期刊文献+

《Asian Journal of Andrology》 CSCD

作品数3535被引量9941H指数30
《亚洲男性学杂志》(Asian Journal of Andrology, AJA)是全英文学术期刊。1999年6月创刊,2000年11月入选SCI,2002年首次SCI影响因子为0.827,2003...查看详情>>
  • 主办单位The Shanghai Institute of Materia Medica, Chinese Academy of Sciences (SIMM);Shanghai Jiao Tong University (SJTU)
  • 国际标准连续出版物号1008-682X
  • 国内统一连续出版物号31-1795/R
  • 出版周期双月刊

二次检索

题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

年份

学科

主题

期刊

机构

共找到3,535篇文章
< 1 2 177 >
每页显示 20 50 100
2023 AJA Outstanding Reviewer Award
1
《Asian Journal of Andrology》 SCIE CAS CSCD 2024年第5期I0004-I0004,共1页
原文传递
Ultrasonographic evaluation of the rete testis thickness:a promising approach to differentiate obstructive from nonobstructive azoospermia
2
作者 Xin Li Ru-Hui Tian +7 位作者 Peng Li Chun-Xiao Li Ming-Hua Yao Chen-Cheng Yao Xiao-Bo Wang Li-Ren Jiang Zheng Li Rong Wu 《Asian Journal of Andrology》 SCIE CAS CSCD 2023年第6期725-730,共6页
This study aimed to evaluate the ability of rete testis thickness(RTT)and testicular shear wave elastography(SWE)to differentiate obstructive azoospermia(OA)from nonobstructive azoospermia(NOA).We assessed 290 testes ... This study aimed to evaluate the ability of rete testis thickness(RTT)and testicular shear wave elastography(SWE)to differentiate obstructive azoospermia(OA)from nonobstructive azoospermia(NOA).We assessed 290 testes of 145 infertile males with azoospermia and 94 testes of 47 healthy volunteers at Shanghai General Hospital(Shanghai,China)between August 2019 and October 2021.The testicular volume(TV),SWE,and RTT were compared among patients with OA and NOA and healthy controls.The diagnostic performances of the three variables were evaluated using the receiver operating characteristic curve.The TV,SWE,and RTT in OA differed significantly from those in NOA(all P≤0.001)but were similar to those in healthy controls.Males with OA and NOA were similar at TVs of 9–11 cm^(3)(P=0.838),with sensitivity,specificity,Youden index,and area under the curve of 50.0%,84.2%,0.34,and 0.662(95%confidence interval[CI]:0.502–0.799),respectively,for SWE cut-off of 3.1 kPa;and 94.1%,79.2%,0.74,and 0.904(95%CI:0.811–0.996),respectively,for RTT cut-off of 1.6 mm.The results showed that RTT performed significantly better than SWE in differentiating OA from NOA in the TV overlap range.In conclusion,ultrasonographic RTT evaluation proved a promising diagnostic approach to differentiate OA from NOA,particularly in the TV overlap range. 展开更多
关键词 AZOOSPERMIA differential diagnosis rete testis thickness shear wave elastography
原文传递
Transsphenoidal surgery for prolactinomas in male patients:a retrospective study
3
作者 Wei-Jie Su Hong-Cai Cai +6 位作者 Guo-Chen Yang Ke-Jun He Hong-Lin Wu Yi-Bing Yang Hong-Xing Tang Li-Xuan Yang Chun-Hua Deng 《Asian Journal of Andrology》 SCIE CAS CSCD 2023年第1期113-118,共6页
Male patients with prolactinomas usually present with typical hyperprolactinemia symptoms,including sexual dysfunction and infertility.However,clinical factors related to sexual dysfunction and surgical outcomes in th... Male patients with prolactinomas usually present with typical hyperprolactinemia symptoms,including sexual dysfunction and infertility.However,clinical factors related to sexual dysfunction and surgical outcomes in these patients remain unclear.This study aimed to investigate the outcomes of male patients with prolactinomas after transsphenoidal surgery and the risk factors affecting sexual dysfunction.This study was conducted on 58 male patients who underwent transsphenoidal surgery for prolactinomas between May 2014 and December 2020 at the First Affiliated Hospital of Sun Yat-sen University,Guangzhou,China.We evaluated the sexual function of patients before and after surgery through International Index of Erectile Function-5 scores,libido,and frequency of morning erection.Of the 58 patients,48(82.8%)patients had sexual intercourse preoperatively.Among those 48 patients,41(85.4%)patients presented with erectile dysfunction.The preoperative International Index of Erectile Function-5 scores in patients with macroprolactinomas were significantly higher than those in patients with giant prolactinomas(17.63±0.91 vs 13.28±1.43;P=0.01).Postoperatively,the incidence of erectile dysfunction was 47.9%,which was significantly lower than that preoperatively(85.4%;P=0.01).Twenty-eight(68.3%)patients demonstrated an improvement in erectile dysfunction.Tumor size and invasiveness were significantly correlated with the improvement of erectile dysfunction.Preoperative testosterone<2.3 ng ml^(-1)was an independent predictor of improvement in erectile dysfunction.In conclusion,our results indicated that tumor size and invasiveness were important factors affecting the improvement of sexual dysfunction in male patients with prolactinoma.The preoperative testosterone level was an independent predictor related to the improvement of erectile dysfunction. 展开更多
关键词 erectile dysfunction PROLACTINOMAS sexual dysfunction transsphenoidal surgery
原文传递
The protective effects and underlying mechanisms of dapagliflozin on diabetes-induced testicular dysfunction 被引量:3
4
作者 Zhi-Chao Luo Zi-Run Jin +5 位作者 Ya-Fei Jiang Tian-Jiao Wei Ya-Lei Cao Zhe Zhang Rui Wei Hui Jiang 《Asian Journal of Andrology》 SCIE CAS CSCD 2023年第3期331-338,共8页
Male diabetic individuals present a marked impairment in fertility;however,knowledge regarding the pathogenic mechanisms and therapeutic strategies is unsatisfactory.The new hypoglycemic drug dapagliflozin has shown c... Male diabetic individuals present a marked impairment in fertility;however,knowledge regarding the pathogenic mechanisms and therapeutic strategies is unsatisfactory.The new hypoglycemic drug dapagliflozin has shown certain benefits,such as decreasing the risk of cardiovascular and renal events in patients with diabetes.Even so,until now,the effects and underlying mechanisms of dapagliflozin on diabetic male infertility have awaited clarification.Here,we found that dapagliflozin lowered blood glucose levels,alleviated seminiferous tubule destruction,and increased sperm concentrations and motility in leptin receptor-deficient diabetic db/db mice.Moreover,the glucagon-like peptide-1 receptor(GLP-1R)antagonist exendin(9-39)had no effect on glucose levels but reversed the protective effects of dapagliflozin on testicular structure and sperm quality in db/db mice.We also found that dapagliflozin inhibited the testicular apoptotic process by upregulating the expression of the antiapoptotic protein B-cell lymphoma 2(BCL2)and X-linked inhibitor of apoptosis protein(XIAP)and inhibiting oxidative stress by enhancing the antioxidant status,including total antioxidant capacity,total superoxide dismutase(SOD)activity,and glutathione peroxidase(GPx)activity,as well as decreasing the level of 4-hydroxynonenal(4-HNE).Exendin(9-39)administration partially reversed these effects.Furthermore,dapagliflozin upregulated the glucagon-like peptide-1(GLP-1)level in plasma and GLP-1R expression by promoting AKT8 virus oncogene cellular homolog(Akt)phosphorylation in testicular tissue.Exendin(9-39)partially inhibited Akt phosphorylation.These results suggest that dapagliflozin protects against diabetes-induced spermatogenic dysfunction via activation of the GLP-1R/phosphatidylinositol 3-kinase(PI3K)/Akt signaling pathway.Our results indicate the potential effects of dapagliflozin against diabetes-induced spermatogenic dysfunction. 展开更多
关键词 DAPAGLIFLOZIN diabetes glucagon-like peptide-1 receptor male infertility oxidative stress
原文传递
Endocrine aberrations of human nonobstructive azoospermia
5
作者 Yong Tao 《Asian Journal of Andrology》 SCIE CAS CSCD 2022年第3期274-286,共13页
Nonobstructive azoospermia(NOA)refers to the failure of spermatogenesis,which affects approximately 1%of the male population and contributes to 10%of male infertility.NOA has an underlying basis of endocrine imbalance... Nonobstructive azoospermia(NOA)refers to the failure of spermatogenesis,which affects approximately 1%of the male population and contributes to 10%of male infertility.NOA has an underlying basis of endocrine imbalances since proper human spermatogenesis relies on complex regulation and cooperation of multiple hormones.A better understanding of subtle hormonal disturbances in NOA would help design and improve hormone therapies with reduced risk in human fertility clinics.The purpose of this review is to summarize the research on the endocrinological aspects of NOA,especially the hormones involved in hypothalamic–pituitary–testis axis(HPTA),including gonadotropin-releasing hormone,follicle-stimulating hormone,luteinizing hormone,prolactin,testosterone,estradiol,sex hormone binding globulin,inhibin B,anti-Müllerian hormone,and leptin.For the NOA men associated with primary testicular failure,the quality of currently available evidence has not been sufficient enough to recommend any general hormone optimization therapy.Some other NOA patients,especially those with hypogonadotropic hypogonadism,could be treated with hormonal replacement.Although these approaches have succeeded in resuming the fertility in many NOA patients,the prudent strategies should be applied in individuals according to specific NOA etiology by balancing fertility benefits and potential risks.This review also discusses how NOA can be induced by immunization against hormones. 展开更多
关键词 ENDOCRINE follicle-stimulating hormone gonadotropin-releasing hormone inhibin B nonobstructive azoospermia PROLACTIN sperm retrieval TESTOSTERONE
原文传递
Whole exome sequencing and trio analysis to broaden the variant spectrum of genes in idiopathic hypogonadotropic hypogonadism
6
作者 Jian Zhang Shu-Yan Tang +6 位作者 Xiao-Bin Zhu Peng Li Jian-Qi Lu Jiang-Shan Cong Ling-Bo Wang Feng Zhang Zheng Li 《Asian Journal of Andrology》 SCIE CAS CSCD 2021年第3期288-293,共6页
Dozens of genes are associated with idiopathic hypogonadotropic hypogonadism(IHH)and an oligogenic etiology has been suggested.However,the associated genes may account for only approximately 50%cases.In addition,a gen... Dozens of genes are associated with idiopathic hypogonadotropic hypogonadism(IHH)and an oligogenic etiology has been suggested.However,the associated genes may account for only approximately 50%cases.In addition,a genomic systematic pedigree analysis is still lacking.Here,we conducted whole exome sequencing(WES)on 18 unrelated men affected by IHH and their corresponding parents.Notably,one reported and 10 novel variants in eight known IHH causative genes(AXL,CCDC141,CHD7,DMXL2,FGFR1,PNPLA6,POLR3A,and PR0KR2),nine variants in nine recently reported candidate genes(DCAF17,DCC,EGF,IGSF10,NOTCH1,PDE3A,RELN,SLIT2,and TRAPPC9),and four variants in four novel candidate genes for IHH(CCDC88C,CDON,GADL1,and SPRED3)were identified in 77.8%(14/18)of IHH cases.Among them,eight(8/18,44.4%)cases carried more than one variant in IHH-related genes,supporting the oligogenic model.Interestingly,we found that those variants tended to be maternally inherited(maternal with n=17 vs paternal with n=7;P=0.028).Our further retrospective investigation of published reports replicated the maternal bias(maternal with n=46 i^s paternal with n=28;P=0.024).Our study extended a variant spectrum for IHH and provided the first evidence that women are probably more tolerant to variants of IHH-related genes than men. 展开更多
关键词 idiopathic hypogonadotropic hypogonadism maternal inheritance oligogenic inheritance whole exome sequencing
原文传递
Spongiosum-combined glanuloplasty reduces glans complications after proximal hypospadias repair 被引量:3
7
作者 Yi-Qing Lyu Lin Yu +5 位作者 Hua Xie Yi-Chen Huang Xiao-Xi Li Li Sun Yan Liang Fang Chen 《Asian Journal of Andrology》 SCIE CAS CSCD 2021年第5期532-536,共5页
We aim to design a new glanuloplasty procedure combined with spongiosum to reduce the incidence of glans dehiscence and coronal fistula after proximal hypospadias repair.Patients who underwent urethroplasty by dorsal ... We aim to design a new glanuloplasty procedure combined with spongiosum to reduce the incidence of glans dehiscence and coronal fistula after proximal hypospadias repair.Patients who underwent urethroplasty by dorsal preputial island flap for proximal hypospadias between January 2014 and December 2016 were reviewed in this retrospective cohort study.Those who underwent spongiosum-combined glanuloplasty comprised the new-maneuver group,whereas those who underwent conventional glanuloplasty comprised the control group.The incidence of complications was then compared.In the new-maneuver group,dysplastic corpus spongiosum alongside lateral Buck's fascia(0.3-0.4 cm wide)on both sides of the urethral plate was separated from the proximal normal spongy tissue,joining into the glans wings to increase tissue volume and covering the neourethra in the glans penis.In the control group,the neourethra was covered with superficial fascia under the coronal sulcus.As a result,the new-maneuver and control groups comprised 47 and 28 patients,respectively.In the new-maneuver group,no glans dehiscence was detected;however,two(4.3%)patients had coronal fistula,two(4.3%)had urethral stricture,and four(8.5%)had diverticulum.In the control group,two(7.1%)patients had glans dehiscence,eight(28.6%)had coronal fistula,four(14.3%)had urethral stricture,one(3.6%)had diverticulum,and one(3.6%)had penile curvature recurrence.The new-maneuver group had less incidences of coronal fistula(P<0.001),glans dehiscence(P=0.033),and urethral stricture(P=0.008)but had a higher incidence of diverticulum than the control group(P=0.040).It clearly demonstrates that spongiosum-combined glanuloplasty can significantly reduce the incidences of coronal fistula and glans dehisce. 展开更多
关键词 glans dehiscence glanuloplasty HYPOSPADIAS urinary fistula
原文传递
Prevalence of late-onset hypogonadism among middle-aged and elderly males in China:results from a national survey 被引量:10
8
作者 Yi-Jun Liu Xu-Bo Shen +6 位作者 Na Yu Xue-Jun Shang Yi-Qun Gu Lian-Dong Zuo Cheng-Liang Xiong Zhen Ye Yuan-Zhong Zhou 《Asian Journal of Andrology》 SCIE CAS CSCD 2021年第2期170-177,共8页
This study aimed to propose an operational definition of late-onset hypogonadism(LOH)that incorporates both clinical symptoms and serum testosterone measurements to evaluate the prevalence of LOH in aging males in Chi... This study aimed to propose an operational definition of late-onset hypogonadism(LOH)that incorporates both clinical symptoms and serum testosterone measurements to evaluate the prevalence of LOH in aging males in China.A population-based sample of 6296 men aged 40 years-79 years old was enrolled from six representative provinces in China.Serum total testosterone(TT),sex hormone-binding globulin(SHBG),and luteinizing hormone(LH)were measured and free testosterone(cFT)was calculated.The Aging Males’Symptoms(AMS)scale was used to evaluate the LOH symptoms.Finally,5078 men were included in this analysis.The TT levels did not decrease with age(P=0.59),and had no relationship with AMS symptoms(P=0.87 for AMS total score,P=0.74 for≥3 sexual symptoms).The cFT levels decreased significantly with age(P<0.01)and showed a negative association with the presence of≥3 sexual symptoms(P=0.03).The overall estimated prevalence of LOH was 7.8%(395/5078)if a cFT level<210 pmol l−1 combined with the presence of≥3 sexual symptoms was used as the criterion of LOH.Among them,26.1%(103/395)and 73.9%(292/395)had primary and secondary hypogonadism,respectively.After adjustment for confounding factors,primary and secondary hypogonadism was positively related to age and comorbidities.Body mass index was an independent risk factor for secondary hypogonadism.The results suggest that the AMS total score is not an appropriate indicator for decreased testosterone,and that the cFT level is more reliable than TT for LOH diagnosis.Secondary hypogonadism is the most common form of LOH. 展开更多
关键词 Aging Males'Symptoms calculated free testosterone late-onset hypogonadism middle-aged and elderly male total testosterone
原文传递
Contemporary trends in radical prostatectomy and predictors of recovery of urinary continence in men aged over 70 years:comparisons between cohorts aged over 70 and less than 70 years 被引量:5
9
作者 Young Ju Lee Jin-Woo Jung +6 位作者 Sangchul Lee Sang Wook Lee Jeong Hyun Kim Sung Kyu Hong Seok-Soo Byun Sang Eun Lee Seong Jin Jeong 《Asian Journal of Andrology》 SCIE CAS CSCD 2020年第3期280-286,共7页
We evaluated contemporary trends in radical prostatectomy(RP)in men aged>70 years and investigated associations of selected variables with recovery of urinary continence(UC)in two age groups:>70 and<70 years.... We evaluated contemporary trends in radical prostatectomy(RP)in men aged>70 years and investigated associations of selected variables with recovery of urinary continence(UC)in two age groups:>70 and<70 years.A retrospective cohort of 2301 eligible patients attending our institution from 2004 to 2015 was reviewed.Patients were divided into two groups based on age at surgery(>70 years[n=610]vs<70 years[n=1691])and four groups by year of surgery.Over the study period,the proportion of patients aged>70 years gradually increased up to 30.0%,and the rate of robot-assisted RP and neurovascular bundle(NVB)saving increased continually to 80.0%and 67.4%of older patients,respectively.Although the rate of recovery of UC within 12 months(3 months)in patients aged>70 years was lower than that in those aged S70 years(81.5%[52.6%]vs 88.6%[60.9%],respectively;both P<0.001),the gap between age groups in the rate of recovery within 12 mon ths n arrowed from the sec ond quarter of the study period.Among youn ger patie nts,age,robot-assisted RP,prostate volume,membra nous urethral length(MUL),and NVB savi ng were predictors of recovery of UC within 3 or 12 months.In contrast,only age and MUL were predictors of recovery of UC within 3 and 12 months in patients aged>70 years.Therefore,unlike younger patients,only variables(age and MUL),possibly associated with the inhere nt fun ction of the urinary sphi ncter,were predictors of recovery of UC in patients aged>70 years. 展开更多
关键词 elderly PREDICTOR prostate cancer radical prostatectomy urinary incontinence
原文传递
AJA Outstanding Paper Award of 2019
10
《Asian Journal of Andrology》 SCIE CAS CSCD 2020年第6期F0002-F0002,共1页
Lidia Minguez-Alarcon,Jorge E Chavarro,Jaime Mendiola,Manuela Roca,Cigdem Tanrikut,Jesus Vioque,Niels Jorgensen,Alberto M Torres-Cantero.Fatty acid intake in relation to reproductive hormones and testicular volume amo... Lidia Minguez-Alarcon,Jorge E Chavarro,Jaime Mendiola,Manuela Roca,Cigdem Tanrikut,Jesus Vioque,Niels Jorgensen,Alberto M Torres-Cantero.Fatty acid intake in relation to reproductive hormones and testicular volume among young healthy men.Asian Journal ofAndrology 2017;19:184-90. 展开更多
关键词 INTAKE YOUNG Outstanding
原文传递
National Natural Science Foundation of China leads the comprehensive development of basic research in the field of male reproductive health in China 被引量:2
11
作者 Shu-Jie Liao Yan-Ying Xu +1 位作者 Rui-Juan Sun Qun-Yan Lyu 《Asian Journal of Andrology》 SCIE CAS CSCD 2020年第6期547-548,共2页
"Reproductive health"was officially defined as humans and their individual activities related to reproduction throughout their lives,which should be in good health in physical,psychological,and social aspect... "Reproductive health"was officially defined as humans and their individual activities related to reproduction throughout their lives,which should be in good health in physical,psychological,and social aspects.1 The basic research on male reproductive health in China can be traced back to the 1960s.2 Since the National Natural Science Foundation of China(NSFC)began systematic support for basic research on male reproductive health in 1988,the field has been systematically developed in China.In this regard,we analyze the role of the NSFC on the development of basic research in the field of male reproductive health in China. 展开更多
关键词 NSFC China. FIELD
原文传递
Altered microRNA profiles of testicular biopsies from patients with nonobstructive azoospermia 被引量:5
12
作者 Hai-Tao Zhang Zhe Zhang +6 位作者 Kai Hong Wen-Hao Tang De-Feng Liu Jia-Ming Mao Yu-Zhuo Yang Hao-Cheng Lin Hui Jiang 《Asian Journal of Andrology》 SCIE CAS CSCD 2020年第1期100-105,共6页
Many studies have shown that microRNAs(miRNAs)play vital roles during the spermatogenesis.However,little is known about the altered miRNA profiles of testicular tissues in nonobstructive azoospermia(NOA).Using microar... Many studies have shown that microRNAs(miRNAs)play vital roles during the spermatogenesis.However,little is known about the altered miRNA profiles of testicular tissues in nonobstructive azoospermia(NOA).Using microarray technology,the miRNA expression profiles of testicular biopsies from patients with NOA and of normal testicular tissues were determined.Bioinformatics analyses were conducted to predict the enriched biological processes and functions of identified miRNAs.The microarray data were validated by quantitative reverse transcriptase polymerase chain reaction(qRT-PCR),the results of which were then validated with a larger sample size.Correlations between the miRNA expression levels and clinical characteristics were analyzed.Receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic ability of miRNAs for azoospermia.Hierarchical clustering showed that 129 miRNAs were significantly differentially expressed between the NOA and control groups.Bioinformatics analysis indicated that the differentially expressed miRNAs were involved in spermatogenesis,cell cycle,and mitotic prometaphase.In the subsequent qRT-PCR assays,the selected miRNA expression levels were consistent with the microarray results,and similar validated results were obtained with a larger sample size.Some clinical characteristics were significantly associated with the expression of certain miRNAs.In particular,we identified a combination of two miRNAs(miR-10b-3p and miR-34b-5p)that could serve as a predictive biomarker of azoospermia.This study provides altered miRNA profiles of testicular biopsies from NOA patients and examines the roles of miRNAs in spermatogenesis.These profiles may be useful for predicting and diagnosing the presence of testicular sperm in individuals with azoospermia. 展开更多
关键词 male INFERTILITY MICRORNA nonobstructive AZOOSPERMIA SPERMATOGENESIS
原文传递
Establishing the lower limits of total serum testosterone among Chinese proven fertile men who received treatment of assisted reproductive technology
13
作者 Hui-Yu Xu Hui Jiang +9 位作者 Guo-Shuang Feng Ying Feng Yong Han Wen-Hao Tang Hong-Xian Zhang Feng-Hua Chen Hong-Xia Zhang De-Feng Liu Rong Li Jie Qiao 《Asian Journal of Andrology》 SCIE CAS CSCD 2020年第4期396-400,共5页
Testosterone(T)plays a crucial role in spermatogenesis because extremely low levels of intratesticular T lead to correspondingly low serum levels of total T(tT),severe disorders of spermatogenesis,and male sterility.H... Testosterone(T)plays a crucial role in spermatogenesis because extremely low levels of intratesticular T lead to correspondingly low serum levels of total T(tT),severe disorders of spermatogenesis,and male sterility.However,there is little consensus on the lower limits of serum tT in proven fertile men undergoing assisted reproductive technology treatments in Chinese or other Asian populations.We aimed to establish the reference range of serum tT based on a population of 868 fertile Chinese men undergoing in vitro fertilization or intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET)treatments.We defined a fertile man as having had a live baby with his partner as recorded in our IVF registration system.The lower limits of serum tT were established using a Siemens IMMULITE 2000 chemiluminescent system.The 1st,2.5th,and 5th percentiles and their 95%confidence intervals(CIs)were 3.6(95%CI:2.7–4.1)nmol l−1,4.3(95%CI:4.1–5.0)nmol l−1,and 5.6(95%CI:4.8–5.8)nmol l−1,respectively.Using the linear correlation of serum tT between the Siemens platform and a liquid chromatography–tandem mass spectrometry platform,the calculated lower limits of serum tT were also established for fertile Chinese men undergoing IVF/ICSI-ET treatments,which will benefit the clinical diagnosis and treatment of male infertility during such procedures. 展开更多
关键词 CHEMILUMINESCENCE fertile men in vitro fertilization or intracytoplasmic sperm injection and embryo transfer liquid chromatography-tandem mass spectrometry lower reference limits serum total T
原文传递
A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility 被引量:6
14
作者 Francesco Del Giudice Gian Maria Busetto +6 位作者 Ettore De Berardinis Isabella Sperduti Matteo Ferro Martina Maggi Martin S Gross Alessandro Sciarra Michael L Eisenberg 《Asian Journal of Andrology》 SCIE CAS CSCD 2020年第4期360-367,共8页
Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particula... Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particularly in those with hypogonadism,elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic–pituitary–testicular axis by suppressing follicle-stimulating hormone(FSH)and luteinizing hormone(LH)production and impaired spermatogenesis.Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment.We carried out a systematic review and meta-analysis of the literature of the past 30 years in order to evaluate the benefits of the use of aromatase inhibitors in the medical management of infertile/hypoandrogenic males.Overall,eight original articles were included and critically evaluated.Either steroidal(Testolactone)or nonsteroidal(Anastrozole and Letrozole)aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile.While the evidence is promising,future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications. 展开更多
关键词 aromatase inhibitor HYPOGONADISM male infertility META-ANALYSIS systematic review
原文传递
A de novo frameshift mutation of the SRY gene leading to a patient with 46,XY complete gonadal dysgenesis 被引量:1
15
作者 Xiao-Bo Wang Yu-Long Liang +6 位作者 Zi-Jue Zhu Yong Zhu Peng Li Jia-Ping Cao Qun-Ying Zhang Qiang Liu Zheng Li 《Asian Journal of Andrology》 SCIE CAS CSCD 2019年第5期522-524,共3页
Dear Editor,Sex in mammals is genetically determined and defined at the cellular level by the sex chromosome constitution(XY males and XX females)and at the phenotypic level by the development of genderspecific anatom... Dear Editor,Sex in mammals is genetically determined and defined at the cellular level by the sex chromosome constitution(XY males and XX females)and at the phenotypic level by the development of genderspecific anatomy,physiology,and behavior.146,XY complete gonadal dysgenesis(46,XY CGD),first reported by Swyer in 1955,^2 is a rare congenital condition with completely or partially disordered gonadal development,leading to discordance between the genetic,gonadal,and phenotypic sex.Affected patients have a 46,XY karyotype,a female phenotype,normal female external genitalia,and CGD("streak gonads")without sperm production and follicular or steroid function. 展开更多
关键词 46 XY ANATOMY gonadal
原文传递
Predictive factors for pituitary response to pulsatile GnRH therapy in patients with congenital hypogonadotropic hypogonadism 被引量:3
16
作者 Jiang-Feng Mao Xi Wang +5 位作者 Jun-Jie Zheng Zhao-Xiang Liu Hong-Li Xu Bing-Kun Huang Min Nie Xue-Yan Wu 《Asian Journal of Andrology》 SCIE CAS CSCD 2018年第4期319-323,共5页
Pulsatile gonadotropin-releasing hormone (GnRH) may induce spermatogenesis in most patients with congenital hypogonadotropic hypogonadism (CHH) by stimulating gonadotropin production, while the predictors for a pi... Pulsatile gonadotropin-releasing hormone (GnRH) may induce spermatogenesis in most patients with congenital hypogonadotropic hypogonadism (CHH) by stimulating gonadotropin production, while the predictors for a pituitary response to pulsatile GnRH therapy were rarely investigated. Therefore, the aim of our study is to investigate predictors of the pituitary response to pulsatile GnRH therapy. This retrospective cohort study included 82 CHH patients who received subcutaneous pulsatile GnRH therapy for at least 1 month. Patients were categorized into poor or normal luteinizing hormone (LH) response subgroups according to their LH level (LH 〈2 IU 1-1 or LH P_2 IU 1-1) 1 month into pulsatile GnRH therapy. Gonadotropin and testosterone levels, testicular size, and sperm count were compared between the two subgroups before and after GnRH therapy. Among all patients, LH increased from 0.4±0.5 IUI^-1 to 7.5±4.4 IUI^-1 and follicle-stimulating hormone (FSH) increased from 1.1±0.9 IUI^-1 to 8.8±5.3 IU 1-1. A Cox regression analysis showed that basal testosterone level (6 = 0.252, P = 0.029) and triptorelin-stimulated FSH60min(13 = 0.518, P = 0.01) were two favorable predictors for pituitary response to GnRH therapy. Nine patients (9/82, 11.0%) with low LH response to GnRH therapy were classified into the poor LH response subgroup. After pulsatile GnRH therapy, total serum testosterone level was 39± 28 ng dl^-1 versus 248±158 ng d1^-1 (P=0.001), and testicular size was 4.0±3.1 ml versus 7.9±4.5 ml (P= 0.005) in the poor and normal LH response subgroups, respectively. It is concluded that higher levels of triptorelin-stimulated FSH60min. and basal total serum testosterone are favorable predictors of pituitary LH response to GnRH therapy. 展开更多
关键词 congenital hypogonadotropic hypogonadism pulsatile GnRH therapy treatment
原文传递
A rare cellular angiofibroma of the epididymis 被引量:1
17
作者 Qiang Guo Jian-Dong Zhang +3 位作者 Li Li Jian-Ping Xie Ding Ma Yan-Gang Zhang 《Asian Journal of Andrology》 SCIE CAS CSCD 2018年第1期95-96,共2页
Dear Editor, Cellular angiofibroma (CAF) is a rare benign mesenchymal lesion, which was first described in 1997 by Nucci et al.1 In previous reports, it has occurred mainly in the superficial soft tissue of the gen... Dear Editor, Cellular angiofibroma (CAF) is a rare benign mesenchymal lesion, which was first described in 1997 by Nucci et al.1 In previous reports, it has occurred mainly in the superficial soft tissue of the genital region, such as the scrotum, perineal, groin, vaginal introitus, and vulva,2 and rarely occurs in other locations. Here, we report a cellular angiofibroma in the epididymis; to our knowledge, such an epididymal location has not been reported in the literature so far. In this case, a 63-year-old male presented with a painless and well-circumscribed mass in the right epididymis. 展开更多
原文传递
Management and outcomes of penile fracture: a retrospective analysis of 62 cases with long-term assessment 被引量:2
18
作者 Zhuang Tang Lu Wang +5 位作者 Qiang Wei Fan Wang Liang-Ren Liu Ping Tan Shi Qiu Yu Fan 《Asian Journal of Andrology》 SCIE CAS CSCD 2018年第4期412-413,共2页
Dear Editor, Penile fracture (PF) is defined as a traumatic rupture of the tunica albuginea of the corpora cavernosa with an estimated incidence of 500-600 cases per year in the USA) Sexual intercourse, masturbati... Dear Editor, Penile fracture (PF) is defined as a traumatic rupture of the tunica albuginea of the corpora cavernosa with an estimated incidence of 500-600 cases per year in the USA) Sexual intercourse, masturbation, forced penile manipulation, and rolling over in bed onto the erect penis are considered common causes of this fracture. 展开更多
原文传递
An in vitro prototype of a porcine biomimetic testis-like cell culture system: a novel tool for the study of reassembled Sertoli and Leydig cells 被引量:4
19
作者 Iva Arato Giovanni Luca +7 位作者 Francesca Mancuso Catia Bellucci Cinzia Lilli Mario Calvitti Barbara C Hansen Domenico Milardi Giuseppe Grande Riccardo Calafiore 《Asian Journal of Andrology》 SCIE CAS CSCD 2018年第2期160-165,共6页
At present, there is no reliable in vitro assembled prepubertal testis-like biomimetic organ culture system designed to assess the functional effects of human gonadotropins on Sertoli and Leydig cells. Spermatogenesis... At present, there is no reliable in vitro assembled prepubertal testis-like biomimetic organ culture system designed to assess the functional effects of human gonadotropins on Sertoli and Leydig cells. Spermatogenesis is regulated by endocrine, paracrine, and juxtacrine factors (testicular cross-talk), mainly orchestrated by gonadotropins such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that play a pivotal role by stimulating Leydig and Sertoli cells, respectively. The aim of our study was to set up an in vitro prepubertal porcine bioengineered construct as a new model for experimental studies on reassembled Sertoli and Leydig cells. We have evaluated Sertoli and Leydig cells obtained from 15- to 20-day-old neonatal pig testes in terms of purity and function. Subsequently, purified Sertoli and enriched Leydig cells were subjected to coincubation to obtain an in vitro prepubertal porcine testis-like culture system. We performed enzyme-linked immunosorbent assay (ELISA) for anti-Mullerian hormone (AMH), inhibin B, and testosterone secretion in the medium, and Real-lime PCR analysis of AMH, inhibin B, FSH-r, aromatase, LHr, and 3βHSD mRNA expression levels. This in vitro testis-like system was highly responsive to the effects of human gonadotropins and testosterone. AMH mRNA expression and secretion declined, and inhibin-B increased, while FSH-receptor expression was downregulated upon FSH/LH exposure/treatment. Finally, the production of testosterone was increased selectively upon LH treatment. In summary, our proposed model could help to better determine the action of human gonadotropins on Sertoli and Leydig cells. The potential usefulness of the system for shedding light into male infertility-related issues is evident. 展开更多
关键词 human gonadotropins Leydig cells prepubertal biomimetic testis Sertoli cells
原文传递
Strong association of SLCIA1 and DPF3 gene variants with idiopathic male infertility in Han Chinese 被引量:2
20
作者 Shu-Yuan Liu Chang-Jun Zhang +6 位作者 Hai-Ying Peng Hao Sun Ke-Qin Lin Xiao-Qin Huang Kai Huang Jia-You Chu Zhao-Qing Yang 《Asian Journal of Andrology》 SCIE CAS CSCD 2017年第4期486-492,共7页
Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In recent years, several genome-wide single-nucleotide polymorphism (SNP) association studies (GWAS) have been performed on a... Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In recent years, several genome-wide single-nucleotide polymorphism (SNP) association studies (GWAS) have been performed on azoospermia and/or oligozoospermia in different populations including two GWAS on nonobstructive azoospermia in China; however, the association of SNPs with idiopathic male infertility, especially asthenozoospermia and oligozoospermia, and their correlation with semen parameters are still not clear. To investigate genetic variants associated with idiopathic male infertility (asthenozoospermia, oligozoospermia, and oligoasthenozoospermia) in Chinese Han people, 20 candidate SNPs were selected from GWAS results and genotyped using the Sequenom MassARRAY assay. A total of 136 subfertile men and 456 healthy fertile men were recruited, rs6476866 in SLCIA1 (P = 1.919E-4, OR = 0.5905, 95% Ch 0.447-0.78) and rs10129954 in DPF3 (P = 0.0023, OR = 2.199, 95% Ch 1.311-3.689) were strongly associated with idiopathic male infertility. In addition, positive associations were observed between asthenozoospermia and rs215702 in LSM5 (P= 0.0016, OR = 1.479, 95% CI: 1.075-2.033) and between oligoasthenozoospermia and rs2477686 in PEXIO (P= 0.0011, OR = 2.935, 95% Ch 1.492-5.775). In addition, six SNPs (rs215702 in LSMS, rs6476866 in SLCIA1, rs10129954 in DPF3, rs1801133 in MTHFR, rs2477686 in PEXIO, and rs10841496 in PED3A) were significantly correlated with semen quality alterations. Our results suggest that idiopathic male infertility in different ethnic groups may share the same mechanism or pathway. Cohort expansion and further mechanistic studies on the role of genetic factors that influence spermatogenesis and sperm progressive motility are suggested. 展开更多
关键词 candidate SNPs Han Chinese idiopathic male infertility semen quality
原文传递
上一页 1 2 177 下一页 到第
使用帮助 返回顶部