The stabilization of the formamidinium lead iodide(FAPbI_(3))structure is pivotal for the development of efficient photovoltaic devices.Employing two-dimensional(2D)layers to passivate the threedimensional(3D)perovski...The stabilization of the formamidinium lead iodide(FAPbI_(3))structure is pivotal for the development of efficient photovoltaic devices.Employing two-dimensional(2D)layers to passivate the threedimensional(3D)perovskite is essential for maintaining the a-phase of FAPbI_(3) and enhancing the power conversion efficiency(PCE)of perovskite solar cells(PSCs).However,the role of bulky ligands in the phase management of 2D perovskites,crucial for the stabilization of FAPbI_(3),has not yet been elucidated.In this study,we synthesized nanoscale 2D perovskite capping crusts with<n>=1 and 2 Ruddlesden-Popper(RP)perovskite layers,respectively,which form a type-Ⅱ 2D/3D heterostructure.This heterostructure stabilizes the a-phase of FAPbI_(3),and facilitates ultrafast carrier extraction from the 3D perovskite network to transport contact layer.We introduced tri-fluorinated ligands to mitigate defects caused by the halide vacancies and uncoordinated Pb^(2+)ions,thereby reducing nonradiative carrier recombination and extending carrier lifetime.The films produced were incorporated into PSCs that not only achieved a PCE of 25.39%but also maintained 95%of their initial efficiency after 2000 h of continuous light exposure without encapsulation.These findings underscore the effectiveness of a phase-pure 2D/3D heterostructure-terminated film in inhibiting phase transitions passivating the iodide anion vacancy defects,facilitating the charge carrier extraction,and boosting the performance of optoelectronic devices.展开更多
Excitatory amino acid transporters(EAATs) are responsible for excitatory amino acid transportation and are associated with auto-immune diseases in the central nervous system and peripheral tissues.However, the subcell...Excitatory amino acid transporters(EAATs) are responsible for excitatory amino acid transportation and are associated with auto-immune diseases in the central nervous system and peripheral tissues.However, the subcellular location and function of EAAT2 in macrophages are still obscure. In this study,we demonstrated that LPS stimulation increases expression of EAAT2(coded by Slc1a2) via NF-κB signaling. EAAT2 is necessary for inflammatory macrophage polarization through sustaining mTORC1 activation. Mechanistically, lysosomal EAAT2 mediates lysosomal glutamate and aspartate efflux to maintain V-ATPase activation, which sustains macropinocytosis and mTORC1. We also found that mice with myeloid depletion of Slc1a2 show alleviated inflammatory responses in LPS-induced systemic inflammation and high-fat diet induced obesity. Notably, patients with type Ⅱ diabetes(T2D) have a higher level of expression of lysosomal EAAT2 and activation of mTORC1 in blood macrophages. Taken together, our study links the subcellular location of amino acid transporters with the fate decision of immune cells,which provides potential therapeutic targets for the treatment of inflammatory diseases.展开更多
A"once-in-a-millennium"super rainstorm battered Zhengzhou,central China,from 07/17/2021 to 07/22/2021(named"7.20"Zhengzhou rainstorm).It killed 398 people and caused billions of dollars in damage.A...A"once-in-a-millennium"super rainstorm battered Zhengzhou,central China,from 07/17/2021 to 07/22/2021(named"7.20"Zhengzhou rainstorm).It killed 398 people and caused billions of dollars in damage.A pressing question is whether rainstorms of this intensity can be effectively documented by geological archives to understand better their historical variabilities beyond the range of meteorological data.Here,four land snail shells were collected from Zhengzhou,and weekly to daily resolved snail shellδ^(18)O records from June to September of 2021 were obtained by gas-source mass spectrometry and secondary ion mass spectrometry.The daily resolved records show a dramatic negative shift between 06/18/2021 and 09/18/2021,which has been attributed to the"7.20"Zhengzhou rainstorm.Moreover,the measured amplitude of this shift is consistent with the theoretical value estimated from the flux balance model and instrumental data for the"7.20"Zhengzhou rainstorm.Our results suggest that the ultra-high resolutionδ^(18)O of land snail shells have the potential to reconstruct local synoptic scale rainstorms quantitatively,and thus fossil snail shells in sedimentary strata can be valuable material for investigating the historical variability of local rainstorms under different climate backgrounds.展开更多
Diabetic retinopathy(DR)is the primary cause of blindness in working-age individuals and ranks among the most prevalent complications of diabetes mellitus(DM)worldwide.As the population with diabetes continues to soar...Diabetic retinopathy(DR)is the primary cause of blindness in working-age individuals and ranks among the most prevalent complications of diabetes mellitus(DM)worldwide.As the population with diabetes continues to soar,the prevalence of DR is on a rapid upward trajectory[1,2].The International Diabetes Federation(IDF)estimates that by 2045,the global prevalence of DM will reach a staggering 700 million,resulting in a proportional increase in DR cases and imposing substantial societal and economic burdens[2,3].展开更多
Recently,in their 2024 study,Dong et al.[1]revealed the pivotal role of neutrophils in the immune response of myocardial ischemia-reperfusion injury(MIRI)via single-cell RNA sequencing(sc RNA-seq),and identified the e...Recently,in their 2024 study,Dong et al.[1]revealed the pivotal role of neutrophils in the immune response of myocardial ischemia-reperfusion injury(MIRI)via single-cell RNA sequencing(sc RNA-seq),and identified the existence and function of a novel neutrophil subset with repair phenotype,which participates in the cardio-protection of MIRI by regulating the polarization of macrophages via Ym-1.This finding not only deepens our understanding of cellular interactions within MIRI but also opens new therapeutic avenues.展开更多
Age-related cognitive decline and dementia are significant manifestations of brain aging.As the elderly population grows rapidly,the health and socio-economic impacts of cognitive dysfunction have become increasingly ...Age-related cognitive decline and dementia are significant manifestations of brain aging.As the elderly population grows rapidly,the health and socio-economic impacts of cognitive dysfunction have become increasingly significant.Although clinical treatment of dementia has faced considerable challenges over the past few decades,with limited breakthroughs in slowing its progression,there has been substantial progress in understanding the molecular mechanisms and hallmarks of age-related dementia(ARD).This progress brings new hope for the intervention and treatment of this disease.In this review,we categorize the latest findings in ARD biomarkers into four stages based on disease progression:Healthy brain,preclinical,mild cognitive impairment,and dementia.We then systematically summarize the most promising therapeutic approaches to prevent or slow ARD at four levels:Genome and epigenome,organelle,cell,and organ and organism.We emphasize the importance of early prevention and detection,along with the implementation of combined treatments as multimodal intervention strategies,to address brain aging and ARD in the future.展开更多
The heavy consumption of non-renewable fossil feedstocks has induced several vital problems such as global warming and energy crises.Biomass,particularly lignin,is a promising renewable resource to substitute fossil f...The heavy consumption of non-renewable fossil feedstocks has induced several vital problems such as global warming and energy crises.Biomass,particularly lignin,is a promising renewable resource to substitute fossil fuels for producing value-added chemicals and fuels[1–3].Lignin has a highly irregular and recalcitrant structure that constituted by coumaryl,coniferyl and sinapyl alcohol monomers via intermolecular C–O and C–C bonds in a random order.For a long time,lignin has been regarded as a waste source and burnt for heat.Recently,the high values of lignin as a feedstock to bridge future gaps to supply aromatics have been extensively recognized and various catalytic strategies to transform lignin into arenes,cycloalkanes,etc.have been reported.展开更多
Water scarcity is a growing global issue due to population growth,water pollution,climate change,and so forth.In remote,arid areas where clean ground water and seawater are unavailable,atmospheric water harvesting(AWH...Water scarcity is a growing global issue due to population growth,water pollution,climate change,and so forth.In remote,arid areas where clean ground water and seawater are unavailable,atmospheric water harvesting(AWH)technology,especially sorption-based AWH(S-AWH)technology,provides a promising means to alleviate local water stress.It utilizes a variety of sorption materials to capture moisture from the air and solar energy to drive the desorption process through heating the sorbents,during which no external power supply such as electricity is required,therefore leaving very few carbon footprints.Following desorption,condensation is usually needed if we were to further collect the water,and the condenser commonly used is a passive component powered by ambient cooling like a glass cover or a cold plate[1].Given the magnitude of atmospheric water($13,000 billion tons)and its flowing characteristics,human extraction will have little influence on it[1,2].展开更多
The Tibetan Plateau(TP)is an important link between the South Asian monsoon(SAM)region,the East Asian monsoon region,and the drylands of Central Asia.Climate changes within these regions are dominated by both the mons...The Tibetan Plateau(TP)is an important link between the South Asian monsoon(SAM)region,the East Asian monsoon region,and the drylands of Central Asia.Climate changes within these regions are dominated by both the monsoon and the westerlies.This has prompted the scientific community to adopt a broad spatial perspective,proposing concepts such as the"Pan-Third Poleoor"Asian summer precipitationo,to better understand the regional climate dynamics,their driving mechanisms,and the resulting major ecological and environmental impacts.展开更多
The Greenland ice sheet(GrIS)is the second largest ice sheet in the world,but it is the largest contributor to sea level rise[1]as global warming continues.If its mass was lost completely,global mean sea level would r...The Greenland ice sheet(GrIS)is the second largest ice sheet in the world,but it is the largest contributor to sea level rise[1]as global warming continues.If its mass was lost completely,global mean sea level would rise by about 7.2 m[2].Over the recent three decades,mass loss of the GrIS driven by oceanic and atmospheric warming has been significantly increased[3].展开更多
I was excited when reading the recent Science news article[1](Supplementary materials online)saying“deep(drill)cores fulfil60-year-old quest”.I wished I were an International Ocean Discovery Program(IODP)399 partici...I was excited when reading the recent Science news article[1](Supplementary materials online)saying“deep(drill)cores fulfil60-year-old quest”.I wished I were an International Ocean Discovery Program(IODP)399 participant to share with the public my personal involvement in this historical event.展开更多
铁基硫酸盐聚阴离子材料因其成本低廉、电化学性能优异等优点,是钠离子电池大规模应用最有前景的候选材料之一.尽管Na_(2)Fe_(2)(SO_(4))_(3),Na_(2)Fe_(1.5)(SO_(4))_(3),Na_(2.4)Fe_(1.8)(SO_(4))_(3)和Na_(2.4)Fe_(1.8)(SO_(4))_(3)...铁基硫酸盐聚阴离子材料因其成本低廉、电化学性能优异等优点,是钠离子电池大规模应用最有前景的候选材料之一.尽管Na_(2)Fe_(2)(SO_(4))_(3),Na_(2)Fe_(1.5)(SO_(4))_(3),Na_(2.4)Fe_(1.8)(SO_(4))_(3)和Na_(2.4)Fe_(1.8)(SO_(4))_(3)等Na_(6-2x)Fe_(x)(SO_(4))_(3)(NFSO-x 1.5≤x≤2.0)材料在储钠方面取得了巨大成果,但这些NFSO-x的相和结构特性仍存在争议,难以实现具有最佳电化学性能的纯相材料.本文通过实验方法和密度泛函理论计算研究了6个具有不同x的NFSO-x样品,以分析其相和结构特性.结果表明在NFSO-x的1.6≤x≤1.7区域存在纯相,部分Na离子倾向于占据Fe位点以形成更稳定的框架.NFSO-1.7在NFSO-x样品中表现出最佳的电化学性能,具有高的放电容量(0.1 C时为104.5 mAh g^(-1),接近其理论容量105 mAh g^(-1))、出色的倍率性能(30 C时为81.5 mAh g^(-1)),并在10,000次循环中具有超长的循环稳定性,容量保持率为72.4%.本研究有助于阐明铁基硫酸盐聚阴离子材料的相和结构特征,以促进其在大规模储能中的应用.展开更多
In recent years,mesenchymal stem cells(MSCs)have been widely applied in the treatment of various clinical diseases because of multiple advantages and significant therapeutic effects.Despite the long research time and ...In recent years,mesenchymal stem cells(MSCs)have been widely applied in the treatment of various clinical diseases because of multiple advantages and significant therapeutic effects.Despite the long research time and complicated approval procedures,MSC therapy has been gradually progressing and gaining popularity worldwide,including in China.展开更多
Lung cancer is a deadly disease,being the most common of all cancer forms.In 2020,there are more than 1.8 million deaths caused by lung cancer worldwide[1].Among all cases,patients with non-small cell lung cancer take...Lung cancer is a deadly disease,being the most common of all cancer forms.In 2020,there are more than 1.8 million deaths caused by lung cancer worldwide[1].Among all cases,patients with non-small cell lung cancer take up 80%and lung adenocarcinoma(LUAD)represents more than 60%of non-small cell lung cancers(NSCLC)[2].In general,five treatment options are available for lung cancer treatment,including surgery,radiation,chemotherapy。展开更多
Most of today’s integrated circuits,known as chips or microchips,are fabricated using complementary metal–oxide–semiconductor(CMOS)technology.Conventional CMOS devices(mainly referred to as Si-based transistors)hav...Most of today’s integrated circuits,known as chips or microchips,are fabricated using complementary metal–oxide–semiconductor(CMOS)technology.Conventional CMOS devices(mainly referred to as Si-based transistors)have reached their fundamental physical limits and are facing energy-efficient challenges.展开更多
基金the Science and Technology Development Fund,Macao SAR(FDCT-0082/2021/A2,0010/2022/AMJ,0060/2023/RIA1,0136/2022/A3,006/2022/ALC,and EF044/IAPME-HG/2022/MUST)UM’s research fund(MYRG2022-00241IAPME,MYRG-GRG2023-00065-IAPME-UMDF,and MYRGCRG2022-00009-FHS)+8 种基金the research fund from Wuyi University(EF38/IAPME-XGC/2022/WYU)Shaanxi Fundamental Science Research Project for Mathematics and Physics(22JSY015 and 23JSY005)Shaanxi Province science and technology activities for overseas students selected funding project(2023015)the State Key Laboratory for Strength and Vibration of Mechanical Structures(SV2023-KF-18)Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic Systems(2023B1212010003)the China Fundamental Research Funds for the Central Universities,Young Talent Fund of Xi’an Association for Science and Technology(959202313020)the project of Innovative Team of Shaanxi Province(2020TD-001)the Natural Science Research Start-up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications(NY223053)the National Natural Science Foundation of China(61935017,62105292,62175268,62288102 and 62304111)。
文摘The stabilization of the formamidinium lead iodide(FAPbI_(3))structure is pivotal for the development of efficient photovoltaic devices.Employing two-dimensional(2D)layers to passivate the threedimensional(3D)perovskite is essential for maintaining the a-phase of FAPbI_(3) and enhancing the power conversion efficiency(PCE)of perovskite solar cells(PSCs).However,the role of bulky ligands in the phase management of 2D perovskites,crucial for the stabilization of FAPbI_(3),has not yet been elucidated.In this study,we synthesized nanoscale 2D perovskite capping crusts with<n>=1 and 2 Ruddlesden-Popper(RP)perovskite layers,respectively,which form a type-Ⅱ 2D/3D heterostructure.This heterostructure stabilizes the a-phase of FAPbI_(3),and facilitates ultrafast carrier extraction from the 3D perovskite network to transport contact layer.We introduced tri-fluorinated ligands to mitigate defects caused by the halide vacancies and uncoordinated Pb^(2+)ions,thereby reducing nonradiative carrier recombination and extending carrier lifetime.The films produced were incorporated into PSCs that not only achieved a PCE of 25.39%but also maintained 95%of their initial efficiency after 2000 h of continuous light exposure without encapsulation.These findings underscore the effectiveness of a phase-pure 2D/3D heterostructure-terminated film in inhibiting phase transitions passivating the iodide anion vacancy defects,facilitating the charge carrier extraction,and boosting the performance of optoelectronic devices.
基金supported by the National Natural Science Foundation of China (32225047 and U22A20510)Laboratory of Lingnan Modern Agriculture Project (NT2021005)+1 种基金National Center of Technology Innovation for Pigs (NCTIP-XD/B13)double first-class discipline promotion project (2023B10564001)。
文摘Excitatory amino acid transporters(EAATs) are responsible for excitatory amino acid transportation and are associated with auto-immune diseases in the central nervous system and peripheral tissues.However, the subcellular location and function of EAAT2 in macrophages are still obscure. In this study,we demonstrated that LPS stimulation increases expression of EAAT2(coded by Slc1a2) via NF-κB signaling. EAAT2 is necessary for inflammatory macrophage polarization through sustaining mTORC1 activation. Mechanistically, lysosomal EAAT2 mediates lysosomal glutamate and aspartate efflux to maintain V-ATPase activation, which sustains macropinocytosis and mTORC1. We also found that mice with myeloid depletion of Slc1a2 show alleviated inflammatory responses in LPS-induced systemic inflammation and high-fat diet induced obesity. Notably, patients with type Ⅱ diabetes(T2D) have a higher level of expression of lysosomal EAAT2 and activation of mTORC1 in blood macrophages. Taken together, our study links the subcellular location of amino acid transporters with the fate decision of immune cells,which provides potential therapeutic targets for the treatment of inflammatory diseases.
基金supported by the National Natural Science Foundation of China(42221003,4202530442103084)the Research Projects from the Chinese Academy of Sciences(XDB40000000)+1 种基金the Science and Technology Innovation Project of Laoshan Laboratory(LSKJ202203300)the CAS Youth Interdisciplinary Team。
文摘A"once-in-a-millennium"super rainstorm battered Zhengzhou,central China,from 07/17/2021 to 07/22/2021(named"7.20"Zhengzhou rainstorm).It killed 398 people and caused billions of dollars in damage.A pressing question is whether rainstorms of this intensity can be effectively documented by geological archives to understand better their historical variabilities beyond the range of meteorological data.Here,four land snail shells were collected from Zhengzhou,and weekly to daily resolved snail shellδ^(18)O records from June to September of 2021 were obtained by gas-source mass spectrometry and secondary ion mass spectrometry.The daily resolved records show a dramatic negative shift between 06/18/2021 and 09/18/2021,which has been attributed to the"7.20"Zhengzhou rainstorm.Moreover,the measured amplitude of this shift is consistent with the theoretical value estimated from the flux balance model and instrumental data for the"7.20"Zhengzhou rainstorm.Our results suggest that the ultra-high resolutionδ^(18)O of land snail shells have the potential to reconstruct local synoptic scale rainstorms quantitatively,and thus fossil snail shells in sedimentary strata can be valuable material for investigating the historical variability of local rainstorms under different climate backgrounds.
文摘Diabetic retinopathy(DR)is the primary cause of blindness in working-age individuals and ranks among the most prevalent complications of diabetes mellitus(DM)worldwide.As the population with diabetes continues to soar,the prevalence of DR is on a rapid upward trajectory[1,2].The International Diabetes Federation(IDF)estimates that by 2045,the global prevalence of DM will reach a staggering 700 million,resulting in a proportional increase in DR cases and imposing substantial societal and economic burdens[2,3].
文摘Recently,in their 2024 study,Dong et al.[1]revealed the pivotal role of neutrophils in the immune response of myocardial ischemia-reperfusion injury(MIRI)via single-cell RNA sequencing(sc RNA-seq),and identified the existence and function of a novel neutrophil subset with repair phenotype,which participates in the cardio-protection of MIRI by regulating the polarization of macrophages via Ym-1.This finding not only deepens our understanding of cellular interactions within MIRI but also opens new therapeutic avenues.
基金supported by the National Key R&D Program of China(2021YFA0804900 and 2020YFA0509300)the National Natural Science Foundation of China(82125009,82330045,31871082,91849101,32121002,82071185,and 92149303)+7 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000)CAS Project for Young Scientists in Basic Research(YSBR-013)Plans for Major Provincial Science&Technology Projects(202303a07020004)the Collaborative Innovation Program of Hefei Science Center,CAS(2022HSC-CIP003)Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM(QYZD20220003)Anhui Provincial Natural Science Foundation(2208085Y28)National Natural Science Foundation Incubation Program of the Second Affiliated Hospital of Anhui Medical University(2021GMFY02)Translational Medicine Research Foundation of the Second Affiliated Hospital of Anhui Medical University(2022ZHYJ02)。
文摘Age-related cognitive decline and dementia are significant manifestations of brain aging.As the elderly population grows rapidly,the health and socio-economic impacts of cognitive dysfunction have become increasingly significant.Although clinical treatment of dementia has faced considerable challenges over the past few decades,with limited breakthroughs in slowing its progression,there has been substantial progress in understanding the molecular mechanisms and hallmarks of age-related dementia(ARD).This progress brings new hope for the intervention and treatment of this disease.In this review,we categorize the latest findings in ARD biomarkers into four stages based on disease progression:Healthy brain,preclinical,mild cognitive impairment,and dementia.We then systematically summarize the most promising therapeutic approaches to prevent or slow ARD at four levels:Genome and epigenome,organelle,cell,and organ and organism.We emphasize the importance of early prevention and detection,along with the implementation of combined treatments as multimodal intervention strategies,to address brain aging and ARD in the future.
文摘The heavy consumption of non-renewable fossil feedstocks has induced several vital problems such as global warming and energy crises.Biomass,particularly lignin,is a promising renewable resource to substitute fossil fuels for producing value-added chemicals and fuels[1–3].Lignin has a highly irregular and recalcitrant structure that constituted by coumaryl,coniferyl and sinapyl alcohol monomers via intermolecular C–O and C–C bonds in a random order.For a long time,lignin has been regarded as a waste source and burnt for heat.Recently,the high values of lignin as a feedstock to bridge future gaps to supply aromatics have been extensively recognized and various catalytic strategies to transform lignin into arenes,cycloalkanes,etc.have been reported.
基金supported by the National Natural Science Foundation of China(52322812)the Research Grants Council of Hong Kong(CityU 11218922)Environmental and Conservation Fund of Hong Kong(76/2022)。
文摘Water scarcity is a growing global issue due to population growth,water pollution,climate change,and so forth.In remote,arid areas where clean ground water and seawater are unavailable,atmospheric water harvesting(AWH)technology,especially sorption-based AWH(S-AWH)technology,provides a promising means to alleviate local water stress.It utilizes a variety of sorption materials to capture moisture from the air and solar energy to drive the desorption process through heating the sorbents,during which no external power supply such as electricity is required,therefore leaving very few carbon footprints.Following desorption,condensation is usually needed if we were to further collect the water,and the condenser commonly used is a passive component powered by ambient cooling like a glass cover or a cold plate[1].Given the magnitude of atmospheric water($13,000 billion tons)and its flowing characteristics,human extraction will have little influence on it[1,2].
基金National Natural Science Foundation of China project Basic Science Center for Tibetan Plateau Earth System(41988101)。
文摘The Tibetan Plateau(TP)is an important link between the South Asian monsoon(SAM)region,the East Asian monsoon region,and the drylands of Central Asia.Climate changes within these regions are dominated by both the monsoon and the westerlies.This has prompted the scientific community to adopt a broad spatial perspective,proposing concepts such as the"Pan-Third Poleoor"Asian summer precipitationo,to better understand the regional climate dynamics,their driving mechanisms,and the resulting major ecological and environmental impacts.
基金supported by the National Key Research and Development Program of China(2019YFC1509104 and 2018YFC1406101)the Guangdong Basic and Applied Basic Research Foundation(2021B1515020032)+1 种基金the National Science Fund for Distinguished Young Scholars(41925027)the Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(311021008).
文摘The Greenland ice sheet(GrIS)is the second largest ice sheet in the world,but it is the largest contributor to sea level rise[1]as global warming continues.If its mass was lost completely,global mean sea level would rise by about 7.2 m[2].Over the recent three decades,mass loss of the GrIS driven by oceanic and atmospheric warming has been significantly increased[3].
基金by National Science Foundation of the USAAustralian Research Council+11 种基金Natural Environmental Research Council of the United KingdomNational Natural Science Foundation of China(91958215 and 41630968)the Royal Societythe Leverhulme TrustChina Geological SurveyChinese Academy of SciencesThe University of QueenslandCardiff UniversityUniversity of HoustonLanzhou UniversityChina University of Geosciences in Beijing(111 Project B18048)Durham University。
文摘I was excited when reading the recent Science news article[1](Supplementary materials online)saying“deep(drill)cores fulfil60-year-old quest”.I wished I were an International Ocean Discovery Program(IODP)399 participant to share with the public my personal involvement in this historical event.
基金the support by the National Natural Science Foundation of China(12047505)State Key Laboratory of Nuclear Physics and Technology,Peking University+4 种基金supported in part by the National Natural Science Foundation of China(12125501,12141501,and 11775002)National Key Research and Development Program of China(2020YFA0406400)supported in part by the National Natural Science Foundation of China(12070131001)supported in part by Chinese Academy of Sciences Interdisciplinary Innovation Team and the National Natural Science Foundation of China(11935017,12293060,and 12293063)partly supported by Highperformance Computing Platform of Peking University。
基金supported by the National Natural Science Foundation of China(U20A20249,22209125,and 21972108)the Key Research Program of Hubei Province(2020BAA030)。
文摘铁基硫酸盐聚阴离子材料因其成本低廉、电化学性能优异等优点,是钠离子电池大规模应用最有前景的候选材料之一.尽管Na_(2)Fe_(2)(SO_(4))_(3),Na_(2)Fe_(1.5)(SO_(4))_(3),Na_(2.4)Fe_(1.8)(SO_(4))_(3)和Na_(2.4)Fe_(1.8)(SO_(4))_(3)等Na_(6-2x)Fe_(x)(SO_(4))_(3)(NFSO-x 1.5≤x≤2.0)材料在储钠方面取得了巨大成果,但这些NFSO-x的相和结构特性仍存在争议,难以实现具有最佳电化学性能的纯相材料.本文通过实验方法和密度泛函理论计算研究了6个具有不同x的NFSO-x样品,以分析其相和结构特性.结果表明在NFSO-x的1.6≤x≤1.7区域存在纯相,部分Na离子倾向于占据Fe位点以形成更稳定的框架.NFSO-1.7在NFSO-x样品中表现出最佳的电化学性能,具有高的放电容量(0.1 C时为104.5 mAh g^(-1),接近其理论容量105 mAh g^(-1))、出色的倍率性能(30 C时为81.5 mAh g^(-1)),并在10,000次循环中具有超长的循环稳定性,容量保持率为72.4%.本研究有助于阐明铁基硫酸盐聚阴离子材料的相和结构特征,以促进其在大规模储能中的应用.
基金supported by the National Key R&D Program of China (2022YFC2504200)Capital Characteristic Clinical Application Research Project (Z181100001718208)+5 种基金the National Natural Science Foundation of China (82030031,81991504,and 81974149)Research Unit of Tooth Development and Regeneration,Chinese Academy of Medical Sciences (2019-12M-5-031)Beijing Municipal Government Grant (Beijing Laboratory of Oral Health,PXM2021_014226)Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX202121)Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University (CXTD202202)Beijing Municipal Administration of Hospitals’Ascent Plan (DFL20181501)。
文摘In recent years,mesenchymal stem cells(MSCs)have been widely applied in the treatment of various clinical diseases because of multiple advantages and significant therapeutic effects.Despite the long research time and complicated approval procedures,MSC therapy has been gradually progressing and gaining popularity worldwide,including in China.
基金the National Natural Science Foundation of China(31970611)the Chinese Universities Scientific Fund(2023TC016)。
文摘Lung cancer is a deadly disease,being the most common of all cancer forms.In 2020,there are more than 1.8 million deaths caused by lung cancer worldwide[1].Among all cases,patients with non-small cell lung cancer take up 80%and lung adenocarcinoma(LUAD)represents more than 60%of non-small cell lung cancers(NSCLC)[2].In general,five treatment options are available for lung cancer treatment,including surgery,radiation,chemotherapy。
文摘Most of today’s integrated circuits,known as chips or microchips,are fabricated using complementary metal–oxide–semiconductor(CMOS)technology.Conventional CMOS devices(mainly referred to as Si-based transistors)have reached their fundamental physical limits and are facing energy-efficient challenges.