The development of microbial-based products requires certain criteria for them to be successfully commercialized. The product must meet the following desirable criteria: effectiveness, contamination free, stability, c...The development of microbial-based products requires certain criteria for them to be successfully commercialized. The product must meet the following desirable criteria: effectiveness, contamination free, stability, cost-effectiveness, and a prolonged shelf life. Controlling the drying process is crucial for ensuring the stability and durability of the product. The traditional approach, which involved mechanical and natural drying, led to decreased productivity and quality. The objective of this research endeavour was to achieve a dry process enhancement while preserving the microbial quality of Trichoderma asperellum (M103). The temperature and relative humidity during the drying period were monitored under two conditions: with and without a dehumidifier. The results demonstrate that the dehumidifier increases drying period efficiency by up to 63%.展开更多
实车动力电池的健康状态(state of health,SOH)评估存在数据质量差、工况不统一、数据利用率低等问题,本文面向阶梯倍率充电工况构建多源特征提取及SOH估计模型。首先,通过数据清洗、切割、填充,获取独立的充电片段;其次,基于不同电流...实车动力电池的健康状态(state of health,SOH)评估存在数据质量差、工况不统一、数据利用率低等问题,本文面向阶梯倍率充电工况构建多源特征提取及SOH估计模型。首先,通过数据清洗、切割、填充,获取独立的充电片段;其次,基于不同电流阶段计算容量,实现原始数据利用率达96.9%,并与单独限定SOC范围计算容量的方法相比,误差降低48.1%以上;然后,从当前工况、历史累积两个维度提取多个健康因子,对于当前工况特征值,通过灰色关联度及干扰性随机森林重要度分析双重筛选。对于历史累积特征值,利用Spearson相关性分析和核主成分分析方法(kernel principal component analysis,KPCA)降低信息冗余;最后,对门控循环单元网络模型(gated recurrent unit,GRU)引入注意力机制和龙格库塔优化算法(Runge Kutta optimizer,RUN),建立RUN-GRU-attention模型,基于实车运行数据集与现有5种模型进行对比,实验结果表明,无论是包含单阶段还是多阶段电流的测试样本,优化模型的估计精度更佳,误差不高于0.0086,并且随着充电循环次数增加表现出良好的误差收敛性,可有效预测SOH波动趋势。展开更多
It is well known that Diabetes Specific Nutritional Supplements (DSNSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of DSNSs in prediabetics is limited. This was a t...It is well known that Diabetes Specific Nutritional Supplements (DSNSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of DSNSs in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose Response (ABGR) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGR of DSNS versus an isocaloric snack, measured by incremental Area under the Curve (iAUC). Test and control received 60 g of DSNS and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. During the 4 weeks intervention phase, the test group received DSNS with lifestyle counselling (DSNS + LC) and was compared with the control receiving lifestyle counselling alone (LC alone). Impact was studied on FBG, HbA1C, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of DSNS was also studied using CGM between two 14-day phases: CGM1 baseline (days 1 - 14) and CGM2 endline (days 28 - 42). DSNS showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by DSNS + LC versus LC alone. No other significant changes were reported between groups. It may be concluded that DSNS may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.展开更多
In the field of dual-pulse laser-induced breakdown spectroscopy(DP-LIBS)research,the pursuit of methods for determining pulse intervals and other parameters quickly and conveniently in order to achieve optimal spectra...In the field of dual-pulse laser-induced breakdown spectroscopy(DP-LIBS)research,the pursuit of methods for determining pulse intervals and other parameters quickly and conveniently in order to achieve optimal spectral signal enhancement is paramount.To aid researchers in identification of optimal signal enhancement conditions and more accurate interpretation of the underlying signal enhancement mechanisms,theoretical simulations of the spatiotemporal processes of coaxial DP-LIBS-induced plasma have been established in this work.Using a model based on laser ablation and two-dimensional axisymmetric fluid dynamics,plasma evolutions during aluminum–magnesium alloy laser ablation under single-pulse and coaxial dualpulse excitations have been simulated.The influences of factors,such as delay time,laser fluence,plasma temperature,and particle number density,on the DP-LIBS spectral signals are investigated.Under pulse intervals ranging from 50 to 1500 ns,the time evolutions of spectral line intensity,dual-pulse emission enhancement relative to the single-pulse results,laser irradiance,spatial distribution of plasma temperature and species number density,as well as laser irradiance shielded by plasma have been obtained.The study indicates that the main reason behind the radiation signal enhancement in coaxial DP-LIBS-induced plasma is attributed to the increased species number density and plasma temperature caused by the second laser,and it is inferred that the shielding effect of the plasma mainly occurs in the boundary layer of the stagnation point flow over the target surface.This research provides a theoretical basis for experimental research,parameter optimization,and signal enhancement tracing in DP-LIBS.展开更多
农村房地一体档案是对农村宅基地、集体建设用地使用权及房屋所有权进行确权登记的重要依据,将签章后的纸质档案转为电子档案进行存储对不动产权证书办理具有重要意义。由于目前缺乏能识别档案内容并进行分类归档的工具,设计并实现了基...农村房地一体档案是对农村宅基地、集体建设用地使用权及房屋所有权进行确权登记的重要依据,将签章后的纸质档案转为电子档案进行存储对不动产权证书办理具有重要意义。由于目前缺乏能识别档案内容并进行分类归档的工具,设计并实现了基于Tesseract-OCR的农村房地一体归档系统。使用光学字符识别(Optical Character Recognition,OCR)对档案扫描图像进行识别,训练校正字库,提取图像中的文字信息,实现档案资料的分类存储。运用四川省某县的部分房地一体档案进行系统测验,应用结果表明,系统的识别归档准确率为96.5%,能满足房地一体档案归档需求,降低了人工识别归档的繁琐性,极大提高了归档的工作效率,提升了档案分类的准确度。展开更多
Objectives: The existing inflammatory models are concentrated in relatively complex medical fields, and most of them use a single type of cell, and the induction conditions are not uniform, so the current LPS-induced ...Objectives: The existing inflammatory models are concentrated in relatively complex medical fields, and most of them use a single type of cell, and the induction conditions are not uniform, so the current LPS-induced inflammation model is less conducive to the study of skin inflammation. The aim of this research is to enhance the existing LPS-induced inflammation model and establish a skin inflammation model that is suitable for the swift screening of anti-inflammatory agents in the cosmetics industry. Methods: LPS was used to induce inflammatory responses in KC and THP-1 cells. Enzyme-linked immunosorbent assay (ELISA) was employed to assess the levels of IL-1α, IL-8, and TNF-α in the two cell types, while the DCFH-DA probe was utilized to label the levels of reactive oxygen species (ROS) in both cell types. Results: In KC cells, 10 μg/mL of LPS induced a significant upregulation of IL-8 but did not result in elevated expression of IL-1α. However, at 100 μg/mL of LPS, both IL-8 and IL-1α were highly expressed in KC cells. LPS concentrations ranging from 0.01 to 100 μg/mL failed to stimulate TNF-α production in KC cells but induced a gradient increase in ROS levels. In THP-1 cells, LPS concentrations from 0.01 to 100 μg/mL did not induce IL-1α production but significantly elevated IL-8 and led to a gradient increase in TNF-α and ROS. After treatment with 100 μg/mL of LPS, the cosmetic ingredient Rucika KGM mitigated the elevated levels of IL-1α, IL-8, and ROS in LPS-induced KC cells and IL-8 and ROS in THP-1 cells. Conclusion: This study has successfully developed an application-oriented model suitable for investigating skin inflammation, enabling the rapid and comprehensive screening of cosmetic ingredients with anti-inflammatory activity. .展开更多
Introduction: External otitis (OE) is an acute or chronic inflammation or infection of the external ear resulting from an imbalance in the external auditory canal secondary to microtrauma, maceration, eczema, or a for...Introduction: External otitis (OE) is an acute or chronic inflammation or infection of the external ear resulting from an imbalance in the external auditory canal secondary to microtrauma, maceration, eczema, or a foreign body in the external auditory canal. Objective: To study cases of external otitis at the Mamou Regional Hospital. Materials and Methods: This was a prospective descriptive study conducted over a period of six (6) months from July 1st to December 31st, 2016. It included all patients admitted to the ENT department of the Mamou Regional Hospital. Results: During the study period, 712 patients were admitted to the department for various pathologies, of which 103 met our selection criteria, representing a frequency of 14.46%. The mean age of the patients was 33.74 years with a range of 1 to 90 years. Males predominated in the sample, accounting for 59.22%. The vast majority of patients resided in urban areas, constituting 61.17% of the sample. In our study, all patients consulted for otalgia (100%), and over half (53.39%) for hypoacusis. We formally identified rhinitis in 66.66% of cases, while diabetes was found in only 4 patients (11.11%). Otomycosis was the most commonly identified condition (53.39%), followed by furuncles (33.98%). Ear drops containing antibiotics were administered to all patients, although 66.60% received antibiotic therapy. Conclusion: External otitis is a relatively common condition, particularly among children and the elderly. Diagnosis can be made based on pain upon traction of the pinna and pressure on the tragus.展开更多
With the rapid advancement of laser decontamination technology and growing awareness of microbial hazards,it becomes crucial to employ theoretical model to simulate and evaluate decontamination processes by laser-indu...With the rapid advancement of laser decontamination technology and growing awareness of microbial hazards,it becomes crucial to employ theoretical model to simulate and evaluate decontamination processes by laser-induced plasma.This study employs a two-dimensional axisymmetric fluid dynamics model to simulate the power density of plasma bombardment on bacteria and access its decontamination effects.The model considers the transport processes of vapor plasma and background gas molecules.Based on the destructive impact of high-speed moving particles in the plasma on bacteria,we investigate the bombardment power density under various conditions,including different laser spot sizes,wavelengths,plate's tilt angles,and plate-target spacing.The results reveal that the bombardment power density increases with a decrease in laser spot size and wavelength.For instance,when the plate is parallel to the target surface with a 1 mm spacing,the bombardment power density triples as the laser spot size decreases from 0.8 mm to 0.5 mm and quadruples as the wavelength decreases from 1064 nm to 266 nm.Notably,when the plate is parallel to the target with a relatively close spacing of 0.5 mm,the bombardment power density at 0°inclination increases sevenfold compared to 45°.This simulation study is essential for optimizing optical parameters and designing component layouts in decontamination devices using laser-induced plasma.The reduction of laser spot size,wavelength,plate-target spacing and aligning the plate parallel to the target,collectively contribute to achieving precise and effective decontamination.展开更多
Antiozonants and antioxidants are additives commonly used in the rubber industry to enhance the durability and performance of rubber products. Ozone, present in the atmosphere, can cause rubber to degrade over time th...Antiozonants and antioxidants are additives commonly used in the rubber industry to enhance the durability and performance of rubber products. Ozone, present in the atmosphere, can cause rubber to degrade over time through a process known as ozone cracking. These rubber additives are added to rubber compounds to protect against this degradation. They work by reacting with ozone, preventing it from attacking and breaking the molecular chains in the rubber, helping to maintain the structural integrity of the rubber product. It is now well known that 6PPD contributes to the extension of the service life of rubber products. However, recent studies have shown that 6PPD can be harmful to the environment, especially when end-of-life tyres (ELTs) are contaminated with the water. With the effect of ozone, 6PPD is converted to 6PPD quinone, which is toxic enough to kill some sensitive fish species such as Coho Salmon (Oncorhynchus kisutch). This study drew attention to new chemical compounds and natural products that can be used as antiozonants and antioxidants in the rubber industry instead of 6PPD. Although the scientific studies are promising, the fact that 6PPD is still used in production shows that more scientific studies and social awareness need to be developed in this area.展开更多
文摘The development of microbial-based products requires certain criteria for them to be successfully commercialized. The product must meet the following desirable criteria: effectiveness, contamination free, stability, cost-effectiveness, and a prolonged shelf life. Controlling the drying process is crucial for ensuring the stability and durability of the product. The traditional approach, which involved mechanical and natural drying, led to decreased productivity and quality. The objective of this research endeavour was to achieve a dry process enhancement while preserving the microbial quality of Trichoderma asperellum (M103). The temperature and relative humidity during the drying period were monitored under two conditions: with and without a dehumidifier. The results demonstrate that the dehumidifier increases drying period efficiency by up to 63%.
文摘实车动力电池的健康状态(state of health,SOH)评估存在数据质量差、工况不统一、数据利用率低等问题,本文面向阶梯倍率充电工况构建多源特征提取及SOH估计模型。首先,通过数据清洗、切割、填充,获取独立的充电片段;其次,基于不同电流阶段计算容量,实现原始数据利用率达96.9%,并与单独限定SOC范围计算容量的方法相比,误差降低48.1%以上;然后,从当前工况、历史累积两个维度提取多个健康因子,对于当前工况特征值,通过灰色关联度及干扰性随机森林重要度分析双重筛选。对于历史累积特征值,利用Spearson相关性分析和核主成分分析方法(kernel principal component analysis,KPCA)降低信息冗余;最后,对门控循环单元网络模型(gated recurrent unit,GRU)引入注意力机制和龙格库塔优化算法(Runge Kutta optimizer,RUN),建立RUN-GRU-attention模型,基于实车运行数据集与现有5种模型进行对比,实验结果表明,无论是包含单阶段还是多阶段电流的测试样本,优化模型的估计精度更佳,误差不高于0.0086,并且随着充电循环次数增加表现出良好的误差收敛性,可有效预测SOH波动趋势。
文摘It is well known that Diabetes Specific Nutritional Supplements (DSNSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of DSNSs in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose Response (ABGR) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGR of DSNS versus an isocaloric snack, measured by incremental Area under the Curve (iAUC). Test and control received 60 g of DSNS and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. During the 4 weeks intervention phase, the test group received DSNS with lifestyle counselling (DSNS + LC) and was compared with the control receiving lifestyle counselling alone (LC alone). Impact was studied on FBG, HbA1C, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of DSNS was also studied using CGM between two 14-day phases: CGM1 baseline (days 1 - 14) and CGM2 endline (days 28 - 42). DSNS showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by DSNS + LC versus LC alone. No other significant changes were reported between groups. It may be concluded that DSNS may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.
基金supported by the National Key R&D Program of China (No. 2017YFA0304203)the National Energy R&D Center of Petroleum Refining Technology (RIPP, SINOPEC)+3 种基金Changjiang Scholars and Innovative Research Team at the University of the Ministry of Education of China (No. IRT_17R70)National Natural Science Foundation of China (NSFC) (Nos. 61975103, 61875108 and 627010407)111 Project (No. D18001)Fund for Shanxi (No. 1331KSC)
文摘In the field of dual-pulse laser-induced breakdown spectroscopy(DP-LIBS)research,the pursuit of methods for determining pulse intervals and other parameters quickly and conveniently in order to achieve optimal spectral signal enhancement is paramount.To aid researchers in identification of optimal signal enhancement conditions and more accurate interpretation of the underlying signal enhancement mechanisms,theoretical simulations of the spatiotemporal processes of coaxial DP-LIBS-induced plasma have been established in this work.Using a model based on laser ablation and two-dimensional axisymmetric fluid dynamics,plasma evolutions during aluminum–magnesium alloy laser ablation under single-pulse and coaxial dualpulse excitations have been simulated.The influences of factors,such as delay time,laser fluence,plasma temperature,and particle number density,on the DP-LIBS spectral signals are investigated.Under pulse intervals ranging from 50 to 1500 ns,the time evolutions of spectral line intensity,dual-pulse emission enhancement relative to the single-pulse results,laser irradiance,spatial distribution of plasma temperature and species number density,as well as laser irradiance shielded by plasma have been obtained.The study indicates that the main reason behind the radiation signal enhancement in coaxial DP-LIBS-induced plasma is attributed to the increased species number density and plasma temperature caused by the second laser,and it is inferred that the shielding effect of the plasma mainly occurs in the boundary layer of the stagnation point flow over the target surface.This research provides a theoretical basis for experimental research,parameter optimization,and signal enhancement tracing in DP-LIBS.
文摘农村房地一体档案是对农村宅基地、集体建设用地使用权及房屋所有权进行确权登记的重要依据,将签章后的纸质档案转为电子档案进行存储对不动产权证书办理具有重要意义。由于目前缺乏能识别档案内容并进行分类归档的工具,设计并实现了基于Tesseract-OCR的农村房地一体归档系统。使用光学字符识别(Optical Character Recognition,OCR)对档案扫描图像进行识别,训练校正字库,提取图像中的文字信息,实现档案资料的分类存储。运用四川省某县的部分房地一体档案进行系统测验,应用结果表明,系统的识别归档准确率为96.5%,能满足房地一体档案归档需求,降低了人工识别归档的繁琐性,极大提高了归档的工作效率,提升了档案分类的准确度。
文摘Objectives: The existing inflammatory models are concentrated in relatively complex medical fields, and most of them use a single type of cell, and the induction conditions are not uniform, so the current LPS-induced inflammation model is less conducive to the study of skin inflammation. The aim of this research is to enhance the existing LPS-induced inflammation model and establish a skin inflammation model that is suitable for the swift screening of anti-inflammatory agents in the cosmetics industry. Methods: LPS was used to induce inflammatory responses in KC and THP-1 cells. Enzyme-linked immunosorbent assay (ELISA) was employed to assess the levels of IL-1α, IL-8, and TNF-α in the two cell types, while the DCFH-DA probe was utilized to label the levels of reactive oxygen species (ROS) in both cell types. Results: In KC cells, 10 μg/mL of LPS induced a significant upregulation of IL-8 but did not result in elevated expression of IL-1α. However, at 100 μg/mL of LPS, both IL-8 and IL-1α were highly expressed in KC cells. LPS concentrations ranging from 0.01 to 100 μg/mL failed to stimulate TNF-α production in KC cells but induced a gradient increase in ROS levels. In THP-1 cells, LPS concentrations from 0.01 to 100 μg/mL did not induce IL-1α production but significantly elevated IL-8 and led to a gradient increase in TNF-α and ROS. After treatment with 100 μg/mL of LPS, the cosmetic ingredient Rucika KGM mitigated the elevated levels of IL-1α, IL-8, and ROS in LPS-induced KC cells and IL-8 and ROS in THP-1 cells. Conclusion: This study has successfully developed an application-oriented model suitable for investigating skin inflammation, enabling the rapid and comprehensive screening of cosmetic ingredients with anti-inflammatory activity. .
文摘Introduction: External otitis (OE) is an acute or chronic inflammation or infection of the external ear resulting from an imbalance in the external auditory canal secondary to microtrauma, maceration, eczema, or a foreign body in the external auditory canal. Objective: To study cases of external otitis at the Mamou Regional Hospital. Materials and Methods: This was a prospective descriptive study conducted over a period of six (6) months from July 1st to December 31st, 2016. It included all patients admitted to the ENT department of the Mamou Regional Hospital. Results: During the study period, 712 patients were admitted to the department for various pathologies, of which 103 met our selection criteria, representing a frequency of 14.46%. The mean age of the patients was 33.74 years with a range of 1 to 90 years. Males predominated in the sample, accounting for 59.22%. The vast majority of patients resided in urban areas, constituting 61.17% of the sample. In our study, all patients consulted for otalgia (100%), and over half (53.39%) for hypoacusis. We formally identified rhinitis in 66.66% of cases, while diabetes was found in only 4 patients (11.11%). Otomycosis was the most commonly identified condition (53.39%), followed by furuncles (33.98%). Ear drops containing antibiotics were administered to all patients, although 66.60% received antibiotic therapy. Conclusion: External otitis is a relatively common condition, particularly among children and the elderly. Diagnosis can be made based on pain upon traction of the pinna and pressure on the tragus.
基金supported by National Key R&D Program of China(No.2017YFA0304203)National Energy R&D Center of Petroleum Refining Technology(RIPP,SINOPEC),Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China(No.IRT_17R70)+2 种基金National Natural Science Foundation of China(Nos.12374377,61975103 and 627010407)111 Project(No.D18001)Fund for Shanxi‘1331KSC’。
文摘With the rapid advancement of laser decontamination technology and growing awareness of microbial hazards,it becomes crucial to employ theoretical model to simulate and evaluate decontamination processes by laser-induced plasma.This study employs a two-dimensional axisymmetric fluid dynamics model to simulate the power density of plasma bombardment on bacteria and access its decontamination effects.The model considers the transport processes of vapor plasma and background gas molecules.Based on the destructive impact of high-speed moving particles in the plasma on bacteria,we investigate the bombardment power density under various conditions,including different laser spot sizes,wavelengths,plate's tilt angles,and plate-target spacing.The results reveal that the bombardment power density increases with a decrease in laser spot size and wavelength.For instance,when the plate is parallel to the target surface with a 1 mm spacing,the bombardment power density triples as the laser spot size decreases from 0.8 mm to 0.5 mm and quadruples as the wavelength decreases from 1064 nm to 266 nm.Notably,when the plate is parallel to the target with a relatively close spacing of 0.5 mm,the bombardment power density at 0°inclination increases sevenfold compared to 45°.This simulation study is essential for optimizing optical parameters and designing component layouts in decontamination devices using laser-induced plasma.The reduction of laser spot size,wavelength,plate-target spacing and aligning the plate parallel to the target,collectively contribute to achieving precise and effective decontamination.
文摘Antiozonants and antioxidants are additives commonly used in the rubber industry to enhance the durability and performance of rubber products. Ozone, present in the atmosphere, can cause rubber to degrade over time through a process known as ozone cracking. These rubber additives are added to rubber compounds to protect against this degradation. They work by reacting with ozone, preventing it from attacking and breaking the molecular chains in the rubber, helping to maintain the structural integrity of the rubber product. It is now well known that 6PPD contributes to the extension of the service life of rubber products. However, recent studies have shown that 6PPD can be harmful to the environment, especially when end-of-life tyres (ELTs) are contaminated with the water. With the effect of ozone, 6PPD is converted to 6PPD quinone, which is toxic enough to kill some sensitive fish species such as Coho Salmon (Oncorhynchus kisutch). This study drew attention to new chemical compounds and natural products that can be used as antiozonants and antioxidants in the rubber industry instead of 6PPD. Although the scientific studies are promising, the fact that 6PPD is still used in production shows that more scientific studies and social awareness need to be developed in this area.
