BACKGROUND Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in literature.Breast metastases are associated with poor prognosis.The following case highlights the dia...BACKGROUND Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in literature.Breast metastases are associated with poor prognosis.The following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized treatment.CASE SUMMARY A 44-year-old G7P5025 with no significant past medical or surgical history presented with heavy vaginal to an outside emergency department where an exam and a pelvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving upper two thirds of vagina,parametria and lymph node metastases.Cervical biopsies confirmed high grade adenocarcinoma with mucinous features.A positron emission tomography/computed tomography(PET/CT)did not show evidence of metastatic disease.She received concurrent cisplatin with external beam radiation therapy.Follow up PET/CT scan three months later showed no suspicious fluorodeoxyglucose uptake in the cervix and no evidence of metastatic disease.Patient was lost to follow up for six months.She was re-imaged on re-presentation and found to have widely metastatic disease including breast disease.Breast biopsy confirmed programmed death-ligand 1 positive metastatic cervical cancer.The patient received six cycles of carboplatin and paclitaxel with pembrolizumab.Restaging imaging demonstrated response.Patient continued on pembrolizumab with disease control.CONCLUSION Metastatic cervical cancer to the breast is uncommon with nonspecific clinical findings that can make diagnosis challenging.Clinical history and immunohistochemical evaluation of breast lesion,and comparison to primary tumor can support diagnosis of metastatic cervical cancer to the breast.Overall,the prognosis is poor,but immunotherapy can be considered in select patients and may result in good disease response.展开更多
The first photometric light curve investigation of the NSVS 8294044,V1023 Her,and V1397 Her binary systems is presented.We used ground-based observations for the NSVS 8294044 system and Transiting Exoplanet Survey Sat...The first photometric light curve investigation of the NSVS 8294044,V1023 Her,and V1397 Her binary systems is presented.We used ground-based observations for the NSVS 8294044 system and Transiting Exoplanet Survey Satellite data for V1023 Her and V1397 Her.The primary and secondary times of minima were extracted from al the data,and,by collecting the literature,a new ephemeris was computed for each system.Linear fits for the O-C diagrams were conducted using the Markov Chain Monte Carlo (MCMC) method.Light curve solutions were performed using the PHysics Of Eclipsing BinariEs Python code and the MCMC approach.The systems were found to be contact binary stars based on the fillout factor and mass ratio.V1023 Her showed the O’Connell effect and a cold starspot on the secondary component was required for the light curve solution.The absolute parameters of the system were estimated based on an empirical relationship between orbital period and mass.We presented a new T–M equation based on a sample of 428 contact binary systems and found that our three target systems were in good agreement with the fit.The positions of the systems were also depicted on the M–L,M–R,q–L_(ratio),and M_(tot)–J_(0)diagrams in the logarithmic scales.展开更多
文摘BACKGROUND Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in literature.Breast metastases are associated with poor prognosis.The following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized treatment.CASE SUMMARY A 44-year-old G7P5025 with no significant past medical or surgical history presented with heavy vaginal to an outside emergency department where an exam and a pelvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving upper two thirds of vagina,parametria and lymph node metastases.Cervical biopsies confirmed high grade adenocarcinoma with mucinous features.A positron emission tomography/computed tomography(PET/CT)did not show evidence of metastatic disease.She received concurrent cisplatin with external beam radiation therapy.Follow up PET/CT scan three months later showed no suspicious fluorodeoxyglucose uptake in the cervix and no evidence of metastatic disease.Patient was lost to follow up for six months.She was re-imaged on re-presentation and found to have widely metastatic disease including breast disease.Breast biopsy confirmed programmed death-ligand 1 positive metastatic cervical cancer.The patient received six cycles of carboplatin and paclitaxel with pembrolizumab.Restaging imaging demonstrated response.Patient continued on pembrolizumab with disease control.CONCLUSION Metastatic cervical cancer to the breast is uncommon with nonspecific clinical findings that can make diagnosis challenging.Clinical history and immunohistochemical evaluation of breast lesion,and comparison to primary tumor can support diagnosis of metastatic cervical cancer to the breast.Overall,the prognosis is poor,but immunotherapy can be considered in select patients and may result in good disease response.
文摘The first photometric light curve investigation of the NSVS 8294044,V1023 Her,and V1397 Her binary systems is presented.We used ground-based observations for the NSVS 8294044 system and Transiting Exoplanet Survey Satellite data for V1023 Her and V1397 Her.The primary and secondary times of minima were extracted from al the data,and,by collecting the literature,a new ephemeris was computed for each system.Linear fits for the O-C diagrams were conducted using the Markov Chain Monte Carlo (MCMC) method.Light curve solutions were performed using the PHysics Of Eclipsing BinariEs Python code and the MCMC approach.The systems were found to be contact binary stars based on the fillout factor and mass ratio.V1023 Her showed the O’Connell effect and a cold starspot on the secondary component was required for the light curve solution.The absolute parameters of the system were estimated based on an empirical relationship between orbital period and mass.We presented a new T–M equation based on a sample of 428 contact binary systems and found that our three target systems were in good agreement with the fit.The positions of the systems were also depicted on the M–L,M–R,q–L_(ratio),and M_(tot)–J_(0)diagrams in the logarithmic scales.
