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Constructing the Training Curriculum of Standardized Patients for OSCE Examination for Undergraduate Nursing Students in Shanxi Medical University 被引量:1
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作者 Jie Zheng Yuejuan Jing +2 位作者 Shujuan Wang Rui-Hua Jin Yuzhen Gao 《Open Journal of Nursing》 2014年第3期132-138,共7页
Objective: The objective of this study is to construct the simulated patient training curriculum for OSCE examination for undergraduate nursing students and to explore the theoretical and practical foundation. Methods... Objective: The objective of this study is to construct the simulated patient training curriculum for OSCE examination for undergraduate nursing students and to explore the theoretical and practical foundation. Methods: To establish TSP training curriculum and SSP training curriculum, 30 experts were invited to finish the questionnaires which were proved by Delphi Method. Findings: We established the training curriculum of TSP and SSP, and set the weight of various curricula and teaching contents. Conclusions: The experts considered that the degree and importance of these two training curricula were comparable. This conclusion lays the foundation for applying these curricula to teaching practice and clinical practice, and enhancing the teaching outcome of undergraduate nursing students. Implications: This study provided a new way of assessing the clinic ability of nursing students. 展开更多
关键词 Students NURSING Objective Structured Clinical EXAMINATION Patient Simulation
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Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer:A metaanalysis
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作者 Mao-Xiu Yuan Qi-Gui Cai +3 位作者 Zhen-Yang Zhang Jian-Zhong Zhou Cai-Yun Lan Jiang-Bo Lin 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第1期214-233,共20页
BACKGROUND The effectiveness of neoadjuvant therapy in esophageal cancer(EC)treatment is still a subject of debate.AIM To compare the clinical efficacy and toxic side effects between neoadjuvant chemoradiotherapy(nCRT... BACKGROUND The effectiveness of neoadjuvant therapy in esophageal cancer(EC)treatment is still a subject of debate.AIM To compare the clinical efficacy and toxic side effects between neoadjuvant chemoradiotherapy(nCRT)and neoadjuvant chemotherapy(nCT)for locally advanced EC(LAEC).METHODS A comprehensive search was conducted using multiple databases,including PubMed,EMBASE,MEDLINE,Science Direct,The Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biomedical Literature Database Article.Studies up to December 2022 comparing nCRT and nCT in patients with EC were selected.RESULTS The analysis revealed significant differences between nCRT and nCT in terms of disease-free survival.The results indicated that nCRT provided better outcomes in terms of the 3-year overall survival rate(OSR)[odds ratio(OR)=0.95],complete response rate(OR=3.15),and R0 clearance rate(CR)(OR=2.25).However,nCT demonstrated a better 5-year OSR(OR=1.02)than nCRT.Moreover,when compared to nCRT,nCT showed reduced risks of cardiac complications(OR=1.15)and pulmonary complications(OR=1.30).CONCLUSION Overall,both nCRT and nCT were effective in terms of survival outcomes for LAEC.However,nCT exhibited better performance in terms of postoperative complications. 展开更多
关键词 Esophageal cancer Neoadjuvant chemoradiotherapy Radical resection for esophageal cancer Neoadjuvant chemotherapy META-ANALYSIS
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Elimination of methicillin‑resistant Staphylococcus aureus biofilms on titanium implants via photothermally‑triggered nitric oxide and immunotherapy for enhanced osseointegration
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作者 Yong‑Lin Yu Jun‑Jie Wu +5 位作者 Chuan‑Chuan Lin Xian Qin Franklin R.Tay Li Miao Bai‑Long Tao Yang Jiao 《Military Medical Research》 SCIE CAS CSCD 2024年第2期157-179,共23页
Background:Treatment of methicillin-resistant Staphylococcus aureus(MRSA)biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium(Ti)implants.There is a need to expl... Background:Treatment of methicillin-resistant Staphylococcus aureus(MRSA)biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium(Ti)implants.There is a need to explore more effective approaches for the treatment of MRSA biofilm infections.Methods:Herein,an interfacial functionalization strategy is proposed by the integration of mesoporous polydopamine nanoparticles(PDA),nitric oxide(NO)release donor sodium nitroprusside(SNP)and osteogenic growth peptide(OGP)onto Ti implants,denoted as Ti-PDA@SNP-OGP.The physical and chemical properties of Ti-PDA@SNP-OGP were assessed by scanning electron microscopy,X-ray photoelectron spectroscope,water contact angle,photothermal property and NO release behavior.The synergistic antibacterial effect and elimination of the MRSA biofilms were evaluated by 2′,7′-dichlorofluorescein diacetate probe,1-N-phenylnaphthylamine assay,adenosine triphosphate intensity,O-nitrophenyl-β-D-galactopyranoside hydrolysis activity,bicinchoninic acid leakage.Fluorescence staining,assays for alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization,quantitative real‑time reverse transcription‑polymerase chain reaction,and enzyme-linked immunosorbent assay(ELISA)were used to evaluate the inflammatory response and osteogenic ability in bone marrow stromal cells(MSCs),RAW264.7 cells and their co-culture system.Giemsa staining,ELISA,micro-CT,hematoxylin and eosin,Masson's trichrome and immunohistochemistry staining were used to evaluate the eradication of MRSA biofilms,inhibition of inflammatory response,and promotion of osseointegration of Ti-PDA@SNP-OGP in vivo.Results:Ti-PDA@SNP-OGP displayed a synergistic photothermal and NO-dependent antibacterial effect against MRSA following near-infrared light(NIR)irradiation,and effectively eliminated the formed MRSA biofilms by inducing reactive oxygen species(ROS)-mediated oxidative stress,destroying bacterial membrane integrity and causing leakage of intracellular components(P<0.01).In vitro experiments revealed that Ti-PDA@SNP-OGP not only facilitated osteogenic differentiation of MSCs,but also promoted the polarization of pro-inflammatory M1 macrophages to the anti-inflammatory M2-phenotype(P<0.05 or P<0.01).The favorable osteo-immune microenvironment further facilitated osteogenesis of MSCs and the anti-inflammation of RAW264.7 cells via multiple paracrine signaling pathways(P<0.01).In vivo evaluation confirmed the aforementioned results and revealed that Ti-PDA@SNP-OGP induced ameliorative osseointegration in an MRSA-infected femoral defect implantation model(P<0.01).Conclusions:Ti-PDA@SNP-OGP is a promising multi-functional material for the high-efficient treatment of MRSA infections in implant replacement surgeries. 展开更多
关键词 Polydopamine nanoparticles Methicillin-resistant Staphylococcus aureus Nitric oxide OSSEOINTEGRATION Osteo-immunomodulation Photothermal effect Titanium implants
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ATF4 regulates lipid metabolism and thermogenesis 被引量:16
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作者 Chunxia Wang Zhiying Huang Ying Du Ying Cheng Shanghai Chen Feifan Guo 《Cell Research》 SCIE CAS CSCD 2010年第2期174-184,共11页
Activating transcription factor 4 (ATF4) has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed tha... Activating transcription factor 4 (ATF4) has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed that Atf4- deficient mice are lean, suggesting a possible role for ATF4 in regulating lipid metabolism. The goal of our current study is to investigate the involvement of ATF4 in lipid metabolism and elucidate the underlying mechanisms. Studies using Atf4-deficient mice revealed increased energy expenditure, as measured by oxygen consumption. These mice also showed increases in lipolysis, expression of uncoupling protein 2 (UCP2) and p-oxidation genes and decreases in expression of lipogenic genes in white adipose tissue (WAT), suggesting increased utilization and decreased synthesis of fatty acids, respectively. Expression of UCP1, 2 and 3 was also increased in brown adipose tissue (BAT), suggesting increased thermogenesis. The effect of ATF4 deletion on expression of UCPs in BAT suggests that increased thermogenesis may underlie increased energy expenditure. Thus, our study identifies a possible new function for ATF4 in regulating lipid metabolism and thermogenesis. 展开更多
关键词 ATF4 lipid metabolism THERMOGENESIS WAT BAT
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Single and joint stress of acetochlor and Pb on three agricultural crops in northeast China 被引量:14
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作者 CHAO Lei ZHOU Qi-xing +2 位作者 CHEN SU CUI Shuang WANG Mei-e 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2007年第6期719-724,共6页
In order to evaluate ecological risk of agrochemicals in agricultural environment, single and joint toxic effects of an important herbicide and a typical heavy metal on root elongation of crops were investigated. Seed... In order to evaluate ecological risk of agrochemicals in agricultural environment, single and joint toxic effects of an important herbicide and a typical heavy metal on root elongation of crops were investigated. Seeds of the three crops including wheat (Triticum aestivum), Chinese cabbage (Brassica pekimensis) and soybean (Glycine max) as the main crops in northeast China were exposed to acetochior as a herbicide and lead (Pb) as a heavy metal using the pot-culture method, and meadow brown soil as one of the main soils distributed in northeast China was applied in the investigation. The results indicated that the interactive effects of the two pollutants on root elongation of the three crops were very complicated although they had markedly significant (P〈0.01) linear interrelationships based on the regression analyses. When the concentration of added Pb^2+ reached 200 mg/kg, acetochlor and Pb had an antagonistic effect on the inhibition of root elongation of the three crops. However, acetochlor and Pb had significantly (P〈0.05) synergic effects on the inhibition of root elongation when concentration of added Pb^2+ was up to 1000 mg/kg. At the low concentration of added Pb, joint toxicity of acetochlor and Pb was more dependent on the concentration of Pb. Among the three crops, wheat was the most sensitive to the toxicity of Pb and Chinese cabbage was the most sensitive to the toxicity of acetochlor. 展开更多
关键词 ACETOCHLOR PB ECOTOXICOLOGY joint effect Chinese cabbage (Brassica pekimensis) soybean (Glycine max) wheat (Triticum aestivum)
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Formation and evolution of the modern warm current system in the East China Sea and the Yellow Sea since the last deglaciation 被引量:14
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作者 李铁刚 南青云 +3 位作者 江波 孙荣涛 张德玉 李青 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2009年第2期237-249,共13页
To reconstruct the formation and evolution process of the warm current system within the East China Sea (ECS) and the Yellow Sea (YS) since the last deglaciation, the paleoceangraphic records in core DGKS9603, cor... To reconstruct the formation and evolution process of the warm current system within the East China Sea (ECS) and the Yellow Sea (YS) since the last deglaciation, the paleoceangraphic records in core DGKS9603, core CSH1 and core YSDP102, which were retrieved from the mainstream of the Kuroshio Current (KC), the edge of the modern Tsushima Warm Current (TWC) and muddy region under cold waters accreted with the Yellow Sea Warm Current (YSWC) respectively, were synthetically analyzed. The results indicate that the formation and evolution of the modern warm current system in the ECS and the YS has been accompanied by the development of the KC and impulse rising of the sea level since the last deglaciation. The influence of the KC on the Okinawa Trough had enhanced since 16 cal kyr BP, and synchronously the modern TWC began to develop with the rising of sea level and finally formed at about 8.5 cal kyr BP. The KC had experienced two weakening process during the Heinrich event 1 and the Younger Drays event from 16 to 8.5 cal kyr BP. The period of 7-6 cal kyr BP was the strongest stage of the KC and the TWC since the last deglaciation. The YSWC has appeared at about 6.4 cal kyr BE Thus the warm current system of the ECS and the YS has ultimately formed. The weakness of the KC, indicated by the occurrence of Pulleniatina minimum event (PME) during the period from 5.3 to 2.8 cal kyr BE caused the main stream of the TWC to shift eastward to the Pacific Ocean around about 3 cal kyr BE The process resulted in the intruding of continent shelf cold water mass with rich nutrients. Synchronously, the strength of the YSWC was relatively weak and the related cold water body was active at the early-mid stage of its appearance against the PME background, which resulted in the quick formation of muddy deposit system in the southeastern YS. The strength of the warm current system in the ECS and the YS has enhanced evidently, and approached to the modern condition gradually since 3 cal kyr BE 展开更多
关键词 last deglaciation the Holocene East China Sea and Yellow Sea warm current system
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Effects of Terracing and Agroforestry on Soil and Water Loss in Hilly Areas of the Sichuan Basin, China 被引量:16
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作者 J.H. ZHANG Z.A. SU G.C. LIU 《Journal of Mountain Science》 SCIE CSCD 2008年第3期241-248,共8页
Soil erosion in hilly areas of the Sichuan Basin is a serious concern over sustainable crop production and sound ecosystem. A 3-year experiment was conducted using the method of runoff plots to examine the effects of ... Soil erosion in hilly areas of the Sichuan Basin is a serious concern over sustainable crop production and sound ecosystem. A 3-year experiment was conducted using the method of runoff plots to examine the effects of terracing and agroforestry in farmland systems on soil and water conservation of slope fields in the hilly areas in Jianyang County, Sichuan Province, Southwestern China. A power function (Y = aXb) can statistically describe the relationship between water runoff (Y) and rainfall (X). The regression equation for the treatment of sloping terraces with crops (Plot 2) is remarkably different from that for the treatment of sloping terraces with grasses and trees (Plot 1) and the conventional up- and down-slope crop system (Plot 3) regarding equation coefficients, while regression equations are similar between Plot 1 and Plot 3. Water runoff amount and runoff coefficient of slope fields increased by 21.5~41.0 % and 27.5~69.7 % respectively, compared to those of sloping terraces, suggesting that terracing notably reduced the water runoff in the field. In the case of sloping terraces, lower amount of water runoff was observed on sloping terraces with crops than on sloping terraces with grasses and trees. Sediment yields on the slope fields in the normal year of rainfall distribution were notably higher (34.41~331.67 % and 37.06~403.44 % for Plot 1 and Plot 2, respectively) than those on sloping terraces, implying that terracing also plays a significant role in the reduction in soil erosion. It is suggested that terracing with crops is significantly effective for soil and water conservation in cultivatedfarmland, while the conventional practice of up- and down- slope cultivation creates high rates of water runoff and soil sediment transport. Terracing with grasses and fruit trees shows a less reduction in water runoff than terracing with crops, which was observed in the 3-year experiments. 展开更多
关键词 AGROFORESTRY sediment transport RUNOFF sloping terrace soil and water conservation
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Dynamics of soil inorganic nitrogen and their responses to nitrogen additions in three subtropical forests, south China 被引量:12
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作者 FANG Yun-ting ZHU Wei-xing +2 位作者 MO Jiang-ming ZHOU Guo-yi GUNDERSEN Per 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2006年第4期752-759,共8页
Three forests with different historical land-use, forest age, and species assemblages in subtropical China were selected to evaluate current soil N status and investigate the responses of soil inorganic N dynamics to ... Three forests with different historical land-use, forest age, and species assemblages in subtropical China were selected to evaluate current soil N status and investigate the responses of soil inorganic N dynamics to monthly ammonium nitrate additions. Results showed that the mature monsoon evergreen broadleaved forest that has been protected for more than 400 years exhibited an advanced soil N status than the pine (Pinus massoniana) and pine-broadleaf mixed forests, both originated from the 1930's clear-cut and pine plantation. Mature forests had greater extractable inorganic N pool, lower N retention capacity, higher inorganic N leaching, and higher soil C/N ratios. Mineral soil extractable NH4^+-N and NO3-N concentrations were significantly increased by experimental N additions on several sampling dates, but repeated ANOVA showed that the effect was not significant over the whole year except NH4^+-N in the mature forest. In contrast, inorganic N (both NH4^+-N and NO3^--N) in soil 20-cm below the surface was significantly elevated by the N additions. From 42% to 74% of N added was retained by the upper 20 cm soils in the pine and mixed forests, while 0%-70% was retained in the mature forest. Our results suggest that land-use history, forest age and species composition were likely to be some of the important factors that determine differing forest N retention responses to elevated N deposition in the study region. 展开更多
关键词 N deposition N saturation extractable inorganic N soil solution inorganic N subtropical China
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Lead Isotopic Composition and Lead Source in the Bainiuchang Ag-polymetallic Deposit, Yunnan Province, China 被引量:8
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作者 ZHU Chaohui ZHANG Qian +2 位作者 SHAO Shuxun ZHU Xiaoqing WANG Dapeng 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2008年第4期845-857,共13页
The Bainiuchang deposit in Yunnan Province, China, is located geographically between the Gejiu ore field and the Dulong ore field. In addition to the 〉7000 t Ag reserves, the deposit also boasts of large-scale Pb, Zn... The Bainiuchang deposit in Yunnan Province, China, is located geographically between the Gejiu ore field and the Dulong ore field. In addition to the 〉7000 t Ag reserves, the deposit also boasts of large-scale Pb, Zn and Sn reserves with a lot of dispersed elements (In, Cd, Ge, Ga, etc.). We have determined systematically the Pb isotope composition of the deposit. The Pb isotope ratios of the ores that are of sea-floor exhalative sedimentary origin in the northwest of the mining district, are 206pb/204pb = 17.758-18.537, 207pb/204pb = 15.175-15.862 and 206pb/204pb = 37.289-39.424, while those of ores that are of magmatic hydrothermal superimposition origin in the southeast of the mining district, are 206pb/204pb = 17.264-18.359, 207pb/204pb = 14.843-15.683 and 208pb/204pb = 36.481-38.838, respectively. In terms of the Pb isotope composition of feldspar in magmatic rocks or magmatic whole- rock samples from the mining district, we have determined the Pb isotope composition and acquired the Pb isotope ratios as: 206pb/204pb -- 18.224-18.700, 207pb/204pb -- 15.595-15.797 and 208pb/204pb -- 38.193-39.608. Then, in the light of the Pb isotope composition of metamorphic rock samples from the Proterozoic basement exposed in the Dulong ore field, we have determined the Pb isotope composition and obtained the isotope ratios as: 206pb/204pb -- 18.434-19.119, 207pb/204pb -- 15.644-15.693, and 208pb/204pb = 38.514-38.832. And the Pb isotope ratios of Cambrian sedimentary rocks, which are exposed in the Bainiuchang mining district, are 206pb/204pb = 18.307-19.206, 207pb/204pb = 15.622-15.809, and 208pb/204pb = 38.436-39.932. By comparing the two types of ores with respect to their Pb isotope compositions, it is indicated that lead in the Bainiuchang deposit was derived largely from the lower-crust granulite which is earlier than Neoproterozoic in age, but the Yanshanian magmatic hydrothermal fluids probably provided a part of ore-forming elements such as Sn for the ore blocks in the south of the mining district. 展开更多
关键词 Bainiuchang Ag-polymetallic deposit lead isotope lead source southeast Yunnan Province
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Rogue Wave, Breathers and Bright-Dark-Rogue Solutions for the Coupled Schrodinger Equations 被引量:8
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作者 GUO Bo-Ling LING Li-Ming 《Chinese Physics Letters》 SCIE CAS CSCD 2011年第11期4-7,共4页
We construct explicit rogue wave solutions,breather solitons,and rogue-bright-dark solutions for the coupled non-linear Schrodinger equations by the Darboux transformation.
关键词 SCHRODINGER transformation SOLITONS
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The three-dimensional structure and seasonal variation of the North Pacific meridional overturning circulation 被引量:7
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作者 LIU Hongwei ZHANG Qilong +1 位作者 DUAN Yongliang HOU Yijun 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2011年第3期33-42,共10页
The three-dimensional structure and the seasonal variation of the North Pacific meridional overturning circulation (NPMOC) are analyzed based on the Simple Ocean Data Assimilation data and Argo profiling float data.... The three-dimensional structure and the seasonal variation of the North Pacific meridional overturning circulation (NPMOC) are analyzed based on the Simple Ocean Data Assimilation data and Argo profiling float data. The NPMOC displays a multi-cell structure with four cells in the North Pacific altogether. The TC and the STC are a strong clockwise meridional cell in the low latitude ocean and a weaker clockwise meridional cell between 7°N and 18°N, respectively, while the DTC and the subpolar cell are a weaker anticlockwise meridional cell between 3°N and 15°N and a weakest anticlockwise meridional cell between 35°N and 50°N, respectively. The DTC, the TC and the STC are all of very strong seasonal variations. As to the DTC, the southward transport is strongest in fall and weakest in spring. For the TC, the northward transport is strongest in winter and weakest in spring, while the southward transport is strongest in fall and weakest in spring, which is associated with the strong southward fiow of the DTC in fall. As the STC, the northward transport is strongest in winter and weakest in summer, while the southward transport is strongest in summer and weakest in spring. This seasonal difference may be associated with the DTC. The zonal wind stress and the east-west slope of sea level play important roles in the seasonal variations of the TC, the STC and the DTC. 展开更多
关键词 North Pacific meridional overturning circulation three-dimensional structure seasonal variation
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Variation and selection analysis of Pinus koraiensis clones in northeast China 被引量:14
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作者 Deyang Liang Changjun Ding +4 位作者 Guanghao Zhao Weiwei Leng Min Zhang Xiyang Zhao Guanzheng Qu 《Journal of Forestry Research》 SCIE CAS CSCD 2018年第3期609-620,共12页
Understanding genetic variation is important for efficiently selecting excellent clones and utilizing genetic resources during tree breeding. We investigated 16 growth traits of 50 32-year-old Pinus koraiensis clones.... Understanding genetic variation is important for efficiently selecting excellent clones and utilizing genetic resources during tree breeding. We investigated 16 growth traits of 50 32-year-old Pinus koraiensis clones. Analyses of variance showed that all the test traits differed significantly among clones. Average height, diameter at breast height(DBH), and volume of all clones were 10.41 m, 21.30 cm,and 0.148 m3, respectively. Phenotypic coefficients of variation and repeatabilities of traits ranged from 4.37 to48.03% and from 0.013 to 0.900, respectively. There exists significant positive correlations among heights, diameter at different heights(1.3, 3.0, 5.0 m), and volumes; genetic correlation was close to phenotype correlation. Using four growth traits(height, DBH, volume, average crown width)as indices for a comprehensive evaluation, five clones(PK11, PK 19, PK 04, PK 14, and PK 28), whose traits scored in the top 10%, were selected as elite clones. For these clones,genetic gains in height, DBH, volume and crown height were 8.58, 13.02, 32.72 and 3.83%, respectively. These results provide important information for improving P.koraiensis breeding programs. 展开更多
关键词 Genetic variation REPLICATION SELECTION Pinus koraiensis
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Highly active catalyst for vinyl acetate synthesis by modified activated carbon 被引量:5
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作者 Chun Yan Hou Liang Rong Feng Fa Li Qiu 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第7期865-868,共4页
A new zinc acetate catalyst which was prepared from modified activated carbon exhibited extreme activity towards the synthesis of vinyl acetate. The activated carbon was modified by nitric acid, vitriol and peroxyacet... A new zinc acetate catalyst which was prepared from modified activated carbon exhibited extreme activity towards the synthesis of vinyl acetate. The activated carbon was modified by nitric acid, vitriol and peroxyacetic acid (PAA). The effect on specific area, structure, pH and surface acidity groups of carders by modification was discussed. Amount of carbonyl and carboxyl groups in activated carbon was increased by peroxyacetic acid treatment. The productivity of the new catalyst was 14.58% higher than that of catalyst prepared using untreated activated carbon. The relationship between amount of carbonyl and carboxyl groups (m) and catalyst productivity (P) was P = 1.83 + 2.26 × 10^-3*e^3.17m. Reaction mechanism was proposed. C 2009 Liang Rong Feng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 展开更多
关键词 Surface acidic groups Peroxyacetic acid Activated carbon Catalyst for vinyl acetate synthesis
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Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death 被引量:7
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作者 Changhai Tian Ping Gao +4 位作者 Yanhua Zheng Wen Yue Xiaohui Wang Haijing Jin Quan Chen 《Cell Research》 SCIE CAS CSCD 2008年第4期458-471,共14页
lntracellular redox homeostasis plays a critical role in determining tumor cells' sensitivity to drug-induced apoptosis. Here we investigated the role of thioredoxin-1 (TRX1), a key component of redox regulation, i... lntracellular redox homeostasis plays a critical role in determining tumor cells' sensitivity to drug-induced apoptosis. Here we investigated the role of thioredoxin-1 (TRX1), a key component of redox regulation, in arsenic trioxide (AS2O3)-induced apoptosis. Over-expression of wild-type TRX1 in HepG2 cells led to the inhibition of As2O3-induced cytochrome c (cyto c) release, caspase activation and apoptosis, and down-regulation of TRX1 expression by RNAi sensitized HepG2 cells to As2O3-induced apoptosis. Interestingly, mutation of the active site of TRX1 from Cys^32/35 to Ser^32/35 converted this molecule from an apoptotic protector to an apoptotic promoter. In an effort to understand the mechanisms of this conversion, we used isolated mitochondria from mouse liver and found that recombinant wild-type TRX1 could protect mitochondria from the apoptotic changes. In contrast, the mutant form of TRX1 alone elicited mitochondria-related apoptotic changes, including the mitochondrial permeability transition pore (mPTP) opening, loss of mitochondrial membrane potential, and cyto c release from mitochondria. These apoptotic effects were inhibited by cyclosporine A (CsA), indicating that mutant TRX1 targeted to mPTP. Alteration of TRX1 from its reduced form to oxidized form in vivo by 2,4-dinitrochlorobenzene (DNCB), a specific inhibitor ofTRX reductase, also sensitized HepG2 cells to As203-induced apoptosis. These data suggest that TRX1 plays a central role in regulating apoptosis by blocking cyto c release, and inactivation of TRX1 by either mutation or oxidization of the active site cysteines may sensitize tumor cells to As2O3-induced apoptosis. 展开更多
关键词 THIOREDOXIN-1 arsenic trioxide MITOCHONDRIA cytochrome c APOPTOSIS
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Different characteristics of the structure of atmospheric boundary layer between dry and rainy periods over the northern Tibetan Plateau 被引量:6
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作者 Ishikawa Hirohiko Shinya Ogino 《Research in Cold and Arid Regions》 2011年第6期509-516,共8页
In this paper, based on in-situ observational data of the Coordinated Enhanced Observing Period (CEOP) Asia-Australia Monsoon Project (CAMP) on the Tibetan'Plateau (CAMP-Tibet), structure of the Atmospheric Bou... In this paper, based on in-situ observational data of the Coordinated Enhanced Observing Period (CEOP) Asia-Australia Monsoon Project (CAMP) on the Tibetan'Plateau (CAMP-Tibet), structure of the Atmospheric Boundary Layer (ABL) was preliminarily studied during the dry and rainy seasons. The main results show: (a) Diurnal variation of the ABL is obvious over the northern Tibetan Plateau area. The height of the ABL is different with the season change, which ranges from 2,211 m to 4,430 m during the pre-monsoon season and from 1,006 m to 2,212 m during the monsoon season. The ABL height is higher during the dry period than during the rainyigeriod. (b) The humidity is lower during the dry period than during the rainy period, and there are reverse humidity during both periods. (c) Horizontal wind direction is mostly west during the dry period, east under the height of 2,500 m and west above the height of 2,500 m during the rainy period. The wind speed is low during both the rainy and dry periods in the lower ABL layer. The wind speed is stronger within the upper ABL during the dry period than dtn-ing the rainy period. 展开更多
关键词 Tibetan Plateau structure characteristics alrnospheric boundary layer dry period rainy period
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Association of resting heart rate and hypertension stages on all-cause and car- diovascular mortality among elderly Koreans: the Kangwha Cohort Study 被引量:7
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作者 Mikyung Ryu Gombojav Bayasgalan +2 位作者 Heejin Kimm Chung Mo Nam Heechoul Ohrr 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第7期573-579,共7页
Background Elevated resting heart rate and hypertension independently increase the risk of mortality. However, their combined ef- fect on mortality in stages of hypertension according to updated clinical guidelines am... Background Elevated resting heart rate and hypertension independently increase the risk of mortality. However, their combined ef- fect on mortality in stages of hypertension according to updated clinical guidelines among dderly population is unclear. Methods We fol- lowed a cohort of 6100 residents (2600 males and 3500 females) of Kangwha County, Korea, ranging from 55 to 99 year-olds as of March 1985, for all-cause and cardiovascular mortality for 20.8 years until December 31, 2005. Mortality data were collected through telephone calls and visits (to 1991), and were confirmed by death record matching with the National Statistical Office (1992-2005). Hazard ratios were calculated for all-cause and cardiovascular mortality by resting heart rate and hypertension defined by Eighth Joint National Committee crite- ria using the Cox proportional hazard model after controlling for confounding factors. Results The hazard ratios associated with resting heart rate 〉 80 beats/min were higher in hypertensive men compared with normotensives with heart rate of 61-79 beats/rain, with hazard ratios values of 1.43 (95% CI: 1.00-1.92) on all-cause mortality for prehypertension, 3.01 (95% CI: 1.07-8.28) on cardiovascular mortality for prehypertension, and 8.34 (95% CI: 2.52-28.19) for stage 2 hypertension. Increased risk (HR: 3.54, 95% CI: 1.16-9.21) was observed among those with both a resting heart rate 〉 80 beats/rain and prehypertension on cardiovascular mortality in women. Conclusions Indi- viduals with coexisting elevated resting heart rate and hypertension, even in prehypertension, have a greater risk for all-cause and cardiovas- cular mortality compared to those with elevated resting heart rate or hypertension alone. These findings suggest that elevated resting heart rate should not be regarded as a less serious risk factor in elderly hypertensive patients. 展开更多
关键词 Cardiovascular diseases Heart rate HYPERTENSION MORTALITY PREHYPERTENSION
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Selenium and Sulfur Systematics of Mafic Dykes in Western Fujian Province,Southern China 被引量:4
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作者 FAN Haifeng WEN Hanjie +1 位作者 ZHANG Guishan HU Ruizhong 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2008年第4期884-895,共12页
Fifteen samples from three study areas (the Bancun diabase dykes, the Bali hornblende gabbro dykes, the Linzifen gabbro-diabase dykes) were collected and analyzed for selenium (Se), sulfur (S), copper (Cu), ma... Fifteen samples from three study areas (the Bancun diabase dykes, the Bali hornblende gabbro dykes, the Linzifen gabbro-diabase dykes) were collected and analyzed for selenium (Se), sulfur (S), copper (Cu), major and trace elements. In general, Se, S and Cu do positively correlate to each other. The concentration of S and Se and the S/Se ratio are higher than the corresponding value of primitive mantle (PM), and the Cu/S ratio falls in a narrow range (0.04-0.29), which is consistent with that of primitive mantle (0.05-0.20). The Bancun diabase dykes and the Bali hornblende gabbro dykes were located in an intraplate environment during the Late Mesozoic. Oceanic subduction was closely related to magmatic activities. The magmatic activities play an important role in the transportation mechanism of Se and S. Because those two groups were closer to fault zones, which may affect the distribution of S and Se and other elements. In the two groups, no crustal contamination was observed, indicating that all analyzed elements may come from enriched mantle metasomtism associated with slab subduction. However, the Linzifen gabbro-diabase dykes were located in an intraplate rift environment, and its invading age is older than the other two groups, the primitive magma comes from mantle, and there is an anomalous relation between S, Se and Al2O3, (La/Sm)N, and all these factors could result in higher S and Se concentration. 展开更多
关键词 selenium and sulfur systematics mafic dyke MESOZOIC Fujian southern China
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Variations in the eastern Indian Ocean warm pool and its relation to the dipole in the tropical Indian Ocean 被引量:3
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作者 张启龙 侯一筠 +1 位作者 齐庆华 白学志 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2009年第3期640-649,共10页
Based on the monthly average SST and 850 hPa monthly average wind data,the seasonal,interannual and long-term variations in the eastern Indian Ocean warm pool(EIWP) and its relationship to the Indian Ocean Dipole(IOD)... Based on the monthly average SST and 850 hPa monthly average wind data,the seasonal,interannual and long-term variations in the eastern Indian Ocean warm pool(EIWP) and its relationship to the Indian Ocean Dipole(IOD),and its response to the wind over the Indian Ocean are analyzed in this study.The results show that the distribution range,boundary and area of the EIWP exhibited obviously seasonal and interannual variations associated with the ENSO cycles.Further analysis suggests that the EIWP had obvious long-term trend in its bound edge and area,which indicated the EIWP migrated westwards by about 14 longitudes for its west edge,southwards by about 5 latitudes for its south edge and increased by 3.52×106 km2 for its area,respectively,from 1950 to 2002.The correlation and composite analyses show that the anomalous westward and northward displacements of the EIWP caused by the easterly wind anomaly and the southerly wind anomaly over the eastern equatorial Indian Ocean played an important and direct role in the formation of the IOD. 展开更多
关键词 the Indian Ocean warm pool ENSO DIPOLE
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Horizontal distribution and levels of heavy metals in the biggest snowstorm in a century in Shenyang,China 被引量:3
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作者 AN Jing ZHOU Qixing +1 位作者 LIU Weitao REN Liping 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2008年第7期846-851,共6页
The horizontal distribution and levels of heavy metals in the biggest snowstorm in Shenyang since 1904 were investigated by analyzing 4 metals (As,Cd,Pb,and Cu) in a series of ultraclean samples collected from 17 site... The horizontal distribution and levels of heavy metals in the biggest snowstorm in Shenyang since 1904 were investigated by analyzing 4 metals (As,Cd,Pb,and Cu) in a series of ultraclean samples collected from 17 sites distributed in different regions of the Shenyang area,China.The results showed that the concentrations of all the 4 heavy metals in snow from the industrial regions were high,up to 7.3 (As),2.2 (Cd),850.0 (Pb),and 0.197-20.2 (Cu)μg/kg,respectively.In the suburb,in contrast,their concentration... 展开更多
关键词 heavy metal DISTRIBUTION pollution level SNOWSTORM extreme climate
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WELL-POSEDNESS IN CRITICAL SPACES FOR THE FULL COMPRESSIBLE MHD EQUATIONS 被引量:2
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作者 边东芬 郭柏灵 《Acta Mathematica Scientia》 SCIE CSCD 2013年第4期1153-1176,共24页
In this paper we prove local well-posedness in critical Besov spaces for the full compressible MHD equations in R^N, N≥ 2, under the assumptions that the initialdensity is bounded away from zero. The proof relies on ... In this paper we prove local well-posedness in critical Besov spaces for the full compressible MHD equations in R^N, N≥ 2, under the assumptions that the initialdensity is bounded away from zero. The proof relies on uniform estimates for a mixed hyperbolic/parabolic linear system with a convection term. 展开更多
关键词 full compressible MHD equations Besov spaces critical spaces Littlewood-Paley theory local well-posedness
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