CXCL3 belongs to the CXC-type chemokine family and is known to play a multifaceted role in various human malignancies.While it's clinical significance and mechanisms of action in uterine cervical cancer(UCC)remain...CXCL3 belongs to the CXC-type chemokine family and is known to play a multifaceted role in various human malignancies.While it's clinical significance and mechanisms of action in uterine cervical cancer(UCC)remain unclear.This investigation demonstrated that the UCC cell line HeL.a expressed CXCL3,and strong expression of CXCL3 was detected in UCC tissues relative to nontumor tissues.In addition,CXCL3 expression was strongly correlated with CXCL5 expression in UCC tissues.In vitro,HeLa cells overexpressing CXCL3,HeLa cells treated with exogenous CXCL3 or treated with conditioned medium from WPMY cells overexpresing CXCL3,exhibited enhanced proliferation and migration activities.展开更多
The transition of the inferior gluteal artery to the popliteal artery is an.extremely rare arterial variation.By using CT angiography(CTA),we found a case whose right inferior gluteal artery transferred to the poplite...The transition of the inferior gluteal artery to the popliteal artery is an.extremely rare arterial variation.By using CT angiography(CTA),we found a case whose right inferior gluteal artery transferred to the popliteal artery.A 73-year-old female patient was admitted to our hospital with num bness,pain and low skin temperature in the right foot without obvious inducement".On physical examination,right dorsal foot artery pulsation disappeared,and lower limb artery embolism or thrombosis were considered clinically.Double lower limbs CTA examination found that the right internal iliac artery ran down the lateral wall of the pelvic cavity to the lesser pelvis,then dividing into main trunk,wall branch and the visceral branch.展开更多
The formation of cerebral cortex is a highly ordered and strictly regulated development process,involving the production of various neural cells and the formation of nerve networks.The proliferation,differentiation,mi...The formation of cerebral cortex is a highly ordered and strictly regulated development process,involving the production of various neural cells and the formation of nerve networks.The proliferation,differentiation,migration and stratification of NSCs are the cytological basis of cerebral cortex development.It is.展开更多
The proper establishment of loop-vessel countercurrent arrangement in medulla provides the basis for formation of the concentrated urine.To date,the morphogenesis of it has not been fully discovered.The present study ...The proper establishment of loop-vessel countercurrent arrangement in medulla provides the basis for formation of the concentrated urine.To date,the morphogenesis of it has not been fully discovered.The present study investigated the spatial arrangement of nephron loop and vessel of developing kidneys using 3D visualization technique and immunohistochemistry for AQP-1 and NKCC2.Five-mm-thick serial paraffin sections were obtained from E14.5 and P5 kidneys and stained with hematoxylin,while 2.5-mm-thick serial epoxy sections were obtained from E17.5 and P56 kidneys and stained with toluidine blue.展开更多
This project intends to deploy image information such as magnetic resonance imaging(MRI)and digital subtraction angiography(DSA)com bined with stereo positioning system to scan,display and locate anatomical structures...This project intends to deploy image information such as magnetic resonance imaging(MRI)and digital subtraction angiography(DSA)com bined with stereo positioning system to scan,display and locate anatomical structures such as bones and joints in corpses and living bodies.We employ 3D point clouds as efficient representations of MRI,and propose point clouds denoising and inpainting leveraging on the field of graph signal processing.Virtual reality surgery for specific patients,such as arthroplasty,can be performed multiple times in the ward,and the calculated force is communicated to the operator through the force feedback device to obtain a feel that is close to the actual operation.展开更多
α-酮戊二酸(AKG)作为三羧酸循环中间体,在维持生理功能和细胞代谢中起重要作用。为总结AKG在生殖系统相关疾病中最新研究进展,查阅Pubmed、Web of Science、Base、EBSCO Host、Spischolar、Springerlink等数据库中的AKG最新相关实验研...α-酮戊二酸(AKG)作为三羧酸循环中间体,在维持生理功能和细胞代谢中起重要作用。为总结AKG在生殖系统相关疾病中最新研究进展,查阅Pubmed、Web of Science、Base、EBSCO Host、Spischolar、Springerlink等数据库中的AKG最新相关实验研究进行分析,总结当前的研究成果。研究表明,AKG可能在延缓生殖系统衰老和生殖系统疾病相关病因中起作用:①在糖代谢过程中,AKG可以显着促进糖代谢紊乱态下的细胞的增殖和分化,作为代谢底物,降低细胞对谷氨酰胺的依赖性,显著增强细胞的抗氧化能力,并提高细胞内ATP的水平,从而确保了能量不足状态下细胞的正常生长和代谢,有助于恢复糖代谢平衡;②在脂代谢过程中,AKG升高诱导肌肉肥大,棕色脂肪组织生热及白色脂肪组织脂肪分解,帮助脂代谢回归正常状态,减轻脂毒性,进一步改善饮食诱导的肥胖大鼠的全身胰岛素敏感性.展开更多
The rapid actions of androgen on synaptic plasticity have been extensively studied.However,the underlying mechanisms remain controversial.In this study,we used mouse hippocampal neuron cell line HT22 cells as a cell r...The rapid actions of androgen on synaptic plasticity have been extensively studied.However,the underlying mechanisms remain controversial.In this study,we used mouse hippocampal neuron cell line HT22 cells as a cell research model to investigate whether Ca^(2+)/CaMKII mediates androgen rapid actions on synaptic plasticity,especially for synaptic protein PSD95 expression.Using calcium imaging,we verified incubation with 100 nmol/L testosterone for 20 min had the most significant effect on intracellular Ca^(2+)level.In addition,the depolarization of resting membrane potential after testosterone stimulation was observed by patch clamp.We found that the depolarization of resting membrane potential was to-40 mV.展开更多
文摘CXCL3 belongs to the CXC-type chemokine family and is known to play a multifaceted role in various human malignancies.While it's clinical significance and mechanisms of action in uterine cervical cancer(UCC)remain unclear.This investigation demonstrated that the UCC cell line HeL.a expressed CXCL3,and strong expression of CXCL3 was detected in UCC tissues relative to nontumor tissues.In addition,CXCL3 expression was strongly correlated with CXCL5 expression in UCC tissues.In vitro,HeLa cells overexpressing CXCL3,HeLa cells treated with exogenous CXCL3 or treated with conditioned medium from WPMY cells overexpresing CXCL3,exhibited enhanced proliferation and migration activities.
文摘The transition of the inferior gluteal artery to the popliteal artery is an.extremely rare arterial variation.By using CT angiography(CTA),we found a case whose right inferior gluteal artery transferred to the popliteal artery.A 73-year-old female patient was admitted to our hospital with num bness,pain and low skin temperature in the right foot without obvious inducement".On physical examination,right dorsal foot artery pulsation disappeared,and lower limb artery embolism or thrombosis were considered clinically.Double lower limbs CTA examination found that the right internal iliac artery ran down the lateral wall of the pelvic cavity to the lesser pelvis,then dividing into main trunk,wall branch and the visceral branch.
文摘The formation of cerebral cortex is a highly ordered and strictly regulated development process,involving the production of various neural cells and the formation of nerve networks.The proliferation,differentiation,migration and stratification of NSCs are the cytological basis of cerebral cortex development.It is.
文摘The proper establishment of loop-vessel countercurrent arrangement in medulla provides the basis for formation of the concentrated urine.To date,the morphogenesis of it has not been fully discovered.The present study investigated the spatial arrangement of nephron loop and vessel of developing kidneys using 3D visualization technique and immunohistochemistry for AQP-1 and NKCC2.Five-mm-thick serial paraffin sections were obtained from E14.5 and P5 kidneys and stained with hematoxylin,while 2.5-mm-thick serial epoxy sections were obtained from E17.5 and P56 kidneys and stained with toluidine blue.
文摘This project intends to deploy image information such as magnetic resonance imaging(MRI)and digital subtraction angiography(DSA)com bined with stereo positioning system to scan,display and locate anatomical structures such as bones and joints in corpses and living bodies.We employ 3D point clouds as efficient representations of MRI,and propose point clouds denoising and inpainting leveraging on the field of graph signal processing.Virtual reality surgery for specific patients,such as arthroplasty,can be performed multiple times in the ward,and the calculated force is communicated to the operator through the force feedback device to obtain a feel that is close to the actual operation.
文摘α-酮戊二酸(AKG)作为三羧酸循环中间体,在维持生理功能和细胞代谢中起重要作用。为总结AKG在生殖系统相关疾病中最新研究进展,查阅Pubmed、Web of Science、Base、EBSCO Host、Spischolar、Springerlink等数据库中的AKG最新相关实验研究进行分析,总结当前的研究成果。研究表明,AKG可能在延缓生殖系统衰老和生殖系统疾病相关病因中起作用:①在糖代谢过程中,AKG可以显着促进糖代谢紊乱态下的细胞的增殖和分化,作为代谢底物,降低细胞对谷氨酰胺的依赖性,显著增强细胞的抗氧化能力,并提高细胞内ATP的水平,从而确保了能量不足状态下细胞的正常生长和代谢,有助于恢复糖代谢平衡;②在脂代谢过程中,AKG升高诱导肌肉肥大,棕色脂肪组织生热及白色脂肪组织脂肪分解,帮助脂代谢回归正常状态,减轻脂毒性,进一步改善饮食诱导的肥胖大鼠的全身胰岛素敏感性.
文摘The rapid actions of androgen on synaptic plasticity have been extensively studied.However,the underlying mechanisms remain controversial.In this study,we used mouse hippocampal neuron cell line HT22 cells as a cell research model to investigate whether Ca^(2+)/CaMKII mediates androgen rapid actions on synaptic plasticity,especially for synaptic protein PSD95 expression.Using calcium imaging,we verified incubation with 100 nmol/L testosterone for 20 min had the most significant effect on intracellular Ca^(2+)level.In addition,the depolarization of resting membrane potential after testosterone stimulation was observed by patch clamp.We found that the depolarization of resting membrane potential was to-40 mV.
