Acupuncture combined with medication for blood-stasis in unstable angina patients with different thrombolysis in myocardial infarction risk stratification

Objective To observe the intervention effects of acupuncture combined with standardized treatment of western medicine on blood-stasis syndrome in unstable angina(UA)patients with different thrombolysis in myocardial infarction(TIMI)risk stratification.Methods According to TIMI risk score,a total of 72 UA patients were included,24 cases in low-risk(0 to 2 points)group,24

Effect of Qingjie Huagong decoction on the pyroptosis of pancreatic acinar cell and intestinal barrier in mice with acute pancreatitis

Objective To explore the mechanism of regulating circRNA homeodomain-interacting protein kinase 3(circHipk3) by Qingjie Huagong Decoction (QJHGD) to alleviate acute pancreatitis (AP) alveolar cell scorching and protect the intestinal barrier in acute pancreatitis.

Correlation between serum KIM-1,NGAL and diabetic kidney disease remission after gastric bypass surgery in obese patiens

Objective To investigate the correlation between serum renal injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in the remission of diabetic kidney disease (DKD) after gastric bypass surgery in obese DKD patients.Methods Seventy-nine obese patients with DKD who received gastric bypass surgery in our hospital from January 2021 to January 2022 were selected and divided into DKD remission group (n=47) and DKD non-remission group (n=32)according to whether UACR decreased to normal level after surgery.Preoperative and postoperative general data were collected and biochemical indices.

Effect of risk stratification of chronic kidney disease on left ventricular hypertrophy in patients with type 2 diabetes mellitus

Objective To investigate the predictive value of chronic kidney disease (CKD) risk stratification for left ventricular hypertrophy (LVH) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 506 patients with T2DM hospitalized in the Department of Endocrinology of Gansu Provincial People's Hospital from October 2021 to October 2022 were enrolled in this study.

Acupoint application for Hashimoto's thyroiditis with liver-qi stagnation:a randomized controlled trial

Objective To observe the clinical efficacy and safety of acupoint application for Hashimoto's thyroiditis (HT)with liver-qi stagnation.Methods One hundred and fifty patients of HT with liver-qi stagnation were randomly divided into an acupoint application group(75 cases,11 cases were excluded,5 cases dropped out) and a control group (75 cases,12 cases excluded,3 cases dropped out).

Application value of portal vein flow velocity after different interventions on rebleeding in patients with hepatitis B cirrhosis complicated with esophageal and gastric variceal bleeding

Objective To investigate the predictors of rebleeding three months after treatment of esophageal and gastric variceal bleeding(EGVB)in patients with hepatitis B cirrhosis and the effects of different treatments on rebleeding.Methods From January 2018 to January 2020,the hepatitis B cirrhosis patients with first onset of EGVB in the First Hospital of Lanzhou University were enrolled and followed up for three months.

Effect of sunitinib and Baofei Dingchuan decoction on pulmonary vascular remodeling in chronic obstructive pulmonary disease complicating diabetes mice model

Objective To observe the effect of Sunitinib and Baofei Dingchuan Decoction(BDD)on pulmonary vascular remodeling in chronic obstructive pulmonary disease(COPD)complicating diabetes mice model,and to study if its mechanism is relevant to the expression of hypoxia-inducible factor-1α(HIF-1α)and vascular endothelial grow factor(VEGF)in lung tissue.Methods Totally 40 ob/ob mice were randomly divided into 4 groups,i.e.,control group,model group,BDD group,and sunitinib group,10 in each group.All the mice except the control group were exposed to cigarette smoke in a homemade box for 14 weeks.On day 1 and 14,lipopolysaccharide(LPS)was dripped into the airway of the mice.After the model was established,mice in the sunitinib group were administered with Sunitinib malate at a dosage of 30 mg/(kg·d)by gastrogavage and mice in the BDD group were administered with BDD at a dosage of 9.3 g/(kg·d)by gastrogavage,for consecutive 2 weeks.The levels of fasting blood glucose(FBG)was measured at week 0,14 and 16.The airway remodeling was observed by HE staining and quantified by total bronchial wall area/basement membrane perimeter(WAt/Pbm),the pulmonary vascular remodeling was quantified by vessel wall thickness/total vascular diameter(WT%)and vessel wall area/total vascular area(WA%).The collagen deposition in peribronchus was observed by Masson staining and quantified by collagen wall area/basement membrane perimeter(WAc/Pbm),the pulmonary vascular smooth muscle layer remodeling was observed by CD31/α-SMA/DAPI immunofluorescence staining.The protein level of HIF-1α and VEGF in lung tissue homogenate were detected by enzyme-linked immunosorbent assay.Relative expressions of HIF-1α and VEGF mRNA in lung tissue were determined by real-time fluorescence quantitative PCR.Results Compared with the control group,the model group showed no significant difference in the level of FBG at week 16(P>0.05),WAt/Pbm,WAc/Pbm,WT% and WA% level increased(P<0.01),thicker pulmonary vascular smooth muscle layer,and increased HIF-1α and VEGF protein level and mRNA level in lung tissue(P<0.01).Compared with the model group,the level of FBG decreased,in the Sunitinib group at week 16(P<0.01)when the BDD group showed no significant difference(P>0.05),both the Sunitinib group and the BDD group showed decreased WAt/Pbm,WAc/Pbm,WT% and WA% level(P<0.01,P<0.05),thinner pulmonary vascular smooth muscle layer,protein and mRNA expressions of HIF-1α and VEGF were decreased in lung tissue(P<0.01,P<0.05).Conclusion Sunitinib and BDD could alleviate the pulmonary vascular remodeling in COPD complicating diabetes mice model by down-regulation of the HIF-1α and VEGF expression in lung tissue.

Miao medicinal crossbow acupuncture therapy as adjuvant treatment for lung cancer pain:a randomized controlled trial

Objective To observe the clinical efficacy of Miao medicinal crossbow acupuncture therapy as adjuvant treatment for lung cancer pain based on oxycodone hydrochloride extended-release tablet.Methods A total of 60 patients with lung cancer pain were randomized into an observation group(30 cases,1 case dropped off)and a control group(30 cases).

Effects of staged acupuncture on endometrial receptivity and anxiety in patients with recurrent implantation failure of thin endometrium based on "thoroughfare vessel is the sea of blood" theory

Objective To compare the clinical efficacy between staged acupuncture based on“thoroughfare vessel is the sea of blood”theory combined with routine hormone replacement cycle treatment and routine hormone replacement cycle treatment for patients with recurrent implantation failure(RIF).

A meta-analysis of randomized controlled trials comparing left with right radial approach for coronary angiography

Objective To compare the efficacy between left radial approach(LRA)and right radial approach(RRA)for coronary angiography(CAG).Methods The following databases were searched,including PubMed,Embase,Web of science,Cochrane Library,CBM,VIP,WAnfang databases and CNKI,from creation of database to January 2013.Two reviewers extracted data independent-

Comparison on efficacy and safety of different bridging anticoagulation therapies in patients undergoing mechanical heart valve replacement surgery

Objective To evaluate the efficacy and safety of different bridging anticoagulant therapies in patients undergoing mechanical heart valve replacement (MHVR) surgery.Methods Consecutive patients undergoing MHVR surgery from January 2018 to December 2018 in First Hospital of Lanzhou University were prospectively enrolled in this study.

Association of serum GSK-3β,BDNF,blood glucose fluctuation with mild cognitive impairment in elderly type 2 diabetic patients

Objective To investigate the association between serum glycogen synthase kinase 3β(GSK-3β),brainderived neurotrophic factor(BDNF),blood glucose fluctuation and mild cognitive impairment(MCI)in elderly patients with type 2 diabetes mellitus(T2DM).Methods 121 elderly T2DM patients who were hospitalized in the endocrinology department of Xuzhou Medical University Affiliated Hospital from May 2021 to January 2022 were selected and divided into cognitive normal group(T2DM,n=68)and MCI group(n=53)based on the scores of Montreal Cognitive Assessment Scale(MoCA)and Minimal Mental State Assessment Scale(MMSE).

Effect of Kuanxiong aerosol for coronary microcirculation in patients with acute myocardial infarction after percutaneous coronary intervention

Objective To observe the effect of Kuanxiong Aerosol for coronary microcirculation in acute myocardial infarction(AMI)patients who received percutaneous coronary intervention(PCI)therapy.Methods Totally 63 AMI patients who received PCI were randomly assigned to experimental group(32 cases)and control group(31 cases).

Preventive effect of different compatibilities of Ramulus Cinnamomai and Radix Paeomiae alba in Guizhi decoction on cardiac sympathetic denervation induced by 6-OHDA

Objective To observe the preventive effect of different compatibilities of Ramulus Cinnamomi(RC)and Radix Paeomiae alba(RPA)in Guizhi Decoction(GZD)on neurotransmitters and their rate-limiting enzymes,and neurotrophic factors of cardiac sympathetic denervation model rats induced by 6-hydroxydopamine(6-OHDA).Methods Totally 54 male Wistar rats were randomly divided into 6 groups,i.e.,the blank control group。

Effect of the change of ghrelin and its receptor on accelerating diabetic encephalopathy by blood glucose fluctuation in GK rats

Objective To explore the the effect of the changes of ghrelin and its receptor(GHSR1a)on accelerating diabetic encephalopathy by blood glucose fluctuation in GK rats.Methods Eight male wistar rats were set as normal control group(NC).16 male GK rats were randomly divided into sustained hyperglycemia group(MS)and blood glucose fluctuation group(MF).MF group