Effects of different flui replacements on serum HSP70 and lymphocyte DNA damage in college athletes during exercise at high ambient temperatures

Purpose：The aim of this study was to investigate the effects of flui replacement by water or sports drinks on serum heat shock protein 70（HSP70） levels and DNA damage during exercise at a high ambient temperature.Methods：Ten male college athletes with an athletic career ranging from 6 to 11 years were recruited from Yonsei University.The subjects ran on a treadmill at 75% of heart rate reserve during 4 different trials：thermoneutral temperature at 18℃（T）,high ambient temperature at 32℃ without flui replacement（H）,high ambient temperature at 32℃ with water replacement（HW）,and high ambient temperature at 32℃ with sports drink replacement（HS）.During each condition,blood samples were collected at the pre-exercise baseline（PEB）,immediately after exercise（IAE）,and60 min post-exercise.Results：Skin temperature significant y increased during exercise and was significant y higher in H compared to T and HS at IAE.Meanwhile,serum HSP70 was significant y increased in all conditions at IAE compared to PEB and was higher in H compared to T at the former time point.Significant y increased lymphocyte DNA damage（DNA in the tail,tail length,tail moment） was observed in all trials at IAE compared to PEB,and attenuated DNA damage（tail moment） was observed in HS compared to H at IAE.Conclusion：Acute exercise elevates serum HSP70 and induces lymphocyte DNA damage.Fluid replacement by sports drink during exercise at high ambient temperature can attenuate HSP response and DNA damage by preventing dehydration and reducing thermal stress.

The effects of aerobic exercise training on oxidant-antioxidant balance, neurotrophic factor levels, and blood-brain barrier function in obese and non-obese men

Purpose: The purpose of this study was to investigate the effects of obesity and aerobic exercise training on oxidant-antioxidant balance,neurotrophic factor levels, and blood-brain barrier(BBB) function.Methods: Ten non-obese healthy men(body mass index < 25 kg/m2) and 10 obese men(body mass index ≥ 25 kg/m2) were included in the study.Both groups performed treadmill exercise for 40 min 3 times weekly for 8 weeks at 70% heart rate reserve. Blood samples were collected to examine oxidant-antioxidant balance(reactive oxygen species(ROS) and superoxide dismutase(SOD) activity levels), neurotrophic factors(brain-derived neurotrophic factor(BDNF), nerve growth factor, and glial cell line-derived neurotrophic factor levels), and BBB function(S100βand neuron-specific enolase(NSE) levels) before and after exercise training.Results: The obese group showed significantly greater changes than the non-obese group in serum ROS(-0.46 ± 0.31 mmol/L vs.-0.10 ±0.17 mmol/L,p=0.005),serum S100 p levels(-8.50 ± 5.92 ng/L vs.-0.78 ± 5.45 ng/L,p=0.007),and serum NSE levels(-0.89 ± 0.54 μg/L vs.-0.01 ± 0.74 μg/L,p= 0.007) after training. At baseline,the obese group showed significantly higher serum ROS and S100β levels and significantly lower serum SOD activity and BDNF levels than the non-obese group(p < 0.05). The obese group showed significantly lower serum ROS, S100β,and NSE levels and significantly higher serum SOD activity and BDNF levels after training compared with baseline(p < 0.05).Conclusion: These results suggest that obesity can reduce serum neurotrophic factor levels and can induce BBB dysfunction. On the other hand,aerobic exercise can improve an oxidant-antioxidant imbalance in obese subjects and limit BBB dysfunction.

On the Application of “Red Culture” in Urban Parks

In recent years, with the support of national policies and the people’s demand for cultural life, a wave of red tourism has been in full swing throughout the country. The revolutionary martyrs opened up new heavens and earth with their flesh and blood, and the great spirit of the Red Revolution carried forward the precious material and spiritual wealth of our socialist country. As the successor of socialism in the new era, inheriting the great spirit of the Chinese revolution and praising the red culture are important tasks for our contemporary people. Therefore, in the development and construction of urban parks, the red cultural connotation of urban parks should be given, which plays a very important role in improving the quality of the city and enhancing the charm of the city.

Research on the Strategy of Integrating Red Culture into Patriotic Education Activities of Young People

Young people are the flowers of the motherland, is the future of the motherland, youth teachers have great responsibilities. Integrate red culture into daily teaching activities, inherit and carry forward, enhance children’s values, cultivate children’s excellent qualities such as patriotism and selfless dedication, improve children’s comprehensive quality, and let children grow up healthily. Taking red culture as the starting point, this paper discusses the strategy of integrating red cultural resources into patriotic education activities of teenagers, points out the existing problems in the current integration of red culture into patriotic education activities of teenagers and finds out the reasons;clarify the relevant concepts of red culture and patriotic education activities for young people;from the three aspects of integrating curriculum resources to enhance the significance of red culture education, creating a red environment to create a red education atmosphere, and digging deep into red cultural resources, this paper discusses the strategy of integrating red culture into patriotic education activities for young people, aiming to promote the organic combination of patriotic education activities and red culture for young people, and increase national and cultural self-confidence.

Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise

Purpose: The purpose of this study was to investigate the effects of obesity and high-intensity acute exercise on oxidant-antioxidant status,neurotrophic factor expression, and blood-brain barrier(BBB) disruption.Methods: Twenty-four healthy, untrained men(12 non-obese(mean 14.9% body fat) and 12 obese subjects(mean 29.8% body fat)) performed20 min of continuous submaximal aerobic exercise at 85% maximal oxygen consumption. Blood sampling was performed to examine the oxidant-antioxidant status(reactive oxygen species(ROS) and superoxide dismutase(SOD)), neurotrophic factors(brain-derived neurotrophic factor(BDNF) and nerve growth factor(NGF)), and BBB disruption(S100β and neuron-specific enolase) before and after acute exercise.Results: The obese group showed significantly higher pre-exercise serum ROS levels and significantly lower pre-exercise serum SOD levels than the non-obese group(p < 0.05). Serum ROS, SOD, BDNF, NGF, and S100β levels were significantly increased post-exercise compared with pre-exercise levels in both the non-obese and the obese groups(p < 0.05). The obese group showed significantly higher serum ROS, BDNF, NGF,and S100β levels post-exercise compared to the non-obese group(p < 0.05).Conclusion: Our study suggests that episodic vigorous exercise can increase oxidative stress and blood neurotrophic factor levels and induce disruption of the BBB. Moreover, high levels of neurotrophic factor in the blood after exercise in the obese group may be due to BBB disruption,and it is assumed that oxidative stress was the main cause of this BBB disruption.

Land Reform in Scotland:from Private to Community

Scotland's history has been, to a large degree, a history of landed power. The Scottish land issue becomes a perennial favourite in folk and in academic field. This paper uses historical analysis to understand the context and content of Scottish land reform. It finds that the land ownership is shifting from private to community body and the process is long but friendly. Furthermore, the land ownership change is a reflection of social development conception change from economic pursuit to sustainable democratic management.

On Legal English Translation from the Perspective of Legal Linguistics

With the deepening trend of globalization and the development of economy and society, the demand for international exchange talents is increasing. Especially with the increasing number of transnational corporations, almost every company should have professional legal translation employees to guarantee their legitimacy of transnational trade and effectively prevent the infringement of related rights and interests. Therefore, to improve the quality in transnational translation business and optimize legal English translation skills from the perspective of legal language can not only offer a reference for the industry, but also provide evidence for the problems arising from the actual legal translation process. Based on the perspective of legal linguistics, this paper tries to puts forward appropriate legal English translation measures mainly by analyzing the skills of legal English translation, with a view to providing some references for relevant scholars.

Agriculture in China——A Goal for Sustainability

China agriculture development, to some extent, is a reflection of China social development. Nowadays, China has goneglobal in industry, agriculture, technology, culture and education. However, China's agriculture development process is long per-ceived as a legend to outside world for unbelievable facts created after China launched its opening-up policy in 1978 and theHousehold Contract Responsibility System(HCRS) was formally established nationwide in 1981.

On Foreign Language Education Reform in America from the White Paper The Teachers We Need

With the further moving of globalization,language is not only a tool to express ideas but also a soft and hard power for a nation's development.Through probing into the white paper published recently The Teachers We Need,we have got much more information on U.S.foreign language education reform.Meanwhile,it provides Chinese researchers some references for the grounding research on language functions and language teachers' career development.