Study on the Expression of hsa-miR-1246 in Hypoxic Glioma Derived Exosomes under Different Radiation Qualities

Hypoxia is a well-recognized characteristic of the glioma microenvironment[l].Moreover,as the primary im mune cells that reside in and around the glioma microenvironment.

Optimization of the Coating Process for Nbg_(3)Sn Cavity

After many years of worldwide exploration and improvement of the post treatment process,niobium(Nb)cavities are now approaching their fundamental limits both in terms of maximum acceleration field and in terms of surface resistance at typical operating temperatures.

Design and Optimization of Beam Shaping Assembly for Thermal Neutron Based on a 2.5 MeV Proton Accelerator for BNCT

The concept of Boron Neutron Capture Therapy(BNCT)is to provoke inside cancerous cells a nuclear reaction between accumulated 10B nuclei and thermal neutron for which the absorption cross section is extremely high.Thus,the cancerous cells can be destroyed by the resulting nuclei with high linear energy transfer[1].

CEE Detector Layout Optimization Based on Beam Path Simulation

Heavy-ion collision(HIC)is the only effective way to create hot and condensed nuclear matter in the laboratory,thus HIC is an unique tool to study phases of strongly interacting matter and nuclear equation of states(EoS).

Transcriptomic Analysis Uncovers the Molecular Mechanism of Early Flowering Mutant of Oil Sunfower Induced by Carbon Ion Beam Irradiation

Flowering time plays an important role in plant developmental biology.It is crucial for the reproduction success of flowering plants and the expansion of cultivated regions[1].So far,little is known regarding the molecular mechanism about regulating flowering characters induced by irradiation.

丰质子核27P的β延迟衰变测量的探测系统

The Tz=-3=2;A=4n+3 series nuclide 27P is four neutrons away from the last stable isotope of phosphorus,and is also predicted to be a proton-halo candidate.Its study has attracted special focus on adjacent to the proton drip-line of P isotope nuclides both in theory and experiments,but the final position about the drip line of phosphorus isotope has not yet been confirmed experimentally[1].The proton halo structure has been predicted in proton-rich nuclei of 26−28P by many kinds of theories such as Relativistic Mean Field(RMF)[2;3],shell model[4]and nonrelativistic theoretical model(SHF)[5].26P and 27P are predicted to be proton halos with one and two valence protons[3]by using the RMF,respectively,and these had been confirmed experimentally.However,the proton drip lines nuclei of phosphorus isotope has not been reached consensus up to now.

利用激光离子源产生质子束

In 2018,the technology of the proton beam production with a laser ion source was developed.To produce proton beams with the laser ion source,a solidified hydrogen target system had been developed by the end of 2017.The experiment on the production of proton beams with the laser ion source was carried out at the beginning of 2018.The 8 ns laser pulse with the 0.5 J energy was focused with a lens of f=500 mm onto the hydrogen ice deposited on a copper sheet attached at the second stage of a 4.2 K cryocooler.The laser power density on the ice was estimated to 2.5109 W
cm−2.As shown in Fig.1(a)and(b),the condition of the hydrogen ice formation can be observed through the laser window before each laser shot.The waveform of the proton beam,shown in Fig.1(c),was measured with a Faraday Cup located 2.5 m away from the target.As shown in Fig.1(c),the current intensity of the proton beam was much lower than other ion species.And the repeatability of the proton beam pulses was also poor,the main reason of which is that the conditions of the deposited hydrogen ice were quite different from shot to shot.

质子滴线核^(27)Pβ延迟衰变的研究进展

Under a continuous-beam mode,the isotopes of interestwere implanted into DSSD1 of 142μm thickness,DSSD2 of 40μm thickness,and DSSD3 of 304μm thickness in a certain proportion,where the subsequent decays were measured and correlated to the preceding implantations by using the position and time information the higherstatistics data onthe well-known protons and γ rays from those beam contaminants decays were also collected,which can be usedas good calibration references to validate and to optimizethe analysis program in obtaining accurate informationfrom-decay spectroscopy.

ADANES中核燃料循环的中子学研究

In an attempt to allow nuclear power to reach high resource utilization,sufficient nuclear safety,nuclear proliferation resistance and lower financial risk,the concept of accelerator-driven advanced nuclear energy system(ADANES)is proposed[1;2].ADANES consists of a burner system and a fuel recycling system.The burner system is constructed based on the existing principles of accelerator-driven system(ADS)by combining nuclear waste transmutation,nuclear fuel breeding,and safety power production.Then,the spent nuclear fuels(SNFs)obtained from the water reactor can be reprocessed in the simple high temperature dry reprocessing[3;4](HT-dry reprocessing).In this reprocessing,a part of the nuclides containing neutron poison in the SNFs can be separated and disposed,while the remaining nuclides can be reused to produce new fuel.Using this method,only a fraction of the fission products(FPs)is removed without fine partitioning.

辐射和微重力引起的生物效应的机制和应对措施研究进展

In Department of Space Radiobiology,the mechanisms of senescence and immune responses of cancer and normal cells induced by ionizing radiation have been investigated in vivo and in vitro during the past year.Meanwhile,along with the growing number of flights in space,astronauts will be exposed to harsh space environments such as microgravity and heavy ions.Space environments can cause serious bone loss and lead to the osteopenia of astronauts at vertebra,pelvis and femur,which is a major challenge in long-term spaceflight.The main achievements on these research fields in the year of 2018 can been summarized as followings。

快重离子辐照引起石墨烯场效应晶体管的电学性能变化研究

Graphene is hailed as the“future material”and“revolutionary material”of the 21st century.It has broad application prospects in the field of emission materials,quantum computers and super-sensitive sensors.Because of the short channel effect and manufacturing cost constraints,the mainstream silicon base material has become the bottleneck of semiconductor development.Graphene is expected to be an alternative material for silicon,becoming an important role in the development of electronic devices in the post-moore law period.However,in irradiation environments,graphene lattice could be destroyed,which may induce the failure of graphene devices.Then the application of graphene devices in radiation environment is greatly limited.

2017年原子分子谱学组工作进展

A beam of 95 MeV/u Ni19+ions was stored in CSRe,and collided with the internal jet-targets of hydrogen,argon,krypton and xenon.The X-rays produced in the collisions were detected by two Silicon Drift Detectors(SDD)and four High-purity Germanium detectors.The K satellite and the hypersatellite lines of the projectile ions are clearly distinguished.Our primary data analyze show that the double-to-single K-shell ionization of the projectile ions increases linearly with the factor κ=Z/v,where Z is the atomic number of the target and v is the projectile velocity.The experimental data in 52-197 MeV/u Xe^(54+)ions with krypton collisions were thoroughly analyzed[1].Energy shifts of the Kα_(1,2)^(s) ,Kα_(1,2)^(h,s) and Kβ_(1,3)^(s) transitions are obtained.Thus,the average number of the spectator L-vacancies presented during the X-ray emission is deduced.The experimental results are compared with a relativistic coupled channel calculation performed within the independent particle approximation.The theory agrees with the present experiment very well at the higher energies,but it fails to reproduce the experiment data at low energies and the reason of this deviation is not clear yet.

EPICS在溅射离子泵控制系统中的应用和实验环控制系统改造

To establish the sputter ion pump remote control system for TR5 and TR6 of HIRFL(Heavy Ion Research Facility in Lanzhou),EPICS(Experimental Physics And Industrial Control System)is adopted to development new control system.Beckhoff PLC and self-designed hardware module have been used to build the hardware platform and the whole system structure is established based on field bus and EtherCAT(Ethernet for Control Automation Technology)technology.EtherCAT is an ideal Ethernet solution for industrial automation,characterized by outstanding performance and particularly simple handling.In the realization process of the system,IOC record device support and PV definition are achieved.At the same time,we have developed a client application in the CSS environment.In this sputter ion pump control system,we realized the basic interlocking protection function in both of hardware and software.The photo of hardware module is shown in Fig.1.The GUI interface is shown in Fig.2.The control system has being stably run since installed in Aug.2017.

TiALC_(2)的辐照损伤及微观结构变化研究

Ceramics compound Ti_(3)AlC_(2) exhibits nano-layered structure and has the properties of both ceramic and metal.It includes easy machinability,good high-temperature resistance and irradiation–damage tolerance.So it’s supposed to be a candidate for future nuclear reactor.For example,it can be used as a coatings on Zr cladding materials.It can withstand severer irradiation damage and prevent the reaction between water and Zr.Therefore the understanding of Ti3AlC2under irradiation is fundamentally important for the development of nuclear materials[1].

2-25 Revisit of Density,Temperature,Symmetry Energy Determination Based on MFM Formalism

In 1967,Fisher proposed a droplet model of a second-order phase transition to describe the power law behavior of the“fragment”mass distribution around the critical point for a liquid-gas phase transition[1].Decades later,the Purdue group generated a novel classical droplet model,which was the so-called Modified Fisher Model(MFM),based on the Fisher Model(FM)and introduced it into nuclear physics[2-4].Taking into account the basic nuclear properties,such as the Coulomb force,pairing effect,proton-neutron two-component mixture,the MFM is capable of describing the general features of the mass and isotopic yields with a minimum number of free parameters[2-4].

4-38 DNA Damage in Bone Marrow Mononuclear Cells of Mice Following Total Body Irradiation with Carbon Ions

Among the many special factors in the space environment,space radiation especially high energy heavy ion radiation is widely regarded as one of the crucial factors that hazard the health and safety of astronaut.It is well known that biological effects of radiation are dependent on the linear-energy-transfer(LET)of the emergent beam.Heavy ions have high LET and could induce complex and clustered DNA damage,which is more difficult to be repaired than individual lesions and is even irreparable.

1-23 Effective Field Theories on Solitons of Generic Shapes

A class of effective field theories for moduli or collective coordinates on solitons of generic shapes is constructed. As an illustration, we consider effective field theories living on solitons in the O(4) non-linear sigma model with higher-derivative terms.In this project we are extending the power techniques of effective field theory to solitons of generic shapes.

6-44 Progress of HIMM Project

Heavy ion beam has been considered to be the most optimal radiation for tumor treatment in the field of radiotherapy due to a high ionization density and a high relative biological effectiveness (RBE), culminating in a sharp maximum at a discrete penetration depth that coincides with the maximum physical dose around the socalled Bragg peak. It is important to develop the hospital-based heavy-ion-therapy facility to make the treatment accessible for public tumor patients.

5-28 A Design of 0.35um CMOS Multi-channel Shaper for PPAC Detector

Radioactive Ion Beam Line in Lanzhou (RIBLL) is the heavy ion radiation beam equipment on Heavy Ion Accelerator in Lanzhou, which can provide a variety of Radioactive Ion Beam （RIB）for physical experiments.In order to improve the efficiency and accuracy of the experiments, we need a high-performance Parallel Plate Avalanche Counter(PPAC) to monitor the RIB online and to measure the track of the incident particles and reaction products.

3-63 Underlying Toxicological Mechanism Acute Injury Induced by Carbon Ion Radiation in Pubertal Mice Testes

Men of reproductive age undergoing radiotherapy are often concerned about the possible effects on fertility and future children[1]. In this investigation, serum testosterone was measured following whole-body irradiation with a 2 Gy carbon ion radiation (CIR), and immunofluorescence were used to investigate protein localization that evaluate the underlying toxicological mechanism of acute injury induced by CIR in pubertal mice testes.