In recent years,non-suicidal self-injury(NSSI)behavior has emerged in a large number of adoles-cent depression.NSSI associated with adolescent depres-sion may be an addictive behavior,which has many sim-ilar neurobiol...In recent years,non-suicidal self-injury(NSSI)behavior has emerged in a large number of adoles-cent depression.NSSI associated with adolescent depres-sion may be an addictive behavior,which has many sim-ilar neurobiological mechanisms to substance addiction.Brain-derived neurotrophic factor(BDNF)and precursor of BDNF(proBDNF)play an important role in addiction behavior,and they may be related to endogenous opioid receptors.The location and distribution of opioidμre-ceptors in the brain are related to reward,motivation and emotion regulated by behavioral addiction.The purpose of this paper is to review the general situation,mechanism and relationship between the characteristics of NSSI be-havior addiction and brain-derived nutritional factors in adolescents with depression.展开更多
Introduction: Medical students worked earlier as independent practitioners before paediatrics courses. Now it is denied. We evaluated students’ experiences of infant contacts before and after the change. Methods: A c...Introduction: Medical students worked earlier as independent practitioners before paediatrics courses. Now it is denied. We evaluated students’ experiences of infant contacts before and after the change. Methods: A cross-sectional questionnaire study consists of students attending paediatrics courses at University of Oulu in 2004-2006 and 2014-2015. Results: 229 of 241 (95.0%) students in the first cohort and 236 of 258 (91.5%) in the second completed the questionnaire. The mean (SD) age of the students was 25.1 (3.0) and 25.9 (3.0) (p = 0.040). In both cohorts two thirds of the students were familiar with holding infants in the lap, but two thirds had never bathed an infant. A half of males and one third of females had never fed an infant. Students approximated to manage with infants and believed to manage increased with age in both cohorts (p < 0.001 vs. p = 0.019). Students’ perspective towards pediatrics as a future carrier choice declined from 30.3% to 22.0%. Conclusions: Students’ experiences in handling and care of infants are quite low before paediatrics courses. The denial not to work as independent practitioner before paediatric courses did not decrease experiences. Medical students are motivated to have infant experiences in practice.展开更多
This study aims to elucidate the nature of cognitive deficits caused by intracranial tumors, as well as to examine how a surgical operation of the tumor may affect tumor-induced cognitive deficits. The patient group i...This study aims to elucidate the nature of cognitive deficits caused by intracranial tumors, as well as to examine how a surgical operation of the tumor may affect tumor-induced cognitive deficits. The patient group included 43 individuals with meningioma or low-grade glioma admitted to a surgical operation of the tumor. Neuropsychological examination was conducted preoperatively, as well as three and 12 months postoperatively. The control group comprised 31 healthy subjects. In the tumor patients, preoperative cognitive performance was compromised in several cognitive domains as compared to the controls. The tumor patients with frontal and large tumors showed impairment virtually across all cognitive domains. Postoperatively, the cognitive performance of the meningioma and the small tumor group improved in all domains, with the performance of the low-grade glioma group and the large tumor group reflecting more modest cognitive improvement. Most of this improvement did not emerge until the 12 months follow-up. Cognitive impairment due to an intracranial tumor is diffuse affecting most cognitive domains. Cognitive recovery after the surgery is more noticeable in patients with meningiomas and small tumors, and the recovery will require a minimum of one year time-wise. This evidence is of significant value when planning both clinical treatment and rehabilitation of intracranial tumor patients.展开更多
Background： With recognition of the important roles of Vitamin D （VitD） in various physiological processes, increasing attention has been drawn to the status of VitD in early life. However, the VitD status of young...Background： With recognition of the important roles of Vitamin D （VitD） in various physiological processes, increasing attention has been drawn to the status of VitD in early life. However, the VitD status of young children and the related factors in rural areas of Southwestern China remain unclear. This study aimed to explore VitD status and its seasonal variation in 18-month-old children living in rural Southwestern China. The association of VitD with biochemical and anthropometric variables was also investigated. Methods： A total of 177 18-month-old children in a rural area of Yunnan Province, Southwestern China, were enrolled. Serum concentrations of 25-hydroxy Vitamin D （25（OH）D） were measured through high-performance liquid chromatogram-tandem mass spectrometry. Parathyroid hormone （PTH） levels were measured with a chemiluminescence assay. Serum concentrations of calcium, phosphorus, and alkaline phosphatase （ALP） were also measured. Anthropometric data and the outdoor activity time of each participant were collected. Results： The serum 25（OH）D concentration was 26.61 ±7.26 ng/ml; concentrations lower than 30 ng/ml accounted for 70.6% of the participants and concentrations lower than 20 ng/ml accounted for 16.4%. The level of serum 25（OH）D was not significantly different among four seasons （P 〉 0.05）. A positive relationship was found between 25（OH）D concentration and the time of outdoor activities （r = 0.168, P 〈 0.05）. Serum PTH concentration was negatively correlated with 25（OH）D concentration （r - 0.163, P 〈 0.05）. A positive relationship was found between the serum concentrations of 25（OH）D and calcium （r = 0.154, P 〈 0.05）. No significant association was observed between 25（OH）D and ALP, phosphorus, or anthropometric variables. Conclusions： The prevalence of VitD insufficiency is high among young children in the rural Southwestern China regardless of the seasons. VitD supplementation is still essential to maintain VitD sufficiency for children living in rural area.展开更多
Ⅰ. INTRODUCTION It is still disputable whether the amount of zinc in human body(B-Zn) can be reflected by the zinc content of hair (H-Zn). Quite a few investigators have demonstrated that the H-Zn is a good index of ...Ⅰ. INTRODUCTION It is still disputable whether the amount of zinc in human body(B-Zn) can be reflected by the zinc content of hair (H-Zn). Quite a few investigators have demonstrated that the H-Zn is a good index of the zinc level in human body. Others hold a contrary opinion. In order to elucidate this question, one needs not only a展开更多
基金Yunnan Province Psychiatric Hospital Project(Shengjing Scientific Research 2022-08).
文摘In recent years,non-suicidal self-injury(NSSI)behavior has emerged in a large number of adoles-cent depression.NSSI associated with adolescent depres-sion may be an addictive behavior,which has many sim-ilar neurobiological mechanisms to substance addiction.Brain-derived neurotrophic factor(BDNF)and precursor of BDNF(proBDNF)play an important role in addiction behavior,and they may be related to endogenous opioid receptors.The location and distribution of opioidμre-ceptors in the brain are related to reward,motivation and emotion regulated by behavioral addiction.The purpose of this paper is to review the general situation,mechanism and relationship between the characteristics of NSSI be-havior addiction and brain-derived nutritional factors in adolescents with depression.
文摘Introduction: Medical students worked earlier as independent practitioners before paediatrics courses. Now it is denied. We evaluated students’ experiences of infant contacts before and after the change. Methods: A cross-sectional questionnaire study consists of students attending paediatrics courses at University of Oulu in 2004-2006 and 2014-2015. Results: 229 of 241 (95.0%) students in the first cohort and 236 of 258 (91.5%) in the second completed the questionnaire. The mean (SD) age of the students was 25.1 (3.0) and 25.9 (3.0) (p = 0.040). In both cohorts two thirds of the students were familiar with holding infants in the lap, but two thirds had never bathed an infant. A half of males and one third of females had never fed an infant. Students approximated to manage with infants and believed to manage increased with age in both cohorts (p < 0.001 vs. p = 0.019). Students’ perspective towards pediatrics as a future carrier choice declined from 30.3% to 22.0%. Conclusions: Students’ experiences in handling and care of infants are quite low before paediatrics courses. The denial not to work as independent practitioner before paediatric courses did not decrease experiences. Medical students are motivated to have infant experiences in practice.
文摘This study aims to elucidate the nature of cognitive deficits caused by intracranial tumors, as well as to examine how a surgical operation of the tumor may affect tumor-induced cognitive deficits. The patient group included 43 individuals with meningioma or low-grade glioma admitted to a surgical operation of the tumor. Neuropsychological examination was conducted preoperatively, as well as three and 12 months postoperatively. The control group comprised 31 healthy subjects. In the tumor patients, preoperative cognitive performance was compromised in several cognitive domains as compared to the controls. The tumor patients with frontal and large tumors showed impairment virtually across all cognitive domains. Postoperatively, the cognitive performance of the meningioma and the small tumor group improved in all domains, with the performance of the low-grade glioma group and the large tumor group reflecting more modest cognitive improvement. Most of this improvement did not emerge until the 12 months follow-up. Cognitive impairment due to an intracranial tumor is diffuse affecting most cognitive domains. Cognitive recovery after the surgery is more noticeable in patients with meningiomas and small tumors, and the recovery will require a minimum of one year time-wise. This evidence is of significant value when planning both clinical treatment and rehabilitation of intracranial tumor patients.
文摘Background： With recognition of the important roles of Vitamin D （VitD） in various physiological processes, increasing attention has been drawn to the status of VitD in early life. However, the VitD status of young children and the related factors in rural areas of Southwestern China remain unclear. This study aimed to explore VitD status and its seasonal variation in 18-month-old children living in rural Southwestern China. The association of VitD with biochemical and anthropometric variables was also investigated. Methods： A total of 177 18-month-old children in a rural area of Yunnan Province, Southwestern China, were enrolled. Serum concentrations of 25-hydroxy Vitamin D （25（OH）D） were measured through high-performance liquid chromatogram-tandem mass spectrometry. Parathyroid hormone （PTH） levels were measured with a chemiluminescence assay. Serum concentrations of calcium, phosphorus, and alkaline phosphatase （ALP） were also measured. Anthropometric data and the outdoor activity time of each participant were collected. Results： The serum 25（OH）D concentration was 26.61 ±7.26 ng/ml; concentrations lower than 30 ng/ml accounted for 70.6% of the participants and concentrations lower than 20 ng/ml accounted for 16.4%. The level of serum 25（OH）D was not significantly different among four seasons （P 〉 0.05）. A positive relationship was found between 25（OH）D concentration and the time of outdoor activities （r = 0.168, P 〈 0.05）. Serum PTH concentration was negatively correlated with 25（OH）D concentration （r - 0.163, P 〈 0.05）. A positive relationship was found between the serum concentrations of 25（OH）D and calcium （r = 0.154, P 〈 0.05）. No significant association was observed between 25（OH）D and ALP, phosphorus, or anthropometric variables. Conclusions： The prevalence of VitD insufficiency is high among young children in the rural Southwestern China regardless of the seasons. VitD supplementation is still essential to maintain VitD sufficiency for children living in rural area.
文摘Ⅰ. INTRODUCTION It is still disputable whether the amount of zinc in human body(B-Zn) can be reflected by the zinc content of hair (H-Zn). Quite a few investigators have demonstrated that the H-Zn is a good index of the zinc level in human body. Others hold a contrary opinion. In order to elucidate this question, one needs not only a
