Emerging evidence suggests that liquid-liquid phase separation(LLPS)represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells(also known as biomolecular conde...Emerging evidence suggests that liquid-liquid phase separation(LLPS)represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells(also known as biomolecular condensates or droplets).Recent studies have revealed evidences that indicate that LLPS plays a vital role in human health and diseases.In this review,we describe our current understanding of LLPS and summarize its physiological functions.We further describe the role of LLPS in the development of human diseases.Additionally,we review the recently developed methods for studying LLPS.Although LLPS research is in its infancy-but is fast-growing-it is clear that LLPS plays an essential role in the development of pathophysiological conditions.This highlights the need for an overview of the recent advances in the field to translate our current knowledge regarding LLPS into therapeutic discoveries.展开更多
基金This work was supported by a special program from the Ministry of Science and Technology of China(2016YFA0502500 to L.Z.)the Chinese National Natural Science Funds(31925013,31671457,and 91753139 to L.Z.+9 种基金31871405 and 31571460 to FZ.92053114,32070632 to H.L.)Zhejiang Provincial Natural Science Foundation of China under Grant(LBY21H060001 to L.Z.)the Medical and the Medical and Health Research Project of Zhejiang Province(2020RC115 to L.Z.)Jiangsu National Science Foundation(BK20180043 and 19KJA550003 to F.Z.)the Zhejiang Natural Science Fund(LD19C070001to L.Z.)the China National Postdoctoral Program for Innovative Talents(BX2021208 to T.D.)the China Postdoctoral Science Foundation(2021M692350 to T.D.)the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003)A project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Emerging evidence suggests that liquid-liquid phase separation(LLPS)represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells(also known as biomolecular condensates or droplets).Recent studies have revealed evidences that indicate that LLPS plays a vital role in human health and diseases.In this review,we describe our current understanding of LLPS and summarize its physiological functions.We further describe the role of LLPS in the development of human diseases.Additionally,we review the recently developed methods for studying LLPS.Although LLPS research is in its infancy-but is fast-growing-it is clear that LLPS plays an essential role in the development of pathophysiological conditions.This highlights the need for an overview of the recent advances in the field to translate our current knowledge regarding LLPS into therapeutic discoveries.
