目的对近10年来报道的黄连温胆汤单独或联合西药治疗痰热内扰型失眠的有效性及安全性进行评估。方法在中国知网、维普、万方、中国生物医学数据库、PubMed、Web of science、Embase和Cochrane Library数据库中检索自2012年1月1日至2022...目的对近10年来报道的黄连温胆汤单独或联合西药治疗痰热内扰型失眠的有效性及安全性进行评估。方法在中国知网、维普、万方、中国生物医学数据库、PubMed、Web of science、Embase和Cochrane Library数据库中检索自2012年1月1日至2022年4月1日黄连温胆汤单独或联合西药治疗痰热内扰型失眠的随机对照试验。经筛选后对纳入文献进行分析,评估黄连温胆汤对痰热内扰型失眠的有效率、匹茨堡睡眠质量指数量表(PSQI)评分、中医证候积分及不良反应的影响。亚组分析黄连温胆汤治疗不同时间后的效果,比较单独使用黄连温胆汤与黄连温胆汤联合西药治疗的效果。结果最终纳入27篇随机对照试验,共计2395例患者。Meta分析结果显示黄连温胆汤单独或联合西药组对比西药组疗效更好[RR=1.14,95%CI(1.06,1.22),P=0.000],黄连温胆汤单独或联合西药组对比西药组PSQI评分[SMD=-0.31,95%CI(-0.42,-0.20),P=0.000]、中医证候积分[SMD=-0.40,95%CI(-0.67,-0.12),P=0.005]、不良反应率[RR=0.21,95%CI(0.15,0.29),P=0.000]显著降低。亚组分析显示黄连温胆汤单独或联合西药组对比西药组,治疗4周疗效更好[RR=1.14,95%CI(1.03,1.26),P<0.05];黄连温胆汤单独或联合西药组对比西药组,疗程为4周时,中医症候积分降低更明显[SMD=-0.60,95%CI(-0.96,-0.25),P<0.05];黄连温胆汤单独或联合西药组对比西药组在治疗周期上与PSQI积分、不良反应率无明显相关性。单独使用黄连温胆汤组与西药组相比有效率[RR=1.09,95%CI(1.00,1.23),P<0.05]较于黄连温胆汤联合西药组对比西药组有效率[RR=1.15,95%CI(1.03,1.29),P<0.05)效果相同;黄连温胆汤联合西药组对比西药组PSQI积分[SMD=-0.44,95%CI(-0.59,-0.30),P<0.05]、中医症候积分[SMD=-1.10,95%CI(-1.59,-0.61),P<0.05]显著降低;单独使用黄连温胆汤不良反应发生率[RR=0.08,95%CI(0.04,0.17),P<0.05]与黄连温胆汤联合西药治疗不良反应发生率[RR=0.36,95%CI(0.24,0.53),P<0.05]无明显差异。结论黄连温胆汤单独或联合西药治疗痰热内扰型失眠疗效是肯定的,有效率高、PSQI评分及中医证候积分显著降低,并且有较好的安全性,最佳疗程是4周。展开更多
Digital Chinese medicine refers to a comprehensive system that utilizes unified scientific technologies to fully explore and reproduce human phenomenology, patterns of physical changes, and related human experiences. ...Digital Chinese medicine refers to a comprehensive system that utilizes unified scientific technologies to fully explore and reproduce human phenomenology, patterns of physical changes, and related human experiences. It encompasses the acquisition, storage, and processing of traditional Chinese medicine (TCM) data, information.展开更多
基金funding support from Chinese Nature Science Foundation (No.81202705)The Effect of Long Dan Xie Gan Formula Granule on Toll Signaling Pathway in the Guinea pigs of Recurrent Genital Herpes Changsha Science and Technology Foundation (No.kh1601195)
基金Basic Research Fund Project of the Central Public Welfare Research Institute of China Academy of Chinese Medical Sciences(Zz13-zd-09).
文摘目的对近10年来报道的黄连温胆汤单独或联合西药治疗痰热内扰型失眠的有效性及安全性进行评估。方法在中国知网、维普、万方、中国生物医学数据库、PubMed、Web of science、Embase和Cochrane Library数据库中检索自2012年1月1日至2022年4月1日黄连温胆汤单独或联合西药治疗痰热内扰型失眠的随机对照试验。经筛选后对纳入文献进行分析,评估黄连温胆汤对痰热内扰型失眠的有效率、匹茨堡睡眠质量指数量表(PSQI)评分、中医证候积分及不良反应的影响。亚组分析黄连温胆汤治疗不同时间后的效果,比较单独使用黄连温胆汤与黄连温胆汤联合西药治疗的效果。结果最终纳入27篇随机对照试验,共计2395例患者。Meta分析结果显示黄连温胆汤单独或联合西药组对比西药组疗效更好[RR=1.14,95%CI(1.06,1.22),P=0.000],黄连温胆汤单独或联合西药组对比西药组PSQI评分[SMD=-0.31,95%CI(-0.42,-0.20),P=0.000]、中医证候积分[SMD=-0.40,95%CI(-0.67,-0.12),P=0.005]、不良反应率[RR=0.21,95%CI(0.15,0.29),P=0.000]显著降低。亚组分析显示黄连温胆汤单独或联合西药组对比西药组,治疗4周疗效更好[RR=1.14,95%CI(1.03,1.26),P<0.05];黄连温胆汤单独或联合西药组对比西药组,疗程为4周时,中医症候积分降低更明显[SMD=-0.60,95%CI(-0.96,-0.25),P<0.05];黄连温胆汤单独或联合西药组对比西药组在治疗周期上与PSQI积分、不良反应率无明显相关性。单独使用黄连温胆汤组与西药组相比有效率[RR=1.09,95%CI(1.00,1.23),P<0.05]较于黄连温胆汤联合西药组对比西药组有效率[RR=1.15,95%CI(1.03,1.29),P<0.05)效果相同;黄连温胆汤联合西药组对比西药组PSQI积分[SMD=-0.44,95%CI(-0.59,-0.30),P<0.05]、中医症候积分[SMD=-1.10,95%CI(-1.59,-0.61),P<0.05]显著降低;单独使用黄连温胆汤不良反应发生率[RR=0.08,95%CI(0.04,0.17),P<0.05]与黄连温胆汤联合西药治疗不良反应发生率[RR=0.36,95%CI(0.24,0.53),P<0.05]无明显差异。结论黄连温胆汤单独或联合西药治疗痰热内扰型失眠疗效是肯定的,有效率高、PSQI评分及中医证候积分显著降低,并且有较好的安全性,最佳疗程是4周。
基金National Famous Old Chinese Medicine Experts Inheritance Studio Construction Project([2022]No.75)Jiangxi Province Chinese Medicine Young and Middle-aged Backbone Talents Training Program([2021]No.4)+1 种基金Jiangxi Province Chinese Medicine Science and Technology Program Key Project(2021Z013)Jiangxi Province Education Department Science and Technology Program(GJJ211216).
基金National Natural Science Foundation of China (8207425)Hunan Provincial Natural Science Foundation(2021JJ30508 and 2020JJ4063)+3 种基金Hunan Provincial Scientific Research Project of Chinese Medicine (2021055)Changsha Outstanding and Innovative Youth Training Program (kq2106060)Key Discipline of Hunan University of Chinese Medicine (Basic Medicine 1)the Excellent Teaching Team of Postgraduates in Hunan Province (Postgraduate Teaching Team of Basic Medicine, 118)。
文摘Digital Chinese medicine refers to a comprehensive system that utilizes unified scientific technologies to fully explore and reproduce human phenomenology, patterns of physical changes, and related human experiences. It encompasses the acquisition, storage, and processing of traditional Chinese medicine (TCM) data, information.
基金the funding support from the National Natural Science Foundation of China (No. 81373551)Hunan Natural Science Foundation (No. 2019JJ40214)+3 种基金Hunan Provincial Health and Family Planning Commission (No. 20190638)Hunan Provincial Brain Hospital (No. 2018B07)Innovation of Graduate Students in Hunan University of Traditional Chinese Medicine (No. 2018CX05 and No. 2018CX25)Postgraduate Innovation in Hunan Province (No. CX20190536 and No. CX20190591)
基金funding support from the National Natural Science Foundation of China (No. 81503041)Project Foundation of Changsha Science and Technology Bureau (No. kq1701073)
基金the National Natural Science Foundation of China (NSFC) (No.30772824 and No.81574031)225 Project of High-Level Medical Talents of Hunan Province+4 种基金Research Project of Science and Technology Department of Hunan Province (No.2015SF2016-6)Research Project of Hunan Provincial Development and Reform Commission (No.[2014]658)Major Project of Changsha Science and Technology Plan (K1501014-31)Construction Project of Key Discipline of Chinese Ophthalmology of State Administration of Traditional Chinese MedicineConstruction Project of Key Discipline of Ophthalmology and Otolaryngology of Chinese Medicine of Hunan Province
基金The National Key Research and Development Plan(2019YFC1712200 and 2019YFC1712204)Traditional Chinese Medicine Standardization Project of National Administration of Traditional Chinese Medicine(GZTFJS-2020-204 and GZY-FJS-2022-048)Scientific Research Project in Key Fields of Traditional Chinese Medicine in Tianjin(2023014).
基金Postgraduate Scientific Research Innovation Key Project of Hunan Province(CX20210680)Key Scientific Research Project of Hunan Provincial Department of Education(21A0224)+1 种基金Scientific Research Project of Hunan Health Commission(202204083613)CHEN Qihua National Studio for Inheritance of TCM Famous Veteran Doctors(2022)。
基金We thank for the funding support from the National Natural Science Foundation of China(No.81503041)Natural Science Foundation of Hunan Province(No.2017JJ4045)Changsha Science and Technology Project(No.kq1701073).
基金National Natural Science Foundation of China(81973670)Natural Science Foundation of Hunan Province(2018JJ2297)+2 种基金Key Program of Scientific Research Fund of Hunan Provincial Education Department(19A370)Domestic First-class Cultivation Discipline Integrated Traditional Chinese and Western Medicine Discipline Project of Hunan Province(2021ZXYJH10)College Student Innovation and Entrepreneurship Training Program of Hunan Province(S201910541046).
基金support from the Youth Development Research Foundation of NIFDC(2014A1)National Science and Technology Major Project(2017ZX09101002-002-008)the National Natural Science Foundation of China(No.81403171 and No.81603517)
基金National Administration of Traditional Chinese Medicine Purchase Service Project“Research on Improving Scientific and Technological Innovation Ability of Traditional Chinese Medicine Medical Devices”(GHC-2020-ZFGM-014)Scientific Research Project of China Ethnic Medicine Association“Research on Improving Innovation Ability of Tibetan Medical Devices”(2021M1152-270007)Self-Selected Project of Institute of Basic Theory of Traditional Chinese Medicine of China Academy of Traditional Chinese Medicine“Analysis and Prospect Research on Current Situation of Traditional Chinese Medicine Technology and Equipment”(YZ-202004).
基金Medical and Health Science and Technology Innovation Project of the Chinese Academy of Medical Sciences(2021-I2M-1-031)Major Science and Technology Special Plan of Yunnan Province(202102AA100020)Science and Technology Talents and Platform Program of Yunnan Province(202205AF150071).