant bacteria,biofilms,persister cells,intracellular bacteria,and small colony variants(SCVs).Moreover,microbial-mediated dysregulation of the bone immune microenvironment impedes the bone regeneration process,leading to impaired bone defect repair.Despite advances in surgical strategies and drug applications for the treatment of bone infections within the last decade,challenges remain in clinical management.The development and application of tissue engineering materials have provided new strategies for the treatment of bone infections,but a comprehensive review of their research progress is lacking.This review discusses the critical pathogenic mechanisms of microbes in the skeletal system and their immunomodulatory effects on bone regeneration,and highlights the prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections.It will inform the development and translation of antimicrobial and bone repair tissue engineering materials for the management of bone infections.

Development of small molecule drugs targeting immune checkpoints

Immune checkpoint inhibitors(ICIs)are used to relieve and refuel anti-tumor immunity by blocking the interaction,transcription,and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune checkpoints.Thousands of small molecule drugs or biological materials,especially antibody-based ICIs,are actively being studied and antibodies are currently widely used.Limitations,such as anti-tumor efficacy,poor membrane permeability,and unneglected tolerance issues of antibody-based ICIs,remain evident but are thought to be overcome by small molecule drugs.Recent structural studies have broadened the scope of candidate immune checkpoint molecules,as well as innovative chemical inhibitors.By way of comparison,small molecule drug-based ICIs represent superior oral bioavailability and favorable pharmacokinetic features.Several ongoing clinical trials are exploring the synergetic effect of ICIs and other therapeutic strategies based on multiple ICI functions,including immune regulation,anti-angiogenesis,and cell cycle regulation.In this review we summarized the current progression of small molecule ICIs and the mechanism underlying immune checkpoint proteins,which will lay the foundation for further exploration.

Recent urbanization increases exposure to humid-heat extreme events over populated regions of China

目前对于高温的研究主要侧重于干热,针对湿热的研究相对较少,但它通常会造成更大的社会影响,尤其对人体健康的威胁.已有研究证实,当环境湿球温度超过35℃时,它会破坏人体正常生理代谢,进而威胁人体健康.本研究指出在过去四十年,中国区域日最高湿球温度几乎没有超过35℃,但部分地区日最高湿球温度超过了30℃,主要集中在中国的人口密集区,包括华东,华南和四川盆地等.进一步分析发现,中国区域近期的快速城市化加剧了极端湿热事件的社会影响,城市地区暴露于极端湿热事件的范围的增加速率明显大于其他地区,这也意味着快速城市化使得人口密集区暴露于极端湿热事件的风险明显增加.初步估算指出,自2000年以来,中国区域暴露于极端湿热事件的人口数以每年每天约3100人次的速率显著增加.