Preparation of nano-sized tungsten carbide via fluidized bed

Ultrafine or nano-sized of tungsten carbide(WC)is the key material to prepare ultrafine grained cemented carbides.In this paper,nano-sized WC powders were directly prepared by using industrial nano-needle violet tungsten oxide(WO2.72)as the raw material,a fluidized bed as the reactor,and CO as the carbonization gas.The relationship between particle sizes and reaction temperatures,residence times,atmospheres has been investigated systematically.In addition,the physical–chemical indexes(such as residual oxygen,total carbon and free carbon)of the products were measured.The results indicated that the particle size of WC increased with the increase of temperature from 800 to 950°C.As the residence time increased,the particle size decreased gradually,and then increased due to slight sintering.The introduction of hydrogen reduced the carbonization rate,and is not beneficial to obtaining nano-sized WC.Products that satisfy the standard were obtained when WO2.72 reacted with CO at 850°C,900°C and 950°C for 3.0 h,2.5 h and 2.0 h,respectively.The particle sizes of the three samples calculated from the specific surface area were 46.4 nm,53.2 nm and 52.1 nm,respectively.

Unforgettable Restaurant: helping older people who are living with disability and dementia return to society

On 25 January 2021,a special restaurant named the‘Unforgettable Restaurant’was opened in a prime locality of Shanghai,China;it emerged from a popular publicly broadcast welfare TV programme of the same name.1 This restaurant’s waiters are older patients with cognitive impairment,and the cumu-lative number of views for the programme has now exceeded 1.4 billion online.23 After the show was broadcast for two consecutive years,the filming party decided to open the restaurant officially,and the waiting duties were assumed by older people living with disability and dementia.

Hepatic HDAC3 Regulates Systemic Iron Homeostasis and Ferroptosis via the Hippo Signaling Pathway

Histone deacetylases(HDACs)are epigenetic regulators that play an important role in determining cell fate and maintaining cellular homeostasis.However,whether and how HDACs regulate iron metabolism and ferroptosis(an iron-dependent form of cell death)remain unclear.Here,the putative role of hepatic HDACs in regulating iron metabolism and ferroptosis was investigated using genetic mouse models.Mice lacking Hdac3 expression in the liver(Hdac3-LKO mice)have significantly reduced hepatic Hamp mRNA(encoding the peptide hormone hepcidin)and altered iron homeostasis.Transcription profiling of Hdac3-LKO mice suggests that the Hippo signaling pathway may be downstream of Hdac3.Moreover,using a Hippo pathway inhibitor and overexpressing the transcriptional regulator Yap(Yes-associated protein)significantly reduced Hamp mRNA levels.Using a promoter reporter assay,we then identified 2 Yap-binding repressor sites within the human HAMP promoter region.We also found that inhibiting Hdac3 led to increased translocation of Yap to the nucleus,suggesting activation of Yap.Notably,knock-in mice expressing a constitutively active form of Yap(Yap K342M)phenocopied the altered hepcidin levels observed in Hdac3-LKO mice.Mechanistically,we show that iron-overload-induced ferroptosis underlies the liver injury that develops in Hdac3-LKO mice,and knocking down Yap expression in Hdac3-LKO mice reduces both iron-overload-and ferroptosis-induced liver injury.These results provide compelling evidence supporting the notion that HDAC3 regulates iron homeostasis via the Hippo/Yap pathway and may serve as a target for reducing ferroptosis in iron-overload-related diseases.