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Schistosomiasis transmission in Zimbabwe:Modelling based on machine learning
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作者 Hong-Mei Li Jin-Xin Zheng +7 位作者 Nicholas Midzi Masceline Jenipher Mutsaka-Makuvaza Shan Lv Shang Xia Ying-jun Qian Ning Xiao Robert Berguist Xiao-Nong Zhou 《Infectious Disease Modelling》 CSCD 2024年第4期1081-1094,共14页
Zimbabwe,located in Southern Africa,faces a significant public health challenge due to schistosomiasis.We investigated this issue with emphasis on risk prediction of schistosomiasis for the entire population.To this e... Zimbabwe,located in Southern Africa,faces a significant public health challenge due to schistosomiasis.We investigated this issue with emphasis on risk prediction of schistosomiasis for the entire population.To this end,we reviewed available data on schistosomiasis in Zimbabwe from a literature search covering the 1980-2022 period considering the potential impact of 26 environmental and socioeconomic variables obtained from public sources.We studied the population requiring praziquantel with regard to whether or not mass drug administration(MDA)had been regularly applied.Three machinelearning algorithms were tested for their ability to predict the prevalence of schistosomiasis in Zimbabwe based on the mean absolute error(MAE),the root mean squared error(RMSE)and the coefficient of determination(R2).The findings revealed different roles of the 26 factors with respect to transmission and there were particular variations between Schistosoma haematobium and S.mansoni infections.We found that the top-five correlation factors,such as the past(rather than current)time,unsettled MDA implementation,constrained economy,high rainfall during the warmest season,and high annual precipitation were closely associated with higher S.haematobium prevalence,while lower elevation,high rainfall during the warmest season,steeper slope,past(rather than current)time,and higher minimum temperature in the coldest month were rather related to higher S.mansoni prevalence.The random forest(RF)algorithm was considered as the formal best model construction method,with MAE=0.108;RMSE=0.143;and R^(2)=0.517 for S.haematobium,and with the corresponding figures for S.mansoni being 0.053;0.082;and 0.458.Based on this optimal model,the current total schistosomiasis prevalence in Zimbabwe under MDA implementation was 19.8%,with that of S.haematobium at 13.8% and that of S.mansoni at 7.1%,requiring annual MDA based on a population of 3,003,928.Without MDA,the current total schistosomiasis prevalence would be 23.2%,that of S.haematobium 17.1% and that of S.mansoni prevalence at 7.4%,requiring annual MDA based on a population of 3,521,466.The study reveals that MDA alone is insufficient for schistosomiasis elimination,especially that due to S.mansoni.This study predicts a moderate prevalence of schistosomiasis in Zimbabwe,with its elimination requiring comprehensive control measures beyond the currently used strategies,including health education,snail control,population surveillance and environmental management. 展开更多
关键词 MACHINE-LEARNING Transmission risk model SCHISTOSOMIASIS Zimbabwe
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Natural variables separate the endemic areas of Clonorchis sinensis and Opisthorchis viverrini along a continuous,straight zone in Southeast Asia
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作者 Jin-Xin Zheng Hui-Hui Zhu +7 位作者 Shang Xia Men-Bao Qian Hung Manh Nguyen Banchob Sripa Somphou Sayasone Virak Khieu Robert Bergquist Xiao-Nong Zhou 《Infectious Diseases of Poverty》 SCIE CAS CSCD 2024年第2期39-51,共13页
Background Clonorchiasis and opisthorchiasis,caused by the liver flukes Clonorchis sinensis and Opisthorchis viverrini respectively,represent significant neglected tropical diseases(NTDs)in Asia.The co-existence of th... Background Clonorchiasis and opisthorchiasis,caused by the liver flukes Clonorchis sinensis and Opisthorchis viverrini respectively,represent significant neglected tropical diseases(NTDs)in Asia.The co-existence of these pathogens in overlapping regions complicates effective disease control strategies.This study aimed to clarify the distribution and interaction of these diseases within Southeast Asia.Methods We systematically collated occurrence records of human clonorchiasis(n=1809)and opisthorchiasis(n=731)across the Southeast Asia countries.Utilizing species distribution models incorporating environmental and climatic data,coupled machine learning algorithms with boosted regression trees,we predicted and distinguished endemic areas for each fluke species.Machine learning techniques,including geospatial analysis,were employed to delineate the boundaries between these flukes.Results Our analysis revealed that the endemic range of C.sinensis and O.viverrini in Southeast Asia primarily spans across part of China,Vietnam,Thailand,Laos,and Cambodia.During the period from 2000 to 2018,we identified C.sinensis infections in 84 distinct locations,predominantly in southern China(Guangxi Zhuang Autonomous Region)and northern Vietnam.In a stark contrast,O.viverrini was more widely distributed,with infections documented in 721 locations across Thailand,Laos,Cambodia,and Vietnam.Critical environmental determinants were quantitatively analyzed,revealing annual mean temperatures ranging between 14 and 20°C in clonorchiasis-endemic areas and 24-30°C in opisthorchiasis regions(P<0.05).The machine learning model effectively mapped a distinct demarcation zone,demonstrating a clear separation between the endemic areas of these two liver flukes with AUC from 0.9 to1.The study in Vietnam delineates the coexistence and geographical boundaries of C.sinensis and O.viverrini,revealing distinct endemic zones and a transitional area where both liver fluke species overlap.Conclusions Our findings highlight the critical role of specific climatic and environmental factors in influencing the geographical distribution of C.sinensis and O.viverrini.This spatial delineation offers valuable insights for integrated surveillance and control strategies,particularly in regions with sympatric transmission.The results underscore the need for tailored interventions,considering regional epidemiological variations.Future collaborations integrating eco-epidemiology,molecular epidemiology,and parasitology are essential to further elucidate the complex interplay of liver fluke distributions in Asia. 展开更多
关键词 Liver fluke CLONORCHIASIS OPISTHORCHIASIS Southeast Asia Machine learning Ecological study
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High-risk spatiotemporal patterns of cutaneous leishmaniasis:a nationwide study in Iran from 2011 to 2020
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作者 Neda Firouraghi Robert Bergquist +4 位作者 Munazza Fatima Alireza Mohammadi Davidson H.Hamer Mohammad Reza Shirzadi Behzad Kiani 《Infectious Diseases of Poverty》 SCIE CAS CSCD 2023年第3期93-93,共1页
Background Cutaneous leishmaniasis(CL)is a wide-reaching infection of major public health concern.Iran is one of the six most endemic countries in the world.This study aims to provide a spatiotemporal visualization of... Background Cutaneous leishmaniasis(CL)is a wide-reaching infection of major public health concern.Iran is one of the six most endemic countries in the world.This study aims to provide a spatiotemporal visualization of CL cases in Iran at the county level from 2011 to 2020,detecting high-risk zones,while also noting the movement of high-risk clusters.Methods On the basis of clinical observations and parasitological tests,data of 154,378 diagnosed patients were obtained from the Iran Ministry of Health and Medical Education.Utilizing spatial scan statistics,we investigated the disease’s purely temporal,purely spatial,spatial variation in temporal trends and spatiotemporal patterns.At P=0.05 level,the null hypothesis was rejected in every instance.Results In general,the number of new CL cases decreased over the course of the 9-year research period.From 2011 to 2020,a regular seasonal pattern,with peaks in the fall and troughs in the spring,was found.The period of September–February of 2014–2015 was found to hold the highest risk in terms of CL incidence rate in the whole country[relative risk(RR)=2.24,P<0.001)].In terms of location,six signifcant high-risk CL clusters covering 40.6%of the total area of the country were observed,with the RR ranging from 1.87 to 9.69.In addition,spatial variation in the temporal trend analysis found 11 clusters as potential high-risk areas that highlighted certain regions with an increasing tendency.Finally,fve space-time clusters were found.The geographical displacement and spread of the disease followed a moving pattern over the 9-year study period afecting many regions of the country.Conclusions Our study has revealed signifcant regional,temporal,and spatiotemporal patterns of CL distribution in Iran.Over the years,there have been multiple shifts in spatiotemporal clusters,encompassing many diferent parts of the country from 2011 to 2020.The results reveal the formation of clusters across counties that cover certain parts of provinces,indicating the importance of conducting spatiotemporal analyses at the county level for studies that encompass entire countries.Such analyses,at a fner geographical scale,such as county level,might provide more precise results than analyses at the scale of the province. 展开更多
关键词 Cutaneous leishmaniasis Spatial epidemiology Geographical Information Systems Spatiotemporal analysis SaTScan Spatial scan statistics Neglected tropical diseases Spatiotemporal clustering Iran
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Control of neglected tropical diseases in Asia Pacific: implications for health information priorities 被引量:6
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作者 Robert Bergquist Maxine Whittaker 《Infectious Diseases of Poverty》 SCIE 2012年第1期15-18,共4页
Poverty magnifies limitations posed by traditional biases and environmental risks.Any approach towards disease control needs to recognise that socially embedded vulnerabilities can be as powerful as externally imposed... Poverty magnifies limitations posed by traditional biases and environmental risks.Any approach towards disease control needs to recognise that socially embedded vulnerabilities can be as powerful as externally imposed infections.Asia Pacific has a specific panorama of infectious diseases,which,in common with other endemic areas,have a tendency to emerge or re-emerge if not carefully monitored.Sustained control aiming at elimination requires strong emphasis on surveillance and response.Well-designed informatics platforms can improve support systems and strengthen control activities,as they rapidly locate high-risk areas and provide detailed,up-to-date information on the performance of ongoing control programmes. 展开更多
关键词 Neglected tropical diseases NTD Health information systems POVERTY Disease surveillance Control programmes Asia Pacific
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Controlling schistosomiasis with praziquantel:How much longer without a viable alternative? 被引量:7
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作者 Robert Bergquist Jürg Utzinger Jennifer Keiser 《Infectious Diseases of Poverty》 SCIE 2017年第1期654-663,共10页
The current approach of morbidity control of schistosomiasis,a helminth disease of poverty with considerable public health and socioeconomic impact,is based on preventive chemotherapy with praziquantel.There is a pres... The current approach of morbidity control of schistosomiasis,a helminth disease of poverty with considerable public health and socioeconomic impact,is based on preventive chemotherapy with praziquantel.There is a pressing need for new drugs against this disease whose control entirely depends on this single drug that has been widely used over the past 40 years.We argue that a broader anthelminthic approach supplementing praziquantel with new antischistosomals targeting different parasite development stages would not only increase efficacy but also reduce the risk for drug resistance.Repositioning drugs already approved for other diseases provides a shortcut to clinical trials,as it is expected that such drugs rapidly pass the regulatory authorities.The antischistosomal properties of antimalarial drugs(e.g.,semisynthetic artemisinins,synthetic trioxolanes,trioxaquines and mefloquine)and of drugs being developed or registered for other purposes(e.g.,moxidectin and miltefosin),administered alone or in combination with praziquantel,have been tested in the laboratory and clinical trials.Another avenue to follow is the continued search for new antischistosomal properties in plants.Here,we summarise recent progress made in schistosomiasis chemotherapy,placing particular emphasis on repositioning of existing drugs against schistosomiasis. 展开更多
关键词 CHEMOTHERAPY Drug repositioning ELIMINATION Morbidity control PRAZIQUANTEL SCHISTOSOMIASIS
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Elimination of schistosomiasis:the tools required 被引量:8
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作者 Robert Bergquist Xiao-Nong Zhou +2 位作者 David Rollinson Jutta Reinhard-Rupp Katharina Klohe 《Infectious Diseases of Poverty》 SCIE 2017年第1期1410-1418,共9页
Background:Historically,the target in the schistosomiasis control has shifted from infection to morbidity,then back to infection,but now as a public health problem,before moving on to transmission control.Currently,al... Background:Historically,the target in the schistosomiasis control has shifted from infection to morbidity,then back to infection,but now as a public health problem,before moving on to transmission control.Currently,all endemic countries are encouraged to increase control efforts and move towards elimination as required by the World Health Organization(WHO)roadmap for the global control of the neglected tropical diseases(NTDs)and the WHA65.21 resolution issued by the World Health Assembly.However,schistosomiasis prevalence is still alarmingly high and the global number of disability-adjusted life years(DALYs)due to this infection has in fact increased due to inclusion of some‘subtle’clinical symptoms not previously counted.Main body:There is a need to restart and improve efforts to reach the elimination goal.To that end,the first conference of the Global Schistosomiasis Alliance(GSA)Research Working Group was held in mid-June 2016 in Shanghai,People’s Republic of China.It reviewed current progress in schistosomiasis control and elimination,identified pressing operational research gaps that need to be addressed and discussed new tools and strategies required to make elimination a reality.The articles emanating from the lectures and discussions during this meeting,together with some additional invited papers,have been collected as a special issue of the‘Infectious Diseases of Poverty’entitled‘Schistosomiasis Research:Providing the Tools Needed for Elimination’,consisting of 26 papers in all.This paper refers to these papers and discusses critical questions arising at the conference related to elimination of schistosomiasis.Conclusion:The currently most burning questions are the following:Can schistosomiasis be eliminated?Does it require better,more highly sensitive diagnostics?What is the role of preventive chemotherapy at the elimination stage?Is praziquantel sufficient or do we need new drugs?Contemplating these questions,it is felt that the heterogeneity of the endemic areas in the world requires WHO policies to be upgraded instituting new,differentiated guidelines. 展开更多
关键词 SCHISTOSOMIASIS TOOLS Morbidity control ELIMINATION Transmission Strategy Surveillance Global alliance
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Neglected tropical diseases in the People’s Republic of China: progress towards elimination 被引量:32
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作者 Men-Bao Qian Jin Chen +5 位作者 Robert Bergquist Zhong-Jie Li Shi-Zhu Li Ning Xiao Jurg Utzinger Xiao-Nong Zhou 《Infectious Diseases of Poverty》 SCIE 2019年第5期6-21,共16页
Since the founding of the People's Republic of China in 1949,considerable progress has been made in the control and elimination of the country's initial set of 11 neglected tropical diseases.Indeed,elimination... Since the founding of the People's Republic of China in 1949,considerable progress has been made in the control and elimination of the country's initial set of 11 neglected tropical diseases.Indeed,elimination as a public health problem has been declared for lymphatic filariasis in 2007 and for trachoma in 2015.The remaining numbers of people affected by soil-transmitted helminth infection,clonorchiasis,taeniasis,and echinococcosis in 2015 were 29.1 million,6.0 million,366200,and 166100,respectively.In 2017,after more than 60 years of uninterrupted,multifaceted schistosomiasis control,has seen the number of cases dwindling from more than 10 million to 37600.Meanwhile,about 6000 dengue cases are reported,while the incidence of leishmaniasis,leprosy,and rabies are down at 600 or fewer per year.Sustained social and economic development,going hand-in-hand with improvement of water,sanitation,and hygiene provide the foundation for continued progress,while rigorous surveillance and specific public health responses will consolidate achievements and shape the elimination agenda.Targets for poverty elimination and strategic plans and intervention packages post-2020 are important opportunities for further control and elimination,when remaining challenges call for sustainable efforts. 展开更多
关键词 CONTROL ELIMINATION People's Republic of China Neglected tropical diseases
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Elimination of tropical disease through surveillance and response 被引量:29
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作者 Xiao-Nong Zhou RobertBergquist Marcel Tanner 《Infectious Diseases of Poverty》 SCIE 2013年第1期1-5,共5页
Surveillance and response represent the final crucial steps in achieving effective control and particularly elimination of communicable diseases as recognized in the area of neglected tropical diseases(NTDs),applied i... Surveillance and response represent the final crucial steps in achieving effective control and particularly elimination of communicable diseases as recognized in the area of neglected tropical diseases(NTDs),applied in increasing numbers in endemic countries with ongoing control and elimination programmers.More and more national NTD elimination initiatives are scheduled based on the innovative and effective One world-One health perspective to detect pockets of transmission and disease reintroduction.Resource-constrained countries,which carry the heaviest NTD burdens,face various challenges how to strengthen the health system as well as developing effective and novel tools for sureillance and response tailored to local settings.Surillance-response approaches take place in two different stages oralling the basic components of the sureillance response system for NTD elimination.Six different research priorities have been identified:(1)dynamic mapping of transmission,(2)near real-time capture of population dynamics,(3)modelling based on a minimum essential database/dataset,(4)implementation of mobile health(m-health)and sensitive diagnostics,(5)design of effective response packages tailored to different transmission settings and levels,and( 6)validation of approaches and responses packages. 展开更多
关键词 ELIMINATION TROPICAL NEGLECTED
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Infestation risk of the intermediate snail host of Schistosomajaponicum in the Yangtze River Basin: improved results by spatial reassessment and a random forest approach 被引量:9
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作者 Jin-Xin Zheng Shang Xia +3 位作者 Shan Lv Yi Zhang Robert Bergquist Xiao-Nong Zhou 《Infectious Diseases of Poverty》 SCIE 2021年第3期34-46,共13页
Background:Oncomelania hupensis is only intermediate snail host of Schistosomajaponicum,and distribution of 0.hupensis is an important indicator for the surveillance of schistosomiasis.This study explored the feasibil... Background:Oncomelania hupensis is only intermediate snail host of Schistosomajaponicum,and distribution of 0.hupensis is an important indicator for the surveillance of schistosomiasis.This study explored the feasibility of a random forest algorithm weighted by spatial distance for risk prediction of schistosomiasis distribution in the Yangtze River Basin in China,with the aim to produce an improved precision reference for the national schistosomiasis control programme by reducing the number of snail survey sites without losing predictive accuracy.Methods:The snail presence and absence records were collected from Anhui,Hunan,Hubei,Jiangxi and Jiangsu provinces in 2018.A machine learning of random forest algorithm based on a set of environmental and climatic variables was developed to predict the breeding sites of the 0.hupensis intermediated snail host of S.japonicum.Different spatial sizes of a hexagonal grid system were compared to estimate the need for required snail sampling sites.The predictive accuracy related to geographic distances between snail sampling sites was estimated by calculating Kappa and the area under the curve(AUC).Results:The highest accuracy(AUC=0.889 and Kappa=0.618)was achieved at the 5 km distance weight.The five factors with the strongest correlation to 0.hupensis infestation probability were:(1)distance to lake(48.9%),(2)distance to river(36.6%),(3)isothermality(29.5%),(4)mean daily difference in temperature(28.1%),and(5)altitude(26.0%).The risk map showed that areas characterized by snail infestation were mainly located along the Yangtze River,with the highest probability in the dividing,slow-flowing river arms in the middle and lower reaches of the Yangtze River in Anhui,followed by areas near the shores of China's two main lakes,the Dongting Lake in Hunan and Hubei and the Poyang Lake in Jiangxi.Conelusions:Applying the machine learning of random forest algorithm made it feasible to precisely predict snail infestation probability,an approach that could improve the sensitivity of the Chinese schistosome surveillance.system.Redesign of the snail surveillance system by spatial bias correction of 0.hupensis infestation in the Yangtze River Basin to reduce the number of sites required to investigate from 2369 to 1747. 展开更多
关键词 SCHISTOSOMIASIS Oncomelania hupensis Snail infestation Yangtze River Random forest Spatial sampling Machine learning China
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Surveillance and response systems for elimination of tropical diseases: summary of a thematic series in Infectious Diseases of Poverty 被引量:12
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作者 Xia Zhou Peiling Yap +3 位作者 Marcel Tanner Robert Bergquist Jürg Utzinger Xiao-Nong Zhou 《Infectious Diseases of Poverty》 SCIE 2016年第1期417-423,共7页
The peer-reviewed journal Infectious Diseases of Poverty provides a new platform to engage with,and disseminate in an open-access format,science outside traditional disciplinary boundaries.The current piece reviews a ... The peer-reviewed journal Infectious Diseases of Poverty provides a new platform to engage with,and disseminate in an open-access format,science outside traditional disciplinary boundaries.The current piece reviews a thematic series on surveillance-response systems for elimination of tropical diseases.Overall,22 contributions covering a broad array of diseases are featured–i.e.clonorchiasis,dengue,hepatitis,human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS),H7N9 avian influenza,lymphatic filariasis,malaria,Middle East respiratory syndrome(MERS),rabies,schistosomiasis and tuberculosis(TB).There are five scoping reviews,a commentary,a letter to the editor,an opinion piece and an editorial pertaining to the theme“Elimination of tropical disease through surveillance and response”.The remaining 13 articles are original contributions mainly covering(i)drug resistance;(ii)innovation and validation in the field of mathematical modelling;(iii)elimination of infectious diseases;and(iv)social media reports on disease outbreak notifications released by national health authorities.Analysis of the authors’affiliations reveals that scientists from the People’s Republic of China(P.R.China)are prominently represented.Possible explanations include the fact that the 2012 and 2014 international conferences pertaining to surveillance-response mechanisms were both hosted by the National Institute of Parasitic Diseases(NIPD)in Shanghai,coupled with P.R.China’s growing importance with regard to the control of infectious diseases.Within 4 to 22 months of publication,three of the 22 contributions were viewed more than 10000 times each.With sustained efforts focusing on relevant and strategic information towards control and elimination of infectious diseases,Infectious Diseases of Poverty has become a leading journal in the field of surveillance and response systems in infectious diseases and beyond. 展开更多
关键词 Infectious diseases Tropical diseases Health systems Surveillance and response systems ELIMINATION People’s Republic of China
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Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia 被引量:4
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作者 Youthanavanh Vonghachack Somphou Sayasone +9 位作者 Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt 《Infectious Diseases of Poverty》 SCIE 2017年第1期1123-1135,共13页
Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes ... Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. 展开更多
关键词 Cambodia Food-borne trematodes Kato-Katz Lao People’s Democratic Republic Point-of-care circulating cathodic antigen Schistosoma mekongi SEROLOGY Soil-transmitted helminths Up-converting phosphorlateral-flow circulating anodic antigen
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Surveillance-response systems: the key to elimination of tropical diseases 被引量:17
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作者 Ernest Tambo Lin Ai +7 位作者 Xia Zhou Jun-Hu Chen Wei Hu Robert Bergquist Jia-Gang Guo Jürg Utzinger Marcel Tanner Xiao-Nong Zhou 《Infectious Diseases of Poverty》 SCIE 2014年第1期157-166,156,共11页
Tropical diseases remain a major cause of morbidity and mortality in developing countries.Although combined health efforts brought about significant improvements over the past 20 years,communities in resource-constrai... Tropical diseases remain a major cause of morbidity and mortality in developing countries.Although combined health efforts brought about significant improvements over the past 20 years,communities in resource-constrained settings lack the means of strengthening their environment in directions that would provide less favourable conditions for pathogens.Still,the impact of infectious diseases is declining worldwide along with progress made regarding responses to basic health problems and improving health services delivery to the most vulnerable populations.The London Declaration on Neglected Tropical Diseases(NTDs),initiated by the World Health Organization’s NTD roadmap,set out the path towards control and eventual elimination of several tropical diseases by 2020,providing an impetus for local and regional disease elimination programmes.Tropical diseases are often patchy and erratic,and there are differing priorities in resources-limited and endemic countries at various levels of their public health systems.In order to identify and prioritize strategic research on elimination of tropical diseases,the‘First Forum on Surveillance-Response System Leading to Tropical Diseases Elimination’was convened in Shanghai in June 2012.Current strategies and the NTD roadmap were reviewed,followed by discussions on how to identify and critically examine prevailing challenges and opportunities,including inter-sectoral collaboration and approaches for elimination of several infectious,tropical diseases.A priority research agenda within a‘One Health-One World’frame of global health was developed,including(i)the establishment of a platform for resource-sharing and effective surveillance-response systems for Asia Pacific and Africa with an initial focus on elimination of lymphatic filariasis,malaria and schistosomiasis;(ii)development of new strategies,tools and approaches,such as improved diagnostics and antimalarial therapies;(iii)rigorous validation of surveillance-response systems;and(iv)designing pilot studies to transfer Chinese experiences of successful surveillance-response systems to endemic countries with limited resources. 展开更多
关键词 Tropical diseases CONTROL ELIMINATION Surveillance-response system Global health China
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Surveillance-based evidence:elimination of schistosomiasis as a public health problem in the Peoples’Republic of China 被引量:24
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作者 Jing Xu Shi-Zhu Li +13 位作者 Li-Juan Zhang Robert Bergquist Hui Dang Qiang Wang Shan Lv Tian-Ping Wang Dan-Dan Lin Jian-Bing Liu Guang-Hui Ren Kun Yang Yang Liu Yi Dong Shi-Qing Zhang Xiao-Nong Zhou 《Infectious Diseases of Poverty》 SCIE 2020年第3期39-50,共12页
Background:A steady progress on schistosomiasis control in the Peoples’Republic of China(P.R.China)was achieved and broadened into the twelve-year medium and long term national plan(MLNP)which marled the implementati... Background:A steady progress on schistosomiasis control in the Peoples’Republic of China(P.R.China)was achieved and broadened into the twelve-year medium and long term national plan(MLNP)which marled the implementation of an integrated control strategy across all endemic areas in P.R.China in 2004.To understand the endemic trends of schistosomiasis to assess the effectiveness of an integrated strategy,we conducted an analysis of schistosomiasis surveillance data spanned from 2005 to 2015.Methods:The schistosomiasis sentinel surveillance data from sentinel sites were collected and analyzed from 2005 to 2015.In these sentinel sites,residents aged 6 years or above were screened annually by indirect hemagglutination assay(IHA),while only antibody positives were followed by stool examination either Kato-katz method(KK)and/or hatching technique(HT).Domestic animals raised in sentinel sites were examined by HT for confirming the infection of schistosomes.Snail investigation was conducted each year through systematic sampling method combined with environmental sampling method.The snails collected from field were tested by microscopic dissection method.The infection rates of schistosomes in residents,domestic animals and snails,as well as the indicators reflecting the snails’distribution were calculated and analyzed.ANOVA analysis was used to examine the changes of the number of eggs per gram feces in population and Chi-square test was used to examine any change in proportions among groups.Results:A total of 148902 residents from sentinel sites attended this study and 631676 blood samples were examined by IHA test during the 11 covered years.The annual average antibody positive rates presented a significant decrease trends,from 17.48%(95%CI:17.20–17.75%)in 2005 to 5.93%(95%CI:5.71–6.15%)(χ2=8890.47,P<0.001)in 2015.During 2005–2015,the average infection rate of schistosomes in residents declined from 2.07%(95%CI:1.96–2.17%)to 0.13%(95%CI:0.09–0.16%),accompanied by significant decrease of infection intensity in population.In 2015,the stool positives were only found in farmers,fishermen and boatmen with infection rate of 0.16%(95%CI:0.11–0.20%),0.17%(95%CI:0–0.50%)respectively.The infection rate of schistosomes in domestic animals dropped from 9.42%(538/5711,95%CI:8.66–10.18%)to 0.08%(2/2360,95%CI:0–0.20%)from 2005 to 2015.Infections were found in eight species of domestic animals at the beginning of surveillance while only two cattle were infected in 2015.Totally 98 ha of new snail habitats were found,while 94.90%(93/98)distributed in lake and marshland regions.The percentage of frames with snails decreased from 16.96%(56884/335391,95%CI:16.83–17.09%)in 2005 to 4.28%(18121/423755,95%CI:4.22–4.34%)in 2014,with a slightly increase in 2015.Meanwhile,the infection rate of schistosomes in snails was decreased from 0.26%(663/256531,95%CI:0.24–0.28%)to zero during 2005–2015.Conclusions:The infection rate of schistosomes declined significantly,providing evidence that the goal of the MLNP was achieved.Elimination of schistosomiasis as a public health problem defined as WHO was also reached in P.R.China nationwide.Surveillance-response system should be improved and strengthened to realize the final goal of schistosomiasis elimination. 展开更多
关键词 SCHISTOSOMIASIS SURVEILLANCE Infection rate ELIMINATION China
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Nobel prize for the artemisinin and ivermectin discoveries: a great boost towards elimination of the global infectious diseases of poverty 被引量:6
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作者 Ernest Tambo Emad IMKhater +2 位作者 Jun-Hu Chen Robert Bergquist Xiao-Nong Zhou 《Infectious Diseases of Poverty》 SCIE 2015年第1期487-494,共8页
The Millennium Development Goals(MDGs)made a marked transformation for neglected and vulnerable communities in the developing countries from the start,but infectious diseases of poverty(IDoPs)continue to inflict a dis... The Millennium Development Goals(MDGs)made a marked transformation for neglected and vulnerable communities in the developing countries from the start,but infectious diseases of poverty(IDoPs)continue to inflict a disproportionate global public health burden with associated consequences,thereby contributing to the vicious cycle of poverty and inequity.However,the effectiveness and large-scale coverage of artemisinin combination therapy(ACT)have revolutionized malaria treatment just as the control of lymphatic filariasis(LF)and onchocerciasis have benefitted from harnessing the broad-spectrum effect of avermectin-based derivatives.The paradigm shift in therapeutic approach,effected by these two drugs and their impact on community-based interventions of parasitic diseases plaguing the endemic low-and middle-income countries(LIMCs),led to the Nobel Prize in Physiology or Medicine in 2015.However,the story would not be complete without mentioning praziquantel.The huge contribution of this drug in modernizing the control of schistosomiasis and also some intestinal helminth infections had already shifted the focus from control to potential elimination of this disease.Together,these new drugs have provided humankind with powerful new tools for the alleviation of infectious diseases that humans have lived with since time immemorial.These drugs all have broad-spectrum effects,yet they are very safe and can even be packaged together in various combinations.The strong effect on so many of the great infectious scourges in the developing countries has not only had a remarkable influence on many endemic diseases,but also contributed to improving the cost structure of healthcare.Significant benefits include improved quality of preventive and curative medicine,promotion of community-based interventions,universal health coverage and the fostering of global partnerships.The laudable progress and benefits achieved are indispensable in championing,strengthening and moving forward elimination of the IDoPs.However,there is an urgent need for further innovative,contextual and integrated approaches along with the advent of the Sustainable Development Goals(SDGs),replacing the MDGs in ensuring global health security,well-being and economic prosperity for all. 展开更多
关键词 Nobel Prize ARTEMISININ AVERMECTIN IVERMECTIN PRAZIQUANTEL Schistosomiasis Intestinal helminths Lymphatic filariasis River blindness Malaria Discovery POVERTY
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Pattern analysis of schistosomiasis prevalence by exploring predictive modeling in Jiangling County,Hubei Province,P.R.China 被引量:1
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作者 Shang Xia Jing-Bo Xue +7 位作者 Xia Zhang He-Hua Hu Eniola Michael Abe David Rollinson Robert Bergquist Yibiao Zhou Shi-Zhu Li Xiao-Nong Zhou 《Infectious Diseases of Poverty》 SCIE 2017年第1期791-800,共10页
Background:The prevalence of schistosomiasis remains a key public health issue in China.Jiangling County in Hubei Province is a typical lake and marshland endemic area.The pattern analysis of schistosomiasis prevalenc... Background:The prevalence of schistosomiasis remains a key public health issue in China.Jiangling County in Hubei Province is a typical lake and marshland endemic area.The pattern analysis of schistosomiasis prevalence in Jiangling County is of significant importance for promoting schistosomiasis surveillance and control in the similar endemic areas.Methods:The dataset was constructed based on the annual schistosomiasis surveillance as well the socio-economic data in Jiangling County covering the years from 2009 to 2013.A village clustering method modified from the K-mean algorithm was used to identify different types of endemic villages.For these identified village clusters,a matrix-based predictive model was developed by means of exploring the one-step backward temporal correlation inference algorithm aiming to estimate the predicative correlations of schistosomiasis prevalence among different years.Field sampling of faeces from domestic animals,as an indicator of potential schistosomiasis prevalence,was carried out and the results were used to validate the results of proposed models and methods.Results:The prevalence of schistosomiasis in Jiangling County declined year by year.The total of 198 endemic villages in Jiangling County can be divided into four clusters with reference to the 5 years’occurrences of schistosomiasis in human,cattle and snail populations.For each identified village cluster,a predictive matrix was generated to characterize the relationships of schistosomiasis prevalence with the historic infection level as well as their associated impact factors.Furthermore,the results of sampling faeces from the front field agreed with the results of the identified clusters of endemic villages.Conclusion:The results of village clusters and the predictive matrix can be regard as the basis to conduct targeted measures for schistosomiasis surveillance and control.Furthermore,the proposed models and methods can be modified to investigate the schistosomiasis prevalence in other regions as well as be used for investigating other parasitic diseases. 展开更多
关键词 SCHISTOSOMIASIS Clustering Predictive modelling
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Elimination of schistosomiasis requires multifactorial diagnostics: evidence from high- and low-prevalence areas in the Nile Delta, Egypt
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作者 Hala Elmorshedy Robert Bergquist +4 位作者 Amel Fayed Wafaa Guirguis Ensaf Abdel-Gawwad Safaa Eissa Rashida Barakat 《Infectious Diseases of Poverty》 SCIE 2020年第2期63-75,共13页
Background:Schistosomiasis is one of the neglected tropical diseases(NTDs)selected for worldwide elimination in the near future.Egypt has made strong progress against its two endemic species of Schistosoma mansoni and... Background:Schistosomiasis is one of the neglected tropical diseases(NTDs)selected for worldwide elimination in the near future.Egypt has made strong progress against its two endemic species of Schistosoma mansoni and S.haematobium.The former is prevalent in the Nile Delta with the latter dominating in the Nile south of Cairo.Innovative efforts are needed to reach the goal as further reduction of the prevalence has stalled due to ongoing transmission.In this study we aimed to explore the difference between low and high prevalence villages with regard to knowledge attitude and practice about schistosomiasis,utilization of health services,infection and transmission indices.Methods:A hybrid cross-sectional longitudinal study was conducted with three annual follow-ups conducted during 1994-1996.We used a representative systematic random sampling technique investigating 993 individuals from the high prevalence village and 614 from the low prevalence village.Data were analyzed using SPSS,comparing proportions with the Chi square test and means with the Student t test,and ANOVA.Results:Compliance of faecal sampling and chemotherapy was above 70%in both villages over the whole study period.Selective praziquantel treatment resulted in a significant reduction of prevalence and intensity of infection in both villages,dropping from 35.8%prevalence to 20.6%,in the low-prevalence village,and from 69.5 to 45.9%in the high-prevalence one.Intensity of infection at the base line was 30 eggs per gram(EPG)of stool in the low-prevalence village versus 105 EPG in the high-prevalence village.However,after the second round,reinfection rebounded by 22%in the high-prevalence village,while a slight improvement of the infection indices was demonstrated in the low-prevalence one.The level of knowledge was modest in both villages:people knew about self-protection and treatment,but not much about the role of human excreta for schistosomiasis transmission.While all participants maintained that using the water from the canals was inevitable,inhabitants in the high-prevalence village showed significantly lower scores reflecting higher water contact compared to the low-prevalence one.Many of them(67%)did not utilize the health centre at all compared to 26%of the people in the low-prevalence village.Interestingly,private clinics were seen as the primary source of health care by both villages,but more frequently so in the high-prevalence village(used by 87.2%of the inhabitants)compared to the low-prevalence one(59.8%).Conclusions:Even if chemotherapy works well as reflected by the observed downregulation of intensity of infection in both villages,reinfection continued due to difficulties to avoid water contact.Efforts must be made to make people understand the role of human excreta for transmission.There is also a need to make people better trust the medical services available. 展开更多
关键词 SCHISTOSOMIASIS Transmission PRAZIQUANTEL Knowledge attitude and practice Utilization of health services POVERTY EGYPT
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Infectious Diseases of Poverty,the first five years
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作者 Wei Wang Jin Chen +4 位作者 Hui-Feng Sheng Na-Na Wang Pin Yang Xiao-Nong Zhou Robert Bergquist 《Infectious Diseases of Poverty》 SCIE 2017年第1期848-858,共11页
Although the focus in the area of health research may be shifting from infectious to non-communicable diseases,the infectious diseases of poverty remain a major burden of disease of global health concern.A global plat... Although the focus in the area of health research may be shifting from infectious to non-communicable diseases,the infectious diseases of poverty remain a major burden of disease of global health concern.A global platform to communicate and share the research on these diseases is needed to facilitate the translation of knowledge into effective approaches and tools for their elimination.Based on the“One health,One world”mission,a new,openaccess journal,Infectious Diseases of Poverty(IDP),was launched by BioMed Central in partnership with the National Institute of Parasitic Diseases(NIPD),Chinese Center for Disease Control and Prevention(China CDC)on October 25,2012.Its aim is to identify and assess research and information gaps that hinder progress towards new interventions for a particular public health problem in the developing world.From the inaugural IDP issue of October 25,2012,a total of 256 manuscripts have been published over the following five years.Apart from a small number of editorials,opinions,commentaries and letters to the editor,the predominant types of publications are research articles(69.5%)and scoping reviews(21.5%).A total of 1081 contributing authors divided between 323 affiliations across 68 countries,territories and regions produced these 256 publications.The journal is indexed in major international biomedical databases,including Web of Science,PubMed,Scopus and Embase.In 2015,it was assigned its first impact factor(4.11),which is now 2.13.During the past five years,IDP has received manuscripts from 90 countries,territories and regions across six continents with an annual acceptance rate of all contributions maintained at less than 40%.Content analysis shows that neglected tropical diseases(NTDs),followed by the“Big Three”(HIV/AIDS,malaria and tuberculosis)and infectious diseases in general comprise 88%of all publications.In addition,a series of 10 thematic issues,covering 118 publications in all,was published as separate parts of the first five volumes.These publications were cited 975 times,which equals an average of 8.3 times per publication.The current challenge is to identify cutting-edge research topics and attract and to publish first-rate publications leading to increasing importance and impact of the journal in its field. 展开更多
关键词 Infectious diseases of poverty IMPACT Impact factor Bibliometric analysis Content analysis
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